JP2005501091A5 - - Google Patents

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Publication number
JP2005501091A5
JP2005501091A5 JP2003519060A JP2003519060A JP2005501091A5 JP 2005501091 A5 JP2005501091 A5 JP 2005501091A5 JP 2003519060 A JP2003519060 A JP 2003519060A JP 2003519060 A JP2003519060 A JP 2003519060A JP 2005501091 A5 JP2005501091 A5 JP 2005501091A5
Authority
JP
Japan
Prior art keywords
alkyl
pharmaceutically acceptable
hydrolyzed
vivo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003519060A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005501091A (ja
Filing date
Publication date
Priority claimed from GBGB0119474.5A external-priority patent/GB0119474D0/en
Application filed filed Critical
Publication of JP2005501091A publication Critical patent/JP2005501091A/ja
Publication of JP2005501091A5 publication Critical patent/JP2005501091A5/ja
Pending legal-status Critical Current

Links

JP2003519060A 2001-08-09 2002-08-08 アリールピペラジンとアリールピペリジン、およびメタロプロテイナーゼ阻害剤としてのそれらの使用 Pending JP2005501091A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119474.5A GB0119474D0 (en) 2001-08-09 2001-08-09 Compounds
PCT/SE2002/001436 WO2003014111A1 (en) 2001-08-09 2002-08-08 Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents

Publications (2)

Publication Number Publication Date
JP2005501091A JP2005501091A (ja) 2005-01-13
JP2005501091A5 true JP2005501091A5 (enExample) 2006-01-12

Family

ID=9920126

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003519060A Pending JP2005501091A (ja) 2001-08-09 2002-08-08 アリールピペラジンとアリールピペリジン、およびメタロプロテイナーゼ阻害剤としてのそれらの使用

Country Status (5)

Country Link
US (2) US7153857B2 (enExample)
EP (1) EP1417201A1 (enExample)
JP (1) JP2005501091A (enExample)
GB (1) GB0119474D0 (enExample)
WO (1) WO2003014111A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
DE10250708A1 (de) * 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017930A1 (de) * 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US20050245529A1 (en) * 2004-04-14 2005-11-03 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
CN101583365B (zh) 2006-12-15 2012-09-26 阿布拉西斯生物科学公司 三嗪衍生物及其治疗应用
US8877924B2 (en) 2009-06-09 2014-11-04 NantBio Inc. Benzyl substituted triazine derivatives and their therapeutical applications
US9078902B2 (en) 2009-06-09 2015-07-14 Nantbioscience, Inc. Triazine derivatives and their therapeutical applications

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5817822A (en) * 1994-06-24 1998-10-06 Novartis Corporation Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
EP0968182B1 (en) 1996-08-07 2004-05-06 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
WO1998016514A1 (en) 1996-10-16 1998-04-23 American Cyanamid Company Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6376506B1 (en) * 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
EP0958287B2 (en) 1997-01-23 2008-04-09 F. Hoffmann-La Roche Ag Sulfamide-metalloprotease inhibitors
EP0925289A1 (en) 1997-07-10 1999-06-30 PHARMACIA & UPJOHN S.p.A. Matrix metalloproteinase inhibitors
US6482827B1 (en) * 1997-07-10 2002-11-19 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
US6294573B1 (en) * 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6235786B1 (en) * 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
ZA988967B (en) 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
US6403632B1 (en) * 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
GB9725782D0 (en) * 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
IL137146A0 (en) 1998-01-30 2001-07-24 Darwin Discovery Ltd Hydroxamic and carboxylic acid derivatives
AU5634999A (en) * 1998-08-29 2000-03-21 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as proteinase inhibitors
GB9919776D0 (en) * 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
AU775701B2 (en) * 1999-02-08 2004-08-12 G.D. Searle & Co. Sulfamato hydroxamic acid metalloprotease inhibitor
US6511993B1 (en) * 1999-06-03 2003-01-28 Kevin Neil Dack Metalloprotease inhibitors
CN1159295C (zh) 1999-06-04 2004-07-28 阿斯特拉曾尼卡有限公司 金属蛋白酶抑制剂
AU783284B2 (en) * 2000-02-21 2005-10-13 Astrazeneca Ab Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases
JP2003524007A (ja) 2000-02-21 2003-08-12 アストラゼネカ・アクチエボラーグ アリールピペラジン類およびそれらのメタロプロテイナーゼ阻害剤（ｍｍｐ）としての使用
IL150882A0 (en) 2000-02-21 2003-02-12 Astrazeneca Ab Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents
ATE254118T1 (de) * 2000-05-15 2003-11-15 Darwin Discovery Ltd Hydroxamsäure derivate
GB0119472D0 (en) 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119473D0 (en) 2001-08-09 2001-10-03 Astrazeneca Compounds

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