JP2002505271A - サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 - Google Patents
サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物Info
- Publication number
- JP2002505271A JP2002505271A JP2000534187A JP2000534187A JP2002505271A JP 2002505271 A JP2002505271 A JP 2002505271A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2002505271 A JP2002505271 A JP 2002505271A
- Authority
- JP
- Japan
- Prior art keywords
- component
- composition
- fatty acid
- composition according
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 108010036941 Cyclosporins Proteins 0.000 title description 8
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- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 12
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- 150000004671 saturated fatty acids Chemical class 0.000 description 10
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 9
- 235000003441 saturated fatty acids Nutrition 0.000 description 9
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 9
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Classifications
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- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9804742.6 | 1998-03-06 | ||
| GBGB9804742.6A GB9804742D0 (en) | 1998-03-06 | 1998-03-06 | Organic compounds |
| GBGB9805104.8A GB9805104D0 (en) | 1998-03-10 | 1998-03-10 | Organic compounds |
| GB9805104.8 | 1998-03-10 | ||
| GB9805199.8 | 1998-03-11 | ||
| GBGB9805199.8A GB9805199D0 (en) | 1998-03-11 | 1998-03-11 | Organic compounds |
| PCT/EP1999/001415 WO1999044584A1 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2004062679A Division JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Publications (2)
| Publication Number | Publication Date |
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| JP2002505271A true JP2002505271A (ja) | 2002-02-19 |
| JP2002505271A5 JP2002505271A5 (cg-RX-API-DMAC7.html) | 2005-11-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2000534187A Withdrawn JP2002505271A (ja) | 1998-03-06 | 1999-03-04 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Country Status (29)
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531515A (ja) * | 1998-12-11 | 2002-09-24 | ファーマソリューションズ・インコーポレイテッド | 水に難溶性の薬剤のための自己乳化組成物 |
| JP2002537317A (ja) * | 1999-02-26 | 2002-11-05 | リポシン インコーポレイテッド | 疎水性治療剤の改善された送達のための組成物および方法 |
| JP2003517470A (ja) * | 1999-11-23 | 2003-05-27 | リポシン インコーポレイテッド | 薬学的組成物における活性成分の改善された送達のための固体キャリア |
| JP2006509785A (ja) * | 2002-11-29 | 2006-03-23 | ハンミ ファーム． シーオー．， エルティーディー． | ビフェニルジメチルジカルボン酸の経口用マイクロエマルション組成物 |
| JP2009132712A (ja) * | 2007-11-21 | 2009-06-18 | Innopharmax Inc | 生物学的利用能を向上した医薬組成物 |
| JP2022513635A (ja) * | 2018-11-26 | 2022-02-09 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| DK1154759T3 (da) * | 1998-12-30 | 2008-12-08 | Dexcel Ltd | Dispergerbart koncentrat til indgift af cyclosporin |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| AU2127400A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof |
| GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
| AU1043201A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | Cyclosporin formulation |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
| WO2003002095A1 (fr) * | 2001-06-28 | 2003-01-09 | Chugai Seiyaku Kabushiki Kaisha | Preparation d'une micro-emulsion de type huile-eau |
| US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
| GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| US8802116B2 (en) | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| KR20040084240A (ko) * | 2003-03-27 | 2004-10-06 | (주) 코스메디 | 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법 |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| JP2008518931A (ja) * | 2004-10-29 | 2008-06-05 | ノバルティス アクチエンゲゼルシャフト | 自発的に分散可能な医薬組成物 |
| MX2007011250A (es) * | 2005-03-21 | 2007-11-14 | Ivax Pharmaceuticals Sro | Inhibidor de la cristalizacion y su uso en capsulas de gelatina. |
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| JP2002537317A (ja) * | 1999-02-26 | 2002-11-05 | リポシン インコーポレイテッド | 疎水性治療剤の改善された送達のための組成物および方法 |
| JP2003517470A (ja) * | 1999-11-23 | 2003-05-27 | リポシン インコーポレイテッド | 薬学的組成物における活性成分の改善された送達のための固体キャリア |
| JP2006509785A (ja) * | 2002-11-29 | 2006-03-23 | ハンミ ファーム． シーオー．， エルティーディー． | ビフェニルジメチルジカルボン酸の経口用マイクロエマルション組成物 |
| JP2009132712A (ja) * | 2007-11-21 | 2009-06-18 | Innopharmax Inc | 生物学的利用能を向上した医薬組成物 |
| JP2022513635A (ja) * | 2018-11-26 | 2022-02-09 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
| JP7489385B2 (ja) | 2018-11-26 | 2024-05-23 | ヘピオン ファーマシューティカルズ インコーポレイテッド | シクロスポリン類似体の医薬製剤 |
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