BR112017011662A2 - parceiros de fusão para a produção de peptídeo - Google Patents

parceiros de fusão para a produção de peptídeo

Info

Publication number
BR112017011662A2
BR112017011662A2 BR112017011662A BR112017011662A BR112017011662A2 BR 112017011662 A2 BR112017011662 A2 BR 112017011662A2 BR 112017011662 A BR112017011662 A BR 112017011662A BR 112017011662 A BR112017011662 A BR 112017011662A BR 112017011662 A2 BR112017011662 A2 BR 112017011662A2
Authority
BR
Brazil
Prior art keywords
fusion partners
peptide production
production
polypeptide
interest
Prior art date
Application number
BR112017011662A
Other languages
English (en)
Inventor
Torben R Bruck
Adam Chapman
Hongfan Jin
Diane M Retallack
Original Assignee
Pfenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfenex Inc filed Critical Pfenex Inc
Publication of BR112017011662A2 publication Critical patent/BR112017011662A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21009—Enteropeptidase (3.4.21.9), i.e. enterokinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção refere-se ao campo da medicina, em particular, ao da produção de grandes quantidades de um polipeptídeo recombinante solúvel como parte de uma proteína de fusão compreendendo um parceiro de fusão de terminal n ligado ao polipeptídeo de interesse.
BR112017011662A 2014-12-01 2015-11-30 parceiros de fusão para a produção de peptídeo BR112017011662A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462086119P 2014-12-01 2014-12-01
PCT/US2015/063027 WO2016089782A1 (en) 2014-12-01 2015-11-30 Fusion partners for peptide production

Publications (1)

Publication Number Publication Date
BR112017011662A2 true BR112017011662A2 (pt) 2018-02-27

Family

ID=56092296

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017011662A BR112017011662A2 (pt) 2014-12-01 2015-11-30 parceiros de fusão para a produção de peptídeo

Country Status (18)

Country Link
US (2) US10118956B2 (pt)
EP (1) EP3227455B1 (pt)
JP (2) JP6817939B2 (pt)
KR (1) KR102353262B1 (pt)
CN (2) CN113444183A (pt)
AR (1) AR102865A1 (pt)
AU (1) AU2015355242B2 (pt)
BR (1) BR112017011662A2 (pt)
CA (1) CA2966358C (pt)
DK (1) DK3227455T3 (pt)
ES (1) ES2952405T3 (pt)
HK (1) HK1245336A1 (pt)
MX (1) MX2017006866A (pt)
NZ (1) NZ732400A (pt)
RU (1) RU2017123283A (pt)
SG (1) SG11201704362VA (pt)
TW (1) TWI702289B (pt)
WO (1) WO2016089782A1 (pt)

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KR102017540B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-1 또는 이의 유사체를 생산하는 방법
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KR20210010367A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 인간부갑상선호르몬1-34 생산용 융합태그
KR20210010368A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-2 또는 이의 유사체 생산용 융합태그
KR20210010366A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-1 또는 이의 유사체 생산용 융합태그
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113151296B (zh) * 2021-03-22 2022-09-13 云南中烟工业有限责任公司 一种烟草热激蛋白相关的基因及其应用
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用
CN112941058B (zh) * 2021-04-02 2023-12-05 重庆科润生物医药研发有限公司 一种重组溶组织梭菌ii型胶原酶及其制备方法和应用
KR20240021234A (ko) * 2021-06-10 2024-02-16 펠리칸 테크놀로지 홀딩스, 인크. 재조합 단백질 발현을 위한 박테리아 숙주
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CN113444183A (zh) 2021-09-28
MX2017006866A (es) 2017-11-15
ES2952405T3 (es) 2023-10-31
CN107532190A (zh) 2018-01-02
DK3227455T3 (da) 2023-08-21
US10118956B2 (en) 2018-11-06
TW201629226A (zh) 2016-08-16
AU2015355242B2 (en) 2020-10-08
KR20170085129A (ko) 2017-07-21
SG11201704362VA (en) 2017-06-29
HK1245336A1 (zh) 2018-08-24
CN107532190B (zh) 2021-07-09
KR102353262B1 (ko) 2022-01-18
US10981968B2 (en) 2021-04-20
US20160159877A1 (en) 2016-06-09
JP6817939B2 (ja) 2021-01-20
AR102865A1 (es) 2017-03-29
CA2966358C (en) 2021-12-07
EP3227455A1 (en) 2017-10-11
RU2017123283A (ru) 2019-01-09
JP2021003117A (ja) 2021-01-14
US20190135889A1 (en) 2019-05-09
JP7148579B2 (ja) 2022-10-05
EP3227455A4 (en) 2018-07-04
AU2015355242A1 (en) 2017-06-22
JP2017536835A (ja) 2017-12-14
WO2016089782A1 (en) 2016-06-09
NZ732400A (en) 2021-07-30
CA2966358A1 (en) 2016-06-09
EP3227455B1 (en) 2023-07-12
TWI702289B (zh) 2020-08-21

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