JP2007526257A5 - - Google Patents
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- Publication number
- JP2007526257A5 JP2007526257A5 JP2007501068A JP2007501068A JP2007526257A5 JP 2007526257 A5 JP2007526257 A5 JP 2007526257A5 JP 2007501068 A JP2007501068 A JP 2007501068A JP 2007501068 A JP2007501068 A JP 2007501068A JP 2007526257 A5 JP2007526257 A5 JP 2007526257A5
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- aryl
- compound
- peg
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical class 0.000 claims 6
- 125000003118 aryl group Chemical class 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000033115 angiogenesis Effects 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 4
- 208000007536 Thrombosis Diseases 0.000 claims 4
- 125000002252 acyl group Chemical class 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical class 0.000 claims 4
- 125000003435 aroyl group Chemical class 0.000 claims 4
- 125000004391 aryl sulfonyl group Chemical class 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 230000015271 coagulation Effects 0.000 claims 4
- 238000005345 coagulation Methods 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000009401 metastasis Effects 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- 150000003852 triazoles Chemical class 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003178 Arterial thrombosis Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 206010043647 Thrombotic Stroke Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000023819 chronic asthma Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- -1 n-octyl Chemical group 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2004901103 | 2004-03-04 | ||
| AU2004901103A AU2004901103A0 (en) | 2004-03-04 | Sulfated Oligosaccharide Derivatives | |
| PCT/AU2005/000314 WO2005085264A1 (en) | 2004-03-04 | 2005-03-04 | Sulfated oligosaccharide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007526257A JP2007526257A (ja) | 2007-09-13 |
| JP2007526257A5 true JP2007526257A5 (enExample) | 2008-04-17 |
| JP5139797B2 JP5139797B2 (ja) | 2013-02-06 |
Family
ID=34916868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501068A Expired - Fee Related JP5139797B2 (ja) | 2004-03-04 | 2005-03-04 | 硫酸化オリゴ糖誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7875592B2 (enExample) |
| EP (1) | EP1720889B1 (enExample) |
| JP (1) | JP5139797B2 (enExample) |
| KR (1) | KR101156273B1 (enExample) |
| CN (3) | CN103788141B (enExample) |
| AU (1) | AU2005219456B2 (enExample) |
| BR (1) | BRPI0508144A (enExample) |
| CA (1) | CA2557989C (enExample) |
| ES (1) | ES2531880T3 (enExample) |
| HK (1) | HK1199263A1 (enExample) |
| IL (1) | IL177870A (enExample) |
| MX (1) | MXPA06010049A (enExample) |
| NO (1) | NO338461B1 (enExample) |
| RU (1) | RU2392281C2 (enExample) |
| TW (1) | TWI426080B (enExample) |
| WO (1) | WO2005085264A1 (enExample) |
| ZA (1) | ZA200607057B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI426080B (zh) * | 2004-03-04 | 2014-02-11 | Progen Pharmaceuticals Ltd | 硫酸化寡醣衍生物 |
| CN101203230A (zh) * | 2005-04-01 | 2008-06-18 | 克里斯托弗·理查德·帕里什 | 用nod因子例如葡糖胺寡糖调节血管发生 |
| US8828952B2 (en) * | 2007-10-16 | 2014-09-09 | Progen Pharmaceuticals Limited | Sulfated oligosaccharide derivatives |
| EP2307440A4 (en) * | 2008-07-01 | 2012-12-19 | Zacharon Pharmaceuticals Inc | HEPARAN SULFATE INHIBITORS |
| EP2149580A1 (en) | 2008-07-15 | 2010-02-03 | Istituto Scientifico di Chimica E Biochimica "G Ronzoni | Mimetics of sulfated oligosaccharides |
| CN101591401A (zh) * | 2009-02-27 | 2009-12-02 | 江南大学 | 一种制备高活性低分子量肝素的方法 |
| JP5701498B2 (ja) * | 2009-12-01 | 2015-04-15 | 公益財団法人微生物化学研究会 | 炎症性細胞からのヘパラナーゼの放出抑制剤、抗炎症剤、及び薬用組成物 |
| CN107362168A (zh) * | 2011-06-09 | 2017-11-21 | 基亚生物科技股份有限公司 | 用于抑制肝癌复发、恶化或转移之医药组成物 |
| US9994605B2 (en) | 2014-03-13 | 2018-06-12 | Universitaet Basel | Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein |
| CN105017341B (zh) * | 2014-04-22 | 2018-05-15 | 华东师范大学 | 硫酸化岩藻-半乳四糖及其制备方法和应用 |
| CN104876979B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种具有抗Xa因子活性的磺酸化五糖化合物 |
| CN105001278B (zh) * | 2015-06-19 | 2018-07-06 | 天津红日药业股份有限公司 | 一种磺达肝癸钠二糖中间体片段的合成方法 |
| CA2996073A1 (en) | 2015-09-16 | 2017-03-23 | Universitat Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| JP2016199579A (ja) * | 2016-07-08 | 2016-12-01 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| WO2018103680A1 (zh) * | 2016-12-10 | 2018-06-14 | 扬州蓝色生物医药科技有限公司 | 甘露寡聚糖类化合物及其作为抗rna病毒药物的应用 |
| BR112019012045A2 (pt) | 2016-12-13 | 2020-08-18 | Beta Therapeutics Pty Ltd | inibidores de heparanase e uso dos mesmos |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| EP3554511B1 (en) | 2016-12-15 | 2024-07-10 | Progen PG500 Series Pty Ltd | Combination of an immune checkpoint inhibitor pd-1 or pd-l1 inhibitor with an heparan sulfate mimetic and the use thereof in the treatment or prevention of cancer |
| US10842804B2 (en) * | 2017-03-01 | 2020-11-24 | Medigen Biotechnology Corporation | Muparfostat for use in treating patients with hepatitis virus-related hepatocellular carcinoma after surgical resection |
| KR102377358B1 (ko) | 2017-10-16 | 2022-03-23 | 삼성전자주식회사 | 반도체 메모리 소자 및 그 제조 방법 |
| WO2019113645A1 (en) | 2017-12-15 | 2019-06-20 | The Australian National University | Compounds for treating and preventing extracellular histone mediated pathologies |
| JP6619830B2 (ja) * | 2018-02-22 | 2019-12-11 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| CN109762032A (zh) * | 2019-01-16 | 2019-05-17 | 天津科技大学 | 一种磺酸化路易斯x三糖及其合成方法和应用 |
| BR112021016812A2 (pt) * | 2019-02-25 | 2021-11-16 | Univ Griffith | Compostos para tratar e prevenir complicações associadas a net |
| CN116813675B (zh) * | 2023-08-23 | 2023-11-24 | 北京远大九和药业有限公司 | 一种化合物晶型及其制备、组合物和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0338092A1 (en) | 1987-10-30 | 1989-10-25 | Chugai Seiyaku Kabushiki Kaisha | Anti-hiv agent |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5739115A (en) * | 1993-10-07 | 1998-04-14 | Glycomed Incorporated | Sulfated maltooligosaccharides with heparin-like properties |
| AU700451B2 (en) * | 1993-10-07 | 1999-01-07 | Glycomed Incorporated | Highly sulfated maltooligosaccharides with heparin-like properties |
| CN1072228C (zh) * | 1995-04-28 | 2001-10-03 | 宝酒造株式会社 | 糖化合物 |
| AUPN261895A0 (en) | 1995-04-28 | 1995-05-18 | Australian National University, The | Preparation and use of sulfated oligosaccharides |
| JPH09183789A (ja) * | 1995-10-31 | 1997-07-15 | Sanwa Kagaku Kenkyusho Co Ltd | 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途 |
| IL120722A (en) * | 1996-05-08 | 1999-07-14 | Akzo Nobel Nv | Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them |
| AUPO556297A0 (en) * | 1997-03-11 | 1997-04-10 | Australian National University, The | Sulfated oligosaccharides having anticoagulant/ antithrombotic activity |
| IL126893A (en) * | 1997-11-19 | 2003-05-29 | Akzo Nobel Nv | Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them |
| FR2773801B1 (fr) * | 1998-01-19 | 2000-05-12 | Sanofi Sa | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
| CN1450075A (zh) * | 2002-04-11 | 2003-10-22 | 中国科学院生态环境研究中心 | 一类寡糖及其硫酸化产物和它们的制备方法及含该寡糖的药物组合物 |
| TWI426080B (zh) * | 2004-03-04 | 2014-02-11 | Progen Pharmaceuticals Ltd | 硫酸化寡醣衍生物 |
-
2005
- 2005-03-04 TW TW094106609A patent/TWI426080B/zh not_active IP Right Cessation
- 2005-03-04 RU RU2006134972/04A patent/RU2392281C2/ru not_active IP Right Cessation
- 2005-03-04 EP EP05706346.3A patent/EP1720889B1/en not_active Expired - Lifetime
- 2005-03-04 JP JP2007501068A patent/JP5139797B2/ja not_active Expired - Fee Related
- 2005-03-04 MX MXPA06010049A patent/MXPA06010049A/es active IP Right Grant
- 2005-03-04 CN CN201410042932.2A patent/CN103788141B/zh not_active Expired - Fee Related
- 2005-03-04 CN CNA2005800068338A patent/CN1989146A/zh active Pending
- 2005-03-04 AU AU2005219456A patent/AU2005219456B2/en not_active Ceased
- 2005-03-04 KR KR1020067020704A patent/KR101156273B1/ko not_active Expired - Fee Related
- 2005-03-04 US US10/591,577 patent/US7875592B2/en not_active Expired - Fee Related
- 2005-03-04 CA CA2557989A patent/CA2557989C/en not_active Expired - Fee Related
- 2005-03-04 ES ES05706346.3T patent/ES2531880T3/es not_active Expired - Lifetime
- 2005-03-04 WO PCT/AU2005/000314 patent/WO2005085264A1/en not_active Ceased
- 2005-03-04 BR BRPI0508144-0A patent/BRPI0508144A/pt not_active Application Discontinuation
- 2005-03-04 CN CN201410353750.7A patent/CN104119404A/zh active Pending
-
2006
- 2006-08-23 ZA ZA2006/07057A patent/ZA200607057B/en unknown
- 2006-09-03 IL IL177870A patent/IL177870A/en active IP Right Grant
- 2006-10-03 NO NO20064489A patent/NO338461B1/no not_active IP Right Cessation
-
2007
- 2007-12-19 HK HK14112830.3A patent/HK1199263A1/xx unknown
-
2010
- 2010-12-03 US US12/960,145 patent/US8173606B2/en not_active Expired - Fee Related