TWI426080B - 硫酸化寡醣衍生物 - Google Patents
硫酸化寡醣衍生物 Download PDFInfo
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- TWI426080B TWI426080B TW094106609A TW94106609A TWI426080B TW I426080 B TWI426080 B TW I426080B TW 094106609 A TW094106609 A TW 094106609A TW 94106609 A TW94106609 A TW 94106609A TW I426080 B TWI426080 B TW I426080B
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- TW
- Taiwan
- Prior art keywords
- sulfo
- tri
- mannopyranosyl
- compound
- mannopyranoside
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07H3/04—Disaccharides
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
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Applications Claiming Priority (1)
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| AU2004901103A AU2004901103A0 (en) | 2004-03-04 | Sulfated Oligosaccharide Derivatives |
Publications (2)
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5139797B2 (ja) * | 2004-03-04 | 2013-02-06 | プロジェン ファーマシューティカルズ リミテッド | 硫酸化オリゴ糖誘導体 |
| WO2006102717A1 (en) * | 2005-04-01 | 2006-10-05 | Christopher Richard Parish | Modulating angiogenesis with nod factors such as glucosamine oligosaccharides |
| RU2483074C2 (ru) * | 2007-10-16 | 2013-05-27 | Проджен Фармасьютикалз Лимитед | Новые сульфатированные производные олигосахаридов |
| WO2010003023A2 (en) * | 2008-07-01 | 2010-01-07 | Zacharon Pharmaceuticals, Inc. | Heparan sulfate inhibitors |
| EP2149580A1 (en) | 2008-07-15 | 2010-02-03 | Istituto Scientifico di Chimica E Biochimica "G Ronzoni | Mimetics of sulfated oligosaccharides |
| CN101591401A (zh) * | 2009-02-27 | 2009-12-02 | 江南大学 | 一种制备高活性低分子量肝素的方法 |
| JP5701498B2 (ja) * | 2009-12-01 | 2015-04-15 | 公益財団法人微生物化学研究会 | 炎症性細胞からのヘパラナーゼの放出抑制剤、抗炎症剤、及び薬用組成物 |
| CN107362168A (zh) * | 2011-06-09 | 2017-11-21 | 基亚生物科技股份有限公司 | 用于抑制肝癌复发、恶化或转移之医药组成物 |
| KR20160132034A (ko) | 2014-03-13 | 2016-11-16 | 우니페르시테트 바젤 | 미엘린-관련 당단백질에 대한 IgM 항체와 결합하는 탄수화물 리간드 |
| CN105017341B (zh) * | 2014-04-22 | 2018-05-15 | 华东师范大学 | 硫酸化岩藻-半乳四糖及其制备方法和应用 |
| CN104876979B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种具有抗Xa因子活性的磺酸化五糖化合物 |
| CN105001278B (zh) * | 2015-06-19 | 2018-07-06 | 天津红日药业股份有限公司 | 一种磺达肝癸钠二糖中间体片段的合成方法 |
| HK1252262A1 (zh) | 2015-09-16 | 2019-05-24 | 巴塞尔大学 | 结合抗糖鞘脂糖蛋白表位抗体的碳水化合物配体 |
| JP2016199579A (ja) * | 2016-07-08 | 2016-12-01 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| CN109069523B (zh) * | 2016-12-10 | 2022-05-06 | 扬州蓝色生物医药科技有限公司 | 甘露寡聚糖类化合物及其作为抗rna病毒药物的应用 |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| BR112019012045A2 (pt) | 2016-12-13 | 2020-08-18 | Beta Therapeutics Pty Ltd | inibidores de heparanase e uso dos mesmos |
| KR20190134591A (ko) | 2016-12-15 | 2019-12-04 | 프로젠 피지500 시리즈 피티와이 리미티드 | 조성물 및 그의 용도 |
| US10842804B2 (en) * | 2017-03-01 | 2020-11-24 | Medigen Biotechnology Corporation | Muparfostat for use in treating patients with hepatitis virus-related hepatocellular carcinoma after surgical resection |
| KR102377358B1 (ko) | 2017-10-16 | 2022-03-23 | 삼성전자주식회사 | 반도체 메모리 소자 및 그 제조 방법 |
| CN117427084A (zh) | 2017-12-15 | 2024-01-23 | 澳大利亚国立大学 | 用于治疗和预防细胞外组蛋白介导的病理的化合物 |
| JP6619830B2 (ja) * | 2018-02-22 | 2019-12-11 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| CN109762032A (zh) * | 2019-01-16 | 2019-05-17 | 天津科技大学 | 一种磺酸化路易斯x三糖及其合成方法和应用 |
| CN113473992A (zh) * | 2019-02-25 | 2021-10-01 | 澳大利亚国立大学 | 用于治疗和预防中性粒细胞胞外陷阱相关并发症的化合物 |
| CN116813675B (zh) * | 2023-08-23 | 2023-11-24 | 北京远大九和药业有限公司 | 一种化合物晶型及其制备、组合物和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996009828A1 (en) * | 1994-09-26 | 1996-04-04 | Glycomed Incorporated | Highly sulfated maltooligosaccharides with heparin-like properties |
| TW446710B (en) * | 1995-04-28 | 2001-07-21 | Univ Australian | Preparation and use of sulfated oligosaccharides |
| TW448180B (en) * | 1997-11-19 | 2001-08-01 | Akzo Nobel Nv | Sulfated pentasaccharide(s) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989003684A1 (fr) | 1987-10-30 | 1989-05-05 | Chugai Seiyaku Kabushiki Kaisha | Agent anti-vih |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP0722326A4 (en) * | 1993-10-07 | 1999-10-06 | Glycomed Inc | HIGHLY SULFATED MALTOOLIGOSSACCHARIDES WITH HEPARIN-LIKE PROPERTIES |
| JP3605414B2 (ja) * | 1995-04-28 | 2004-12-22 | タカラバイオ株式会社 | 糖化合物 |
| JPH09183789A (ja) * | 1995-10-31 | 1997-07-15 | Sanwa Kagaku Kenkyusho Co Ltd | 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途 |
| IL120722A (en) * | 1996-05-08 | 1999-07-14 | Akzo Nobel Nv | Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them |
| AUPO556297A0 (en) | 1997-03-11 | 1997-04-10 | Australian National University, The | Sulfated oligosaccharides having anticoagulant/ antithrombotic activity |
| FR2773801B1 (fr) * | 1998-01-19 | 2000-05-12 | Sanofi Sa | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
| CN1450075A (zh) * | 2002-04-11 | 2003-10-22 | 中国科学院生态环境研究中心 | 一类寡糖及其硫酸化产物和它们的制备方法及含该寡糖的药物组合物 |
| JP5139797B2 (ja) * | 2004-03-04 | 2013-02-06 | プロジェン ファーマシューティカルズ リミテッド | 硫酸化オリゴ糖誘導体 |
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- 2005-03-04 CN CNA2005800068338A patent/CN1989146A/zh active Pending
- 2005-03-04 MX MXPA06010049A patent/MXPA06010049A/es active IP Right Grant
- 2005-03-04 ES ES05706346.3T patent/ES2531880T3/es not_active Expired - Lifetime
- 2005-03-04 CN CN201410042932.2A patent/CN103788141B/zh not_active Expired - Fee Related
- 2005-03-04 CN CN201410353750.7A patent/CN104119404A/zh active Pending
- 2005-03-04 US US10/591,577 patent/US7875592B2/en not_active Expired - Fee Related
- 2005-03-04 TW TW094106609A patent/TWI426080B/zh not_active IP Right Cessation
- 2005-03-04 CA CA2557989A patent/CA2557989C/en not_active Expired - Fee Related
- 2005-03-04 AU AU2005219456A patent/AU2005219456B2/en not_active Ceased
- 2005-03-04 BR BRPI0508144-0A patent/BRPI0508144A/pt not_active Application Discontinuation
- 2005-03-04 KR KR1020067020704A patent/KR101156273B1/ko not_active Expired - Fee Related
- 2005-03-04 WO PCT/AU2005/000314 patent/WO2005085264A1/en not_active Ceased
- 2005-03-04 EP EP05706346.3A patent/EP1720889B1/en not_active Expired - Lifetime
- 2005-03-04 RU RU2006134972/04A patent/RU2392281C2/ru not_active IP Right Cessation
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- 2006-09-03 IL IL177870A patent/IL177870A/en active IP Right Grant
- 2006-10-03 NO NO20064489A patent/NO338461B1/no not_active IP Right Cessation
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996009828A1 (en) * | 1994-09-26 | 1996-04-04 | Glycomed Incorporated | Highly sulfated maltooligosaccharides with heparin-like properties |
| TW446710B (en) * | 1995-04-28 | 2001-07-21 | Univ Australian | Preparation and use of sulfated oligosaccharides |
| TW448180B (en) * | 1997-11-19 | 2001-08-01 | Akzo Nobel Nv | Sulfated pentasaccharide(s) |
Non-Patent Citations (1)
| Title |
|---|
| J.Med.Chem.,46,4601~4608,2003 Macromolecules,27(23),6695~6699,1994 * |
Also Published As
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| BRPI0508144A (pt) | 2007-07-24 |
| IL177870A0 (en) | 2006-12-31 |
| EP1720889A1 (en) | 2006-11-15 |
| EP1720889B1 (en) | 2014-11-26 |
| AU2005219456A1 (en) | 2005-09-15 |
| US8173606B2 (en) | 2012-05-08 |
| CA2557989A1 (en) | 2005-09-15 |
| CN103788141B (zh) | 2016-08-17 |
| MXPA06010049A (es) | 2007-04-10 |
| ZA200607057B (en) | 2008-04-30 |
| NO20064489L (no) | 2006-11-27 |
| CN103788141A (zh) | 2014-05-14 |
| IL177870A (en) | 2011-08-31 |
| KR101156273B1 (ko) | 2012-06-13 |
| WO2005085264A1 (en) | 2005-09-15 |
| US20070185037A1 (en) | 2007-08-09 |
| JP5139797B2 (ja) | 2013-02-06 |
| JP2007526257A (ja) | 2007-09-13 |
| US7875592B2 (en) | 2011-01-25 |
| KR20070007815A (ko) | 2007-01-16 |
| ES2531880T3 (es) | 2015-03-20 |
| CA2557989C (en) | 2013-04-23 |
| TW200602351A (en) | 2006-01-16 |
| AU2005219456B2 (en) | 2011-04-07 |
| EP1720889A4 (en) | 2008-03-19 |
| CN1989146A (zh) | 2007-06-27 |
| NO338461B1 (no) | 2016-08-15 |
| RU2392281C2 (ru) | 2010-06-20 |
| CN104119404A (zh) | 2014-10-29 |
| RU2006134972A (ru) | 2008-04-10 |
| US20110130354A1 (en) | 2011-06-02 |
| HK1199263A1 (en) | 2015-06-26 |
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