CR20220139A - Inhibidor de diacilglicerol aciltransferasa 2 - Google Patents
Inhibidor de diacilglicerol aciltransferasa 2Info
- Publication number
- CR20220139A CR20220139A CR20220139A CR20220139A CR20220139A CR 20220139 A CR20220139 A CR 20220139A CR 20220139 A CR20220139 A CR 20220139A CR 20220139 A CR20220139 A CR 20220139A CR 20220139 A CR20220139 A CR 20220139A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sup
- inhibitor
- diacylglycerol acyltransferase
- inhibitors
- acyltransferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente se describen compuestos de la Formula (I) <img src="data:image/png;base64,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 (***)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962911094P | 2019-10-04 | 2019-10-04 | |
US202063074123P | 2020-09-03 | 2020-09-03 | |
PCT/IB2020/059145 WO2021064590A1 (en) | 2019-10-04 | 2020-09-30 | Diacylglycerol acyltransferase 2 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20220139A true CR20220139A (es) | 2022-05-06 |
Family
ID=72826929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20220139A CR20220139A (es) | 2019-10-04 | 2020-09-30 | Inhibidor de diacilglicerol aciltransferasa 2 |
Country Status (17)
Country | Link |
---|---|
US (2) | US11471458B2 (es) |
EP (1) | EP4038060B1 (es) |
JP (1) | JP7161081B2 (es) |
KR (1) | KR20220079906A (es) |
CN (1) | CN114787146A (es) |
AU (1) | AU2020358955B2 (es) |
CA (1) | CA3095028A1 (es) |
CL (1) | CL2022000835A1 (es) |
CO (1) | CO2022004286A2 (es) |
CR (1) | CR20220139A (es) |
EC (1) | ECSP22026478A (es) |
ES (1) | ES2966340T3 (es) |
IL (1) | IL291763A (es) |
MX (1) | MX2022004035A (es) |
PE (1) | PE20221444A1 (es) |
TW (1) | TWI771766B (es) |
WO (1) | WO2021064590A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR123700A1 (es) | 2020-10-08 | 2023-01-04 | Merck Sharp & Dohme | Preparación de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2 |
CN115429810B (zh) * | 2021-06-03 | 2024-03-08 | 苏州禾研生物技术有限公司 | 异黄酮类化合物在制备预防或治疗酒精性肝损伤或解酒保肝的药物中的用途 |
US20240254114A1 (en) | 2022-12-02 | 2024-08-01 | Merck Sharp & Dohme Llc | Preparation of fused azole derivatives as novel diacylglyceride 0-acyltransferase 2 inhibitors |
Family Cites Families (38)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
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US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
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DE3438830A1 (de) | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
KR0182801B1 (ko) | 1991-04-16 | 1999-05-01 | 아만 히데아키 | 고체 분산체의 제조방법 |
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JP3265680B2 (ja) | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
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TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
MA24852A1 (fr) | 1998-05-04 | 1999-12-31 | Pfizer Prod Inc | Derives d'hygromycine a et leur procede de preparation |
PL201048B1 (pl) | 1998-07-06 | 2009-03-31 | Bristol Myers Squibb Co | Bifenylosulfonamid jako dualny antagonista receptorów angiotensyny i endoteliny oraz jego zastosowanie |
AU2005247684B2 (en) | 2004-05-12 | 2008-10-23 | Pfizer Products Inc. | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors |
CA2648852C (en) | 2006-04-20 | 2012-12-11 | Pfizer Products Inc. | Fused phenyl amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases |
US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
WO2010013161A1 (en) | 2008-07-29 | 2010-02-04 | Pfizer Inc. | Fluorinated heteroaryls |
AU2009286380B2 (en) | 2008-08-28 | 2011-09-15 | Pfizer Inc. | Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives |
EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
PE20120668A1 (es) | 2009-03-11 | 2012-06-01 | Pfizer | Un compuesto n,n-dimetil-5-(2-metil-6-((5-metilpirazin-2-il)carbamoil)benzofuran-4-iloxi)pirimidin-carboxamida como activador de glucocinasa |
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MA37385B1 (fr) * | 2012-04-06 | 2019-09-30 | Pfizer Inc Etat De Delaware | Inhibiteurs de diacylglycérol-acyltransférase 2 |
AR098394A1 (es) | 2013-11-25 | 2016-05-26 | Lilly Co Eli | Inhibidores de dgat2 (diacilglicerol o-aciltransferasa 2) |
AP2016009407A0 (en) * | 2014-03-17 | 2016-08-31 | Pfizer | Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders |
EP3188732B1 (en) | 2014-09-05 | 2019-07-24 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
WO2016036636A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
EP3188731B1 (en) | 2014-09-05 | 2019-04-03 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
AR109179A1 (es) * | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
PL3555064T3 (pl) | 2016-12-16 | 2023-03-06 | Pfizer Inc. | Agoności receptora GLP-1 i ich zastosowania |
JP2022058085A (ja) * | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ2阻害剤とアセチル-CoAカルボキシラーゼ阻害剤との組合せ |
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2020
- 2020-09-28 TW TW109133632A patent/TWI771766B/zh active
- 2020-09-30 WO PCT/IB2020/059145 patent/WO2021064590A1/en unknown
- 2020-09-30 AU AU2020358955A patent/AU2020358955B2/en not_active Expired - Fee Related
- 2020-09-30 CR CR20220139A patent/CR20220139A/es unknown
- 2020-09-30 KR KR1020227014967A patent/KR20220079906A/ko active Search and Examination
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EP4038060B1 (en) | 2023-11-15 |
TWI771766B (zh) | 2022-07-21 |
US11471458B2 (en) | 2022-10-18 |
CL2022000835A1 (es) | 2023-01-27 |
WO2021064590A1 (en) | 2021-04-08 |
JP2022543499A (ja) | 2022-10-12 |
EP4038060A1 (en) | 2022-08-10 |
KR20220079906A (ko) | 2022-06-14 |
IL291763A (en) | 2022-06-01 |
US11065249B2 (en) | 2021-07-20 |
CA3095028A1 (en) | 2021-04-04 |
CO2022004286A2 (es) | 2022-04-29 |
EP4038060C0 (en) | 2023-11-15 |
ES2966340T3 (es) | 2024-04-22 |
ECSP22026478A (es) | 2022-05-31 |
PE20221444A1 (es) | 2022-09-21 |
JP7161081B2 (ja) | 2022-10-25 |
AU2020358955B2 (en) | 2023-08-17 |
US20210100796A1 (en) | 2021-04-08 |
US20210100798A1 (en) | 2021-04-08 |
AU2020358955A1 (en) | 2022-04-21 |
MX2022004035A (es) | 2022-05-02 |
CN114787146A (zh) | 2022-07-22 |
TW202126635A (zh) | 2021-07-16 |
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