JOP20190229A1 - مركبات تثبط بروتين mcl-1 - Google Patents
مركبات تثبط بروتين mcl-1Info
- Publication number
- JOP20190229A1 JOP20190229A1 JOP/2019/0229A JOP20190229A JOP20190229A1 JO P20190229 A1 JOP20190229 A1 JO P20190229A1 JO P20190229 A JOP20190229 A JO P20190229A JO P20190229 A1 JOP20190229 A1 JO P20190229A1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- protein
- mcl
- formula
- inhibit mcl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
يتعلق الاختراع الحالي بمثبطات بروتين سرطان الدم بالخلية النخاعية 1 (Mcl-1)، وطرق لتحضيرها، وتركيبات صيدلانية تتعلق بها، وطرق لاستخدامها. على سبيل المثال، يتعلق الاختراع الحالي بمركبات بالصيغة I، صورة (I) أو أيزومر فراغي منها؛ وأملاح مقبولة صيدلانياً منها وتركيبات صيدلانية تحتوي على المركبات. يمكن استخدام المركبات والتركيبات المقدمة في هذه الوثيقة، على سبيل المثال، في معالجة أمراض أو حالات مرضية، مثل السرطان.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479171P | 2017-03-30 | 2017-03-30 | |
| US201762479230P | 2017-03-30 | 2017-03-30 | |
| PCT/US2018/024723 WO2018183418A1 (en) | 2017-03-30 | 2018-03-28 | Compounds that inhibit mcl-1 protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JOP20190229A1 true JOP20190229A1 (ar) | 2019-09-30 |
| JOP20190229B1 JOP20190229B1 (ar) | 2022-09-15 |
Family
ID=61972255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2019/0229A JOP20190229B1 (ar) | 2017-03-30 | 2018-03-28 | مركبات تثبط بروتين mcl-1 |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US10300075B2 (ar) |
| EP (1) | EP3601297B9 (ar) |
| JP (2) | JP6453507B2 (ar) |
| KR (1) | KR102372322B1 (ar) |
| CN (1) | CN110691784B (ar) |
| AU (2) | AU2018244349B2 (ar) |
| BR (1) | BR112019020459B1 (ar) |
| CA (1) | CA3057882A1 (ar) |
| CL (1) | CL2019002777A1 (ar) |
| CO (1) | CO2019011762A2 (ar) |
| CR (1) | CR20190489A (ar) |
| DK (1) | DK3601297T5 (ar) |
| ES (1) | ES2940641T3 (ar) |
| FI (1) | FI3601297T3 (ar) |
| HR (1) | HRP20221412T2 (ar) |
| HU (1) | HUE060919T2 (ar) |
| IL (1) | IL269603B (ar) |
| JO (1) | JOP20190229B1 (ar) |
| LT (1) | LT3601297T (ar) |
| MX (1) | MX2019011693A (ar) |
| NZ (1) | NZ757606A (ar) |
| PE (1) | PE20200335A1 (ar) |
| PH (1) | PH12019502245A1 (ar) |
| PL (1) | PL3601297T3 (ar) |
| PT (1) | PT3601297T (ar) |
| RS (1) | RS63892B9 (ar) |
| SA (1) | SA519410222B1 (ar) |
| SG (1) | SG11201908945RA (ar) |
| SI (1) | SI3601297T1 (ar) |
| TW (1) | TWI685493B (ar) |
| UA (1) | UA124784C2 (ar) |
| UY (1) | UY37656A (ar) |
| WO (1) | WO2018183418A1 (ar) |
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2018
- 2018-03-27 JP JP2018059341A patent/JP6453507B2/ja active Active
- 2018-03-28 NZ NZ757606A patent/NZ757606A/en unknown
- 2018-03-28 HR HRP20221412TT patent/HRP20221412T2/hr unknown
- 2018-03-28 MX MX2019011693A patent/MX2019011693A/es unknown
- 2018-03-28 PT PT187178116T patent/PT3601297T/pt unknown
- 2018-03-28 WO PCT/US2018/024723 patent/WO2018183418A1/en unknown
- 2018-03-28 PL PL18717811.6T patent/PL3601297T3/pl unknown
- 2018-03-28 RS RS20230036A patent/RS63892B9/sr unknown
- 2018-03-28 US US15/938,001 patent/US10300075B2/en active Active
- 2018-03-28 PE PE2019001963A patent/PE20200335A1/es unknown
- 2018-03-28 AU AU2018244349A patent/AU2018244349B2/en active Active
- 2018-03-28 CA CA3057882A patent/CA3057882A1/en active Pending
- 2018-03-28 HU HUE18717811A patent/HUE060919T2/hu unknown
- 2018-03-28 BR BR112019020459-8A patent/BR112019020459B1/pt active IP Right Grant
- 2018-03-28 LT LTEPPCT/US2018/024723T patent/LT3601297T/lt unknown
- 2018-03-28 SG SG11201908945R patent/SG11201908945RA/en unknown
- 2018-03-28 EP EP18717811.6A patent/EP3601297B9/en active Active
- 2018-03-28 FI FIEP18717811.6T patent/FI3601297T3/fi active
- 2018-03-28 DK DK18717811.6T patent/DK3601297T5/da active
- 2018-03-28 SI SI201830809T patent/SI3601297T1/sl unknown
- 2018-03-28 JO JOP/2019/0229A patent/JOP20190229B1/ar active
- 2018-03-28 CR CR20190489A patent/CR20190489A/es unknown
- 2018-03-28 KR KR1020197029091A patent/KR102372322B1/ko active IP Right Grant
- 2018-03-28 ES ES18717811T patent/ES2940641T3/es active Active
- 2018-03-28 UA UAA201910703A patent/UA124784C2/uk unknown
- 2018-03-28 CN CN201880035818.3A patent/CN110691784B/zh active Active
- 2018-03-30 TW TW107111110A patent/TWI685493B/zh active
- 2018-04-02 UY UY0001037656A patent/UY37656A/es unknown
- 2018-12-11 JP JP2018231352A patent/JP6629419B2/ja active Active
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2019
- 2019-03-11 US US16/297,904 patent/US10500213B2/en active Active
- 2019-08-22 US US16/547,747 patent/US10632128B2/en active Active
- 2019-09-24 IL IL269603A patent/IL269603B/en unknown
- 2019-09-27 CL CL2019002777A patent/CL2019002777A1/es unknown
- 2019-09-27 PH PH12019502245A patent/PH12019502245A1/en unknown
- 2019-09-30 SA SA519410222A patent/SA519410222B1/ar unknown
- 2019-10-24 CO CONC2019/0011762A patent/CO2019011762A2/es unknown
-
2020
- 2020-02-06 US US16/783,269 patent/US10821115B2/en active Active
- 2020-09-23 US US17/029,249 patent/US11224601B1/en active Active
-
2021
- 2021-01-15 AU AU2021200233A patent/AU2021200233A1/en not_active Abandoned
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