AU2005219456B2 - Sulfated oligosaccharide derivatives - Google Patents
Sulfated oligosaccharide derivatives Download PDFInfo
- Publication number
- AU2005219456B2 AU2005219456B2 AU2005219456A AU2005219456A AU2005219456B2 AU 2005219456 B2 AU2005219456 B2 AU 2005219456B2 AU 2005219456 A AU2005219456 A AU 2005219456A AU 2005219456 A AU2005219456 A AU 2005219456A AU 2005219456 B2 AU2005219456 B2 AU 2005219456B2
- Authority
- AU
- Australia
- Prior art keywords
- sulfono
- tri
- mannopyranosyl
- derivative
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002482 oligosaccharides Chemical class 0.000 title description 13
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- 125000003118 aryl group Chemical group 0.000 claims description 26
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- 125000002252 acyl group Chemical group 0.000 claims description 17
- 150000002772 monosaccharides Chemical group 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 16
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
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Priority Applications (1)
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|---|---|---|---|
| AU2005219456A AU2005219456B2 (en) | 2004-03-04 | 2005-03-04 | Sulfated oligosaccharide derivatives |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| AU2004901103A AU2004901103A0 (en) | 2004-03-04 | Sulfated Oligosaccharide Derivatives | |
| AU2004901103 | 2004-03-04 | ||
| PCT/AU2005/000314 WO2005085264A1 (en) | 2004-03-04 | 2005-03-04 | Sulfated oligosaccharide derivatives |
| AU2005219456A AU2005219456B2 (en) | 2004-03-04 | 2005-03-04 | Sulfated oligosaccharide derivatives |
Publications (2)
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| AU2005219456A1 AU2005219456A1 (en) | 2005-09-15 |
| AU2005219456B2 true AU2005219456B2 (en) | 2011-04-07 |
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| RU2392281C2 (ru) * | 2004-03-04 | 2010-06-20 | Проджен Фармасьютикалз Лимитед | Сульфатированные производные олигосахаридов |
| JP2008534519A (ja) * | 2005-04-01 | 2008-08-28 | クリストファー・リチャード・パリッシュ | グルコサミンオリゴ糖などのｎｏｄ因子を用いる血管新生の調節 |
| ES2584927T7 (es) * | 2007-10-16 | 2020-11-05 | Progen Pg500 Series Pty Ltd | Derivados de oligosacáridos sulfatados novedosos |
| JP2011526925A (ja) * | 2008-07-01 | 2011-10-20 | ザカロン ファーマシューティカルズ，インク． | ヘパラン硫酸阻害剤 |
| EP2149580A1 (en) | 2008-07-15 | 2010-02-03 | Istituto Scientifico di Chimica E Biochimica "G Ronzoni | Mimetics of sulfated oligosaccharides |
| CN101591401A (zh) * | 2009-02-27 | 2009-12-02 | 江南大学 | 一种制备高活性低分子量肝素的方法 |
| JP5701498B2 (ja) * | 2009-12-01 | 2015-04-15 | 公益財団法人微生物化学研究会 | 炎症性細胞からのヘパラナーゼの放出抑制剤、抗炎症剤、及び薬用組成物 |
| CN107362168A (zh) * | 2011-06-09 | 2017-11-21 | 基亚生物科技股份有限公司 | 用于抑制肝癌复发、恶化或转移之医药组成物 |
| EP3116887B1 (en) | 2014-03-13 | 2021-02-17 | Universität Basel | Carbohydrate ligands that bind to igm antibodies against myelin-associated glycoprotein |
| CN105017341B (zh) * | 2014-04-22 | 2018-05-15 | 华东师范大学 | 硫酸化岩藻-半乳四糖及其制备方法和应用 |
| CN105001278B (zh) * | 2015-06-19 | 2018-07-06 | 天津红日药业股份有限公司 | 一种磺达肝癸钠二糖中间体片段的合成方法 |
| CN104876979B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种具有抗Xa因子活性的磺酸化五糖化合物 |
| JP6849667B2 (ja) | 2015-09-16 | 2021-03-24 | ウニヴェルズィテート バーゼル | スフィンゴ糖脂質の糖鎖エピトープに対する抗体に結合する炭水化物リガンド |
| JP2016199579A (ja) * | 2016-07-08 | 2016-12-01 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| WO2018103680A1 (zh) * | 2016-12-10 | 2018-06-14 | 扬州蓝色生物医药科技有限公司 | 甘露寡聚糖类化合物及其作为抗rna病毒药物的应用 |
| JP2020503377A (ja) | 2016-12-13 | 2020-01-30 | ベータ セラピューティクス プロプライアタリー リミティド | ヘパラナーゼ阻害剤及びそれの使用 |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| WO2018107244A1 (en) | 2016-12-15 | 2018-06-21 | Progen Pg500 Series Pty Ltd | Composition and uses thereof |
| US10842804B2 (en) * | 2017-03-01 | 2020-11-24 | Medigen Biotechnology Corporation | Muparfostat for use in treating patients with hepatitis virus-related hepatocellular carcinoma after surgical resection |
| KR102377358B1 (ko) | 2017-10-16 | 2022-03-23 | 삼성전자주식회사 | 반도체 메모리 소자 및 그 제조 방법 |
| JP7359396B2 (ja) * | 2017-12-15 | 2023-10-11 | ジ・オーストラリアン・ナショナル・ユニヴァーシティ | 細胞外ヒストンによって媒介される病理を処置及び予防するための化合物 |
| JP6619830B2 (ja) * | 2018-02-22 | 2019-12-11 | 基亜生物科技股▲ふん▼有限公司Ｍｅｄｉｇｅｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． | 肝癌の再発、悪化または転移の抑制に用いる医薬組成物 |
| CN109762032A (zh) * | 2019-01-16 | 2019-05-17 | 天津科技大学 | 一种磺酸化路易斯x三糖及其合成方法和应用 |
| SG11202109032SA (en) * | 2019-02-25 | 2021-09-29 | Univ Australian National | Compounds for treating and preventing net associated complications |
| CN116813675B (zh) * | 2023-08-23 | 2023-11-24 | 北京远大九和药业有限公司 | 一种化合物晶型及其制备、组合物和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989003684A1 (fr) | 1987-10-30 | 1989-05-05 | Chugai Seiyaku Kabushiki Kaisha | Agent anti-vih |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5739115A (en) | 1993-10-07 | 1998-04-14 | Glycomed Incorporated | Sulfated maltooligosaccharides with heparin-like properties |
| JPH09503510A (ja) * | 1993-10-07 | 1997-04-08 | グリコメド・インコーポレイテッド | ヘパリン様特性を有する高硫酸化マルトオリゴ糖 |
| AUPN261895A0 (en) | 1995-04-28 | 1995-05-18 | Australian National University, The | Preparation and use of sulfated oligosaccharides |
| RU2193039C2 (ru) * | 1995-04-28 | 2002-11-20 | Такара Сузо Ко., Лтд. | Соединение сахара |
| JPH09183789A (ja) * | 1995-10-31 | 1997-07-15 | Sanwa Kagaku Kenkyusho Co Ltd | 新規な硫酸化及び燐酸化糖誘導体、その製法及び用途 |
| IL120722A (en) * | 1996-05-08 | 1999-07-14 | Akzo Nobel Nv | Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them |
| AUPO556297A0 (en) | 1997-03-11 | 1997-04-10 | Australian National University, The | Sulfated oligosaccharides having anticoagulant/ antithrombotic activity |
| IL126893A (en) * | 1997-11-19 | 2003-05-29 | Akzo Nobel Nv | Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them |
| FR2773801B1 (fr) * | 1998-01-19 | 2000-05-12 | Sanofi Sa | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
| CN1450075A (zh) * | 2002-04-11 | 2003-10-22 | 中国科学院生态环境研究中心 | 一类寡糖及其硫酸化产物和它们的制备方法及含该寡糖的药物组合物 |
| RU2392281C2 (ru) * | 2004-03-04 | 2010-06-20 | Проджен Фармасьютикалз Лимитед | Сульфатированные производные олигосахаридов |
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- 2005-03-04 EP EP05706346.3A patent/EP1720889B1/en not_active Expired - Lifetime
- 2005-03-04 TW TW094106609A patent/TWI426080B/zh not_active IP Right Cessation
- 2005-03-04 CN CNA2005800068338A patent/CN1989146A/zh active Pending
- 2005-03-04 WO PCT/AU2005/000314 patent/WO2005085264A1/en not_active Ceased
- 2005-03-04 KR KR1020067020704A patent/KR101156273B1/ko not_active Expired - Fee Related
- 2005-03-04 US US10/591,577 patent/US7875592B2/en not_active Expired - Fee Related
- 2005-03-04 CN CN201410042932.2A patent/CN103788141B/zh not_active Expired - Fee Related
- 2005-03-04 CN CN201410353750.7A patent/CN104119404A/zh active Pending
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- 2005-03-04 ES ES05706346.3T patent/ES2531880T3/es not_active Expired - Lifetime
- 2005-03-04 JP JP2007501068A patent/JP5139797B2/ja not_active Expired - Fee Related
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- 2006-10-03 NO NO20064489A patent/NO338461B1/no not_active IP Right Cessation
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2010
- 2010-12-03 US US12/960,145 patent/US8173606B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Khachigian et al, Cardiovascular Drug Reviews, 22(1), 1-6 (2004); Cochran et al, J. Med. Chem., 46, 4601-8 (2003); WO 1996 / 009828 A * |
Also Published As
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|---|---|
| US7875592B2 (en) | 2011-01-25 |
| BRPI0508144A (pt) | 2007-07-24 |
| WO2005085264A1 (en) | 2005-09-15 |
| CA2557989C (en) | 2013-04-23 |
| HK1199263A1 (en) | 2015-06-26 |
| US20110130354A1 (en) | 2011-06-02 |
| KR101156273B1 (ko) | 2012-06-13 |
| EP1720889B1 (en) | 2014-11-26 |
| CN103788141A (zh) | 2014-05-14 |
| NO338461B1 (no) | 2016-08-15 |
| TW200602351A (en) | 2006-01-16 |
| AU2005219456A1 (en) | 2005-09-15 |
| CN104119404A (zh) | 2014-10-29 |
| CN1989146A (zh) | 2007-06-27 |
| IL177870A (en) | 2011-08-31 |
| ZA200607057B (en) | 2008-04-30 |
| MXPA06010049A (es) | 2007-04-10 |
| JP5139797B2 (ja) | 2013-02-06 |
| RU2006134972A (ru) | 2008-04-10 |
| US20070185037A1 (en) | 2007-08-09 |
| NO20064489L (no) | 2006-11-27 |
| US8173606B2 (en) | 2012-05-08 |
| CN103788141B (zh) | 2016-08-17 |
| CA2557989A1 (en) | 2005-09-15 |
| EP1720889A4 (en) | 2008-03-19 |
| EP1720889A1 (en) | 2006-11-15 |
| TWI426080B (zh) | 2014-02-11 |
| IL177870A0 (en) | 2006-12-31 |
| ES2531880T3 (es) | 2015-03-20 |
| RU2392281C2 (ru) | 2010-06-20 |
| JP2007526257A (ja) | 2007-09-13 |
| KR20070007815A (ko) | 2007-01-16 |
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