CN115003689A - 具有改变的表面残基的经设计的锚蛋白重复结构域 - Google Patents

具有改变的表面残基的经设计的锚蛋白重复结构域 Download PDF

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CN115003689A
CN115003689A CN202080093076.7A CN202080093076A CN115003689A CN 115003689 A CN115003689 A CN 115003689A CN 202080093076 A CN202080093076 A CN 202080093076A CN 115003689 A CN115003689 A CN 115003689A
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amino acid
seq
ankyrin repeat
designed ankyrin
protein
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Chinese (zh)
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K·宾兹
J·席林
P·福勒
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Molecular Partners AG
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Molecular Partners AG
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/74—Inducing cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2318/00—Antibody mimetics or scaffolds
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    • C07K2319/00—Fusion polypeptide
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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CN202080093076.7A 2019-12-11 2020-12-11 具有改变的表面残基的经设计的锚蛋白重复结构域 Pending CN115003689A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
EP19215435 2019-12-11
EP19215434.2 2019-12-11
EP19215433.4 2019-12-11
EP19215436.7 2019-12-11
EP19215434 2019-12-11
EP19215435.9 2019-12-11
EP19215433 2019-12-11
EP19215436 2019-12-11
EP20161059.9 2020-03-04
EP20161059 2020-03-04
EP20181234.4 2020-06-19
EP20181234 2020-06-19
PCT/EP2020/085855 WO2021116462A1 (en) 2019-12-11 2020-12-11 Designed ankyrin repeat domains with altered surface residues

Publications (1)

Publication Number Publication Date
CN115003689A true CN115003689A (zh) 2022-09-02

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CN202080093076.7A Pending CN115003689A (zh) 2019-12-11 2020-12-11 具有改变的表面残基的经设计的锚蛋白重复结构域
CN202080093012.7A Pending CN114929730A (zh) 2019-12-11 2020-12-11 重组肽-mhc复合物结合蛋白及其生成和用途

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CN202080093012.7A Pending CN114929730A (zh) 2019-12-11 2020-12-11 重组肽-mhc复合物结合蛋白及其生成和用途

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US (4) US20220106707A1 (https=)
EP (2) EP4073091A1 (https=)
JP (2) JP7794740B2 (https=)
KR (2) KR20220113492A (https=)
CN (2) CN115003689A (https=)
AU (2) AU2020402581A1 (https=)
BR (2) BR112022011456A2 (https=)
CA (2) CA3161326A1 (https=)
IL (2) IL293698A (https=)
MX (2) MX2022007120A (https=)
WO (2) WO2021116469A2 (https=)

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CA3161321A1 (en) 2021-06-17
AU2020402581A1 (en) 2022-06-23
EP4073092A2 (en) 2022-10-19
AU2020399230A1 (en) 2022-06-23
US20230340698A1 (en) 2023-10-26
JP7794740B2 (ja) 2026-01-06
KR20220113491A (ko) 2022-08-12
WO2021116462A1 (en) 2021-06-17
CA3161326A1 (en) 2021-06-17
US12435445B2 (en) 2025-10-07
AU2020402581A9 (en) 2022-07-14
MX2022007120A (es) 2022-09-09
US20230243070A1 (en) 2023-08-03
IL293704A (en) 2022-08-01
WO2021116469A3 (en) 2021-12-02
EP4073091A1 (en) 2022-10-19
BR112022011456A2 (pt) 2022-08-23
JP2023506765A (ja) 2023-02-20
BR112022011177A2 (pt) 2022-09-27
US11578427B2 (en) 2023-02-14
KR20220113492A (ko) 2022-08-12
US20220064234A1 (en) 2022-03-03
MX2022007122A (es) 2022-09-09
CN114929730A (zh) 2022-08-19
WO2021116469A2 (en) 2021-06-17
JP2023506757A (ja) 2023-02-20
US20220106707A1 (en) 2022-04-07
IL293698A (en) 2022-08-01

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