JP2014526881A5 - - Google Patents
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- Publication number
- JP2014526881A5 JP2014526881A5 JP2014515207A JP2014515207A JP2014526881A5 JP 2014526881 A5 JP2014526881 A5 JP 2014526881A5 JP 2014515207 A JP2014515207 A JP 2014515207A JP 2014515207 A JP2014515207 A JP 2014515207A JP 2014526881 A5 JP2014526881 A5 JP 2014526881A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- ubiquitin
- heterodimeric
- modified
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000044159 Ubiquitin Human genes 0.000 claims 48
- 108090000848 Ubiquitin Proteins 0.000 claims 48
- 150000001413 amino acids Chemical class 0.000 claims 18
- 239000000178 monomer Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 8
- 102000037865 fusion proteins Human genes 0.000 claims 8
- 239000004480 active ingredient Substances 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102220523178 Mitogen-activated protein kinase kinase kinase 7_K63W_mutation Human genes 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 102200015255 rs121912297 Human genes 0.000 claims 1
- 102220333332 rs869025616 Human genes 0.000 claims 1
- 102000019485 ubiquitin binding proteins Human genes 0.000 claims 1
- 108091016210 ubiquitin binding proteins Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170054.8 | 2011-06-15 | ||
| EP11170054 | 2011-06-15 | ||
| PCT/EP2012/061455 WO2012172055A1 (en) | 2011-06-15 | 2012-06-15 | Dimeric binding proteins based on modified ubiquitins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526881A JP2014526881A (ja) | 2014-10-09 |
| JP2014526881A5 true JP2014526881A5 (https=) | 2015-05-28 |
| JP6146821B2 JP6146821B2 (ja) | 2017-06-14 |
Family
ID=44680786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515207A Active JP6146821B2 (ja) | 2011-06-15 | 2012-06-15 | 修飾ユビキチンに基づく二量体型結合タンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9492572B2 (https=) |
| EP (1) | EP2721152B1 (https=) |
| JP (1) | JP6146821B2 (https=) |
| AU (1) | AU2012268970B2 (https=) |
| CA (1) | CA2837804C (https=) |
| DK (1) | DK2721152T3 (https=) |
| IL (1) | IL229722A (https=) |
| WO (1) | WO2012172055A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4088742B2 (ja) | 2000-12-26 | 2008-05-21 | 信越化学工業株式会社 | フォトマスクブランクス、フォトマスク及びフォトマスクブランクスの製造方法 |
| JP2002244274A (ja) | 2001-02-13 | 2002-08-30 | Shin Etsu Chem Co Ltd | フォトマスクブランク、フォトマスク及びこれらの製造方法 |
| EP1859028B1 (en) * | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Vascular endothelial cells |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| WO2016124670A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CN109963864B (zh) | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| MX2021007283A (es) | 2018-12-18 | 2021-07-15 | Navigo Proteins Gmbh | Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer. |
| JP7854204B2 (ja) * | 2020-11-09 | 2026-05-01 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｉｉ型コラーゲン結合タンパク質 |
| KR20250090347A (ko) * | 2022-10-24 | 2025-06-19 | 나피고 프로타인스 게엠베하 | 프로그램화 사멸 리간드 1 (pd-l1)에 대한 높은 결합 친화도를 갖는 신규한 단백질 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| US5958684A (en) | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
| WO1997016556A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| WO1998054312A1 (en) | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030045681A1 (en) | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| AU2001239470A1 (en) | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| US6799121B2 (en) | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
| US20110179531A1 (en) | 2000-05-09 | 2011-07-21 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| DE10324447A1 (de) * | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| AU2003250972A1 (en) | 2003-07-14 | 2005-01-28 | Mattex Leisure Industries | Artificial turf filament and artificial turf system |
| WO2005044845A2 (en) | 2003-11-04 | 2005-05-19 | Yale University | Protein binding miniature proteins |
| US7393918B2 (en) | 2003-12-11 | 2008-07-01 | Yale University | Protein binding miniature proteins and uses thereof |
| DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| CA2607954A1 (en) | 2005-05-11 | 2006-11-16 | Philogen S.P.A. | Conjugate for targeting of drug |
| ATE463512T1 (de) | 2005-11-09 | 2010-04-15 | Morphosys Ag | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
| EP1842553A1 (en) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule |
| CA2648484A1 (en) | 2006-05-08 | 2007-11-15 | Philogen Spa | Antibody-targeted cytokines for therapy |
| EP1892248A1 (en) | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| RU2553333C2 (ru) * | 2009-12-14 | 2015-06-10 | Сцил Протеинс Гмбх | Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
-
2012
- 2012-06-15 CA CA2837804A patent/CA2837804C/en active Active
- 2012-06-15 AU AU2012268970A patent/AU2012268970B2/en not_active Ceased
- 2012-06-15 WO PCT/EP2012/061455 patent/WO2012172055A1/en not_active Ceased
- 2012-06-15 JP JP2014515207A patent/JP6146821B2/ja active Active
- 2012-06-15 DK DK12729509.5T patent/DK2721152T3/da active
- 2012-06-15 US US14/126,358 patent/US9492572B2/en active Active
- 2012-06-15 EP EP12729509.5A patent/EP2721152B1/en active Active
-
2013
- 2013-11-28 IL IL229722A patent/IL229722A/en active IP Right Grant
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