JP2004528556A5 - - Google Patents

Download PDF

Info

Publication number
JP2004528556A5
JP2004528556A5 JP2002579778A JP2002579778A JP2004528556A5 JP 2004528556 A5 JP2004528556 A5 JP 2004528556A5 JP 2002579778 A JP2002579778 A JP 2002579778A JP 2002579778 A JP2002579778 A JP 2002579778A JP 2004528556 A5 JP2004528556 A5 JP 2004528556A5
Authority
JP
Japan
Prior art keywords
fluid
channel
reagent
microfluidic device
sample fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002579778A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004528556A (ja
JP3949056B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/010508 external-priority patent/WO2002082057A2/en
Publication of JP2004528556A publication Critical patent/JP2004528556A/ja
Publication of JP2004528556A5 publication Critical patent/JP2004528556A5/ja
Application granted granted Critical
Publication of JP3949056B2 publication Critical patent/JP3949056B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2002579778A 2001-04-03 2002-04-03 スプリット集中サイトメーター Expired - Lifetime JP3949056B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28111401P 2001-04-03 2001-04-03
PCT/US2002/010508 WO2002082057A2 (en) 2001-04-03 2002-04-03 Split focusing cytometer

Publications (3)

Publication Number Publication Date
JP2004528556A JP2004528556A (ja) 2004-09-16
JP2004528556A5 true JP2004528556A5 (https=) 2006-01-05
JP3949056B2 JP3949056B2 (ja) 2007-07-25

Family

ID=23076003

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002579674A Pending JP2005509113A (ja) 2001-04-03 2002-04-03 ミクロ流体構造において使用するための空気バルブ界面
JP2002579778A Expired - Lifetime JP3949056B2 (ja) 2001-04-03 2002-04-03 スプリット集中サイトメーター

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2002579674A Pending JP2005509113A (ja) 2001-04-03 2002-04-03 ミクロ流体構造において使用するための空気バルブ界面

Country Status (6)

Country Link
US (8) US20020172622A1 (https=)
EP (2) EP1377821A2 (https=)
JP (2) JP2005509113A (https=)
AT (1) ATE401566T1 (https=)
DE (1) DE60227649D1 (https=)
WO (2) WO2002081934A2 (https=)

Families Citing this family (307)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264427B1 (en) 1997-01-31 2017-05-03 Xy, Llc Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US8518328B2 (en) * 2005-12-27 2013-08-27 Honeywell International Inc. Fluid sensing and control in a fluidic analyzer
US8071051B2 (en) * 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US7641856B2 (en) 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US20020052571A1 (en) * 2000-09-13 2002-05-02 Fazio Frank A. Artificial kidney and methods of using same
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10057832C1 (de) 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US7713687B2 (en) * 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
ATE497731T1 (de) 2001-06-12 2011-02-15 Pelikan Technologies Inc Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
AU2002312521A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
ATE485766T1 (de) 2001-06-12 2010-11-15 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
CA2448681C (en) 2001-06-12 2014-09-09 Pelikan Technologies, Inc. Integrated blood sampling analysis system with multi-use sampling module
US7141429B2 (en) * 2001-10-09 2006-11-28 University Of Washington Use of liquid junction potentials for electrophoresis without applied voltage in a microfluidic channel
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US20030175980A1 (en) * 2002-03-14 2003-09-18 Hayenga Jon W. Ribbon flow cytometry and cell sorting
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2283917B1 (en) 2002-05-09 2021-12-15 The University of Chicago Device for pressure-driven plug transport and reaction
CA2531176C (en) * 2002-07-22 2018-04-24 Xy, Inc. Sperm cell process system
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
JP4595067B2 (ja) * 2002-08-01 2010-12-08 エックスワイ，エルエルシー 低圧精子細胞分離システム
CA2534394C (en) * 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
EP2359689B1 (en) * 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
US7445926B2 (en) * 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
CA2513880A1 (en) * 2003-01-21 2004-08-05 Micronics Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
EP1604184A4 (en) * 2003-02-27 2010-10-27 Stephen A Lesko STANDARDIZED EVALUATION OF THERAPEUTIC EFFICIENCY BASED ON CELLULAR BIOMARKERS
ATE510605T1 (de) 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
BRPI0408857B1 (pt) 2003-03-28 2018-09-11 Inguran Llc aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo
CA2521171C (en) * 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
DE10320870A1 (de) 2003-05-09 2004-12-09 Evotec Technologies Gmbh Partikelinjektor für einen Zellsortierer
ES2541121T3 (es) * 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
EP1633235B1 (en) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
EP1636564A1 (en) * 2003-06-13 2006-03-22 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US7298478B2 (en) * 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7311476B2 (en) * 2003-10-30 2007-12-25 Cytonome, Inc. Multilayer hydrodynamic sheath flow structure
JP2007519896A (ja) * 2003-12-17 2007-07-19 インバネス、メディカル、スウィッツァランド、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング システム
GB0329220D0 (en) * 2003-12-17 2004-01-21 Inverness Medical Switzerland System
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8592219B2 (en) * 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US20050266433A1 (en) * 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
DK2801363T3 (en) 2004-03-29 2018-05-28 Inguran Llc PROCEDURE FOR STORING SORTED SPERMATOZOES
US7295306B2 (en) * 2004-04-22 2007-11-13 Kowa Company, Ltd. Microchip and fluorescent particle counter with microchip
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
US7032608B2 (en) * 2004-09-01 2006-04-25 Harris Corporation Microfluidic check-valve embedded in LCP
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
CN101099082B (zh) 2004-12-03 2013-03-27 塞通诺米/St有限责任公司 用于粒子处理的整体式盒
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
AU2006204858A1 (en) * 2005-01-13 2006-07-20 Perkinelmer Health Sciences, Inc. Microfluidic rare cell detection device
EP1849005A1 (en) * 2005-01-17 2007-10-31 Gyros Patent Ab A method for detecting an at least bivalent analyte using two affinity reactants
FR2882939B1 (fr) 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1874920A4 (en) * 2005-04-05 2009-11-04 Cellpoint Diagnostics DEVICES AND METHOD FOR ENRICHING AND CHANGING CIRCULATING TUMOR CELLS AND OTHER PARTICLES
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070042427A1 (en) * 2005-05-03 2007-02-22 Micronics, Inc. Microfluidic laminar flow detection strip
CN101253401B (zh) * 2005-07-01 2013-01-02 霍尼韦尔国际公司 带三维流体动力学集中的模制标本盒
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
WO2007021816A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Methods and apparatuses for reducing effects of molecule adsorption within microfluidic channels
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7485153B2 (en) * 2005-12-27 2009-02-03 Honeywell International Inc. Fluid free interface for a fluidic analyzer
US8182767B2 (en) * 2005-12-27 2012-05-22 Honeywell International Inc. Needle-septum interface for a fluidic analyzer
US20070178529A1 (en) * 2006-01-13 2007-08-02 Micronics, Inc. Electromagnetically actuated valves for use in microfluidic structures
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
US8171778B2 (en) * 2006-05-05 2012-05-08 E I Spectra, LLC Thin film particle sensor
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US7520164B1 (en) * 2006-05-05 2009-04-21 E.I. Spectra, Llc Thin film particle sensor
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
ES2393758T3 (es) * 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
CN101534917A (zh) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 采用萃取流体排出流过滤的微流无膜交换系统和方法
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
EP2029779A4 (en) * 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
AU2007265628B2 (en) * 2006-06-23 2012-12-06 Revvity Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
US8252160B2 (en) * 2006-07-28 2012-08-28 Hewlett-Packard Development Company, L.P. Prevention of fluid delivered to reservoir from wicking into channels within microfluidic device
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008066485A1 (en) * 2006-11-28 2008-06-05 Åstc Aerospace Ab Micromechanical slow acting valve system
GB2445738A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
US20090042241A1 (en) * 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
US8186913B2 (en) 2007-04-16 2012-05-29 The General Hospital Corporation Systems and methods for particle focusing in microchannels
US8016260B2 (en) * 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
US9090885B2 (en) * 2007-07-26 2015-07-28 The University Of Chicago Co-incubating confined microbial communities
EP2171420A1 (en) * 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
JP5369111B2 (ja) * 2007-11-26 2013-12-18 アトノミックス アクティーゼルスカブ 物理障壁を含む隔離デバイス
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
EP2249899A4 (en) 2008-02-04 2011-05-11 Univ Columbia FLUID DISTRIBUTION DEVICES, SYSTEMS AND METHODS
KR100931302B1 (ko) 2008-02-05 2009-12-11 한국과학기술원 서로 다른 임계압력을 가지는 밸브를 이용한 마이크로유체분배기
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
DE502008001596D1 (de) 2008-06-02 2010-12-02 Boehringer Ingelheim Micropart Mikrofluidische Folienstruktur zum Dosierren von Flüssigkeiten
WO2010050208A1 (ja) * 2008-10-28 2010-05-06 藤倉化成株式会社 液体流路装置とその製造方法
CA3069082C (en) 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US8318439B2 (en) 2008-10-03 2012-11-27 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
AU2009302464B2 (en) * 2008-10-10 2014-07-03 Cytyc Corporation Microfluidic apparatus and method for preparing cytological specimens
US8435465B2 (en) * 2008-11-03 2013-05-07 Cfd Research Corporation Microfluidic biological extraction chip
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
US8100293B2 (en) * 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
EP2216095A1 (en) * 2009-01-27 2010-08-11 Koninklijke Philips Electronics N.V. Microfluidic device for full blood count
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010097740A1 (en) * 2009-02-24 2010-09-02 Services Petroliers Schlumberger Micro-valve and micro-fluidic device using such
DE102009015395B4 (de) 2009-03-23 2022-11-24 Thinxxs Microtechnology Gmbh Flusszelle zur Behandlung und/oder Untersuchung eines Fluids
US9470609B2 (en) 2009-04-09 2016-10-18 Koninklijke Philips N. V. Preparation of thin layers of a fluid containing cells for analysis
FR2944529B1 (fr) * 2009-04-20 2013-09-06 Commissariat Energie Atomique Methode de dosage d'enzymes plasmatiques dans le sang total
US20100282766A1 (en) * 2009-05-06 2010-11-11 Heiko Arndt Low-Dead Volume Microfluidic Component and Method
US8230744B2 (en) 2009-05-06 2012-07-31 Cequr Sa Low-dead volume microfluidic circuit and methods
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
GB2474888A (en) * 2009-10-30 2011-05-04 Univ Dublin City Microfluidic devices with degassing driven fluid flow
US8584703B2 (en) * 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
CA2786569C (en) 2010-01-29 2019-04-09 Perkinelmer Health Sciences, Inc. Sample-to-answer microfluidic cartridge
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
DE102011015184B4 (de) * 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil
US20130087206A1 (en) * 2010-06-29 2013-04-11 Analogic Corporation Sample carrier
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
KR101776215B1 (ko) * 2010-10-29 2017-09-08 삼성전자 주식회사 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법
CN102465110B (zh) 2010-10-29 2015-08-19 三星电子株式会社 细胞裂解装置和使细胞或病毒裂解的方法
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
DE102011078770B4 (de) 2011-07-07 2016-04-28 Robert Bosch Gmbh Mikrofluidische Vorrichtung, mikrofluidisches System und Verfahren zum Transport von Fluiden
CN103157523A (zh) * 2011-12-15 2013-06-19 三星电子株式会社 微流器件及其制造方法
JP6190822B2 (ja) 2012-01-09 2017-08-30 マイクロニクス， インコーポレイテッド マイクロ流体リアクタシステム
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9738887B2 (en) 2012-02-13 2017-08-22 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
SG11201405072XA (en) * 2012-02-21 2014-09-26 Fluidigm Corp Method and systems for microfluidic logic devices
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
WO2014066376A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
CA2889544A1 (en) * 2012-11-14 2014-05-22 Ams Research Corporation Cell delivery device and system with anti-clumping feature and methods for pelvic tissue treatment
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP6349327B2 (ja) 2012-12-17 2018-06-27 レウコドゥックス，リミテッド 化学的状態を判定するためのシステムおよび方法
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
JP6498125B2 (ja) 2012-12-21 2019-04-10 マイクロニクス， インコーポレイテッド 流体回路および関連する製造方法
KR20150096788A (ko) 2012-12-21 2015-08-25 마이크로닉스 인코포레이티드. 마이크로 유체공학 용도를 위한 저탄성 막
US9207166B2 (en) * 2013-01-31 2015-12-08 Honeywell International Inc. Micro-molded cytometer cartridge with integrated optics
KR20200140929A (ko) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
NZ743491A (en) 2013-03-14 2020-03-27 Cytonome St Llc Hydrodynamic focusing apparatus and methods
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
US9506934B2 (en) * 2013-04-29 2016-11-29 Honeywell International Inc. Polymer test cartridge mixer for cell lysis
EP2994543B1 (en) 2013-05-07 2018-08-15 Micronics, Inc. Device for preparation and analysis of nucleic acids
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
GB2516675A (en) * 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
KR101670826B1 (ko) 2014-05-30 2016-11-10 한국과학기술원 미세유체 유동블럭과 이의 제조방법
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
US10413901B2 (en) 2014-08-29 2019-09-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, devices, and systems for microfluidic stress emulation
CN105467111A (zh) * 2014-09-05 2016-04-06 宏达国际电子股份有限公司 微流道模块
BR112017008877A2 (pt) 2014-10-29 2018-07-03 10X Genomics Inc métodos e composições para sequenciamento de ácido nucleico-alvo
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
JP6769969B2 (ja) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー
US10180388B2 (en) 2015-02-19 2019-01-15 1087 Systems, Inc. Scanning infrared measurement system
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
MX2017010857A (es) 2015-02-24 2017-12-11 10X Genomics Inc Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana.
US20170059459A1 (en) * 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid processing micro-feature devices and methods
US20170059590A1 (en) 2015-08-27 2017-03-02 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US11071982B2 (en) 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
US9366606B1 (en) 2015-08-27 2016-06-14 Ativa Medical Corporation Fluid processing micro-feature devices and methods
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
US10088468B2 (en) * 2016-02-04 2018-10-02 Nova Biomedical Corporation Analyte system and method for determining hemoglobin parameters in whole blood
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
EP3445876B1 (en) 2017-05-26 2023-07-05 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US10648573B2 (en) * 2017-08-23 2020-05-12 Facebook Technologies, Llc Fluidic switching devices
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
US11060968B2 (en) * 2018-03-30 2021-07-13 International Business Machines Corporation Mobile chemical analysis
CN112262218B (zh) 2018-04-06 2024-11-08 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
US11523939B2 (en) * 2018-05-22 2022-12-13 California Institute Of Technology Miniature fixed and adjustable flow restrictor for the body
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
KR102100197B1 (ko) * 2018-08-17 2020-04-14 (주)엠큐빅 플로우 셀을 이용한 미세조류 연속 모니터링 장치
EP3899489B1 (en) 2018-12-21 2025-04-09 ABS Global, Inc. System and methods for sub-population identification
EP3955735B1 (en) 2019-04-18 2024-05-22 ABS Global, Inc. System and process for continuous addition of cryoprotectant
CN110586211A (zh) * 2019-09-20 2019-12-20 济南大学 一种基于数控气阀调节通道压力的微流控芯片制备及控制方法
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US20210252507A1 (en) * 2020-02-16 2021-08-19 University Of Maryland, Baltimore County Apparatus for separating the cellular and liquid portions of a whole blood sample
WO2022087299A1 (en) 2020-10-21 2022-04-28 Abs Global, Inc. Methods and systems for processing genetic samples to determine identity or detect contamination
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
JP7789694B2 (ja) * 2020-11-27 2025-12-22 Ｚａｃｒｏｓ株式会社 血液凝固検査用マイクロチップの製造方法
EP4155712A1 (en) * 2021-09-28 2023-03-29 Siemens Healthcare Diagnostics, Inc. Device and method for optically analyzing blood cells
USD1118965S1 (en) 2021-11-12 2026-03-17 Abs Global, Inc. Flow cytometry device

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2943116C2 (de) * 1979-10-25 1986-06-19 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Einrichtung zur durchflußcytometrischen Reaktions- und/oder Diffusionsmessung
US4663058A (en) * 1983-10-11 1987-05-05 E. I. Du Pont De Nemours And Company Process for continuous separation of leukocyte/platelet-enriched fraction from whole blood
JPS6453965U (https=) * 1987-09-30 1989-04-03
US4858883A (en) * 1987-12-11 1989-08-22 Integrated Fluidics, Inc. Valve with flexible sheet member
JPH01170853A (ja) * 1987-12-25 1989-07-05 Hitachi Ltd 細胞選別装置
US4869282A (en) * 1988-12-09 1989-09-26 Rosemount Inc. Micromachined valve with polyimide film diaphragm
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5197192A (en) * 1990-08-01 1993-03-30 Photovac Incorporated Method of making a fluid control valve
US5176359A (en) * 1991-05-20 1993-01-05 Photovac International, Inc. Fluid control valve arrangement
JP2832117B2 (ja) * 1991-11-29 1998-12-02 キヤノン株式会社 サンプル測定デバイス及びサンプル測定システム
SE501713C2 (sv) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
JPH09505130A (ja) * 1993-09-24 1997-05-20 ローズマウント アナリティカル インコーポレイテッド ミクロ機械加工された弁装置
WO1996027792A1 (en) * 1995-03-03 1996-09-12 Microsensor Technology, Inc. Fixed-volumed injector with backflush capability
JPH08320285A (ja) * 1995-05-25 1996-12-03 Hitachi Ltd 粒子分析装置
US5932100A (en) * 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6184978B1 (en) * 1996-05-15 2001-02-06 International Remote Imaging Systems, Inc. Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide
DE69728269T2 (de) * 1996-06-14 2005-03-10 University Of Washington, Seattle Absorbtionsverbessertes differentielles extraktionsverfahren
US6120666A (en) * 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US5858187A (en) * 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
DE69823347T2 (de) * 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
EP1179585B1 (en) * 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6067157A (en) * 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
ATE556149T1 (de) * 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US6379973B1 (en) * 1999-03-05 2002-04-30 The United States Of America As Represented By The Department Of Health And Human Services Chromatographic separation apparatus and method
US6533938B1 (en) * 1999-05-27 2003-03-18 Worcester Polytechnic Institue Polymer enhanced diafiltration: filtration using PGA
JP4733331B2 (ja) * 2000-03-14 2011-07-27 マイクロニックス、インコーポレーテッド マイクロ流動体分析用デバイス
WO2001075415A2 (en) * 2000-03-31 2001-10-11 Micronics, Inc. Protein crystallization in microfluidic structures
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
CA2408574A1 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
EP1331997B1 (en) * 2000-11-06 2004-06-16 Nanostream, Inc. Microfluidic flow control devices
US7060227B2 (en) * 2001-08-06 2006-06-13 Sau Lan Tang Staats Microfluidic devices with raised walls

Similar Documents

Publication Publication Date Title
JP2004528556A5 (https=)
US20020159920A1 (en) Multiple redundant microfluidic structures cross reference to related applications
Kersaudy-Kerhoas et al. Validation of a blood plasma separation system by biomarker detection
JP4522480B2 (ja) 一体型流体操作カートリッジ
JP4959975B2 (ja) 捕集装置、バイオ濃縮装置及び生物因子を捕集し濃縮する方法
WO2019047498A1 (zh) 一种全血血浆分离系统及方法
US20080067068A1 (en) DC-dielectrophoresis microfluidic apparatus, and applications of same
DE59610059D1 (de) Vorrichtung zum mischen kleiner flüssigkeitsmengen
TWI670497B (zh) 收集與取出流體樣品的設備以及微流體晶片
DK0925494T3 (da) Mikrostrømningssystem til partikelseparation og analyse
CN107012067A (zh) 一种高通量配对捕获单细胞/单颗粒的微流控芯片及其应用
WO2019128841A1 (zh) 一种螺旋形微通道及其使用方法与串、并联安装结构
ATE292799T1 (de) Struktur und verfahren zur kapillaren hämatokritabtrennung
WO2017128768A1 (zh) 用于快速自检血液的多通道微流控芯片
JP6746619B2 (ja) マイクロ流体デバイス
ATE283913T1 (de) Vorrichtung zum trennen und nachweis von bewegungsfähigen spermatozoen
CN207366327U (zh) 一种全血血浆分离系统
CN107110760A (zh) 流体样本颗粒的一种浓缩方法与装置
Wang et al. Sheathless acoustic based flow cell sorter for enrichment of rare cells
JP4234486B2 (ja) Ｄｎａ或いは電荷をもつ線状の分子のトラップ・リリース装置とその方法
Chen et al. Design, fabrication and characterization of nano‐filters in silicon microfluidic channels based on MEMS technology
CN109622078B (zh) 一种用于非牛顿流体中颗粒单一位置富集的微流控芯片
CN117046531A (zh) 一种基于体声波的多功能微流控芯片
CN112553043A (zh) 用于胎儿有核红细胞分离纯化的微流控芯片
US20030152920A1 (en) Hydrodynamic enhanced dielectrophoretic particle trapping