IL143604A0 - Dispersable concentrate for the delivery of cyclosporin - Google Patents

Dispersable concentrate for the delivery of cyclosporin

Info

Publication number
IL143604A0
IL143604A0 IL14360499A IL14360499A IL143604A0 IL 143604 A0 IL143604 A0 IL 143604A0 IL 14360499 A IL14360499 A IL 14360499A IL 14360499 A IL14360499 A IL 14360499A IL 143604 A0 IL143604 A0 IL 143604A0
Authority
IL
Israel
Prior art keywords
surfactant
formulation
cyclosporin
less
dispersable
Prior art date
Application number
IL14360499A
Original Assignee
Dexcel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcel Ltd filed Critical Dexcel Ltd
Publication of IL143604A0 publication Critical patent/IL143604A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

A formulation for the administration of a cyclosporin. This formulation features a hydrophilic solvent which is characterized by being a lower alkyl ester of hydroxyalkanoic acid; and a surfactant, preferably a combination of a surfactant with a high HLB (hydrophilic/lipophilic balance) of at least about 8 and a surfactant with a low HLB of less than about 5. Other ingredients are optional, such as a fatty acid ester such as tricaprin, a phospholipid, and an ethoxylated fat such as Cremophor or another similar substance. Optionally, the ethoxylated fat is substituted for the surfactant. The preferred particle size of the resultant formulation is less than about 100 nm, more preferably less than about 60 nm, and most preferably from about 5 nm to about 50 nm. The formulation of the present invention is characterized by having high bioavailability.
IL14360499A 1998-12-30 1999-12-30 Dispersable concentrate for the delivery of cyclosporin IL143604A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22337898A 1998-12-30 1998-12-30
PCT/IL1999/000710 WO2000040219A1 (en) 1998-12-30 1999-12-30 Dispersible concentrate for the delivery of cyclosporin

Publications (1)

Publication Number Publication Date
IL143604A0 true IL143604A0 (en) 2002-04-21

Family

ID=22836258

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14360499A IL143604A0 (en) 1998-12-30 1999-12-30 Dispersable concentrate for the delivery of cyclosporin

Country Status (12)

Country Link
US (1) US7026290B1 (en)
EP (1) EP1154759B1 (en)
JP (1) JP2002534370A (en)
AT (1) ATE404172T1 (en)
AU (1) AU769429C (en)
CA (1) CA2358448C (en)
DE (1) DE69939335D1 (en)
DK (1) DK1154759T3 (en)
IL (1) IL143604A0 (en)
NZ (1) NZ512599A (en)
PT (1) PT1154759E (en)
WO (1) WO2000040219A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds
AU2006201100B2 (en) * 1999-09-21 2009-09-24 Jagotec Ag Surface modified particulate compositions of biologically active substances
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7919113B2 (en) * 1999-12-30 2011-04-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dispersible concentrate lipospheres for delivery of active agents
AUPR510001A0 (en) * 2001-05-18 2001-06-14 Jupitar Pty Ltd Formulation and method
TNSN03139A1 (en) 2001-06-21 2005-12-23 Pfizer Prod Inc SELF-EMULSIBLE FORMULATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
AU2002952597A0 (en) * 2002-11-11 2002-11-28 Schering-Plough Pty. Limited Topical parasiticide formulations and methods of treatment
DE102006051512A1 (en) * 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmaceutical drug compositions with cyclosporin
DE102006050026A1 (en) * 2006-10-13 2008-04-17 Bio Mac- Privatinstitut für medizinische und zahnmedizinische Forschung, Entwicklung und Diagnostik GmbH Use of lactic acid compounds as tumor necrosis factor-alpha blocker, e.g. for suppressing immune system, for prophylaxis and/or treatment of autoimmune diseases and/or inflammatory diseases, preferably rheumatoid arthritis, spondylitis
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
GB2451811A (en) * 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
MX2010003364A (en) 2007-10-08 2010-07-06 Lux Biosciences Inc Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors.
WO2010144194A1 (en) 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
KR101586791B1 (en) * 2012-12-28 2016-01-19 주식회사 종근당 Sustained-release lipid pre-concentrate of GnRH analogues and pharmaceutical composition comprising the same
US20150352176A1 (en) * 2014-06-06 2015-12-10 Newport Research, Inc. Oil-free and fat-free aqueous suspensions of cyclosporin
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2907460A1 (en) 1978-03-07 1979-09-13 Sandoz Ag NEW RESORBABLE GALENIC COMPOSITIONS
US4215199A (en) 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
AU548156B2 (en) 1980-02-14 1985-11-28 Novartis Ag Cyclo sporin
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US4861580A (en) 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
US5154930A (en) 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
KR880012221A (en) 1987-04-13 1988-11-26 사노 가즈오 Pharmaceutical compositions containing esters or amides as active ingredients
EP0296122B1 (en) 1987-06-17 1993-09-29 Sandoz Ag Cyclosporins and their use as pharmaceuticals
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
US4994267A (en) 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US4814168A (en) 1988-03-04 1989-03-21 Noven Pharmaceuticals, Inc. Transdermal multipolymer drug delivery system
GB8809616D0 (en) 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
SE8804164A0 (en) 1988-11-17 1990-05-18 Per Prisell Pharmaceutical preparation
HU201577B (en) 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
DE69013189T2 (en) 1989-03-15 1995-05-11 Merck & Co Inc Method for producing an immunosuppressive substance (demethimmunomycin) by using a strain mutant of a microorganism.
US5272068A (en) 1989-03-15 1993-12-21 Merck & Co., Inc. Process for producing immunosuppressant agent L-683942 by fermentation
US5227165A (en) 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
IE904098A1 (en) 1989-11-13 1991-05-22 Nova Pharm Corp Lipospheres for controlled delivery of substances
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5178866A (en) 1990-03-23 1993-01-12 Alza Corporation Dosage form for delivering drug to the intestine
CZ280909B6 (en) 1990-11-02 1996-05-15 Novartis Ag Cyclosporins, their use when preparing a medicament for treating and prevention of aids, process of their preparation and mould strains usable in the process
HU208491B (en) 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
JP3099365B2 (en) 1991-01-25 2000-10-16 藤沢薬品工業株式会社 Method for producing cyclosporin A and / or C
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5683714A (en) 1991-04-19 1997-11-04 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin pharmaceutical formulation
EP0580817B1 (en) 1991-04-19 1996-06-19 NeXstar Pharmaceuticals, Inc. Pharmaceutical formulation and process
IL101007A (en) 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
US5529785A (en) 1993-05-12 1996-06-25 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
US5637317A (en) 1992-05-18 1997-06-10 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
HU213553B (en) 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
US5759566A (en) 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
CZ278863B6 (en) 1992-09-07 1994-07-13 Galena Medicinal preparations with n-methylated cyclic undecapeptides
FI92334C (en) 1992-12-30 1994-10-25 Leiras Oy Process for producing cyclosporins and new Tolypocladium strain useful in the process
EP0813865B1 (en) 1993-04-20 2001-09-19 Hexal Ag Drug patch
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
CH686761A5 (en) 1993-05-27 1996-06-28 Sandoz Ag Pharmaceutical formulations.
US5639474A (en) 1993-07-01 1997-06-17 Hanmi Pharm. Ind., Ltd. Cyclosporin soft capsule composition
ATE198041T1 (en) 1993-09-28 2000-12-15 Scherer Gmbh R P PRODUCTION OF SOFT GELATIN CAPSULES
DE4340781C3 (en) 1993-11-30 2000-01-27 Novartis Ag Liquid preparations containing cyclosporin and process for their preparation
EP0797432B1 (en) * 1994-02-04 2001-06-13 Scotia Lipidteknik Ab Oil-in-water emulsions
US5891846A (en) 1994-02-17 1999-04-06 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
KR0146671B1 (en) 1994-02-25 1998-08-17 김충환 Cyclosporin-containing powder composition
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5430021A (en) 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5651980A (en) 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
DK0756489T3 (en) 1994-06-01 1999-12-06 Yuhan Corp Cyclosporin-containing preparation and process for its preparation
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
KR100304324B1 (en) 1994-10-13 2001-11-22 김용규 Method for manufacturing cyclosporine a
KR0126610B1 (en) 1994-10-18 1997-12-29 김충환 Producing method of cyclosporina by cell fusioned microorganism
US5603951A (en) 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
DE4440337A1 (en) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate
HU215966B (en) 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Oral multiple emulsion-preconcentrate containing cyclosporin
KR0167613B1 (en) 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 Cyclosporin-containing soft capsule compositions
EP0725076B1 (en) 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
US5573783A (en) 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
FI102758B (en) 1995-03-03 1999-02-15 Santen Pharmaceutical Co Ltd Process for producing pure cyclosporine form
IE75744B1 (en) 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
AU692255B2 (en) 1995-04-24 1998-06-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Self-emulsifiable formulation producing an oil-in-water emulsion
US5716928A (en) 1995-06-07 1998-02-10 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5656287A (en) 1995-06-07 1997-08-12 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications
US5665386A (en) 1995-06-07 1997-09-09 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US5827822A (en) 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
EP0760237A1 (en) 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
US5968972A (en) 1995-10-26 1999-10-19 Baker Norton Pharmaceuticals, Inc. Method for increasing the oral bioactivity of pharmaceutical agents
NZ280689A (en) 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
KR970064620A (en) * 1996-03-05 1997-10-13 임성기 Cyclosporin-containing external-use pharmaceutical composition
DE19611094C2 (en) 1996-03-21 1999-06-17 Dresden Arzneimittel Process for the purification of cyclosporin A and / or related cyclosporins from a cyclosporin-containing crude extract using chromatographic processes using silica gel as the adsorbent
IL117773A (en) 1996-04-02 2000-10-31 Pharmos Ltd Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
US5660858A (en) 1996-04-03 1997-08-26 Research Triangle Pharmaceuticals Cyclosporin emulsions
US5747330A (en) 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US5709797A (en) 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5958876A (en) 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
US5958378A (en) 1996-07-03 1999-09-28 Research Development Foundation High dose liposomal aerosol formulations containing cyclosporin A or budesonide
KR980008239A (en) 1996-07-26 1998-04-30 김충환 Cyclosporin-containing pharmaceutical composition
US5798333A (en) 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
IL131609A0 (en) 1997-03-12 2001-01-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine
US5891845A (en) 1997-11-21 1999-04-06 Fuisz Technologies Ltd. Drug delivery systems utilizing liquid crystal structures
US6028067A (en) * 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
ID25908A (en) * 1998-03-06 2000-11-09 Novartis Ag EMULSION PRACTONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDES
FR2780061B1 (en) 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa NOVEL PROCESS FOR THE PREPARATION OF CYCLOSPORIN DERIVATIVES
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6057289A (en) 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system
TNSN03139A1 (en) * 2001-06-21 2005-12-23 Pfizer Prod Inc SELF-EMULSIBLE FORMULATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS

Also Published As

Publication number Publication date
ATE404172T1 (en) 2008-08-15
CA2358448A1 (en) 2000-07-13
US7026290B1 (en) 2006-04-11
EP1154759A4 (en) 2005-07-20
EP1154759B1 (en) 2008-08-13
AU769429C (en) 2004-10-28
EP1154759A1 (en) 2001-11-21
AU769429B2 (en) 2004-01-29
WO2000040219A1 (en) 2000-07-13
AU1796200A (en) 2000-07-24
NZ512599A (en) 2003-10-31
JP2002534370A (en) 2002-10-15
DE69939335D1 (en) 2008-09-25
DK1154759T3 (en) 2008-12-08
CA2358448C (en) 2009-02-10
PT1154759E (en) 2008-11-20

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