JP2002505271A5 - - Google Patents
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- Publication number
- JP2002505271A5 JP2002505271A5 JP2000534187A JP2000534187A JP2002505271A5 JP 2002505271 A5 JP2002505271 A5 JP 2002505271A5 JP 2000534187 A JP2000534187 A JP 2000534187A JP 2000534187 A JP2000534187 A JP 2000534187A JP 2002505271 A5 JP2002505271 A5 JP 2002505271A5
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- JP
- Japan
- Prior art keywords
- composition
- weight
- component
- composition according
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 17
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 6
- 108010036949 Cyclosporine Proteins 0.000 claims 6
- 229960001265 ciclosporin Drugs 0.000 claims 6
- 229930182912 cyclosporin Natural products 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 2
- 239000004530 micro-emulsion Substances 0.000 claims 2
- 229960001295 tocopherol Drugs 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 229940099371 diacetylated monoglycerides Drugs 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- -1 medium chain fatty acid triglycerides Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 150000003138 primary alcohols Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9804742.6 | 1998-03-06 | ||
| GBGB9804742.6A GB9804742D0 (en) | 1998-03-06 | 1998-03-06 | Organic compounds |
| GBGB9805104.8A GB9805104D0 (en) | 1998-03-10 | 1998-03-10 | Organic compounds |
| GB9805104.8 | 1998-03-10 | ||
| GB9805199.8 | 1998-03-11 | ||
| GBGB9805199.8A GB9805199D0 (en) | 1998-03-11 | 1998-03-11 | Organic compounds |
| PCT/EP1999/001415 WO1999044584A1 (en) | 1998-03-06 | 1999-03-04 | Emulsion preconcentrates containing cyclosporin or a macrolide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004062679A Division JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002505271A JP2002505271A (ja) | 2002-02-19 |
| JP2002505271A5 true JP2002505271A5 (cg-RX-API-DMAC7.html) | 2005-11-04 |
Family
ID=27269231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534187A Withdrawn JP2002505271A (ja) | 1998-03-06 | 1999-03-04 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004062679A Pending JP2004189753A (ja) | 1998-03-06 | 2004-03-05 | サイクロスポリン類またはマクロライド含有エマルジョン前濃縮物 |
Country Status (29)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| JP2002531515A (ja) * | 1998-12-11 | 2002-09-24 | ファーマソリューションズ・インコーポレイテッド | 水に難溶性の薬剤のための自己乳化組成物 |
| DK1154759T3 (da) * | 1998-12-30 | 2008-12-08 | Dexcel Ltd | Dispergerbart koncentrat til indgift af cyclosporin |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| AU2127400A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof |
| GB2362573A (en) * | 2000-05-25 | 2001-11-28 | Cipla Ltd | Cyclosporin formulation |
| AU1043201A (en) * | 1999-11-02 | 2001-05-14 | Cipla Limited | Cyclosporin formulation |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
| WO2003002095A1 (fr) * | 2001-06-28 | 2003-01-09 | Chugai Seiyaku Kabushiki Kaisha | Preparation d'une micro-emulsion de type huile-eau |
| US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
| GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| KR20040047056A (ko) * | 2002-11-29 | 2004-06-05 | 한미약품 주식회사 | 비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물 |
| US8802116B2 (en) | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| KR20040084240A (ko) * | 2003-03-27 | 2004-10-06 | (주) 코스메디 | 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법 |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| JP2008518931A (ja) * | 2004-10-29 | 2008-06-05 | ノバルティス アクチエンゲゼルシャフト | 自発的に分散可能な医薬組成物 |
| MX2007011250A (es) * | 2005-03-21 | 2007-11-14 | Ivax Pharmaceuticals Sro | Inhibidor de la cristalizacion y su uso en capsulas de gelatina. |
| CN101032620B (zh) * | 2007-03-08 | 2010-05-19 | 上海凯昭医药科技有限公司 | 一种环孢素自乳化制剂及其制备方法 |
| US20090130198A1 (en) * | 2007-11-21 | 2009-05-21 | Innopharmax Inc. | Pharmaceutical composition with enhanced bioavailability |
| AU2009226019C1 (en) | 2008-03-20 | 2014-02-20 | Virun, Inc. | Emulsions including a PEG-derivative of tocopherol |
| CN102036661B (zh) | 2008-03-20 | 2016-12-28 | 维尔恩公司 | 维生素衍生物及其用途 |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| JP5567909B2 (ja) * | 2010-06-17 | 2014-08-06 | 東洋カプセル株式会社 | タクロリムス含有カプセル剤 |
| US8741373B2 (en) | 2010-06-21 | 2014-06-03 | Virun, Inc. | Compositions containing non-polar compounds |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| JP5717034B2 (ja) * | 2012-08-27 | 2015-05-13 | 丸和バイオケミカル株式会社 | マクロライド系化合物を含有する土壌線虫防除用薬剤 |
| US20150374835A1 (en) | 2012-12-31 | 2015-12-31 | Jrx Biotechnology, Inc. | Liquid topical pharmaceutical nano-emulsion formulations |
| KR101458466B1 (ko) * | 2013-06-24 | 2014-11-07 | 한국화학연구원 | 면역억제제가 봉입된 마이셀을 함유하는 경구제 |
| WO2016033556A1 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| CN108024914A (zh) | 2015-09-17 | 2018-05-11 | Jrx生物技术有限公司 | 改善皮肤的水合作用或润湿作用的方法 |
| WO2018098501A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| WO2020018974A1 (en) | 2018-07-20 | 2020-01-23 | Lipocine Inc. | Liver disease |
| SI3886813T1 (sl) * | 2018-11-26 | 2023-05-31 | Hepion Pharmaceuticals, Inc. | Farmacevtske formulacije analogov ciklosporina |
| WO2024014958A2 (en) * | 2022-07-15 | 2024-01-18 | Seranovo Holding B.V. | Lides formulation platform |
| WO2024014959A2 (en) * | 2022-07-15 | 2024-01-18 | Seranovo Holding B.V. | Micelle-generating formulations with improved hydrophobicity |
| CN117797093A (zh) * | 2024-02-29 | 2024-04-02 | 中国农业科学院农业环境与可持续发展研究所 | 一种以大环内酯类药物为活性成分的兽用口服纳米液体制剂 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| JP2632010B2 (ja) * | 1988-01-29 | 1997-07-16 | 三共株式会社 | シクロスポリン製剤 |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| EP1142568A1 (en) * | 1992-09-25 | 2001-10-10 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
| GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| WO1995022343A1 (en) * | 1994-02-17 | 1995-08-24 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| JP3131112B2 (ja) * | 1994-02-17 | 2001-01-31 | 株式会社資生堂 | シクロスポリン含有乳化組成物 |
| DK0786986T3 (da) * | 1994-10-26 | 2002-04-29 | Novartis Ag | Anvendelse af en umættet fedtalkohol |
| IL129547A (en) * | 1994-10-26 | 2001-01-11 | Novartis Ag | Pharmaceutical compositions comprising a macrolide and an acid |
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| KR970064620A (ko) * | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
| KR980008239A (ko) * | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
| US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
| DE69842121D1 (de) * | 1997-12-10 | 2011-03-17 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
-
1998
- 1998-10-16 ID IDW20001708A patent/ID25908A/id unknown
-
1999
- 1999-03-04 FR FR9902748A patent/FR2775596B1/fr not_active Expired - Fee Related
- 1999-03-04 HU HU0101080A patent/HUP0101080A3/hu unknown
- 1999-03-04 EP EP03013016A patent/EP1354582A3/en not_active Withdrawn
- 1999-03-04 DE DE19983012T patent/DE19983012T1/de not_active Withdrawn
- 1999-03-04 CA CA002322845A patent/CA2322845C/en not_active Expired - Fee Related
- 1999-03-04 CZ CZ20003222A patent/CZ301967B6/cs not_active IP Right Cessation
- 1999-03-04 BR BR9908597-6A patent/BR9908597A/pt not_active IP Right Cessation
- 1999-03-04 IL IL13824899A patent/IL138248A0/xx active IP Right Grant
- 1999-03-04 PE PE1999000178A patent/PE20000324A1/es not_active Application Discontinuation
- 1999-03-04 GB GB0021495A patent/GB2350791B/en not_active Expired - Fee Related
- 1999-03-04 WO PCT/EP1999/001415 patent/WO1999044584A1/en not_active Ceased
- 1999-03-04 SK SK1319-2000A patent/SK285139B6/sk not_active IP Right Cessation
- 1999-03-04 AT AT99908952T patent/ATE277599T1/de active
- 1999-03-04 AR ARP990100910A patent/AR015729A1/es not_active Application Discontinuation
- 1999-03-04 CN CNB99803746XA patent/CN1195495C/zh not_active Expired - Fee Related
- 1999-03-04 JP JP2000534187A patent/JP2002505271A/ja not_active Withdrawn
- 1999-03-04 EP EP99908952A patent/EP1059913B1/en not_active Revoked
- 1999-03-04 PT PT99908952T patent/PT1059913E/pt unknown
- 1999-03-04 ES ES99908952T patent/ES2228014T3/es not_active Expired - Lifetime
- 1999-03-04 BE BE9900153A patent/BE1012400A5/fr not_active IP Right Cessation
- 1999-03-04 DE DE69920668T patent/DE69920668T2/de not_active Expired - Lifetime
- 1999-03-04 KR KR10-2000-7009861A patent/KR100443306B1/ko not_active Expired - Fee Related
- 1999-03-04 NZ NZ506644A patent/NZ506644A/xx not_active IP Right Cessation
- 1999-03-04 TR TR2000/02586T patent/TR200002586T2/xx unknown
- 1999-03-04 AU AU28361/99A patent/AU749217B2/en not_active Ceased
- 1999-03-05 CO CO99013726A patent/CO4930289A1/es unknown
- 1999-03-05 MY MYPI99000807A patent/MY129274A/en unknown
- 1999-03-05 IT IT1999MI000452A patent/IT1313550B1/it active
- 1999-05-21 TW TW094129536A patent/TWI257870B/zh not_active IP Right Cessation
- 1999-05-21 TW TW093120909A patent/TWI248368B/zh not_active IP Right Cessation
- 1999-05-21 TW TW088107417A patent/TWI236912B/zh not_active IP Right Cessation
- 1999-11-09 BE BE9900732A patent/BE1013423A5/fr not_active IP Right Cessation
-
2000
- 2000-08-18 BE BE2000/0520A patent/BE1013648A5/fr not_active IP Right Cessation
- 2000-08-29 NO NO20004299A patent/NO331800B1/no not_active IP Right Cessation
- 2000-09-05 IL IL138248A patent/IL138248A/en not_active IP Right Cessation
- 2000-10-25 FR FR0013782A patent/FR2800277B1/fr not_active Expired - Fee Related
-
2004
- 2004-03-05 JP JP2004062679A patent/JP2004189753A/ja active Pending
- 2004-03-26 FR FR0403163A patent/FR2853546B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-05 FR FR0600097A patent/FR2881956A1/fr not_active Withdrawn
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