IT1251376B - Pregna 1,4-diene-3,20-dione-16,17-acetal-21-esteri, procedimento per la loro preparazione, composizione e metodi per il trattamento di stati infiammatori - Google Patents

Pregna 1,4-diene-3,20-dione-16,17-acetal-21-esteri, procedimento per la loro preparazione, composizione e metodi per il trattamento di stati infiammatori

Info

Publication number
IT1251376B
IT1251376B ITMI912296A ITMI912296A IT1251376B IT 1251376 B IT1251376 B IT 1251376B IT MI912296 A ITMI912296 A IT MI912296A IT MI912296 A ITMI912296 A IT MI912296A IT 1251376 B IT1251376 B IT 1251376B
Authority
IT
Italy
Prior art keywords
preparation
esteri
pregna
dione
acetal
Prior art date
Application number
ITMI912296A
Other languages
English (en)
Inventor
Jose Calatayud
Jose Ramon Conde
Manuel Luna
Original Assignee
Elmu Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elmu Sa filed Critical Elmu Sa
Publication of ITMI912296A0 publication Critical patent/ITMI912296A0/it
Publication of ITMI912296A1 publication Critical patent/ITMI912296A1/it
Application granted granted Critical
Publication of IT1251376B publication Critical patent/IT1251376B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invenzione riguarda composti aventi la formula FORMULA 1 sotto forma di un epimero R, un epimero S, oppure una miscela stereoisometrica degli epimeri R e S in termini dell'orientamento dei sostituenti sull'atomo di carbonio in posizione 22, riguarda nuovi intermedi e un metodo per la loro preparazione mediante idrolisi-chetalizzazione e l'impiego di tali composti come farmaci e/o come agenti terapeutici.
ITMI912296A 1990-09-07 1991-08-28 Pregna 1,4-diene-3,20-dione-16,17-acetal-21-esteri, procedimento per la loro preparazione, composizione e metodi per il trattamento di stati infiammatori IT1251376B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57894290A 1990-09-07 1990-09-07

Publications (3)

Publication Number Publication Date
ITMI912296A0 ITMI912296A0 (it) 1991-08-28
ITMI912296A1 ITMI912296A1 (it) 1993-02-28
IT1251376B true IT1251376B (it) 1995-05-09

Family

ID=24314964

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912296A IT1251376B (it) 1990-09-07 1991-08-28 Pregna 1,4-diene-3,20-dione-16,17-acetal-21-esteri, procedimento per la loro preparazione, composizione e metodi per il trattamento di stati infiammatori

Country Status (19)

Country Link
US (1) US5482934A (it)
JP (1) JP3292928B2 (it)
KR (1) KR100193085B1 (it)
AT (1) AT402930B (it)
AU (1) AU649472B2 (it)
BE (1) BE1005876A5 (it)
BR (1) BR1100860A (it)
CA (1) CA2050812C (it)
CH (1) CH683343A5 (it)
DE (2) DE4129535C2 (it)
ES (1) ES2034893B1 (it)
FR (1) FR2666585B1 (it)
GB (1) GB2247680B (it)
GR (1) GR1001529B (it)
HK (1) HK1005881A1 (it)
IT (1) IT1251376B (it)
LU (2) LU88001A1 (it)
NL (2) NL194917C (it)
PT (1) PT98897B (it)

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DE3640709A1 (de) * 1986-11-28 1988-06-09 Schering Ag Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate

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GR910100353A (en) 1992-09-11
PT98897A (pt) 1992-07-31
ATA176991A (de) 1997-02-15
DE4129535C2 (de) 2001-03-15
LU88001A1 (fr) 1992-06-01
ITMI912296A0 (it) 1991-08-28
US5482934A (en) 1996-01-09
FR2666585B1 (fr) 1994-09-09
ITMI912296A1 (it) 1993-02-28
AT402930B (de) 1997-09-25
ES2034893A1 (es) 1993-04-01
JP3292928B2 (ja) 2002-06-17
LU91205I2 (fr) 2006-05-30
DE122005000030I1 (de) 2005-10-06
HK1005881A1 (en) 1999-01-29
CA2050812C (en) 2003-07-29
BE1005876A5 (nl) 1994-02-22
FR2666585A1 (fr) 1992-03-13
AU8368691A (en) 1992-03-12
ES2034893B1 (es) 1994-01-01
DE4129535A1 (de) 1992-03-12
DE122005000030I2 (de) 2007-12-06
BR1100860A (pt) 1999-08-31
CH683343A5 (de) 1994-02-28
GB2247680B (en) 1994-06-01
CA2050812A1 (en) 1992-03-08
NL300196I2 (nl) 2005-10-03
KR100193085B1 (ko) 1999-06-15
KR920006365A (ko) 1992-04-27
GR1001529B (el) 1994-03-31
GB9118967D0 (en) 1991-10-23
AU649472B2 (en) 1994-05-26
GB2247680A (en) 1992-03-11

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