JP2004521117A - メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン - Google Patents
メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン Download PDFInfo
- Publication number
- JP2004521117A JP2004521117A JP2002559409A JP2002559409A JP2004521117A JP 2004521117 A JP2004521117 A JP 2004521117A JP 2002559409 A JP2002559409 A JP 2002559409A JP 2002559409 A JP2002559409 A JP 2002559409A JP 2004521117 A JP2004521117 A JP 2004521117A
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- 0 C=*CC(C1)[*+]Cc2c1cccc2 Chemical compound C=*CC(C1)[*+]Cc2c1cccc2 0.000 description 14
- XSSWFYSBSGAYOD-UHFFFAOYSA-N CC(C)(C)OC(N1C(CC(O)=O)c2ccccc2C1)=O Chemical compound CC(C)(C)OC(N1C(CC(O)=O)c2ccccc2C1)=O XSSWFYSBSGAYOD-UHFFFAOYSA-N 0.000 description 2
- KZGANJFEUHORED-UHFFFAOYSA-N C=[Br]c1c(C=C(CC2)N3CCOCC3)c2ccc1 Chemical compound C=[Br]c1c(C=C(CC2)N3CCOCC3)c2ccc1 KZGANJFEUHORED-UHFFFAOYSA-N 0.000 description 1
- ZTXJCCMGHPXAGQ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c1c(cncc2)c2ccc1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1c(cncc2)c2ccc1)=O ZTXJCCMGHPXAGQ-UHFFFAOYSA-N 0.000 description 1
- ZAWPAGYWUKXQNK-VQCQRNETSA-N CC(C)(C)OC(N1C(CC(N[C@H](Cc(cc2)ccc2Cl)C(OC)=O)=O)c2ccccc2C1)=O Chemical compound CC(C)(C)OC(N1C(CC(N[C@H](Cc(cc2)ccc2Cl)C(OC)=O)=O)c2ccccc2C1)=O ZAWPAGYWUKXQNK-VQCQRNETSA-N 0.000 description 1
- WCSOQNUPONWLSG-UHFFFAOYSA-N CCOC(C(C1)NC(C)(C)c(cc2)c1cc2OC)=O Chemical compound CCOC(C(C1)NC(C)(C)c(cc2)c1cc2OC)=O WCSOQNUPONWLSG-UHFFFAOYSA-N 0.000 description 1
- RMKUIMTVLKSVEX-UHFFFAOYSA-N CCOC(C(Cc1c2)NC(C)(C)c1ccc2O)=O Chemical compound CCOC(C(Cc1c2)NC(C)(C)c1ccc2O)=O RMKUIMTVLKSVEX-UHFFFAOYSA-N 0.000 description 1
- YXOVIGZJPGLNGM-UHFFFAOYSA-N Cc1cccc2c1CCCC2 Chemical compound Cc1cccc2c1CCCC2 YXOVIGZJPGLNGM-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N OS(C(F)(F)F)(=O)=O Chemical compound OS(C(F)(F)F)(=O)=O ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26359501P | 2001-01-23 | 2001-01-23 | |
| PCT/US2002/000516 WO2002059107A1 (en) | 2001-01-23 | 2002-01-23 | Substituted piperidines/piperazines as melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521117A true JP2004521117A (ja) | 2004-07-15 |
| JP2004521117A5 JP2004521117A5 (enExample) | 2005-12-22 |
Family
ID=23002443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559409A Pending JP2004521117A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7157463B2 (enExample) |
| EP (1) | EP1368339A1 (enExample) |
| JP (1) | JP2004521117A (enExample) |
| CA (1) | CA2433025A1 (enExample) |
| WO (1) | WO2002059107A1 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1358163A1 (en) | 2001-01-23 | 2003-11-05 | Eli Lilly And Company | Melanocortin receptor agonists |
| JP2004523530A (ja) | 2001-01-23 | 2004-08-05 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
| EP1363898A4 (en) | 2001-03-02 | 2004-12-08 | Bristol Myers Squibb Co | COMPOUNDS SUITABLE AS MODULATORS OF MELANOCORTIN RECEPTORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| EP1469851B1 (en) | 2002-01-23 | 2006-10-11 | Eli Lilly And Company | Melanocortin receptor agonists |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7414057B2 (en) | 2002-09-11 | 2008-08-19 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| US7132539B2 (en) * | 2002-10-23 | 2006-11-07 | The Procter & Gamble Company | Melanocortin receptor ligands |
| AU2003281978A1 (en) * | 2002-11-22 | 2004-06-18 | Boehringer Ingelheim International Gmbh | 2,5-diketopiperazines for the treatment of obesity |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7160886B2 (en) | 2003-03-03 | 2007-01-09 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
| JP2006515341A (ja) | 2003-03-03 | 2006-05-25 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６調節物質として使用するための２，５−および２，６−置換テトラヒドロイソキノリン |
| EP1468999A1 (en) * | 2003-03-20 | 2004-10-20 | MyoContract Ltd. | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators |
| ATE474577T1 (de) | 2003-03-26 | 2010-08-15 | Merck Sharp & Dohme | Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| US20050192286A1 (en) * | 2003-10-22 | 2005-09-01 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| US20050119252A1 (en) * | 2003-10-22 | 2005-06-02 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| TWI341835B (en) | 2003-11-12 | 2011-05-11 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| EP1892241B1 (en) | 2005-05-30 | 2016-03-30 | Msd K.K. | Novel piperidine derivative |
| EP1916239A4 (en) | 2005-08-10 | 2009-10-21 | Banyu Pharma Co Ltd | PYRIDOLVERBINDUNG |
| US7875633B2 (en) | 2005-08-24 | 2011-01-25 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| KR20080048502A (ko) | 2005-09-29 | 2008-06-02 | 머크 앤드 캄파니 인코포레이티드 | 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체 |
| CA2625877A1 (en) | 2005-10-18 | 2007-04-26 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
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| RU2428423C2 (ru) | 2005-11-10 | 2011-09-10 | Баниу Фармасьютикал Ко., Лтд. | Азазамещенные спиропроизводные |
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| AU2017342083A1 (en) | 2016-10-14 | 2019-04-11 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| KR102695210B1 (ko) * | 2018-06-05 | 2024-08-13 | 크리네틱스 파마슈티칼스, 인크. | 멜라노코르틴 아형-2 수용체(mc2r) 길항제 및 이의 용도 |
| EP3883930A1 (en) | 2018-11-20 | 2021-09-29 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| WO2021039023A1 (ja) * | 2019-08-23 | 2021-03-04 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の製造方法 |
| MX2023004731A (es) * | 2020-10-29 | 2023-05-10 | Lg Chemical Ltd | Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma. |
| CN116507615A (zh) * | 2020-10-29 | 2023-07-28 | 株式会社Lg化学 | 黑皮质素受体激动剂化合物的晶型i及其制备方法 |
| EP4219471A4 (en) * | 2020-10-29 | 2024-03-13 | Lg Chem, Ltd. | Amorphous melanocortin-4 receptor agonist |
| PE20240366A1 (es) * | 2020-10-29 | 2024-03-04 | Lg Chemical Ltd | Forma cristalina iii del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma |
| EP4219473A4 (en) * | 2020-10-29 | 2024-03-13 | Lg Chem, Ltd. | CRYSTAL TYPE II OF A MALANOCORTIN RECEPTOR AGONIST COMPOUND AND METHOD FOR THE PRODUCTION THEREOF |
| CA3202315A1 (en) * | 2020-12-22 | 2022-06-30 | Hee Dong Park | Use as selective agonist of malanocortin-4 receptor |
| TWI814185B (zh) * | 2020-12-22 | 2023-09-01 | 南韓商Ｌｇ化學股份有限公司 | 黑皮質素受體促效劑化合物之晶型ii及其製備方法 |
| TWI810757B (zh) * | 2020-12-22 | 2023-08-01 | 南韓商Ｌｇ化學股份有限公司 | 黑皮質素受體促效劑化合物的晶型ｉ及其製備方法 |
| JP2024501829A (ja) | 2020-12-22 | 2024-01-16 | エルジー・ケム・リミテッド | メラノコルチン受容体アゴニスト化合物の結晶形ｉｉｉおよびその製造方法 |
| TWI804170B (zh) * | 2021-01-21 | 2023-06-01 | 南韓商Ｌｇ化學股份有限公司 | 黑皮質素-4受體促效劑的用途 |
| TWI826938B (zh) * | 2021-02-26 | 2023-12-21 | 南韓商Ｌｇ化學股份有限公司 | 黑皮質素-4受體促效劑 |
| CN117255786A (zh) * | 2021-05-06 | 2023-12-19 | 株式会社Lg 化学 | 黑皮质素受体激动剂化合物的晶型vii及其制备方法 |
| KR102854595B1 (ko) * | 2021-05-06 | 2025-09-03 | 주식회사 엘지화학 | 멜라노코르틴 수용체 작용제 화합물의 결정형 v 및 이의 제조방법 |
| KR102854598B1 (ko) * | 2021-05-07 | 2025-09-03 | 주식회사 엘지화학 | 멜라노코르틴 수용체 작용제 화합물의 황산염의 결정형 및 이의 제조방법 |
| JP2024517271A (ja) * | 2021-05-07 | 2024-04-19 | エルジー・ケム・リミテッド | メラノコルチン受容体アゴニスト化合物の有機酸塩の結晶形ｉｖおよびその製造方法 |
| US20240239769A1 (en) * | 2021-05-07 | 2024-07-18 | Lg Chem, Ltd. | Co-crystal of melanocortin receptor agonist compound and vanillin and method for preparing same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282166B6 (sk) | 1992-12-11 | 2001-11-06 | Merck & Co., Inc. | Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom |
| US6127381A (en) | 1998-04-28 | 2000-10-03 | Basu; Amaresh | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| US6294534B1 (en) * | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| AU742425B2 (en) * | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO2000074679A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| JP2003527444A (ja) * | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体アゴニストとして作用するスピロピペリジン誘導体 |
| CA2403686C (en) * | 2000-03-23 | 2010-01-26 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| JP2004506687A (ja) * | 2000-08-23 | 2004-03-04 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作働薬としての置換ピペリジン類 |
| JP2004523530A (ja) | 2001-01-23 | 2004-08-05 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
| EP1358163A1 (en) | 2001-01-23 | 2003-11-05 | Eli Lilly And Company | Melanocortin receptor agonists |
| EP1363898A4 (en) | 2001-03-02 | 2004-12-08 | Bristol Myers Squibb Co | COMPOUNDS SUITABLE AS MODULATORS OF MELANOCORTIN RECEPTORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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- 2002-01-23 CA CA002433025A patent/CA2433025A1/en not_active Abandoned
- 2002-01-23 WO PCT/US2002/000516 patent/WO2002059107A1/en not_active Ceased
- 2002-01-23 US US10/466,249 patent/US7157463B2/en not_active Expired - Fee Related
- 2002-01-23 EP EP02701923A patent/EP1368339A1/en not_active Withdrawn
- 2002-01-23 JP JP2002559409A patent/JP2004521117A/ja active Pending
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| WO2002059107A1 (en) | 2002-08-01 |
| WO2002059107A8 (en) | 2003-11-06 |
| CA2433025A1 (en) | 2002-08-01 |
| US20040058936A1 (en) | 2004-03-25 |
| EP1368339A1 (en) | 2003-12-10 |
| US7157463B2 (en) | 2007-01-02 |
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