JP2003522099A - 遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン - Google Patents
遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジンInfo
- Publication number
- JP2003522099A JP2003522099A JP2000533458A JP2000533458A JP2003522099A JP 2003522099 A JP2003522099 A JP 2003522099A JP 2000533458 A JP2000533458 A JP 2000533458A JP 2000533458 A JP2000533458 A JP 2000533458A JP 2003522099 A JP2003522099 A JP 2003522099A
- Authority
- JP
- Japan
- Prior art keywords
- glp
- lys
- arg
- group
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK27498 | 1998-02-27 | ||
DK0274/98 | 1998-02-27 | ||
US8435798P | 1998-05-05 | 1998-05-05 | |
US60/084,357 | 1998-05-05 | ||
PCT/DK1999/000086 WO1999043708A1 (fr) | 1998-02-27 | 1999-02-25 | Derives de gpl-1 et de l'extendine au profil d'action etendu |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2003522099A true JP2003522099A (ja) | 2003-07-22 |
Family
ID=26063667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000533458A Withdrawn JP2003522099A (ja) | 1998-02-27 | 1999-02-25 | 遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン |
Country Status (5)
Country | Link |
---|---|
US (3) | US7226990B2 (fr) |
EP (1) | EP1056775B1 (fr) |
JP (1) | JP2003522099A (fr) |
AU (1) | AU3247799A (fr) |
WO (1) | WO1999043708A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008511557A (ja) * | 2004-09-03 | 2008-04-17 | フィリップス−ウニベルジテート・マールブルク | Glp−1およびエキセンディンに関する発明 |
JP2008515857A (ja) * | 2004-10-07 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 遅延性のエキセンディン−4化合物 |
JP2017510636A (ja) * | 2014-03-21 | 2017-04-13 | エニジェン カンパニー.,リミテッド. | 新規なエキセナチド類似体及びその用途 |
Families Citing this family (164)
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US6849708B1 (en) * | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
AU4063697A (en) | 1996-08-08 | 1998-02-25 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
EP1056775B1 (fr) * | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | Derives de gpl-1 et de l'extendine au profil d'action etendu |
CN100356978C (zh) * | 1999-01-14 | 2007-12-26 | 安米林药品公司 | 新型exendin激动剂制剂及其给药方法 |
US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
AU3273500A (en) | 1999-03-17 | 2000-10-04 | Novo Nordisk A/S | Method for acylating peptides and novel acylating agents |
US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
NZ514916A (en) * | 1999-04-30 | 2004-06-25 | Amylin Pharmaceuticals Inc | Exendins and exendin agonists linked to polyethylene glycol polymers |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
EP1133312B8 (fr) | 1999-06-21 | 2007-10-17 | Eli Lilly And Company | Utilisation combinee de thiazolidinediones et de peptide-1 de type glucagone et d'agonistes de ces derniers pour traiter diabetes non insulino-dependant. |
EP1076066A1 (fr) * | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides abaissant le taux de glucose sanguin |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
US6667313B1 (en) | 1999-08-27 | 2003-12-23 | Ligand Pharmaceuticals Inc. | 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU778655B2 (en) | 1999-08-27 | 2004-12-16 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
JP2003519664A (ja) * | 2000-01-11 | 2003-06-24 | ノボ ノルディスク アクティーゼルスカブ | Glp−1誘導体の経上皮送達 |
AU2001228327A1 (en) * | 2000-01-31 | 2001-08-14 | Novo-Nordisk A/S | Crystallisation of a glp-1 analogue |
US6844321B2 (en) | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
US20030040490A1 (en) * | 2000-02-24 | 2003-02-27 | Yasuo Sugiyama | Drugs containing combined active ingredients |
ATE309818T1 (de) | 2000-03-08 | 2005-12-15 | Novo Nordisk As | Senkung des serum cholesterols |
US20030040469A1 (en) * | 2000-03-08 | 2003-02-27 | Knudsen Liselotte Bjerre | Lowering serum lipids |
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JP2004521093A (ja) | 2000-12-13 | 2004-07-15 | イーライ・リリー・アンド・カンパニー | グルカゴン様インスリン刺激性ペプチドを用いる長期治療計画 |
AU2002233089B2 (en) * | 2001-02-16 | 2005-12-22 | Conjuchem Biotechnologies Inc. | Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders |
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KR20050086948A (ko) | 2002-12-27 | 2005-08-30 | 디오벡스, 인코포레이티드 | 인슐린으로 인한 저혈당증을 예방하고 조절하기 위한조성물 및 방법 |
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-
1999
- 1999-02-25 EP EP99936077A patent/EP1056775B1/fr not_active Expired - Lifetime
- 1999-02-25 WO PCT/DK1999/000086 patent/WO1999043708A1/fr active Application Filing
- 1999-02-25 AU AU32477/99A patent/AU3247799A/en not_active Abandoned
- 1999-02-25 JP JP2000533458A patent/JP2003522099A/ja not_active Withdrawn
-
2001
- 2001-06-21 US US09/886,311 patent/US7226990B2/en not_active Expired - Fee Related
-
2007
- 2007-04-26 US US11/789,953 patent/US20080103097A1/en not_active Abandoned
-
2010
- 2010-08-23 US US12/861,511 patent/US20110053839A1/en not_active Abandoned
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008511557A (ja) * | 2004-09-03 | 2008-04-17 | フィリップス−ウニベルジテート・マールブルク | Glp−1およびエキセンディンに関する発明 |
JP2008515857A (ja) * | 2004-10-07 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 遅延性のエキセンディン−4化合物 |
US8772232B2 (en) | 2004-10-07 | 2014-07-08 | Novo Nordisk A/S | Protracted exendin-4 compounds |
JP2017510636A (ja) * | 2014-03-21 | 2017-04-13 | エニジェン カンパニー.,リミテッド. | 新規なエキセナチド類似体及びその用途 |
US11103557B2 (en) | 2014-03-21 | 2021-08-31 | Anygen Co., Ltd. | Exenatide analogue and use thereof |
Also Published As
Publication number | Publication date |
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WO1999043708A1 (fr) | 1999-09-02 |
US20110053839A1 (en) | 2011-03-03 |
US7226990B2 (en) | 2007-06-05 |
US20080103097A1 (en) | 2008-05-01 |
US20010047084A1 (en) | 2001-11-29 |
AU3247799A (en) | 1999-09-15 |
EP1056775A1 (fr) | 2000-12-06 |
EP1056775B1 (fr) | 2010-04-28 |
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