JP2004527525A5 - - Google Patents
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- Publication number
- JP2004527525A5 JP2004527525A5 JP2002578726A JP2002578726A JP2004527525A5 JP 2004527525 A5 JP2004527525 A5 JP 2004527525A5 JP 2002578726 A JP2002578726 A JP 2002578726A JP 2002578726 A JP2002578726 A JP 2002578726A JP 2004527525 A5 JP2004527525 A5 JP 2004527525A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- suspension
- sorbitan
- liquid suspension
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006194 liquid suspension Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000002562 thickening agent Substances 0.000 claims 7
- 239000007788 liquid Substances 0.000 claims 6
- 239000002736 nonionic surfactant Substances 0.000 claims 5
- -1 polyoxyethylene Polymers 0.000 claims 5
- 239000007853 buffer solution Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 230000000843 anti-fungal effect Effects 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 235000000346 sugar Nutrition 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical group CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- 239000004147 Sorbitan trioleate Substances 0.000 claims 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940100692 oral suspension Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001570 sorbitan monopalmitate Substances 0.000 claims 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims 1
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
- 229960000391 sorbitan trioleate Drugs 0.000 claims 1
- 239000001589 sorbitan tristearate Substances 0.000 claims 1
- 235000011078 sorbitan tristearate Nutrition 0.000 claims 1
- 229960004129 sorbitan tristearate Drugs 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28113901P | 2001-04-03 | 2001-04-03 | |
| PCT/US2002/010093 WO2002080678A1 (en) | 2001-04-03 | 2002-04-01 | Antifungal composition with enhanced bioavailability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008036719A Division JP2008120836A (ja) | 2001-04-03 | 2008-02-18 | 増大したバイオアベイラビリティーを有する抗真菌組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004527525A JP2004527525A (ja) | 2004-09-09 |
| JP2004527525A5 true JP2004527525A5 (enExample) | 2005-06-09 |
| JP4308902B2 JP4308902B2 (ja) | 2009-08-05 |
Family
ID=23076102
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578726A Expired - Lifetime JP4308902B2 (ja) | 2001-04-03 | 2002-04-01 | 増大したバイオアベイラビリティーを有する抗真菌組成物 |
| JP2008036719A Pending JP2008120836A (ja) | 2001-04-03 | 2008-02-18 | 増大したバイオアベイラビリティーを有する抗真菌組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008036719A Pending JP2008120836A (ja) | 2001-04-03 | 2008-02-18 | 増大したバイオアベイラビリティーを有する抗真菌組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20030055067A1 (enExample) |
| EP (2) | EP1372394A1 (enExample) |
| JP (2) | JP4308902B2 (enExample) |
| KR (1) | KR100607742B1 (enExample) |
| CN (1) | CN100415234C (enExample) |
| AR (1) | AR033096A1 (enExample) |
| AU (1) | AU2002257104B2 (enExample) |
| BR (1) | BR0208626A (enExample) |
| CA (1) | CA2443089C (enExample) |
| HU (1) | HUP0400856A3 (enExample) |
| MX (1) | MXPA03009021A (enExample) |
| NO (1) | NO20034419L (enExample) |
| NZ (1) | NZ528363A (enExample) |
| PE (1) | PE20020994A1 (enExample) |
| PL (1) | PL212985B1 (enExample) |
| TW (1) | TWI311464B (enExample) |
| WO (1) | WO2002080678A1 (enExample) |
| ZA (1) | ZA200307684B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| CN1558755A (zh) | 2001-09-26 | 2004-12-29 | ���ع��ʹ�˾ | 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒 |
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| AU2005249502A1 (en) * | 2004-05-28 | 2005-12-15 | Schering Corporation | Particulate-stabilized injectable pharmaceutical compositions of posaconazole |
| US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| US7473684B2 (en) * | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
| MX2008015275A (es) * | 2006-05-30 | 2009-02-06 | Elan Pharma Int Ltd | Formulaciones de posaconazol en nanoparticulas. |
| EP2037914B1 (en) | 2006-06-14 | 2013-10-23 | Intervet International BV | A suspension comprising benzimidazole carbamate and a polysorbate |
| GB0624090D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amine salts |
| GB0624084D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
| GB0624087D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril combination salt |
| FR2910323A1 (fr) * | 2006-12-26 | 2008-06-27 | Virbac Sa Sa | Composition liquide anhydre destinee a etre incorporee a l'eau de boisson des animaux d'elevage. |
| DE102008004893A1 (de) | 2008-01-17 | 2009-07-23 | Add Technologies Ltd. | Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung |
| AU2009236290A1 (en) * | 2008-04-15 | 2009-10-22 | Merck Sharp & Dohme Corp. | Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and HPMCAS |
| WO2009129300A2 (en) * | 2008-04-15 | 2009-10-22 | Schering Corporation | High density compositions containing posaconazole and formulations comprising the same |
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2011003992A1 (en) | 2009-07-09 | 2011-01-13 | Sandoz Ag | A crystalline form of posaconazole |
| EP2571868B1 (en) | 2010-05-19 | 2016-05-04 | Sandoz AG | Preparation of posaconazole intermediates |
| EP2571871B1 (en) | 2010-05-19 | 2017-06-21 | Sandoz AG | Process for the preparation of chiral triazolones |
| JP5955837B2 (ja) | 2010-05-19 | 2016-07-20 | サンド・アクチエンゲゼルシヤフト | ポサコナゾール及びポサコナゾール中間体の精製 |
| BR112012029225B1 (pt) | 2010-05-19 | 2020-10-27 | Sandoz Ag | processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral |
| CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
| EP2861213A1 (en) | 2012-06-14 | 2015-04-22 | Sandoz AG | Pharmaceutical composition comprising crystalline posaconazole |
| KR102579848B1 (ko) | 2014-12-05 | 2023-09-18 | 풀모사이드 리미티드 | 항진균 화합물 |
| AU2016263669B2 (en) * | 2015-05-21 | 2020-04-30 | Pulmocide Limited | Antifungal 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4- difluorophenyl)tetrahydrofuran-3-yl) methoxy)-3-methylphenyl)piperazin-1-yl)-N- (2-hydroxycyclohexyl) benzamide, or a pharmaceutically acceptable salt thereof |
| CN105030668B (zh) * | 2015-06-26 | 2018-03-27 | 济川药业集团有限公司 | 泊沙康唑口服混悬剂及其制备方法 |
| CN106333925B (zh) * | 2015-07-10 | 2019-06-18 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑液体混悬剂及其制备方法 |
| US10464922B2 (en) | 2015-12-30 | 2019-11-05 | Nqp 1598, Ltd. | Metalloenzyme inhibitor compounds |
| CN106389390A (zh) * | 2016-06-30 | 2017-02-15 | 重庆华邦制药有限公司 | 泊沙康唑涂膜剂及其制备方法 |
| CN107625729A (zh) * | 2017-09-29 | 2018-01-26 | 重庆华邦制药有限公司 | 泊沙康唑口服混悬液及其制备方法 |
| CN110507609B (zh) * | 2018-05-21 | 2021-09-17 | 上海医药工业研究院 | 泊沙康唑口服混悬剂的制备方法 |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| BR112022022795A2 (pt) * | 2020-05-12 | 2022-12-13 | Cellix Bio Private Ltd | Processo para preparação de sais de triazol, e sais de triazol preparados pelo processo |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| US4788220A (en) * | 1987-07-08 | 1988-11-29 | American Home Products Corporation (Del.) | Pediatric ibuprofen compositions |
| NZ234143A (en) * | 1989-06-28 | 1991-10-25 | Mcneil Ppc Inc | Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| AU642066B2 (en) | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| US5552160A (en) | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
| SK283035B6 (sk) * | 1993-12-21 | 2003-02-04 | Schering Corporation | Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok |
| US5661151A (en) * | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5580579A (en) * | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| AU7587496A (en) * | 1995-11-20 | 1997-06-11 | Banyu Pharmaceutical Co., Ltd. | Antifungal composition |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| CA2289618A1 (en) * | 1997-05-14 | 1998-11-19 | Shin-Ichi Yasueda | Aqueous suspension preparations with excellent redispersibility |
| ES2216517T3 (es) | 1998-05-29 | 2004-10-16 | Skyepharma Canada Inc. | Composiciones de microcapsulas termoprotegidas y procedimiento para su esterilizacion terminal con vapor. |
| US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
-
2002
- 2002-04-01 MX MXPA03009021A patent/MXPA03009021A/es active IP Right Grant
- 2002-04-01 BR BR0208626-3A patent/BR0208626A/pt not_active Application Discontinuation
- 2002-04-01 EP EP02726689A patent/EP1372394A1/en not_active Ceased
- 2002-04-01 JP JP2002578726A patent/JP4308902B2/ja not_active Expired - Lifetime
- 2002-04-01 NZ NZ528363A patent/NZ528363A/en not_active IP Right Cessation
- 2002-04-01 WO PCT/US2002/010093 patent/WO2002080678A1/en not_active Ceased
- 2002-04-01 HU HU0400856A patent/HUP0400856A3/hu not_active Application Discontinuation
- 2002-04-01 CN CNB028077407A patent/CN100415234C/zh not_active Expired - Lifetime
- 2002-04-01 AU AU2002257104A patent/AU2002257104B2/en not_active Expired
- 2002-04-01 CA CA2443089A patent/CA2443089C/en not_active Expired - Lifetime
- 2002-04-01 PL PL363965A patent/PL212985B1/pl unknown
- 2002-04-01 US US10/114,612 patent/US20030055067A1/en not_active Abandoned
- 2002-04-01 EP EP09158184A patent/EP2090165A3/en not_active Withdrawn
- 2002-04-01 KR KR1020037012936A patent/KR100607742B1/ko not_active Expired - Lifetime
- 2002-04-02 AR ARP020101198A patent/AR033096A1/es not_active Application Discontinuation
- 2002-04-02 PE PE2002000263A patent/PE20020994A1/es active IP Right Grant
- 2002-04-02 TW TW091106644A patent/TWI311464B/zh not_active IP Right Cessation
-
2003
- 2003-10-01 ZA ZA2003/07684A patent/ZA200307684B/en unknown
- 2003-10-02 NO NO20034419A patent/NO20034419L/no not_active Application Discontinuation
-
2008
- 2008-02-18 JP JP2008036719A patent/JP2008120836A/ja active Pending
-
2011
- 2011-06-15 US US13/161,097 patent/US8263600B2/en not_active Expired - Fee Related
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