JP2001509805A - 細胞増殖阻害剤としてのピリド〔２，３−ｄ〕ピリミジンおよび４−アミノピリミジン - Google Patents

細胞増殖阻害剤としてのピリド〔２，３−ｄ〕ピリミジンおよび４−アミノピリミジン

Info

Publication number
JP2001509805A
JP2001509805A JP53297198A JP53297198A JP2001509805A JP 2001509805 A JP2001509805 A JP 2001509805A JP 53297198 A JP53297198 A JP 53297198A JP 53297198 A JP53297198 A JP 53297198A JP 2001509805 A JP2001509805 A JP 2001509805A
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JP
Japan
Prior art keywords
pyrido
pyrimidin
phenylamino
ethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP53297198A
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English (en)
Japanese (ja)
Other versions
JP2001509805A5 (https=
Inventor
ボシェリ，ダイアン・ハリス
ドーブルシン，エレン・マイラ
ドウアティ，アネット・メアリアン
ファターシー，アリ
フライ，デイヴィッド・ダブルユー
バーヴィアン，マーク・アール
カルマイアー，ズザーネ・トルムプ
ウー，ジペイ
Original Assignee
ワーナー−ランバート・コンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ワーナー−ランバート・コンパニー filed Critical ワーナー−ランバート・コンパニー
Publication of JP2001509805A publication Critical patent/JP2001509805A/ja
Publication of JP2001509805A5 publication Critical patent/JP2001509805A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP53297198A 1997-02-05 1998-01-26 細胞増殖阻害剤としてのピリド〔２，３−ｄ〕ピリミジンおよび４−アミノピリミジン Ceased JP2001509805A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3722097P 1997-02-05 1997-02-05
US60/037,220 1997-02-05
US6974397P 1997-12-16 1997-12-16
US60/069,743 1997-12-16
PCT/US1998/001343 WO1998033798A2 (en) 1997-02-05 1998-01-26 Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation

Publications (2)

Publication Number Publication Date
JP2001509805A true JP2001509805A (ja) 2001-07-24
JP2001509805A5 JP2001509805A5 (https=) 2005-09-08

Family

ID=26713919

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53297198A Ceased JP2001509805A (ja) 1997-02-05 1998-01-26 細胞増殖阻害剤としてのピリド〔２，３−ｄ〕ピリミジンおよび４−アミノピリミジン

Country Status (11)

Country Link
EP (1) EP0964864B1 (https=)
JP (1) JP2001509805A (https=)
KR (1) KR20000070751A (https=)
AT (1) ATE391719T1 (https=)
AU (1) AU749750B2 (https=)
BR (1) BR9807305A (https=)
CA (1) CA2271157A1 (https=)
DE (1) DE69839338T2 (https=)
ES (1) ES2301194T3 (https=)
HR (1) HRP980060A2 (https=)
WO (1) WO1998033798A2 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
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JP2006508997A (ja) * 2002-11-28 2006-03-16 シエーリング アクチエンゲゼルシャフト Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用
JP2007522241A (ja) * 2004-02-14 2007-08-09 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
JP2008523099A (ja) * 2004-12-13 2008-07-03 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用なピリドピリミジノン、ジヒドロピリミドピリミジノンおよびプテリジノン
JP2009511498A (ja) * 2005-10-07 2009-03-19 エクセリクシス， インク． ＰＩ３Ｋαのピリドピリミジノン型阻害剤
JP2009511504A (ja) * 2005-10-07 2009-03-19 エクセリクシス， インク． ＰＩ３Ｋαのピリドピリミジノン型阻害剤
JP2010500994A (ja) * 2006-08-16 2010-01-14 エグゼリクシス， インコーポレイテッド Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法
JP2010523677A (ja) * 2007-04-11 2010-07-15 エクセリクシス， インク． 癌の治療のためのＰＩ３Ｋα阻害剤としてのピリド［２，３−Ｄ］ピリミジン−７−オン
JP2011518854A (ja) * 2008-04-29 2011-06-30 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドンインヒビター
JP2012500281A (ja) * 2008-08-20 2012-01-05 シェーリング コーポレイション エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
JP2021525247A (ja) * 2018-05-21 2021-09-24 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 複素縮合ピリドン化合物及びｉｄｈ阻害剤としてのこれらの使用
JP2023179797A (ja) * 2011-04-22 2023-12-19 シグナル ファーマシューティカルズ，エルエルシー 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法

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JP2010523677A (ja) * 2007-04-11 2010-07-15 エクセリクシス， インク． 癌の治療のためのＰＩ３Ｋα阻害剤としてのピリド［２，３−Ｄ］ピリミジン−７−オン
JP2011518854A (ja) * 2008-04-29 2011-06-30 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドンインヒビター
JP2012500281A (ja) * 2008-08-20 2012-01-05 シェーリング コーポレイション エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
JP2023179797A (ja) * 2011-04-22 2023-12-19 シグナル ファーマシューティカルズ，エルエルシー 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法
JP2021525247A (ja) * 2018-05-21 2021-09-24 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 複素縮合ピリドン化合物及びｉｄｈ阻害剤としてのこれらの使用
JP7304896B2 (ja) 2018-05-21 2023-07-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 複素縮合ピリドン化合物及びｉｄｈ阻害剤としてのこれらの使用

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KR20000070751A (ko) 2000-11-25
DE69839338T2 (de) 2008-07-10
DE69839338D1 (de) 2008-05-21
EP0964864A2 (en) 1999-12-22
WO1998033798A3 (en) 1998-11-05
ATE391719T1 (de) 2008-04-15
EP0964864B1 (en) 2008-04-09
AU6648098A (en) 1998-08-25
HRP980060A2 (en) 1999-06-30
AU749750B2 (en) 2002-07-04
WO1998033798A2 (en) 1998-08-06

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