|
EP1358163A1
(en)
|
2001-01-23 |
2003-11-05 |
Eli Lilly And Company |
Melanocortin receptor agonists
|
|
JP2004523530A
(ja)
|
2001-01-23 |
2004-08-05 |
イーライ・リリー・アンド・カンパニー |
メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体
|
|
EP1363898A4
(en)
|
2001-03-02 |
2004-12-08 |
Bristol Myers Squibb Co |
COMPOUNDS SUITABLE AS MODULATORS OF MELANOCORTIN RECEPTORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
|
|
US6911447B2
(en)
|
2001-04-25 |
2005-06-28 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
US6977264B2
(en)
|
2001-07-25 |
2005-12-20 |
Amgen Inc. |
Substituted piperidines and methods of use
|
|
US7115607B2
(en)
|
2001-07-25 |
2006-10-03 |
Amgen Inc. |
Substituted piperazinyl amides and methods of use
|
|
US7354923B2
(en)
|
2001-08-10 |
2008-04-08 |
Palatin Technologies, Inc. |
Piperazine melanocortin-specific compounds
|
|
US7456184B2
(en)
|
2003-05-01 |
2008-11-25 |
Palatin Technologies Inc. |
Melanocortin receptor-specific compounds
|
|
EP1469851B1
(en)
|
2002-01-23 |
2006-10-11 |
Eli Lilly And Company |
Melanocortin receptor agonists
|
|
US7026335B2
(en)
|
2002-04-30 |
2006-04-11 |
The Procter & Gamble Co. |
Melanocortin receptor ligands
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
US7414057B2
(en)
|
2002-09-11 |
2008-08-19 |
Merck & Co., Inc. |
Piperazine urea derivatives as melanocortin-4 receptor agonists
|
|
US7132539B2
(en)
*
|
2002-10-23 |
2006-11-07 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
AU2003281978A1
(en)
*
|
2002-11-22 |
2004-06-18 |
Boehringer Ingelheim International Gmbh |
2,5-diketopiperazines for the treatment of obesity
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US7160886B2
(en)
|
2003-03-03 |
2007-01-09 |
Merck & Co., Inc. |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
|
|
JP2006515341A
(ja)
|
2003-03-03 |
2006-05-25 |
エフ．ホフマン−ラ ロシュ アーゲー |
５−ｈｔ６調節物質として使用するための２，５−および２，６−置換テトラヒドロイソキノリン
|
|
EP1468999A1
(en)
*
|
2003-03-20 |
2004-10-20 |
MyoContract Ltd. |
Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators
|
|
ATE474577T1
(de)
|
2003-03-26 |
2010-08-15 |
Merck Sharp & Dohme |
Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
|
|
WO2005028438A1
(ja)
|
2003-09-22 |
2005-03-31 |
Banyu Pharmaceutical Co., Ltd. |
新規ピペリジン誘導体
|
|
US20050192286A1
(en)
*
|
2003-10-22 |
2005-09-01 |
Neurocrine Biosciences, Inc. |
Ligands of melanocortin receptors and compositions and methods related thereto
|
|
US20050119252A1
(en)
*
|
2003-10-22 |
2005-06-02 |
Neurocrine Biosciences, Inc. |
Ligands of melanocortin receptors and compositions and methods related thereto
|
|
TWI341835B
(en)
|
2003-11-12 |
2011-05-11 |
Lg Life Sciences Ltd |
Melanocortin receptor agonists
|
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
|
US7449481B2
(en)
*
|
2004-04-13 |
2008-11-11 |
Cephalon, Inc. |
Thio-substituted biaryl-methanesulfinyl derivatives
|
|
EP1892241B1
(en)
|
2005-05-30 |
2016-03-30 |
Msd K.K. |
Novel piperidine derivative
|
|
EP1916239A4
(en)
|
2005-08-10 |
2009-10-21 |
Banyu Pharma Co Ltd |
PYRIDOLVERBINDUNG
|
|
US7875633B2
(en)
|
2005-08-24 |
2011-01-25 |
Banyu Pharmaceutical Co., Ltd. |
Phenylpyridone derivative
|
|
WO2007029847A1
(ja)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
二環性芳香族置換ピリドン誘導体
|
|
KR20080048502A
(ko)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
|
CA2625877A1
(en)
|
2005-10-18 |
2007-04-26 |
Merck & Co., Inc. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
RU2008119687A
(ru)
|
2005-10-21 |
2009-11-27 |
Новартис АГ (CH) |
Комбинации органических соединений
|
|
AU2006307046A1
(en)
|
2005-10-27 |
2007-05-03 |
Msd K.K. |
Novel benzoxathiin derivative
|
|
RU2428423C2
(ru)
|
2005-11-10 |
2011-09-10 |
Баниу Фармасьютикал Ко., Лтд. |
Азазамещенные спиропроизводные
|
|
TWI332501B
(en)
*
|
2006-07-14 |
2010-11-01 |
Lg Life Sciences Ltd |
Melanocortin receptor agonists
|
|
AU2007300627B2
(en)
|
2006-09-22 |
2012-02-16 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
EP2072519A4
(en)
|
2006-09-28 |
2009-10-21 |
Banyu Pharma Co Ltd |
DIARYLKETIMINDERIVAT
|
|
AU2008233662B2
(en)
|
2007-04-02 |
2012-08-23 |
Msd K.K. |
Indoledione derivative
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
WO2008151257A2
(en)
|
2007-06-04 |
2008-12-11 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
AU2009220605A1
(en)
|
2008-03-06 |
2009-09-11 |
Msd K.K. |
Alkylaminopyridine derivative
|
|
CA2717384A1
(en)
|
2008-03-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
ES2627848T3
(es)
|
2008-06-04 |
2017-07-31 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
|
|
AU2009261248A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diarylketoxime derivative
|
|
US8227628B2
(en)
|
2008-07-09 |
2012-07-24 |
Northwestern University |
Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein
|
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
|
US20110124674A1
(en)
|
2008-07-30 |
2011-05-26 |
Hiroyuki Kishino |
5/5-or 5/6-membered condensed ring cycloalkylamine derivative
|
|
US8410284B2
(en)
|
2008-10-22 |
2013-04-02 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
WO2010051206A1
(en)
|
2008-10-31 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
UA99555C2
(en)
|
2008-11-12 |
2012-08-27 |
Элджи Лайф Саенсез Лтд. |
Melanocortin receptor agonists
|
|
JP5514831B2
(ja)
|
2008-11-17 |
2014-06-04 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病の治療のための置換二環式アミン
|
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
CA2768577A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
US8476227B2
(en)
|
2010-01-22 |
2013-07-02 |
Ethicon Endo-Surgery, Inc. |
Methods of activating a melanocortin-4 receptor pathway in obese subjects
|
|
US9044606B2
(en)
|
2010-01-22 |
2015-06-02 |
Ethicon Endo-Surgery, Inc. |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
US8785634B2
(en)
|
2010-04-26 |
2014-07-22 |
Merck Sharp & Dohme Corp |
Spiropiperidine prolylcarboxypeptidase inhibitors
|
|
WO2011143057A1
(en)
|
2010-05-11 |
2011-11-17 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
EP2579873A4
(en)
|
2010-06-11 |
2013-11-27 |
Merck Sharp & Dohme |
NOVEL PROLYLCARBOXYPEPTIDASE HEMMER
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CA2826649C
(en)
|
2011-02-25 |
2016-07-26 |
Merck Sharp & Dohme Corp. |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
US20140045746A1
(en)
|
2012-08-02 |
2014-02-13 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
JP2016516004A
(ja)
|
2013-02-22 |
2016-06-02 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
抗糖尿病二環式化合物
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
EP2968439A2
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
PL3004138T3
(pl)
|
2013-06-05 |
2024-07-29 |
Bausch Health Ireland Limited |
Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
|
|
TR201807959T4
(tr)
|
2013-07-22 |
2018-06-21 |
Idorsia Pharmaceuticals Ltd |
1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
AR099789A1
(es)
|
2014-03-24 |
2016-08-17 |
Actelion Pharmaceuticals Ltd |
Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
|
|
BR112017003745A2
(pt)
|
2014-08-29 |
2017-12-05 |
Tes Pharma S R L |
inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
|
|
US10092738B2
(en)
|
2014-12-29 |
2018-10-09 |
Ethicon Llc |
Methods and devices for inhibiting nerves when activating brown adipose tissue
|
|
US10080884B2
(en)
|
2014-12-29 |
2018-09-25 |
Ethicon Llc |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
AR103399A1
(es)
|
2015-01-15 |
2017-05-10 |
Actelion Pharmaceuticals Ltd |
Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
|
|
RS58349B1
(sr)
|
2015-01-15 |
2019-03-29 |
Idorsia Pharmaceuticals Ltd |
Hidroksialkil-piperazinski derivati kao modulatori cxcr3 receptora
|
|
AU2017342083A1
(en)
|
2016-10-14 |
2019-04-11 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
WO2018106518A1
(en)
|
2016-12-06 |
2018-06-14 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
WO2018118670A1
(en)
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
|
KR102695210B1
(ko)
*
|
2018-06-05 |
2024-08-13 |
크리네틱스 파마슈티칼스, 인크. |
멜라노코르틴 아형-2 수용체(mc2r) 길항제 및 이의 용도
|
|
EP3883930A1
(en)
|
2018-11-20 |
2021-09-29 |
Tes Pharma S.r.l. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
WO2021039023A1
(ja)
*
|
2019-08-23 |
2021-03-04 |
持田製薬株式会社 |
ヘテロシクリデンアセトアミド誘導体の製造方法
|
|
MX2023004731A
(es)
*
|
2020-10-29 |
2023-05-10 |
Lg Chemical Ltd |
Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma.
|
|
CN116507615A
(zh)
*
|
2020-10-29 |
2023-07-28 |
株式会社Lg化学 |
黑皮质素受体激动剂化合物的晶型i及其制备方法
|
|
EP4219471A4
(en)
*
|
2020-10-29 |
2024-03-13 |
Lg Chem, Ltd. |
Amorphous melanocortin-4 receptor agonist
|
|
PE20240366A1
(es)
*
|
2020-10-29 |
2024-03-04 |
Lg Chemical Ltd |
Forma cristalina iii del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma
|
|
EP4219473A4
(en)
*
|
2020-10-29 |
2024-03-13 |
Lg Chem, Ltd. |
CRYSTAL TYPE II OF A MALANOCORTIN RECEPTOR AGONIST COMPOUND AND METHOD FOR THE PRODUCTION THEREOF
|
|
CA3202315A1
(en)
*
|
2020-12-22 |
2022-06-30 |
Hee Dong Park |
Use as selective agonist of malanocortin-4 receptor
|
|
TWI814185B
(zh)
*
|
2020-12-22 |
2023-09-01 |
南韓商Ｌｇ化學股份有限公司 |
黑皮質素受體促效劑化合物之晶型ii及其製備方法
|
|
TWI810757B
(zh)
*
|
2020-12-22 |
2023-08-01 |
南韓商Ｌｇ化學股份有限公司 |
黑皮質素受體促效劑化合物的晶型ｉ及其製備方法
|
|
JP2024501829A
(ja)
|
2020-12-22 |
2024-01-16 |
エルジー・ケム・リミテッド |
メラノコルチン受容体アゴニスト化合物の結晶形ｉｉｉおよびその製造方法
|
|
TWI804170B
(zh)
*
|
2021-01-21 |
2023-06-01 |
南韓商Ｌｇ化學股份有限公司 |
黑皮質素-4受體促效劑的用途
|
|
TWI826938B
(zh)
*
|
2021-02-26 |
2023-12-21 |
南韓商Ｌｇ化學股份有限公司 |
黑皮質素-4受體促效劑
|
|
CN117255786A
(zh)
*
|
2021-05-06 |
2023-12-19 |
株式会社Lg 化学 |
黑皮质素受体激动剂化合物的晶型vii及其制备方法
|
|
KR102854595B1
(ko)
*
|
2021-05-06 |
2025-09-03 |
주식회사 엘지화학 |
멜라노코르틴 수용체 작용제 화합물의 결정형 v 및 이의 제조방법
|
|
KR102854598B1
(ko)
*
|
2021-05-07 |
2025-09-03 |
주식회사 엘지화학 |
멜라노코르틴 수용체 작용제 화합물의 황산염의 결정형 및 이의 제조방법
|
|
JP2024517271A
(ja)
*
|
2021-05-07 |
2024-04-19 |
エルジー・ケム・リミテッド |
メラノコルチン受容体アゴニスト化合物の有機酸塩の結晶形ｉｖおよびその製造方法
|
|
US20240239769A1
(en)
*
|
2021-05-07 |
2024-07-18 |
Lg Chem, Ltd. |
Co-crystal of melanocortin receptor agonist compound and vanillin and method for preparing same
|