MX2023002691A - Desimetrización de diol mediante sustitución aromática nucleófila. - Google Patents

Desimetrización de diol mediante sustitución aromática nucleófila.

Info

Publication number
MX2023002691A
MX2023002691A MX2023002691A MX2023002691A MX2023002691A MX 2023002691 A MX2023002691 A MX 2023002691A MX 2023002691 A MX2023002691 A MX 2023002691A MX 2023002691 A MX2023002691 A MX 2023002691A MX 2023002691 A MX2023002691 A MX 2023002691A
Authority
MX
Mexico
Prior art keywords
desymmetrization
diol
aromatic substitution
nucleophilic aromatic
compound
Prior art date
Application number
MX2023002691A
Other languages
English (en)
Inventor
Joseph Dennis
Neil Fred Langille
Jason S Tedrow
Peter K Dornan
Matthew G Beaver
Steven Mennen
Carolyn Cohen
Andreas Rene Rotheli
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023002691A publication Critical patent/MX2023002691A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporcionan en la presente procesos para sintetizar inhibidores de Mcl-1 y productos intermedios tales como el compuesto Y que pueden usarse para prepararlos, donde el R1 variable es tal como se define en la presente. En particular, se proporcionan en la presente procesos para sintetizar el compuesto A1, y sales o solvatos del mismo, el compuesto A2, y sales y solvatos del mismo, y el compuesto A3 y sales y solvatos del mismo.(ver fórmulas).
MX2023002691A 2020-09-03 2021-09-01 Desimetrización de diol mediante sustitución aromática nucleófila. MX2023002691A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063074241P 2020-09-03 2020-09-03
PCT/US2021/048588 WO2022051317A1 (en) 2020-09-03 2021-09-01 Diol desymmetrization by nucleophilic aromatic substitution

Publications (1)

Publication Number Publication Date
MX2023002691A true MX2023002691A (es) 2023-05-03

Family

ID=77924515

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002691A MX2023002691A (es) 2020-09-03 2021-09-01 Desimetrización de diol mediante sustitución aromática nucleófila.

Country Status (11)

Country Link
US (1) US20230365588A1 (es)
EP (1) EP4208467A1 (es)
JP (1) JP2023540083A (es)
KR (1) KR20230058694A (es)
CN (1) CN116249705A (es)
AU (1) AU2021337589A1 (es)
CA (1) CA3193132A1 (es)
CL (1) CL2023000605A1 (es)
IL (1) IL300977A (es)
MX (1) MX2023002691A (es)
WO (1) WO2022051317A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020391106B2 (en) 2019-11-26 2024-03-21 Gilead Sciences, Inc. Processes and intermediates for preparing MCL1 inhibitors
CN116457334A (zh) * 2020-11-19 2023-07-18 吉利德科学公司 用于制备大环mcl1抑制剂的方法和中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
JP6453507B2 (ja) 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
TWI745836B (zh) * 2019-01-18 2021-11-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑製劑的大螺環醚

Also Published As

Publication number Publication date
EP4208467A1 (en) 2023-07-12
JP2023540083A (ja) 2023-09-21
CA3193132A1 (en) 2022-03-10
IL300977A (en) 2023-04-01
KR20230058694A (ko) 2023-05-03
AU2021337589A1 (en) 2023-03-30
US20230365588A1 (en) 2023-11-16
WO2022051317A1 (en) 2022-03-10
CL2023000605A1 (es) 2023-08-11
CN116249705A (zh) 2023-06-09

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