RU99121398A - PHARMACEUTICAL COMPOSITIONS - Google Patents
PHARMACEUTICAL COMPOSITIONSInfo
- Publication number
- RU99121398A RU99121398A RU99121398/14A RU99121398A RU99121398A RU 99121398 A RU99121398 A RU 99121398A RU 99121398/14 A RU99121398/14 A RU 99121398/14A RU 99121398 A RU99121398 A RU 99121398A RU 99121398 A RU99121398 A RU 99121398A
- Authority
- RU
- Russia
- Prior art keywords
- fatty acid
- cyclosporine
- surfactant
- preparation
- containing cyclosporin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 13
- 108010036949 Cyclosporine Proteins 0.000 claims 13
- 229960001265 ciclosporin Drugs 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 229940119017 Cyclosporine Drugs 0.000 claims 5
- -1 fatty acid ester Chemical class 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- BVDRUCCQKHGCRX-UHFFFAOYSA-N 2,3-dihydroxypropyl formate Chemical compound OCC(O)COC=O BVDRUCCQKHGCRX-UHFFFAOYSA-N 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Chemical group CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- RUOJZAUFBMNUDX-UHFFFAOYSA-N Propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 150000003138 primary alcohols Chemical class 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
Claims (10)
(1) циклоспорин в качестве действующего вещества,
(2) пропиленкарбонат,
(3) одно соединение или смесь двух или более соединений, выбранного(ых) из группы, включающей эфир жирной кислоты и первичного спирта, триглицерид жирной кислоты со средней длиной цепи и моноглицерид жирной кислоты, в качестве замасливателя и
(4) поверхностно-активное вещество, имеющее значение ГЛБ (гидрофильно-липофильный баланс) от 8 до 17.1. A drug containing cyclosporin, which includes a composition containing:
(1) cyclosporine as an active ingredient,
(2) propylene carbonate,
(3) one compound or a mixture of two or more compounds selected from the group consisting of a fatty acid ester and a primary alcohol, a medium chain length fatty acid triglyceride, and a fatty acid monoglyceride as a lubricant, and
(4) a surfactant having an HLB value (hydrophilic-lipophilic balance) of 8 to 17.
(1) циклоспорин в качестве действующего вещества и
(2) пропиленкарбонат.8. A preparation containing cyclosporin, which includes a composition comprising:
(1) cyclosporine as an active ingredient and
(2) propylene carbonate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1997/8750 | 1997-03-14 | ||
| KR1019970008750A KR19980073479A (en) | 1997-03-14 | 1997-03-14 | Cyclosporine-containing soft capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99121398A true RU99121398A (en) | 2001-12-27 |
| RU2185188C2 RU2185188C2 (en) | 2002-07-20 |
Family
ID=19499792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99121398/14A RU2185188C2 (en) | 1997-03-14 | 1998-03-12 | Pharmaceutical compositions |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0969857A1 (en) |
| JP (1) | JP3748573B2 (en) |
| KR (2) | KR19980073479A (en) |
| CN (1) | CN1161150C (en) |
| AR (1) | AR012054A1 (en) |
| AU (1) | AU741923B2 (en) |
| BR (1) | BR9808324A (en) |
| CA (1) | CA2283901A1 (en) |
| CO (1) | CO4940404A1 (en) |
| CZ (1) | CZ324399A3 (en) |
| DE (1) | DE19882184T1 (en) |
| GB (1) | GB2337703A (en) |
| HU (1) | HUP0001515A3 (en) |
| ID (1) | ID23531A (en) |
| IL (1) | IL131703A0 (en) |
| MY (1) | MY118614A (en) |
| NO (1) | NO994436L (en) |
| PE (1) | PE59499A1 (en) |
| PL (1) | PL335729A1 (en) |
| RU (1) | RU2185188C2 (en) |
| SK (1) | SK123299A3 (en) |
| TR (1) | TR199902229T2 (en) |
| WO (1) | WO1998041225A1 (en) |
| ZA (1) | ZA982117B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2380674B (en) * | 1998-03-06 | 2003-05-28 | Novartis Ag | Emulsion preconcentrates containing cyclosporin or a macrolide |
| US7203158B2 (en) * | 2000-12-06 | 2007-04-10 | Matsushita Electric Industrial Co., Ltd. | OFDM signal transmission system, portable terminal, and e-commerce system |
| GB0526419D0 (en) * | 2005-12-23 | 2006-02-08 | Cyclacel Ltd | Formulation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
| KR0167613B1 (en) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | Cyclosporin-containing soft capsule compositions |
| US6465627B2 (en) * | 1995-07-28 | 2002-10-15 | The Regents Of The University Of California | DAX-1 protein, methods for production and use thereof |
| NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| SK283361B6 (en) * | 1996-06-19 | 2003-06-03 | Novartis Ag | Cyclosporin-containing soft capsule preparations |
| KR0183449B1 (en) * | 1996-06-19 | 1999-05-01 | 한스 루돌프 하우스, 니콜 케르커 | Cyclosporin-containing soft capsule preparations |
-
1997
- 1997-03-14 KR KR1019970008750A patent/KR19980073479A/en active Application Filing
-
1998
- 1998-03-12 JP JP54011298A patent/JP3748573B2/en not_active Expired - Fee Related
- 1998-03-12 ZA ZA982117A patent/ZA982117B/en unknown
- 1998-03-12 EP EP98912470A patent/EP0969857A1/en not_active Withdrawn
- 1998-03-12 GB GB9921495A patent/GB2337703A/en not_active Withdrawn
- 1998-03-12 CA CA002283901A patent/CA2283901A1/en not_active Abandoned
- 1998-03-12 RU RU99121398/14A patent/RU2185188C2/en not_active IP Right Cessation
- 1998-03-12 IL IL13170398A patent/IL131703A0/en unknown
- 1998-03-12 AU AU67293/98A patent/AU741923B2/en not_active Ceased
- 1998-03-12 SK SK1232-99A patent/SK123299A3/en unknown
- 1998-03-12 PE PE1998000174A patent/PE59499A1/en not_active Application Discontinuation
- 1998-03-12 BR BR9808324-4A patent/BR9808324A/en not_active Application Discontinuation
- 1998-03-12 TR TR1999/02229T patent/TR199902229T2/en unknown
- 1998-03-12 CZ CZ993243A patent/CZ324399A3/en unknown
- 1998-03-12 HU HU0001515A patent/HUP0001515A3/en unknown
- 1998-03-12 DE DE19882184T patent/DE19882184T1/en not_active Withdrawn
- 1998-03-12 ID IDW990997A patent/ID23531A/en unknown
- 1998-03-12 PL PL98335729A patent/PL335729A1/en unknown
- 1998-03-12 WO PCT/EP1998/001432 patent/WO1998041225A1/en not_active Application Discontinuation
- 1998-03-12 KR KR1019997008022A patent/KR20000075940A/en not_active Application Discontinuation
- 1998-03-12 MY MYPI98001086A patent/MY118614A/en unknown
- 1998-03-12 CN CNB988033569A patent/CN1161150C/en not_active Expired - Fee Related
- 1998-03-13 AR ARP980101125A patent/AR012054A1/en not_active Application Discontinuation
- 1998-03-13 CO CO98014254A patent/CO4940404A1/en unknown
-
1999
- 1999-09-13 NO NO994436A patent/NO994436L/en not_active Application Discontinuation
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