JP2003523938A5 - - Google Patents
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- JP2003523938A5 JP2003523938A5 JP2000612314A JP2000612314A JP2003523938A5 JP 2003523938 A5 JP2003523938 A5 JP 2003523938A5 JP 2000612314 A JP2000612314 A JP 2000612314A JP 2000612314 A JP2000612314 A JP 2000612314A JP 2003523938 A5 JP2003523938 A5 JP 2003523938A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- unsubstituted
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 29
- -1 3-quinolyl Chemical group 0.000 description 14
- 239000000203 mixture Substances 0.000 description 8
- 125000003710 aryl alkyl group Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 description 4
- 125000005018 aryl alkenyl group Chemical group 0.000 description 3
- 125000005015 aryl alkynyl group Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12972999P | 1999-04-16 | 1999-04-16 | |
| US60/129,729 | 1999-04-16 | ||
| US14017599P | 1999-06-18 | 1999-06-18 | |
| US60/140,175 | 1999-06-18 | ||
| US17215499P | 1999-12-17 | 1999-12-17 | |
| US17215999P | 1999-12-17 | 1999-12-17 | |
| US60/172,154 | 1999-12-17 | ||
| US60/172,159 | 1999-12-17 | ||
| US17380599P | 1999-12-30 | 1999-12-30 | |
| US17380499P | 1999-12-30 | 1999-12-30 | |
| US60/173,804 | 1999-12-30 | ||
| US60/173,805 | 1999-12-30 | ||
| US09/550,045 | 2000-04-14 | ||
| PCT/US2000/009914 WO2000063224A2 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
| US09/550,045 US6395710B1 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523938A JP2003523938A (ja) | 2003-08-12 |
| JP2003523938A5 true JP2003523938A5 (https=) | 2007-05-17 |
Family
ID=27568857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000612314A Pending JP2003523938A (ja) | 1999-04-16 | 2000-04-14 | マクロライド系抗感染剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6395710B1 (https=) |
| EP (1) | EP1171446B1 (https=) |
| JP (1) | JP2003523938A (https=) |
| KR (2) | KR100710605B1 (https=) |
| CN (1) | CN1241931C (https=) |
| AT (1) | ATE340183T1 (https=) |
| AU (2) | AU775637B2 (https=) |
| BR (1) | BR0010680A (https=) |
| CA (1) | CA2369816A1 (https=) |
| DE (1) | DE60030847T2 (https=) |
| ES (1) | ES2272273T3 (https=) |
| ID (1) | ID30547A (https=) |
| IL (2) | IL145777A0 (https=) |
| MX (1) | MXPA01010524A (https=) |
| NZ (1) | NZ515027A (https=) |
| WO (2) | WO2000063224A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| CA2359708C (en) | 1999-01-27 | 2005-10-25 | Pfizer Products Inc. | Ketolide antibiotics |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| EP1167376B1 (en) | 2000-06-30 | 2004-07-14 | Pfizer Products Inc. | Macrolide antibiotics |
| US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| MXPA03008460A (es) * | 2001-03-21 | 2004-06-30 | Dow Agrosciences Llc | Derivados pesticidas de espinosina. |
| WO2003024986A1 (en) | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
| AU2002346475A1 (en) | 2001-12-05 | 2003-06-23 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials |
| US8063021B2 (en) * | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
| SI1483251T1 (sl) | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| US20040014691A1 (en) * | 2002-04-25 | 2004-01-22 | Searle Xenia Beebe | 9-Oxime macrolide antibacterials |
| US20040009932A1 (en) * | 2002-04-26 | 2004-01-15 | Kathleen Phelan | Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae |
| CN1671726A (zh) | 2002-05-31 | 2005-09-21 | 詹森药业有限公司 | 3－脱克拉定糖基－6－o－氨基甲酰基和6－o－烷氧基羰基大环内酯抗菌药 |
| US7427493B2 (en) | 2002-06-28 | 2008-09-23 | Kosan Biosciences Incorporated | Recombinant genes for polyketide modifying enzymes |
| SI1532131T1 (sl) * | 2002-08-29 | 2009-04-30 | Pfizer | Motilidne spojine |
| EP1638549A4 (en) * | 2003-03-10 | 2011-06-15 | Optimer Pharmaceuticals Inc | NEW ANTIBACTERIAL AGENTS |
| US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
| US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
| AU2003304705A1 (en) * | 2003-12-24 | 2005-08-03 | Enanta Pharmaceuticals, Inc. | 11-csubsituted erythromycin derivatives |
| UA85937C2 (uk) * | 2004-12-21 | 2009-03-10 | Пфайзер Продактс Інк. | Макроліди |
| US7595300B2 (en) | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| EP2214484A4 (en) | 2007-10-25 | 2013-01-02 | Cempra Pharmaceuticals Inc | PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS |
| CA2714389C (en) * | 2008-02-08 | 2016-10-18 | Basilea Pharmaceutica Ag | Macrolides and uses of macrolides |
| JP5711135B2 (ja) | 2008-10-24 | 2015-04-30 | センプラ ファーマシューティカルズ，インコーポレイテッド | 胃腸疾患を治療するための方法 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| ES2608285T3 (es) | 2009-09-10 | 2017-04-07 | Cempra Pharmaceuticals, Inc. | Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC |
| MX361413B (es) | 2010-03-22 | 2018-12-05 | Cempra Pharmaceuticals Inc Star | Formas cristalinas de un macrólido y usos para las mismas. |
| CN102917708B (zh) | 2010-05-20 | 2015-11-25 | 森普拉制药公司 | 制备大环内酯和酮内酯及其中间体的方法 |
| US8796474B1 (en) | 2010-08-23 | 2014-08-05 | Rutgers, The State University Of New Jersey | Macrolide compounds and methods and intermediates useful for their preparation |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES |
| JP5718488B2 (ja) * | 2011-03-01 | 2015-05-13 | ウォックハート リミテッド | ケトライド中間体の調製方法 |
| NZ700182A (en) | 2012-03-27 | 2017-02-24 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
| CN102718816B (zh) * | 2012-07-11 | 2014-11-05 | 山东大学 | 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物 |
| AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| CN105188712A (zh) | 2013-03-15 | 2015-12-23 | 森普拉制药公司 | 用于制备大环内酯抗菌剂的收敛方法 |
| US12559514B2 (en) | 2020-05-22 | 2026-02-24 | Merck Sharp & Dohme Llc | Synthesis of fluorinated nucleotides |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141926A (en) | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| US5523399A (en) * | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
| JP3259429B2 (ja) * | 1992-04-22 | 2002-02-25 | 大正製薬株式会社 | ５−ｏ−デソサミニルエリスロノライドａ誘導体 |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| ATE286133T1 (de) | 1995-07-06 | 2005-01-15 | Univ Leland Stanford Junior | Zellfreie synthese von polyketiden |
| FR2739620B1 (fr) * | 1995-10-09 | 1997-12-19 | Roussel Uclaf | Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs |
| US6274715B1 (en) | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5750510A (en) * | 1997-04-04 | 1998-05-12 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
| DE69734678T2 (de) | 1996-05-07 | 2006-08-17 | Abbott Laboratories, Abbott Park | 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung |
| FR2748746B1 (fr) * | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| ES2244001T3 (es) | 1996-07-05 | 2005-12-01 | Biotica Technology Limited | Eritromicinas y procedimiento para su preparacion. |
| US6271255B1 (en) | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
| FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| DE69733422T2 (de) * | 1996-09-04 | 2006-05-04 | Abbott Laboratories, Abbott Park | 6-0-substituierte ketoliden mit antibakteriellen wirkung |
| FR2754821B1 (fr) * | 1996-10-23 | 2003-04-04 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| WO1998018808A1 (fr) * | 1996-10-31 | 1998-05-07 | Taisho Pharmaceutical Co., Ltd. | Derives de l'erythromycine |
| FR2757168B1 (fr) * | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| CA2279259A1 (en) * | 1997-02-04 | 1998-08-06 | Abbott Laboratories | Pain reducing parenteral liposome formulation |
| FR2760017B1 (fr) * | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
| EP0988308A1 (en) * | 1997-06-11 | 2000-03-29 | Pfizer Products Inc. | 9-oxime erythromycin derivatives |
| BR9812577A (pt) * | 1997-09-30 | 2000-10-17 | Abbott Lab | Composto, processo para preparar o mesmo, composição farmacêutica, e, processo para tratar infecções bacterianas |
| US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| CO4990960A1 (es) * | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
| ZA989830B (en) * | 1997-10-29 | 1999-05-04 | Taisho Pharmaceutical Co Ltd | Erythromycin a derivatives |
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| ATE275151T1 (de) | 1998-03-03 | 2004-09-15 | Pfizer Prod Inc | 3,6-ketal-makrolidantibiotika |
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| EP0952157B1 (en) * | 1998-04-24 | 2003-06-18 | Pfizer Products Inc. | 9A, 11B-Dehydro derivatives of 9-oxime-3-keto-6-0-methylerythromycin |
| FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
| JP2003512013A (ja) | 1998-10-29 | 2003-04-02 | コーサン バイオサイエンシーズ， インコーポレイテッド | 組換えオレアンドライドポリケチドシンターゼ |
| TR200101241T2 (tr) | 1998-11-03 | 2001-09-21 | Pfizer Products Inc. | Yeni makrolit antibiyotikler |
| DE69933897T2 (de) | 1998-12-10 | 2007-03-15 | Pfizer Products Inc., Groton | Carbamat- und Carbazatketolid-Antibiotika |
| CA2359708C (en) * | 1999-01-27 | 2005-10-25 | Pfizer Products Inc. | Ketolide antibiotics |
| KR20020008127A (ko) * | 1999-03-15 | 2002-01-29 | 스티븐 에프. 웨인스톡 | 항균 활성을 갖는 6-ｏ-치환된 매크롤라이드 |
| CA2370743A1 (en) * | 1999-04-16 | 2000-10-26 | Dennis Hlasta | Ketolide antibacterials |
| HUP0201516A3 (en) | 1999-05-24 | 2003-03-28 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them |
-
2000
- 2000-04-14 AT AT00922149T patent/ATE340183T1/de not_active IP Right Cessation
- 2000-04-14 ID IDW00200102465A patent/ID30547A/id unknown
- 2000-04-14 CN CNB008090718A patent/CN1241931C/zh not_active Expired - Fee Related
- 2000-04-14 MX MXPA01010524A patent/MXPA01010524A/es active IP Right Grant
- 2000-04-14 CA CA002369816A patent/CA2369816A1/en not_active Abandoned
- 2000-04-14 JP JP2000612314A patent/JP2003523938A/ja active Pending
- 2000-04-14 KR KR1020017013150A patent/KR100710605B1/ko not_active Expired - Fee Related
- 2000-04-14 US US09/550,045 patent/US6395710B1/en not_active Expired - Lifetime
- 2000-04-14 WO PCT/US2000/009914 patent/WO2000063224A2/en not_active Ceased
- 2000-04-14 KR KR1020017013225A patent/KR20020007374A/ko not_active Withdrawn
- 2000-04-14 NZ NZ515027A patent/NZ515027A/xx unknown
- 2000-04-14 BR BR0010680-1A patent/BR0010680A/pt not_active IP Right Cessation
- 2000-04-14 AU AU44578/00A patent/AU775637B2/en not_active Ceased
- 2000-04-14 IL IL14577700A patent/IL145777A0/xx active IP Right Grant
- 2000-04-14 ES ES00922149T patent/ES2272273T3/es not_active Expired - Lifetime
- 2000-04-14 WO PCT/US2000/009915 patent/WO2000063225A2/en not_active Ceased
- 2000-04-14 EP EP00922149A patent/EP1171446B1/en not_active Expired - Lifetime
- 2000-04-14 DE DE60030847T patent/DE60030847T2/de not_active Expired - Fee Related
- 2000-04-14 AU AU42379/00A patent/AU773678B2/en not_active Ceased
-
2001
- 2001-10-04 IL IL145777A patent/IL145777A/en unknown
-
2002
- 2002-02-13 US US10/075,466 patent/US6593302B2/en not_active Ceased
-
2005
- 2005-07-13 US US11/182,038 patent/USRE39836E1/en not_active Expired - Lifetime
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