JP2005521712A5 - - Google Patents
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- Publication number
- JP2005521712A5 JP2005521712A5 JP2003579811A JP2003579811A JP2005521712A5 JP 2005521712 A5 JP2005521712 A5 JP 2005521712A5 JP 2003579811 A JP2003579811 A JP 2003579811A JP 2003579811 A JP2003579811 A JP 2003579811A JP 2005521712 A5 JP2005521712 A5 JP 2005521712A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- carbon atoms
- composition
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 34
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 25
- 239000001257 hydrogen Substances 0.000 claims 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 25
- -1 nitro, methyl Chemical group 0.000 claims 24
- 239000000872 buffer Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 230000002378 acidificating effect Effects 0.000 claims 6
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 6
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- 125000005430 oxychloro group Chemical group 0.000 claims 6
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000006013 carbendazim Substances 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001556 benzimidazoles Chemical class 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- OHVAUORVDZJNLE-UHFFFAOYSA-N CC(C1)C=Nc2c1nc(-c1ccc[s]1)[nH]2 Chemical compound CC(C1)C=Nc2c1nc(-c1ccc[s]1)[nH]2 OHVAUORVDZJNLE-UHFFFAOYSA-N 0.000 description 1
- 0 CC=C[C@@]1N=C(*)N(*)C1C=C Chemical compound CC=C[C@@]1N=C(*)N(*)C1C=C 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36868402P | 2002-03-26 | 2002-03-26 | |
| PCT/US2003/009668 WO2003082273A1 (en) | 2002-03-26 | 2003-03-26 | Solubilization of weak bases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521712A JP2005521712A (ja) | 2005-07-21 |
| JP2005521712A5 true JP2005521712A5 (enExample) | 2006-05-11 |
Family
ID=28675527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579811A Pending JP2005521712A (ja) | 2002-03-26 | 2003-03-26 | 弱塩基の可溶化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7022712B2 (enExample) |
| EP (1) | EP1487439A1 (enExample) |
| JP (1) | JP2005521712A (enExample) |
| AU (1) | AU2003220585A1 (enExample) |
| CA (1) | CA2478470A1 (enExample) |
| MX (1) | MXPA04009201A (enExample) |
| WO (1) | WO2003082273A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002239395A1 (en) * | 2000-11-01 | 2002-06-03 | The Procter And Gamble Company | Hiv treatment with benzimidazoles |
| US20080132419A1 (en) * | 2006-10-04 | 2008-06-05 | Nair Rodriguez-Hornedo | Dissolution and precipitation of cocrystals with ionizable components |
| CA2930565A1 (en) | 2013-11-14 | 2015-05-21 | Insys Pharma, Inc. | Ondansetron sublingual spray formulation |
| RS61418B1 (sr) * | 2014-11-06 | 2021-03-31 | Xellia Pharmaceuticals Aps | Kompozicije glikopeptida |
| US10172833B2 (en) | 2015-08-11 | 2019-01-08 | Insys Development Company, Inc. | Sublingual ondansetron spray |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3738995A (en) * | 1971-05-14 | 1973-06-12 | Du Pont | Solvent process for the preparation of 1 - carbamoyl-substituted 2 - benzimidazolecarbamates |
| DE2340741A1 (de) * | 1973-08-11 | 1975-02-20 | Basf Ag | Fungizid |
| DE2952239A1 (de) | 1979-12-22 | 1981-07-02 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Fungizide mischungen |
| FI68498C (fi) | 1981-06-25 | 1985-10-10 | Web Berlin Chemie | Blandning foer bekaempning av fytopatogeniska svampar och bakterier |
| DE3323024A1 (de) | 1983-06-25 | 1985-01-03 | Hoechst Ag, 6230 Frankfurt | Verfahren zur verminderung von nebenproduktanteilen bei der herstellung von carbendazim |
| GB8521082D0 (en) | 1985-08-22 | 1985-09-25 | Ici Plc | Fungicides |
| GB8629360D0 (en) | 1986-12-09 | 1987-01-21 | Sandoz Ltd | Fungicides |
| US5591744A (en) | 1987-04-16 | 1997-01-07 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US5198444A (en) | 1987-04-17 | 1993-03-30 | Imperial Chemical Industries Plc | Methyl α-(2-substituted)pyrid-3-yl-β-methoxyacrylates, compositions containing them and their use as fungicides |
| HU202728B (en) | 1988-01-14 | 1991-04-29 | Eszakmagyar Vegyimuevek | Synergetic fungicide and acaricide compositions containing two or three active components |
| DE4142731A1 (de) | 1991-12-21 | 1993-06-24 | Hoechst Ag | Biozide polymerisate und polymerisatdispersionen, verfahren zu ihrer herstellung und ihre verwendung |
| DE4242389C2 (de) | 1992-12-08 | 1995-09-21 | Schuelke & Mayr Gmbh | Wäßrige Dispersion mit fungizider und algistatischer Wirkung |
| US5629341A (en) | 1995-04-12 | 1997-05-13 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6479526B1 (en) * | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| NZ305784A (en) | 1995-04-12 | 2001-03-30 | Procter & Gamble | Benzimidazole containing medicaments for treating cancers, tumors and viral infections |
| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| ZA962879B (en) | 1995-04-12 | 1997-03-17 | Procter & Gamble | A pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| GB9725445D0 (en) | 1997-12-01 | 1998-01-28 | Ciba Geigy Ag | Organic compounds |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| BR9814719A (pt) | 1997-12-01 | 2000-10-03 | Novartis Ag Novartins Sa Novar | "combinações fungicidas que compreendem quinazolinona" |
| JP4424763B2 (ja) | 1998-04-09 | 2010-03-03 | サントリーホールディングス株式会社 | 超臨界水処理による芳香族化合物の製造方法 |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| ATE298569T1 (de) * | 1999-03-31 | 2005-07-15 | Uaf Technologies And Res Llc | Virus behandlung |
| US6197805B1 (en) | 1999-05-27 | 2001-03-06 | Troy Technology Corporation, Inc. | Broad spectrum antimicrobial mixtures |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6228400B1 (en) | 1999-09-28 | 2001-05-08 | Carlsbad Technology, Inc. | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
| US6384049B1 (en) | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
| US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6407105B1 (en) | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6608096B1 (en) | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| AU2001292796B2 (en) | 2000-09-26 | 2005-12-22 | Uaf Technologies And Research Llc | Benzimidazoles and methods for use thereof in the treatment of cancer or viral infections |
| AU2002239395A1 (en) | 2000-11-01 | 2002-06-03 | The Procter And Gamble Company | Hiv treatment with benzimidazoles |
-
2003
- 2003-03-26 AU AU2003220585A patent/AU2003220585A1/en not_active Abandoned
- 2003-03-26 WO PCT/US2003/009668 patent/WO2003082273A1/en not_active Ceased
- 2003-03-26 CA CA002478470A patent/CA2478470A1/en not_active Abandoned
- 2003-03-26 JP JP2003579811A patent/JP2005521712A/ja active Pending
- 2003-03-26 EP EP03716899A patent/EP1487439A1/en not_active Withdrawn
- 2003-03-26 MX MXPA04009201A patent/MXPA04009201A/es unknown
- 2003-03-26 US US10/402,347 patent/US7022712B2/en not_active Expired - Fee Related
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