JP2010529860A5 - - Google Patents
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- Publication number
- JP2010529860A5 JP2010529860A5 JP2010512391A JP2010512391A JP2010529860A5 JP 2010529860 A5 JP2010529860 A5 JP 2010529860A5 JP 2010512391 A JP2010512391 A JP 2010512391A JP 2010512391 A JP2010512391 A JP 2010512391A JP 2010529860 A5 JP2010529860 A5 JP 2010529860A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- amino acid
- fusion protein
- amino acids
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 16
- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 108020001756 ligand binding domains Proteins 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000036252 glycation Effects 0.000 claims 2
- 102000049409 human MOK Human genes 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94399407P | 2007-06-14 | 2007-06-14 | |
| US60/943,994 | 2007-06-14 | ||
| PCT/US2008/066956 WO2008157378A2 (en) | 2007-06-14 | 2008-06-13 | Page fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015038891A Division JP5887441B2 (ja) | 2007-06-14 | 2015-02-27 | Ｒａｇｅ融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529860A JP2010529860A (ja) | 2010-09-02 |
| JP2010529860A5 true JP2010529860A5 (https=) | 2011-07-28 |
| JP5706688B2 JP5706688B2 (ja) | 2015-04-22 |
Family
ID=40156919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512391A Active JP5706688B2 (ja) | 2007-06-14 | 2008-06-13 | Ｒａｇｅ融合タンパク質 |
| JP2015038891A Active JP5887441B2 (ja) | 2007-06-14 | 2015-02-27 | Ｒａｇｅ融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015038891A Active JP5887441B2 (ja) | 2007-06-14 | 2015-02-27 | Ｒａｇｅ融合タンパク質 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8398977B2 (https=) |
| EP (1) | EP2158210B1 (https=) |
| JP (2) | JP5706688B2 (https=) |
| KR (2) | KR101595634B1 (https=) |
| CN (1) | CN101842382A (https=) |
| AU (1) | AU2008265983B2 (https=) |
| CA (1) | CA2690056C (https=) |
| CO (1) | CO6241158A2 (https=) |
| EC (1) | ECSP099804A (https=) |
| ES (1) | ES2564634T3 (https=) |
| IL (1) | IL202443B (https=) |
| MX (1) | MX2009013194A (https=) |
| NZ (1) | NZ581550A (https=) |
| PL (1) | PL2158210T3 (https=) |
| RU (1) | RU2513695C2 (https=) |
| WO (1) | WO2008157378A2 (https=) |
| ZA (1) | ZA200908649B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20105110B (en) | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| PL2185589T3 (pl) | 2007-06-01 | 2016-09-30 | Środki wiążące receptor regionu stałego Fc immunoglobuliny | |
| RU2553225C2 (ru) | 2008-05-23 | 2015-06-10 | Сива Корпорейшн | Способ облегчения регенерации |
| AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| WO2011102845A1 (en) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| TWI542597B (zh) | 2010-07-28 | 2016-07-21 | 吉林尼克公司 | 產生依序多聚體化免疫球蛋白ｆｃ組合物之天然人類蛋白質片段之融合蛋白 |
| ES2725852T3 (es) | 2010-09-27 | 2019-09-27 | Siwa Corp | Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| WO2013112986A1 (en) * | 2012-01-27 | 2013-08-01 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
| EP3711484A1 (en) * | 2013-07-05 | 2020-09-23 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Soluble cd33 for treating myelodysplastic syndromes (mds) |
| EP3194439B1 (en) | 2014-09-19 | 2022-01-19 | Siwa Corporation | Anti-age antibodies for treating inflammation and auto-immune disorders |
| JP6679096B2 (ja) * | 2014-10-21 | 2020-04-15 | 学校法人 久留米大学 | Ｒａｇｅアプタマーおよびその用途 |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| KR20250053203A (ko) | 2015-07-24 | 2025-04-21 | 글리크닉 인코포레이티드 | 향상된 상보체 결합을 갖는 규칙적으로 다형체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| HUE058854T2 (hu) | 2016-02-19 | 2022-09-28 | Siwa Corp | Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával |
| KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
| AU2017279538A1 (en) | 2016-06-07 | 2019-01-03 | Gliknik Inc. | Cysteine-optimized stradomers |
| JP2019518763A (ja) | 2016-06-23 | 2019-07-04 | シワ コーポレーション | 様々な疾患及び障害の治療において使用するためのワクチン |
| CN110022898B (zh) | 2016-12-09 | 2023-07-04 | 格利克尼克股份有限公司 | 用多价Fc化合物治疗炎性疾病的方法 |
| MX2019006573A (es) | 2016-12-09 | 2019-11-18 | Gliknik Inc | Optimizacion de fabricacion de gl-2045 un stradomer multimerizante. |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| JP6964322B2 (ja) * | 2017-03-13 | 2021-11-10 | 学校法人 久留米大学 | ループス腎炎を処置または予防するための医薬組成物およびループス腎炎のバイオマーカー |
| CA3059803A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| JP7307178B2 (ja) * | 2018-09-14 | 2023-07-11 | バイオエイジ ラブス， インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するｒａｇｅ融合タンパク質ならびにその使用 |
| US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
| CN118043351A (zh) * | 2021-08-31 | 2024-05-14 | 上海医药集团股份有限公司 | 靶向Siglec15的抗原结合蛋白及其用途 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| AU670125B2 (en) | 1992-09-15 | 1996-07-04 | Immunex Corporation | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5656261A (en) * | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
| DE69629176T2 (de) * | 1995-01-18 | 2004-06-03 | Alteon Inc. | Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung |
| FI119756B (fi) * | 1995-01-18 | 2009-03-13 | Alteon Inc | Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa |
| AU1832797A (en) | 1996-01-26 | 1997-08-20 | Trustees Of Columbia University In The City Of New York, The | A polypeptide from lung extract which binds amyloid-beta peptide |
| WO1997039121A1 (en) | 1996-04-16 | 1997-10-23 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| US5819341A (en) * | 1996-05-24 | 1998-10-13 | Simantob; Constance | Collapsible and convertible combination baby bed and baby carrier system |
| US6790442B1 (en) * | 1996-06-27 | 2004-09-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6555651B2 (en) * | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| JP2001514661A (ja) | 1997-03-11 | 2001-09-11 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病の処置における使用のための薬剤の同定 |
| US7101838B2 (en) | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
| US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6465422B1 (en) | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| WO2000018970A1 (fr) | 1998-09-29 | 2000-04-06 | Asahi Kasei Kabushiki Kaisha | Procede de commande de liberation de granules |
| US6753150B2 (en) | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| AU765719B2 (en) * | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| US6787566B2 (en) * | 1999-04-05 | 2004-09-07 | City Of Hope | Breakers of advanced glycation endproducts |
| US6605642B2 (en) * | 1999-04-05 | 2003-08-12 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGES) |
| US6589944B1 (en) | 1999-04-05 | 2003-07-08 | City Of Hope | Breakers of advanced glycation endproducts |
| FR2797402B1 (fr) | 1999-07-15 | 2004-03-12 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| CA2382095A1 (en) | 1999-08-13 | 2001-02-22 | The Trustees Of Columbia University In The City Of New York | Methods of inhibiting binding of .beta.-sheet fibril to rage and consequences thereof |
| EP1219639A4 (en) | 1999-09-08 | 2009-03-25 | Toray Industries | CIPO - Patent |
| CA2356207C (en) | 1999-10-21 | 2012-10-09 | Case Western Reserve University | Gene expression profiling of inflammatory bowel disease |
| JP2003516150A (ja) * | 1999-12-08 | 2003-05-13 | ジェンセット | 潜在性分泌タンパク質をコードする全長ヒトｃＤＮＡ |
| NZ521437A (en) | 2000-02-25 | 2004-04-30 | Immunex Corp | Integrin antagonists suitable as inhibitors of angiogenesis |
| US6716635B2 (en) * | 2000-04-14 | 2004-04-06 | University Of Kentucky Research Foundation | Method for identifying regulators of protein-advanced glycation end product (protein-AGE) formation |
| AU2001255436A1 (en) | 2000-04-17 | 2001-10-30 | Transtech Pharma | Protein expression system arrays and use in biological screening |
| US7140063B2 (en) | 2000-05-05 | 2006-11-28 | Osborne James J | Multi-use and decorative bathing implement |
| JP2005520479A (ja) | 2000-05-09 | 2005-07-14 | ジェネティクス インスティテュート，エルエルシー | 乾癬の確認、評価、予防および治療のための組成物、キットおよび方法 |
| US6613801B2 (en) | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US6908741B1 (en) | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US20020052475A1 (en) | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| DE60123998T2 (de) | 2000-08-08 | 2007-09-06 | Zymogenetics, Inc., Seattle | Lösliche zcyctor 11 cytokinrezeptoren |
| US6825164B1 (en) * | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| CA2424246A1 (en) * | 2000-10-02 | 2002-04-11 | Shianlen Cahoon | Methods and compositions for the treatment of inflammatory diseases |
| EP1373501A2 (en) | 2000-10-06 | 2004-01-02 | Novartis AG | Targeting molecules for adenoviral vectors |
| AU2002213192A1 (en) | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| PL366250A1 (en) * | 2000-12-29 | 2005-01-24 | Reddy Us Therapeutics, Inc. | Detection of compounds that modulate inflammatory responses |
| DE10164805B4 (de) | 2001-02-28 | 2011-02-10 | Koch-Pelster, Brigitte, Dr. | Verfahren und Mittel zur Modifikation humaner Angiogenese |
| JP3837494B2 (ja) * | 2001-03-19 | 2006-10-25 | 国立大学法人金沢大学 | 可溶型ｒａｇｅタンパク質 |
| EP1575513A4 (en) * | 2002-08-16 | 2007-04-04 | Wyeth Corp | COMPOSITIONS AND METHODS FOR TREATING RAGE-ASSOCIATED DISEASES |
| EP1771565B1 (en) * | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| SG161242A1 (en) * | 2004-08-03 | 2010-05-27 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| GEP20105110B (en) * | 2004-08-03 | 2010-11-10 | Transtech Pharma Inc | Rage fusion proteins and their use |
| WO2006036922A2 (en) * | 2004-09-27 | 2006-04-06 | Centocor, Inc. | Srage mimetibody, compositions, methods and uses |
| EP1833976A2 (en) * | 2004-12-03 | 2007-09-19 | Xoma Technology Ltd. | Methods and materials for expression of a recombinant protein |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| WO2007011606A2 (en) | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| NZ612578A (en) | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
| SG171670A1 (en) | 2006-05-05 | 2011-06-29 | Transtech Pharma Inc | Rage fusion proteins, formulations, and methods of use thereof |
| NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
| WO2008100470A2 (en) | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| WO2008137552A2 (en) | 2007-05-02 | 2008-11-13 | Medimmune, Llc | Anti-rage antibodies and methods of use thereof |
| US20100254983A1 (en) | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
-
2008
- 2008-06-13 KR KR1020137011740A patent/KR101595634B1/ko active Active
- 2008-06-13 EP EP08771049.7A patent/EP2158210B1/en active Active
- 2008-06-13 ES ES08771049.7T patent/ES2564634T3/es active Active
- 2008-06-13 WO PCT/US2008/066956 patent/WO2008157378A2/en not_active Ceased
- 2008-06-13 PL PL08771049T patent/PL2158210T3/pl unknown
- 2008-06-13 RU RU2010100913/10A patent/RU2513695C2/ru active
- 2008-06-13 CN CN200880102246A patent/CN101842382A/zh active Pending
- 2008-06-13 US US12/664,111 patent/US8398977B2/en active Active
- 2008-06-13 JP JP2010512391A patent/JP5706688B2/ja active Active
- 2008-06-13 CA CA2690056A patent/CA2690056C/en active Active
- 2008-06-13 KR KR1020107000753A patent/KR101361355B1/ko active Active
- 2008-06-13 MX MX2009013194A patent/MX2009013194A/es active IP Right Grant
- 2008-06-13 NZ NZ581550A patent/NZ581550A/en unknown
- 2008-06-13 AU AU2008265983A patent/AU2008265983B2/en active Active
-
2009
- 2009-12-01 IL IL202443A patent/IL202443B/en active IP Right Grant
- 2009-12-07 ZA ZA200908649A patent/ZA200908649B/xx unknown
- 2009-12-11 CO CO09142110A patent/CO6241158A2/es active IP Right Grant
- 2009-12-14 EC EC2009009804A patent/ECSP099804A/es unknown
-
2013
- 2013-02-14 US US13/767,081 patent/US9066927B2/en active Active
-
2015
- 2015-02-27 JP JP2015038891A patent/JP5887441B2/ja active Active
- 2015-05-22 US US14/720,107 patent/US9399668B2/en active Active
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