JP2004535195A5 - - Google Patents
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- Publication number
- JP2004535195A5 JP2004535195A5 JP2003507263A JP2003507263A JP2004535195A5 JP 2004535195 A5 JP2004535195 A5 JP 2004535195A5 JP 2003507263 A JP2003507263 A JP 2003507263A JP 2003507263 A JP2003507263 A JP 2003507263A JP 2004535195 A5 JP2004535195 A5 JP 2004535195A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- slyd
- fkpa
- group
- fkbp chaperone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037240 fusion proteins Human genes 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims 5
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims 5
- 230000000875 corresponding Effects 0.000 claims 5
- 108020004511 Recombinant DNA Proteins 0.000 claims 3
- 108060002923 TIG Proteins 0.000 claims 3
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 3
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Claims (7)
- 標的ポリペプチドをコードする少なくとも１つのヌクレオチド配列およびFKBPシャペロンをコードする少なくとも１つのヌクレオチド配列をその上流に含んでなる、融合タンパク質をコードする組換えDNA分子であって、該FKBPシャペロンがFkpA、SlyDおよびトリガー因子からなる群より選択されることに特徴を有する組換えDNA分子。
- 操作可能に連結された請求項１記載の組換えDNA分子を含んでなる発現ベクター。
- FkpA、SlyDおよびトリガー因子からなる群より選択されるFKBPシャペロンに対応する少なくとも１つのポリペプチド配列ならびに標的ペプチドに対応する少なくとも１つのポリペプチド配列を含有してなる組換え的に生成された融合タンパク質。
- FkpA、SlyDおよびトリガー因子からなる群より選択されるFKBPシャペロンに対応する少なくとも１つのポリペプチド配列、標的ペプチドに対応する少なくとも１つのポリペプチド配列、ならびに10〜100個のアミノ酸の少なくとも１つのペプチドリンカー配列を含有してなる組換え的に生成された融合タンパク質。
- 少なくとも１つの標的ポリペプチド、FkpA、SlyDおよびトリガー因子からなる群より選択されるFKBPシャペロンに対応する２つの配列ならびに10〜100個のアミノ酸の２つのペプチドリンカー配列を含有してなる組換え的に生成された融合タンパク質。
- 研究動物の免疫化への、請求項３〜５いずれか記載の組換え的に生成された融合タンパク質の使用。
- 免疫学的検定法における請求項３〜５いずれか記載の組換え的に生成された融合タンパク質の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01115225 | 2001-06-22 | ||
| EP01120939 | 2001-08-31 | ||
| PCT/EP2002/006957 WO2003000878A2 (en) | 2001-06-22 | 2002-06-24 | Use of fkbp chaperones as expression tool |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006326846A Division JP4309910B2 (ja) | 2001-06-22 | 2006-12-04 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535195A JP2004535195A (ja) | 2004-11-25 |
| JP2004535195A5 true JP2004535195A5 (ja) | 2005-08-25 |
| JP4174422B2 JP4174422B2 (ja) | 2008-10-29 |
Family
ID=26076626
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507262A Expired - Fee Related JP4262594B2 (ja) | 2001-06-22 | 2002-06-24 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
| JP2003507263A Expired - Fee Related JP4174422B2 (ja) | 2001-06-22 | 2002-06-24 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
| JP2006326846A Expired - Fee Related JP4309910B2 (ja) | 2001-06-22 | 2006-12-04 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
| JP2007183508A Expired - Fee Related JP4320351B2 (ja) | 2001-06-22 | 2007-07-12 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
| JP2008286959A Withdrawn JP2009102320A (ja) | 2001-06-22 | 2008-11-07 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
| JP2009025509A Expired - Fee Related JP4523660B2 (ja) | 2001-06-22 | 2009-02-06 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507262A Expired - Fee Related JP4262594B2 (ja) | 2001-06-22 | 2002-06-24 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006326846A Expired - Fee Related JP4309910B2 (ja) | 2001-06-22 | 2006-12-04 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
| JP2007183508A Expired - Fee Related JP4320351B2 (ja) | 2001-06-22 | 2007-07-12 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
| JP2008286959A Withdrawn JP2009102320A (ja) | 2001-06-22 | 2008-11-07 | レトロウイルス表面糖タンパク質を含む可溶性複合体 |
| JP2009025509A Expired - Fee Related JP4523660B2 (ja) | 2001-06-22 | 2009-02-06 | 発現ツールとしてのｆｋｂｐシャペロンの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7244819B2 (ja) |
| EP (3) | EP1402041B1 (ja) |
| JP (6) | JP4262594B2 (ja) |
| KR (2) | KR100611545B1 (ja) |
| CN (1) | CN100510068C (ja) |
| AT (2) | ATE522603T1 (ja) |
| AU (2) | AU2002317841A1 (ja) |
| BR (1) | BRPI0210598B8 (ja) |
| CA (3) | CA2449747C (ja) |
| DE (1) | DE60233942D1 (ja) |
| DK (2) | DK1402015T3 (ja) |
| ES (3) | ES2333108T3 (ja) |
| HK (1) | HK1068918A1 (ja) |
| MX (1) | MXPA03011455A (ja) |
| PL (2) | PL218245B1 (ja) |
| WO (2) | WO2003000877A2 (ja) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1402015T3 (da) * | 2001-06-22 | 2011-12-05 | Hoffmann La Roche | Opløseligt kompleks omfattende et retroviralt overfladeglycoprotein og FkpA eller SlyD |
| EP1516928B1 (en) * | 2002-06-25 | 2010-02-17 | Sekisui Chemical Co., Ltd. | Expression vector, host, fused protein, process for producing fused protein and process for producing protein |
| AU2003283205A1 (en) * | 2002-11-26 | 2004-06-18 | Danmarks Fodevare- Og Veterinaerforskning | Dendrimer conjugates for selective of protein aggregates |
| EP1621555A4 (en) * | 2003-04-18 | 2006-08-02 | Sekisui Chemical Co Ltd | IMMUNOGENIC, COMPOSITION FOR IMMUNOLOGICAL USE AND METHOD FOR THE PRODUCTION OF ANTIBODIES WITH THEIR USE |
| US9057061B2 (en) * | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
| US7604935B2 (en) | 2005-10-26 | 2009-10-20 | Roche Diagnostics Operations, Inc. | Soluble rubella E1 envelope protein variants |
| WO2007077008A1 (en) | 2006-01-03 | 2007-07-12 | Roche Diagnostics Gmbh | Chimaeric fusion protein with superior chaperone and folding activities |
| WO2007141650A2 (en) * | 2006-01-17 | 2007-12-13 | Instituto De Medicina Molecular | Compositions and methods for diagnosing hiv-2 infection |
| US8962262B2 (en) | 2006-05-11 | 2015-02-24 | Arbor Vita Corporation | Method of protein extraction from cells |
| GB0611405D0 (en) | 2006-06-09 | 2006-07-19 | Univ Belfast | FKBP-L: A novel inhibitor of angiogenesis |
| ATE529436T1 (de) | 2007-04-20 | 2011-11-15 | Hoffmann La Roche | Erkennung von primären infektionen mit krankheitserregern |
| WO2009031852A2 (en) * | 2007-09-06 | 2009-03-12 | Korea University Industry and Academy Cooperation Foundation | Preparation method of recombinant protein by use of a fusion expression partner |
| US9207240B2 (en) | 2007-11-14 | 2015-12-08 | Arbor Vita Corporation | Method of efficient extraction of protein from cells |
| ES2450998T3 (es) | 2007-12-13 | 2014-03-26 | F. Hoffmann-La Roche Ag | Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéola |
| EP2127678A1 (en) * | 2008-05-26 | 2009-12-02 | Roche Diagnostics GmbH | SlpA as a tool for recombinant protein and enzyme technology |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| CA2826142A1 (en) * | 2011-02-03 | 2012-08-09 | Xoma Technology Ltd. | Methods and materials for enhancing functional protein expression in bacteria |
| AR086250A1 (es) * | 2011-05-05 | 2013-11-27 | Hoffmann La Roche | Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| EP2617731A1 (en) | 2012-01-19 | 2013-07-24 | Roche Diagnostics GmbH | Soluble immunoreactive Treponema pallidum TpN47 antigens |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2706115A1 (en) | 2012-09-06 | 2014-03-12 | Roche Diagnostics GmbH | Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays |
| US9725511B2 (en) * | 2012-11-08 | 2017-08-08 | Hoffmann-La Roche Inc. | Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4 |
| ES2603589T3 (es) * | 2012-11-08 | 2017-02-28 | F. Hoffmann-La Roche Ag | Ácidos nucleicos que codifican polipéptidos quiméricos para la identificación sistemática de bibliotecas |
| AU2013343667A1 (en) | 2012-11-08 | 2015-04-02 | F. Hoffmann-La Roche Ag | HER3 antigen binding proteins binding to the beta-hairpin of HER3 |
| EP2827146A1 (en) | 2013-07-18 | 2015-01-21 | Roche Diagnostics GmbH | Vibrio cholerae lipoprotein 15 (Lp15) variants as anti-interference additive in TpN17-based immunoassays for detection of anti-Treponema antibodies |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| WO2015044083A1 (en) * | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Thermus thermophilus slyd fkbp domain specific antibodies |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP2913338A1 (en) | 2014-02-28 | 2015-09-02 | Roche Diagniostics GmbH | Soluable and immunoreactive variants of HTLV capsid antigen p24 |
| JP2015215244A (ja) * | 2014-05-12 | 2015-12-03 | 富士レビオ株式会社 | 免疫測定における抗ｈｔｌｖ抗体の検出感度を向上させる方法 |
| BR112016024457A2 (pt) | 2014-05-14 | 2018-01-23 | Hoffmann La Roche | anticorpo isolado, imunoconjugado, uso do anticorpo, formulação farmacêutica, ácido nucleico isolado, célula hospedeira e método de produção de um anticorpo |
| MX2016014862A (es) * | 2014-05-14 | 2017-02-27 | Hoffmann La Roche | Her3 / her2 anticuerpos biespecificos que se unen a la horquilla beta de her3 y al dominio ii de her2. |
| BR112017011662A2 (pt) | 2014-12-01 | 2018-02-27 | Pfenex Inc | parceiros de fusão para a produção de peptídeo |
| US20180023098A1 (en) * | 2015-02-13 | 2018-01-25 | Sekisui Chemical Co., Ltd. | Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| JP6967002B2 (ja) * | 2015-12-15 | 2021-11-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | トランスグルタミナーゼ認識部位を有するｆｋｂｐドメイン |
| JP7044721B2 (ja) | 2016-05-31 | 2022-03-30 | エフ．ホフマン－ラ ロシュ アーゲー | Ｈｃｖコア抗原の迅速な検出のための前処理法 |
| KR102165623B1 (ko) | 2016-05-31 | 2020-10-15 | 에프. 호프만-라 로슈 아게 | 바이러스 항원의 혈청학적 탐지 방법 |
| EP3472322B1 (en) * | 2016-06-20 | 2022-01-05 | MetGen Oy | Method for obtaining active insoluble xylose isomerase |
| ES2865511T3 (es) | 2017-02-02 | 2021-10-15 | Hoffmann La Roche | Inmunoanálisis que usa al menos dos agentes de unión específica a analito pegilado |
| CN110709410A (zh) | 2017-04-26 | 2020-01-17 | 豪夫迈·罗氏有限公司 | 可溶性和免疫反应性寨卡病毒ns1多肽 |
| BR112019027491A2 (pt) | 2017-07-27 | 2020-07-07 | F. Hoffmann-La Roche Ag | proteína de fusão multiepítopo, método de produção de uma proteína, uso de uma proteína, método para detectar o antígeno e kit |
| CN110066343B (zh) * | 2019-05-23 | 2021-04-09 | 北京新创生物工程有限公司 | 一种用于检测hiv新发感染的重组抗原及其应用 |
| WO2021214248A1 (en) | 2020-04-23 | 2021-10-28 | F. Hoffmann-La Roche Ag | Corona nucleocapsid antigen for use in antibody-immunoassays |
| WO2023012321A1 (en) | 2021-08-06 | 2023-02-09 | Roche Diagnostics Gmbh | Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification |
| WO2023213758A1 (en) | 2022-05-03 | 2023-11-09 | F. Hoffmann-La Roche Ag | Hiv gp41 variants for immunodiagnostic assays |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2095818B (en) | 1981-03-27 | 1985-10-02 | Exxon Research Engineering Co | Staged adsorption/resorption heat pump |
| US4735896A (en) | 1986-03-04 | 1988-04-05 | United Biomedical, Inc. | Synthetic peptide and process of using same for the detection and diagnosis of AIDS and pre-AIDS conditions |
| US4879212A (en) | 1986-04-02 | 1989-11-07 | United Biomedical Inc. | Peptide composition and method for the detection of antibodies to HTLV-III |
| US5811128A (en) | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| DE3705686C2 (de) | 1987-02-23 | 1995-11-30 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von Antikörpern |
| NZ224663A (en) | 1987-05-28 | 1990-11-27 | Amrad Corp Ltd | Fusion proteins containing glutathione-s-transferase and expression of foreign polypeptides using glutathione-s-transferase encoding vectors |
| SE8704185L (sv) | 1987-10-28 | 1989-04-29 | Ferring Ab | Nya peptider, artificiella antigener och immunoanalystestsatser |
| CA2003383A1 (en) * | 1988-11-23 | 1990-05-23 | Sushil G. Devare | Synthetic dna derived recombinant hiv antigens |
| AU667669B2 (en) | 1991-06-14 | 1996-04-04 | Idexx Laboratories, Inc. | Detection of mammalian immunodeficiency viruses |
| JPH07504561A (ja) * | 1991-12-20 | 1995-05-25 | ノボ ノルディスク アクティーゼルスカブ | リパーゼの製造のための方法 |
| JP2001504572A (ja) | 1992-04-09 | 2001-04-03 | アボツト・ラボラトリーズ | Ｈｉｖ抗原及びｈｉｖ抗体を検出するためのアッセイ |
| AU4400593A (en) | 1992-06-05 | 1994-01-04 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
| EP0663010B1 (en) | 1992-10-02 | 2000-08-09 | Research Corporation Technologies, Inc. | Methods for increasing secretion of overexpressed proteins |
| US5459051A (en) | 1993-03-26 | 1995-10-17 | Celtrix Pharmaceuticals, Inc. | Methods and vectors for over-expression of ubiquitin fusion proteins in host cells |
| DE4428705A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
| AU3968595A (en) | 1994-10-25 | 1996-05-15 | Board Of Trustees Of The Leland Stanford Junior University | Conditional transformation of genetically engineered cells |
| CA2219080A1 (en) | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamycin-based regulation of biological events |
| EP0855029A4 (en) | 1995-09-15 | 2000-03-08 | Merck & Co Inc | HIGH YIELD ASSAY USING FUSION PROTEINS |
| US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| GB9614114D0 (en) | 1996-07-05 | 1996-09-04 | Amcor Packaging Uk Ltd | New packages |
| JP2001501093A (ja) | 1996-09-26 | 2001-01-30 | メディカル リサーチ カウンシル | シャペロン断片 |
| US6225082B1 (en) | 1997-05-09 | 2001-05-01 | Research Corporation Technologies, Inc. | Myelin basic protein MRNA transport and translation enhancer sequences |
| US5989868A (en) * | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
| JP2002508971A (ja) | 1998-01-15 | 2002-03-26 | アリアド・ジーン・セラピューティクス・インコーポレーテッド | 多量体キメラ蛋白質を使用する生物学的イベントの調節 |
| DE19913117A1 (de) * | 1998-05-06 | 1999-11-11 | Roche Diagnostics Gmbh | Entstörung durch Rheumafaktoren |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| ATE473755T1 (de) * | 1998-10-02 | 2010-07-15 | Rhein Biotech Proz & Prod Gmbh | Methode zur herstellung von (poly)peptiden unter verwendung von verkürzten varianten von sv40 large t antigen mit einem intakten n terminus |
| WO2000028011A2 (en) | 1998-11-06 | 2000-05-18 | President And Fellows Of Harvard College | Fk506-based regulation of biological events |
| WO2000055183A1 (en) | 1999-03-17 | 2000-09-21 | Medical Research Council | Method for refolding molecules of polypeptides containing ig domains |
| EP1189934A2 (en) | 1999-05-14 | 2002-03-27 | Medical Research Council | Oligomeric chaperone proteins |
| GB9913437D0 (en) | 1999-06-09 | 1999-08-11 | Medical Res Council | Fusion proteins |
| EP1077263A1 (de) * | 1999-07-29 | 2001-02-21 | F.Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen |
| CA2403718A1 (en) | 2000-03-17 | 2001-09-27 | Panacos Pharmaceuticals, Inc. | A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of hiv envelope proteins |
| JP2002262883A (ja) * | 2001-03-13 | 2002-09-17 | Sekisui Chem Co Ltd | モノクローナル抗体の製造方法 |
| DK1402015T3 (da) * | 2001-06-22 | 2011-12-05 | Hoffmann La Roche | Opløseligt kompleks omfattende et retroviralt overfladeglycoprotein og FkpA eller SlyD |
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2002
- 2002-06-24 DK DK02758265.9T patent/DK1402015T3/da active
- 2002-06-24 JP JP2003507262A patent/JP4262594B2/ja not_active Expired - Fee Related
- 2002-06-24 KR KR1020067005314A patent/KR100611545B1/ko not_active IP Right Cessation
- 2002-06-24 CA CA2449747A patent/CA2449747C/en not_active Expired - Lifetime
- 2002-06-24 AT AT02758265T patent/ATE522603T1/de active
- 2002-06-24 CN CNB028124715A patent/CN100510068C/zh not_active Expired - Lifetime
- 2002-06-24 PL PL397776A patent/PL218245B1/pl unknown
- 2002-06-24 EP EP02747428A patent/EP1402041B1/en not_active Expired - Lifetime
- 2002-06-24 ES ES02747428T patent/ES2333108T3/es not_active Expired - Lifetime
- 2002-06-24 AT AT02747428T patent/ATE445016T1/de active
- 2002-06-24 EP EP10173342A patent/EP2267452B8/en not_active Expired - Lifetime
- 2002-06-24 EP EP02758265A patent/EP1402015B1/en not_active Expired - Lifetime
- 2002-06-24 WO PCT/EP2002/006956 patent/WO2003000877A2/en active IP Right Grant
- 2002-06-24 CA CA2770453A patent/CA2770453C/en not_active Expired - Fee Related
- 2002-06-24 JP JP2003507263A patent/JP4174422B2/ja not_active Expired - Fee Related
- 2002-06-24 CA CA2450476A patent/CA2450476C/en not_active Expired - Lifetime
- 2002-06-24 US US10/179,038 patent/US7244819B2/en not_active Expired - Lifetime
- 2002-06-24 KR KR1020037016770A patent/KR100702373B1/ko active IP Right Grant
- 2002-06-24 AU AU2002317841A patent/AU2002317841A1/en not_active Abandoned
- 2002-06-24 MX MXPA03011455A patent/MXPA03011455A/es active IP Right Grant
- 2002-06-24 AU AU2002325265A patent/AU2002325265B2/en not_active Expired
- 2002-06-24 BR BRPI0210598 patent/BRPI0210598B8/pt not_active IP Right Cessation
- 2002-06-24 PL PL367679A patent/PL215170B1/pl unknown
- 2002-06-24 ES ES02758265T patent/ES2372031T3/es not_active Expired - Lifetime
- 2002-06-24 ES ES10173342T patent/ES2391623T3/es not_active Expired - Lifetime
- 2002-06-24 DE DE60233942T patent/DE60233942D1/de not_active Expired - Lifetime
- 2002-06-24 DK DK10173342.6T patent/DK2267452T3/da active
- 2002-06-24 WO PCT/EP2002/006957 patent/WO2003000878A2/en active Search and Examination
-
2005
- 2005-02-21 HK HK05101435.6A patent/HK1068918A1/xx not_active IP Right Cessation
-
2006
- 2006-12-04 JP JP2006326846A patent/JP4309910B2/ja not_active Expired - Fee Related
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2007
- 2007-04-13 US US11/786,847 patent/US8426167B2/en active Active
- 2007-07-12 JP JP2007183508A patent/JP4320351B2/ja not_active Expired - Fee Related
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2008
- 2008-11-07 JP JP2008286959A patent/JP2009102320A/ja not_active Withdrawn
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2009
- 2009-02-06 JP JP2009025509A patent/JP4523660B2/ja not_active Expired - Fee Related
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