JP2002505271A - サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 - Google Patents
サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物Info
- Publication number
- JP2002505271A JP2002505271A JP2000534187A JP2000534187A JP2002505271A JP 2002505271 A JP2002505271 A JP 2002505271A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2002505271 A JP2002505271 A JP 2002505271A
- Authority
- JP
- Japan
- Prior art keywords
- component
- composition
- fatty acid
- composition according
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 108010036941 Cyclosporins Proteins 0.000 title description 8
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- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 12
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- 150000004671 saturated fatty acids Chemical class 0.000 description 10
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 9
- 235000003441 saturated fatty acids Nutrition 0.000 description 9
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 9
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| GB9804742.6 | 1998-03-06 | ||
| GBGB9804742.6A GB9804742D0 (en) | 1998-03-06 | 1998-03-06 | Organic compounds |
| GB9805104.8 | 1998-03-10 | ||
| GBGB9805104.8A GB9805104D0 (en) | 1998-03-10 | 1998-03-10 | Organic compounds |
| GBGB9805199.8A GB9805199D0 (en) | 1998-03-11 | 1998-03-11 | Organic compounds |
| GB9805199.8 | 1998-03-11 | ||
| PCT/EP1999/001415 WO1999044584A1 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2004062679A Division JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
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| JP2002505271A true JP2002505271A (ja) | 2002-02-19 |
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| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
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| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
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| BR (1) | BR9908597A (enExample) |
| CA (1) | CA2322845C (enExample) |
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| HU (1) | HUP0101080A3 (enExample) |
| ID (1) | ID25908A (enExample) |
| IL (2) | IL138248A0 (enExample) |
| IT (1) | IT1313550B1 (enExample) |
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| NZ (1) | NZ506644A (enExample) |
| PE (1) | PE20000324A1 (enExample) |
| PT (1) | PT1059913E (enExample) |
| SK (1) | SK285139B6 (enExample) |
| TR (1) | TR200002586T2 (enExample) |
| TW (3) | TWI257870B (enExample) |
| WO (1) | WO1999044584A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531515A (ja) * | 1998-12-11 | 2002-09-24 | ファーマソリューションズ・インコーポレイテッド | 水に難溶性の薬剤のための自己乳化組成物 |
| JP2002537317A (ja) * | 1999-02-26 | 2002-11-05 | リポシン インコーポレイテッド | 疎水性治療剤の改善された送達のための組成物および方法 |
| JP2003517470A (ja) * | 1999-11-23 | 2003-05-27 | リポシン インコーポレイテッド | 薬学的組成物における活性成分の改善された送達のための固体キャリア |
| JP2006509785A (ja) * | 2002-11-29 | 2006-03-23 | ハンミ ファーム． シーオー．， エルティーディー． | ビフェニルジメチルジカルボン酸の経口用マイクロエマルション組成物 |
| JP2009132712A (ja) * | 2007-11-21 | 2009-06-18 | Innopharmax Inc | 生物学的利用能を向上した医薬組成物 |
| JP2022513635A (ja) * | 2018-11-26 | 2022-02-09 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| IL143604A0 (en) * | 1998-12-30 | 2002-04-21 | Dexcel Ltd | Dispersable concentrate for the delivery of cyclosporin |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| AU2127400A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof |
| GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
| WO2001032142A1 (en) * | 1999-11-02 | 2001-05-10 | Cipla Limited | Cyclosporin formulation |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
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1999
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- 1999-03-04 ES ES99908952T patent/ES2228014T3/es not_active Expired - Lifetime
- 1999-03-04 CZ CZ20003222A patent/CZ301967B6/cs not_active IP Right Cessation
- 1999-03-04 AR ARP990100910A patent/AR015729A1/es not_active Application Discontinuation
- 1999-03-04 WO PCT/EP1999/001415 patent/WO1999044584A1/en not_active Ceased
- 1999-03-04 EP EP99908952A patent/EP1059913B1/en not_active Revoked
- 1999-03-04 AT AT99908952T patent/ATE277599T1/de active
- 1999-03-04 SK SK1319-2000A patent/SK285139B6/sk not_active IP Right Cessation
- 1999-03-04 TR TR2000/02586T patent/TR200002586T2/xx unknown
- 1999-03-04 PT PT99908952T patent/PT1059913E/pt unknown
- 1999-03-04 KR KR10-2000-7009861A patent/KR100443306B1/ko not_active Expired - Fee Related
- 1999-03-04 DE DE69920668T patent/DE69920668T2/de not_active Expired - Lifetime
- 1999-03-04 HU HU0101080A patent/HUP0101080A3/hu unknown
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- 1999-03-04 EP EP03013016A patent/EP1354582A3/en not_active Withdrawn
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- 1999-03-04 JP JP2000534187A patent/JP2002505271A/ja not_active Withdrawn
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- 1999-03-04 AU AU28361/99A patent/AU749217B2/en not_active Ceased
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- 1999-05-21 TW TW094129536A patent/TWI257870B/zh not_active IP Right Cessation
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| JP2003517470A (ja) * | 1999-11-23 | 2003-05-27 | リポシン インコーポレイテッド | 薬学的組成物における活性成分の改善された送達のための固体キャリア |
| JP2006509785A (ja) * | 2002-11-29 | 2006-03-23 | ハンミ ファーム． シーオー．， エルティーディー． | ビフェニルジメチルジカルボン酸の経口用マイクロエマルション組成物 |
| JP2009132712A (ja) * | 2007-11-21 | 2009-06-18 | Innopharmax Inc | 生物学的利用能を向上した医薬組成物 |
| JP2022513635A (ja) * | 2018-11-26 | 2022-02-09 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
| JP7489385B2 (ja) | 2018-11-26 | 2024-05-23 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
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