RU2392281C2 - Сульфатированные производные олигосахаридов - Google Patents

Сульфатированные производные олигосахаридов Download PDF

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RU2392281C2
RU2392281C2 RU2006134972/04A RU2006134972A RU2392281C2 RU 2392281 C2 RU2392281 C2 RU 2392281C2 RU 2006134972/04 A RU2006134972/04 A RU 2006134972/04A RU 2006134972 A RU2006134972 A RU 2006134972A RU 2392281 C2 RU2392281 C2 RU 2392281C2
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mixture
compound
group
compounds
nmr
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Вито ФЕРРО (AU)
Вито ФЕРРО
Джон Крюгер ФЭЙРВЕТЕР (AU)
Джон Крюгер ФЭЙРВЕТЕР
Томислав КАРОЛИ (AU)
Томислав КАРОЛИ
Лигун ЛИУ (AU)
Лигун ЛИУ
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Проджен Фармасьютикалз Лимитед
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    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04Disaccharides
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    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium

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RU2006134972/04A 2004-03-04 2005-03-04 Сульфатированные производные олигосахаридов RU2392281C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2004901103A AU2004901103A0 (en) 2004-03-04 Sulfated Oligosaccharide Derivatives
AU2004901103 2004-03-04

Publications (2)

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RU2006134972A RU2006134972A (ru) 2008-04-10
RU2392281C2 true RU2392281C2 (ru) 2010-06-20

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US (2) US7875592B2 (enExample)
EP (1) EP1720889B1 (enExample)
JP (1) JP5139797B2 (enExample)
KR (1) KR101156273B1 (enExample)
CN (3) CN1989146A (enExample)
AU (1) AU2005219456B2 (enExample)
BR (1) BRPI0508144A (enExample)
CA (1) CA2557989C (enExample)
ES (1) ES2531880T3 (enExample)
HK (1) HK1199263A1 (enExample)
IL (1) IL177870A (enExample)
MX (1) MXPA06010049A (enExample)
NO (1) NO338461B1 (enExample)
RU (1) RU2392281C2 (enExample)
TW (1) TWI426080B (enExample)
WO (1) WO2005085264A1 (enExample)
ZA (1) ZA200607057B (enExample)

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RU2392281C2 (ru) * 2004-03-04 2010-06-20 Проджен Фармасьютикалз Лимитед Сульфатированные производные олигосахаридов
JP2008534519A (ja) * 2005-04-01 2008-08-28 クリストファー・リチャード・パリッシュ グルコサミンオリゴ糖などのnod因子を用いる血管新生の調節
ES2584927T7 (es) * 2007-10-16 2020-11-05 Progen Pg500 Series Pty Ltd Derivados de oligosacáridos sulfatados novedosos
JP2011526925A (ja) * 2008-07-01 2011-10-20 ザカロン ファーマシューティカルズ,インク. ヘパラン硫酸阻害剤
EP2149580A1 (en) 2008-07-15 2010-02-03 Istituto Scientifico di Chimica E Biochimica "G Ronzoni Mimetics of sulfated oligosaccharides
CN101591401A (zh) * 2009-02-27 2009-12-02 江南大学 一种制备高活性低分子量肝素的方法
JP5701498B2 (ja) * 2009-12-01 2015-04-15 公益財団法人微生物化学研究会 炎症性細胞からのヘパラナーゼの放出抑制剤、抗炎症剤、及び薬用組成物
CN107362168A (zh) * 2011-06-09 2017-11-21 基亚生物科技股份有限公司 用于抑制肝癌复发、恶化或转移之医药组成物
EP3116887B1 (en) 2014-03-13 2021-02-17 Universität Basel Carbohydrate ligands that bind to igm antibodies against myelin-associated glycoprotein
CN105017341B (zh) * 2014-04-22 2018-05-15 华东师范大学 硫酸化岩藻-半乳四糖及其制备方法和应用
CN105001278B (zh) * 2015-06-19 2018-07-06 天津红日药业股份有限公司 一种磺达肝癸钠二糖中间体片段的合成方法
CN104876979B (zh) * 2015-06-19 2018-10-09 天津红日药业股份有限公司 一种具有抗Xa因子活性的磺酸化五糖化合物
JP6849667B2 (ja) 2015-09-16 2021-03-24 ウニヴェルズィテート バーゼル スフィンゴ糖脂質の糖鎖エピトープに対する抗体に結合する炭水化物リガンド
JP2016199579A (ja) * 2016-07-08 2016-12-01 基亜生物科技股▲ふん▼有限公司Medigen Biotechnology Corp. 肝癌の再発、悪化または転移の抑制に用いる医薬組成物
WO2018103680A1 (zh) * 2016-12-10 2018-06-14 扬州蓝色生物医药科技有限公司 甘露寡聚糖类化合物及其作为抗rna病毒药物的应用
JP2020503377A (ja) 2016-12-13 2020-01-30 ベータ セラピューティクス プロプライアタリー リミティド ヘパラナーゼ阻害剤及びそれの使用
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
WO2018107244A1 (en) 2016-12-15 2018-06-21 Progen Pg500 Series Pty Ltd Composition and uses thereof
US10842804B2 (en) * 2017-03-01 2020-11-24 Medigen Biotechnology Corporation Muparfostat for use in treating patients with hepatitis virus-related hepatocellular carcinoma after surgical resection
KR102377358B1 (ko) 2017-10-16 2022-03-23 삼성전자주식회사 반도체 메모리 소자 및 그 제조 방법
JP7359396B2 (ja) * 2017-12-15 2023-10-11 ジ・オーストラリアン・ナショナル・ユニヴァーシティ 細胞外ヒストンによって媒介される病理を処置及び予防するための化合物
JP6619830B2 (ja) * 2018-02-22 2019-12-11 基亜生物科技股▲ふん▼有限公司Medigen Biotechnology Corp. 肝癌の再発、悪化または転移の抑制に用いる医薬組成物
CN109762032A (zh) * 2019-01-16 2019-05-17 天津科技大学 一种磺酸化路易斯x三糖及其合成方法和应用
SG11202109032SA (en) * 2019-02-25 2021-09-29 Univ Australian National Compounds for treating and preventing net associated complications
CN116813675B (zh) * 2023-08-23 2023-11-24 北京远大九和药业有限公司 一种化合物晶型及其制备、组合物和用途

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RU2133752C1 (ru) * 1993-04-22 1999-07-27 Елф Санофи Производные 3-дезоксиолигосахаридов, способ их получения (варианты), промежуточные соединения и фармацевтическая композиция
RU99121187A (ru) * 1997-03-11 2001-07-20 Дзе Острэйлиан Нэшнл Юниверсити Сульфатированные олигосахариды, обладающие антикоагулянтной/антитромботической активностью
RU2183638C2 (ru) * 1996-05-08 2002-06-20 Акцо Нобель Н.В. Углеводные производные, фармацевтическая композиция на их основе
RU2193039C2 (ru) * 1995-04-28 2002-11-20 Такара Сузо Ко., Лтд. Соединение сахара
RU2193040C2 (ru) * 1998-01-19 2002-11-20 Санофи-Синтелябо Новые пентасахариды и содержащие их фармацевтические композиции
RU2210573C2 (ru) * 1997-11-19 2003-08-20 Акцо Нобель Н.В. Углеводные производные

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US5739115A (en) 1993-10-07 1998-04-14 Glycomed Incorporated Sulfated maltooligosaccharides with heparin-like properties
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AUPN261895A0 (en) 1995-04-28 1995-05-18 Australian National University, The Preparation and use of sulfated oligosaccharides
JPH09183789A (ja) * 1995-10-31 1997-07-15 Sanwa Kagaku Kenkyusho Co Ltd 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途
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CN1450075A (zh) * 2002-04-11 2003-10-22 中国科学院生态环境研究中心 一类寡糖及其硫酸化产物和它们的制备方法及含该寡糖的药物组合物
RU2392281C2 (ru) * 2004-03-04 2010-06-20 Проджен Фармасьютикалз Лимитед Сульфатированные производные олигосахаридов

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RU2133752C1 (ru) * 1993-04-22 1999-07-27 Елф Санофи Производные 3-дезоксиолигосахаридов, способ их получения (варианты), промежуточные соединения и фармацевтическая композиция
RU2193039C2 (ru) * 1995-04-28 2002-11-20 Такара Сузо Ко., Лтд. Соединение сахара
RU2183638C2 (ru) * 1996-05-08 2002-06-20 Акцо Нобель Н.В. Углеводные производные, фармацевтическая композиция на их основе
RU99121187A (ru) * 1997-03-11 2001-07-20 Дзе Острэйлиан Нэшнл Юниверсити Сульфатированные олигосахариды, обладающие антикоагулянтной/антитромботической активностью
RU2210573C2 (ru) * 1997-11-19 2003-08-20 Акцо Нобель Н.В. Углеводные производные
RU2193040C2 (ru) * 1998-01-19 2002-11-20 Санофи-Синтелябо Новые пентасахариды и содержащие их фармацевтические композиции

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GAREGG PER J., OLSSON L., OSCARSON S. // BIOORGANIC & MEDICINAL CHEMISTRY, Vol:4, Nr.11, P.1867-1871. KHACHIGIAN L.M, PARISH C.R. CARDIOVASCULAR DRUG REVIEWS, Vol:22, P.1-6. *

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Publication number Publication date
US7875592B2 (en) 2011-01-25
BRPI0508144A (pt) 2007-07-24
WO2005085264A1 (en) 2005-09-15
AU2005219456B2 (en) 2011-04-07
CA2557989C (en) 2013-04-23
HK1199263A1 (en) 2015-06-26
US20110130354A1 (en) 2011-06-02
KR101156273B1 (ko) 2012-06-13
EP1720889B1 (en) 2014-11-26
CN103788141A (zh) 2014-05-14
NO338461B1 (no) 2016-08-15
TW200602351A (en) 2006-01-16
AU2005219456A1 (en) 2005-09-15
CN104119404A (zh) 2014-10-29
CN1989146A (zh) 2007-06-27
IL177870A (en) 2011-08-31
ZA200607057B (en) 2008-04-30
MXPA06010049A (es) 2007-04-10
JP5139797B2 (ja) 2013-02-06
RU2006134972A (ru) 2008-04-10
US20070185037A1 (en) 2007-08-09
NO20064489L (no) 2006-11-27
US8173606B2 (en) 2012-05-08
CN103788141B (zh) 2016-08-17
CA2557989A1 (en) 2005-09-15
EP1720889A4 (en) 2008-03-19
EP1720889A1 (en) 2006-11-15
TWI426080B (zh) 2014-02-11
IL177870A0 (en) 2006-12-31
ES2531880T3 (es) 2015-03-20
JP2007526257A (ja) 2007-09-13
KR20070007815A (ko) 2007-01-16

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