FR2666585B1 - Nouveaux pregnadiene-1,4 dione-3,20 acetal-16-17 esters-21, procede pour leur fabrication, compositions, et methodes pour le traitement des etats inflammatoires. - Google Patents

Nouveaux pregnadiene-1,4 dione-3,20 acetal-16-17 esters-21, procede pour leur fabrication, compositions, et methodes pour le traitement des etats inflammatoires.

Info

Publication number
FR2666585B1
FR2666585B1 FR919110682A FR9110682A FR2666585B1 FR 2666585 B1 FR2666585 B1 FR 2666585B1 FR 919110682 A FR919110682 A FR 919110682A FR 9110682 A FR9110682 A FR 9110682A FR 2666585 B1 FR2666585 B1 FR 2666585B1
Authority
FR
France
Prior art keywords
pregnadiene
dione
acetal
esters
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR919110682A
Other languages
English (en)
Other versions
FR2666585A1 (fr
Inventor
Jose Calatayud
Jose Ramon Conde
Manuel Luna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Especialidades Latinas Medicamentos Universales SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Especialidades Latinas Medicamentos Universales SA filed Critical Especialidades Latinas Medicamentos Universales SA
Publication of FR2666585A1 publication Critical patent/FR2666585A1/fr
Application granted granted Critical
Publication of FR2666585B1 publication Critical patent/FR2666585B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR919110682A 1990-09-07 1991-08-28 Nouveaux pregnadiene-1,4 dione-3,20 acetal-16-17 esters-21, procede pour leur fabrication, compositions, et methodes pour le traitement des etats inflammatoires. Expired - Lifetime FR2666585B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57894290A 1990-09-07 1990-09-07

Publications (2)

Publication Number Publication Date
FR2666585A1 FR2666585A1 (fr) 1992-03-13
FR2666585B1 true FR2666585B1 (fr) 1994-09-09

Family

ID=24314964

Family Applications (1)

Application Number Title Priority Date Filing Date
FR919110682A Expired - Lifetime FR2666585B1 (fr) 1990-09-07 1991-08-28 Nouveaux pregnadiene-1,4 dione-3,20 acetal-16-17 esters-21, procede pour leur fabrication, compositions, et methodes pour le traitement des etats inflammatoires.

Country Status (19)

Country Link
US (1) US5482934A (fr)
JP (1) JP3292928B2 (fr)
KR (1) KR100193085B1 (fr)
AT (1) AT402930B (fr)
AU (1) AU649472B2 (fr)
BE (1) BE1005876A5 (fr)
BR (1) BR1100860A (fr)
CA (1) CA2050812C (fr)
CH (1) CH683343A5 (fr)
DE (2) DE122005000030I2 (fr)
ES (1) ES2034893B1 (fr)
FR (1) FR2666585B1 (fr)
GB (1) GB2247680B (fr)
GR (1) GR1001529B (fr)
HK (1) HK1005881A1 (fr)
IT (1) IT1251376B (fr)
LU (2) LU88001A1 (fr)
NL (2) NL194917C (fr)
PT (1) PT98897B (fr)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW197380B (fr) * 1990-03-02 1993-01-01 Glaxo Group Ltd
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
SK280967B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
NZ265054A (en) * 1993-04-02 1997-08-22 Byk Gulden Lomberg Chem Fab 16-hydroxy prednisolone cyclohexanecarboxaldehyde acetal derivatives
ES2154725T3 (es) * 1994-03-09 2001-04-16 Byk Gulden Lomberg Chem Fab Nuevos compuestos de sililo y su utilizacion.
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
SE9604751D0 (sv) * 1996-12-20 1996-12-20 Astra Ab New therapy
US6120752A (en) * 1997-05-21 2000-09-19 3M Innovative Properties Company Medicinal aerosol products containing formulations of ciclesonide and related steroids
US6264923B1 (en) 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
WO2003079972A2 (fr) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
US7468433B2 (en) 2000-11-10 2008-12-23 Nycomed Gmbh Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
PL373433A1 (en) * 2002-08-30 2005-08-22 Altana Pharma Ag The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
WO2004033478A2 (fr) * 2002-10-08 2004-04-22 Sepracor Inc. Formes modifiees par l'acide gras des glucocorticoides
ATE405275T1 (de) 2002-12-12 2008-09-15 Nycomed Gmbh Kombinationsarzneimittel aus r,r-formoterol und ciclesonide
CN100404545C (zh) * 2003-03-27 2008-07-23 尼科梅德有限责任公司 具有规定粒径的结晶环缩松的制备方法
MY143936A (en) 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
CA2528479A1 (fr) 2003-06-13 2004-12-23 Altana Pharma Ag Combinaison de formoterol et de ciclesonide
GB0315889D0 (en) * 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
BRPI0413330A (pt) * 2003-08-29 2006-10-10 Ranbaxy Lab Ltd inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação
ATE476185T1 (de) * 2003-09-15 2010-08-15 Nycomed Gmbh Verwendung von ciclesonid zur behandlung von entzündlichen darmerkrankungen
CA2538419C (fr) * 2003-09-16 2012-07-03 Altana Pharma Ag Utilisation de ciclesonide dans le traitement de maladies respiratoires
WO2005051931A2 (fr) * 2003-11-26 2005-06-09 Ranbaxy Laboratories Limited Inhibiteurs de la phosphodiestérase
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
WO2005102354A1 (fr) * 2004-04-20 2005-11-03 Altana Pharma Ag Utilisation de ciclesonide pour le traitement des maladies respiratoires chez des patients fumeurs
CN100338089C (zh) * 2004-08-12 2007-09-19 重庆医药工业研究院有限责任公司 一种哮喘病治疗药物环索奈德的新的制备方法
EP1796679A1 (fr) * 2004-09-10 2007-06-20 Altana Pharma AG Combinaison de ciclesonide et d'inhibiteur de syk et procedes d'utilisation
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
AU2006259604A1 (en) * 2005-06-14 2006-12-28 Gilead Sciences, Inc. Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction
CN1325508C (zh) * 2005-06-21 2007-07-11 浙江仙琚制药股份有限公司 一锅法制备泼尼松龙衍生物
TW200738634A (en) 2005-08-02 2007-10-16 Astrazeneca Ab New salt
NZ566128A (en) * 2005-09-02 2011-03-31 Nicox Sa Nitrooxy derivatives of glucocorticoids
EP1934219A1 (fr) 2005-09-16 2008-06-25 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
WO2007045980A1 (fr) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions d'inhibiteurs de la phosphodiesterase de type iv
WO2007056181A2 (fr) * 2005-11-02 2007-05-18 Sicor, Inc. Procede perfectionne destine a la preparation de ciclesonide
WO2007092574A2 (fr) * 2006-02-08 2007-08-16 Sicor, Inc. Formes cristallines de ciclesonide
US20070232578A1 (en) * 2006-02-15 2007-10-04 Pierluigi Rossetto Crystalline forms of ciclesonide
ES2296516B1 (es) * 2006-04-27 2009-04-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
WO2008015696A2 (fr) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Procédé pour préparer le ciclésonide
WO2008010765A1 (fr) 2006-07-19 2008-01-24 Astrazeneca Ab Nouveaux composés
EP2474531A3 (fr) * 2006-08-22 2013-12-04 Ranbaxy Laboratories Limited Inhibiteurs de métalloprotéase de matrice
WO2008062450A2 (fr) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Polymorphes cristallins de ciclésonide
AU2007298770B2 (en) 2006-09-19 2013-01-31 Cipla Limited Processes for the preparation of ciclesonide and its crystal form
US20110021473A1 (en) * 2006-09-22 2011-01-27 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-iv
US20100029728A1 (en) * 2006-09-22 2010-02-04 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
ES2302447B1 (es) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
ES2385681T3 (es) 2006-12-19 2012-07-30 Astrazeneca Ab Derivados de quinuclidinol como antagonistas de receptores muscarínicos
ES2306595B1 (es) * 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
EP1958947A1 (fr) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibiteurs de la phosphodiestérase de type 4
NZ579645A (en) * 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
EP2124943A1 (fr) * 2007-03-14 2009-12-02 Ranbaxy Laboratories Limited Dérivés de pyrazolo[3,4-b]pyridine comme inhibiteurs de phosphodiestérases
EP2022796A1 (fr) * 2007-08-07 2009-02-11 Nycomed GmbH Ciclésonide amorphe
US20090075959A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched ciclesonide
ES2320961B1 (es) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2096105A1 (fr) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Dérivés de 4-(2-amino-1-hydroxyethyl)phénol en tant qu'antagonistes du récepteur adrénergique b2
CA2714653A1 (fr) * 2008-03-13 2009-09-17 Farmabios S.P.A. Procede pour la preparation de derives de pregnane
EP2111861A1 (fr) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions d'inhibiteurs de type IV de la phosphodiestérase
BRPI0912657A2 (pt) * 2008-05-13 2016-01-26 Astrazeneca Ab produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor
BRPI0822693A2 (pt) 2008-05-13 2015-07-07 Astrazeneca Ab Derivados de quinuclidina como antagonistas do receptor muscarínico m3
WO2009144494A1 (fr) 2008-05-27 2009-12-03 Astrazeneca Ab Dérivés de phénoxypyridinylamide et leur utilisation dans le traitement d'états pathologiques induits par la phosphodiésterase 4 (pde4)
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
WO2010067102A1 (fr) 2008-12-09 2010-06-17 Astrazeneca Ab Dérivés de diazaspiro[5.5]undécane et composés associés utilisés comme antagonistes des récepteurs muscariniques et agonistes des récepteurs bêta adrénergiques dans le traitement des affections pulmonaires
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
ES2471145T3 (es) 2009-03-09 2014-06-25 Mikasa Seiyaku Co,. Ltd. Compuesto esteroide
EP2228368A1 (fr) 2009-03-12 2010-09-15 Almirall, S.A. Procédé de fabrication de 5-(2-{[6-(2,2-difluoro-2-ph2nyl2thoxy)hexyl]amino}-1-hydroxy2thyl)-8-hydroxyquinolin-2(1h)-one
ES2683864T3 (es) 2009-10-01 2018-09-28 Adare Pharmaceuticals, Inc. Composiciones de corticosteroides administradas oralmente
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
JP2013515741A (ja) * 2009-12-23 2013-05-09 サイヴィーダ ユーエス，インコーポレイテッド 持続放出性送達デバイス
WO2011093814A2 (fr) 2010-01-29 2011-08-04 Mahmut Bilgic Compositions pharmaceutiques combinées comprenant du formotérol et du ciclésonide
WO2011136752A1 (fr) 2010-04-26 2011-11-03 Mahmut Bilgic Composition pharmaceutique combinée comprenant du carmotérol et du ciclésonide pour le traitement de maladies respiratoires
CN102477064B (zh) * 2010-11-23 2014-06-11 天津金耀集团有限公司 一种制备环索奈德的16,17缩酮中间体
AU2012296880A1 (en) 2011-08-18 2014-03-27 Astrazeneca Ab Pharmaceutical aerosol product for administration by oral or nasal inhalation
EP2578570A1 (fr) 2011-10-07 2013-04-10 Almirall, S.A. Nouveau procédé de fabrication de 5-(2-{[6-(2,2-difluoro-2-phényléthoxy)hexyl]amino}-1-hydroxyéthyl)-8-hydroxyquinolin-2(1h)-one via de nouveaux intermédiaires de synthèse
WO2013109212A1 (fr) 2012-01-16 2013-07-25 Mahmut Bilgic Formulations en poudre sèche comprenant de la ciclésonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
EP2641900A1 (fr) 2012-03-20 2013-09-25 Almirall, S.A. Nouvelles formes polymorphes de héminapadisylate de 5-(2-{[6-(2,2-difluoro-2-phényléthoxy) hexyl]amino}-1-(R)-hydroxyéthyl)-8-hydroxyquinolin-2(1h)-one en tant qu'agoniste du récepteur adrénergique ß2
WO2014007770A2 (fr) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions d'inhalation comprenant un corticostéroïde et du sorbitol
WO2014007772A2 (fr) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions d'inhalation contenant du glucose anhydre
WO2014007771A2 (fr) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions d'inhalation comprenant un antagoniste du récepteur muscarinique
WO2014007781A2 (fr) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions d'inhalation
WO2015034678A2 (fr) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticostéroïde contenant des compositions de comprimés se désintégrant par voie orale pour œsophagite à éonisophiles
US10233210B2 (en) 2015-01-30 2019-03-19 Coral Drugs Pvt. Ltd. Process for preparation of glucocorticoid steroids
TWI728172B (zh) 2016-08-18 2021-05-21 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
CN106749493A (zh) * 2017-01-09 2017-05-31 河南利华制药有限公司 一种哈西奈德中间体的制备工艺
AU2019287541A1 (en) 2018-06-14 2021-01-21 Astrazeneca Uk Limited Methods for treating and preventing symptoms of asthma with a corticosteroid pharmaceutical composition
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
WO2024020164A2 (fr) * 2022-07-21 2024-01-25 Firefly Bio, Inc. Agonistes du récepteur des glucocorticoïdes et leurs conjugués

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3079384A (en) * 1960-10-10 1963-02-26 Olin Mathieson C-ring substituted 6alpha-halo steroids and process for producing them
SE378109B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (fr) * 1972-05-19 1975-08-18 Bofors Ab
US4272446A (en) * 1974-02-27 1981-06-09 Pierrel S.P.A. Steroids and process for preparing the same
CH608244A5 (en) * 1974-02-27 1978-12-29 Pierrel Spa Process for the preparation of steroids
GB1504294A (en) * 1974-03-05 1978-03-15 Palladino G 6 beta-fluoropregnane compounds
NL7412537A (nl) * 1974-05-17 1975-11-19 Lark Spa Werkwijze voor het bereiden van 16.17-cyclische acetalen en ketalen van 9-(alpha)-halogeensteroiden.
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
DE3012888A1 (de) * 1980-03-31 1981-10-08 Schering Ag Berlin Und Bergkamen, 1000 Berlin Neue steroide und verfahren zu ihrer herstellung
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
DE3640709A1 (de) * 1986-11-28 1988-06-09 Schering Ag Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate

Also Published As

Publication number Publication date
CH683343A5 (de) 1994-02-28
NL9101472A (nl) 1992-04-01
GB9118967D0 (en) 1991-10-23
IT1251376B (it) 1995-05-09
ITMI912296A1 (it) 1993-02-28
KR920006365A (ko) 1992-04-27
DE4129535C2 (de) 2001-03-15
ATA176991A (de) 1997-02-15
DE4129535A1 (de) 1992-03-12
NL300196I1 (nl) 2005-08-01
KR100193085B1 (ko) 1999-06-15
AT402930B (de) 1997-09-25
LU88001A1 (fr) 1992-06-01
BR1100860A (pt) 1999-08-31
GB2247680B (en) 1994-06-01
GB2247680A (en) 1992-03-11
PT98897A (pt) 1992-07-31
NL194917C (nl) 2003-09-01
CA2050812A1 (fr) 1992-03-08
DE122005000030I1 (de) 2005-10-06
ITMI912296A0 (it) 1991-08-28
DE122005000030I2 (de) 2007-12-06
HK1005881A1 (en) 1999-01-29
BE1005876A5 (nl) 1994-02-22
FR2666585A1 (fr) 1992-03-13
NL300196I2 (nl) 2005-10-03
GR910100353A (en) 1992-09-11
AU649472B2 (en) 1994-05-26
ES2034893B1 (es) 1994-01-01
JP3292928B2 (ja) 2002-06-17
JPH04257599A (ja) 1992-09-11
PT98897B (pt) 2000-10-31
GR1001529B (el) 1994-03-31
CA2050812C (fr) 2003-07-29
US5482934A (en) 1996-01-09
LU91205I2 (fr) 2006-05-30
ES2034893A1 (es) 1993-04-01
AU8368691A (en) 1992-03-12

Similar Documents

Publication Publication Date Title
FR2666585B1 (fr) Nouveaux pregnadiene-1,4 dione-3,20 acetal-16-17 esters-21, procede pour leur fabrication, compositions, et methodes pour le traitement des etats inflammatoires.
FI820280L (fi) Aromatiska heterocykliska estrar av steroider deras framstaellning och dessa innehaollande farmaceutiska blandningar
FR2565104B1 (fr) Nouvelles preparations solides de nifedipine, utiles notamment comme agents vasodilatateurs, et procede pour leur fabrication
FR2508431B1 (fr) Composition de traitement, son procede de fabrication et son utilisation pour le traitement des eaux d'egout
DE69004081T2 (de) Verwendung der Stearidonsäure zur Behandlung von Entzündungserkrankungen.
RO77557A (fr) Procede pour la preparation continue du 1,4-butandiol
MA18939A1 (fr) Procede de preparation d'un agent pour le traitement de theilerioses
BE887544A (fr) Procede de traitement de mattes sulfureuses
FR2636985B1 (fr) Composition assouplissante et procede pour le traitement de textiles
FR2664585B1 (fr) Structures refractaires refroidies et procede pour leur fabrication.
FR2657081B1 (fr) Nouveaux derives d'arylvinylamide, leur procede de fabrication et leur application en therapeutique.
FR2665461B1 (fr) Aciers non affines a tenacite elevee et procede pour leur fabrication.
FR2728142B1 (fr) Composition pour le traitement anti-germinatif de tubercules ou de bulbes ; procede de traitement
FR2667884B3 (fr) Element de construction et procede pour sa fabrication.
MA21849A1 (fr) Procede de fabrication d'alkyl - ethoxy - carboxylates .
FR2658814B1 (fr) Procede de fabrication du bisphenol-a.
FR2656549B1 (fr) Procede pour la fabrication d'un coude et coude fabrique suivant ce procede.
BE883732A (fr) Procede et equipement pour la fabrication d'articles par etirage, et articles ainsi produits
FR2713657B1 (fr) Nouveaux vecteurs pour le traitement du sida.
FR2308628A1 (fr) Nouvelles 4-amino-5-thione-1,2,4-triazines, leur procede de preparation et leur application comme herbicides
RO79428A2 (fr) Composition medicamenteuse pour le traitement des dermatoses
BE889339A (fr) 6-hydrazono-pyrido(2,1-b)quinazoline-11-ones et procede pour leur preparation
FR2681618B1 (fr) Cóoeur de croisement perfectionne et procede pour sa fabrication.
FR2548884B3 (fr) Nouveaux cintres pour vetements, et leur procede de fabrication
BE894544A (fr) Compositions detergentes, unites de dosage qui les contiennent, procede pour leur fabrication et leur emploi

Legal Events

Date Code Title Description
TP Transmission of property
TP Transmission of property
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: CICLESONIDE; NAT. REGISTRATION NO/DATE: NL 34299 20090223; FIRST REGISTRATION: GB - PL 20141/0004 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

CD Change of name or company name
CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: PRODUCT NAME: CICLESONIDE; REGISTRATION NO/DATE IN FRANCE: NL 34299 DU 20090223; REGISTRATION NO/DATE AT EEC: PL 20141/0004 DU 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

CP Supplementary protection certificate (spc) filed
AV Other action affecting the existence or the validity of an industrial property right
CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: PRODUCT NAME: CICLESONIDE; REGISTRATION NO/DATE IN FRANCE: NL 34299 DU 20090223; REGISTRATION NO/DATE AT EEC: PL 20141/0004 DU 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

Extension date: 20160827

SPCC Change of owner's name or address for a supplementary protection certificate

Owner name: TAKEDA GMBH, DE

Free format text: PRODUCT NAME: CICLESONIDE; NAT. REGISTRATION NO/DATE: NL 34299 20090223; FIRST REGISTRATION: PL 20141/0004 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

SPAY Annual fee for spc paid

Free format text: PRODUCT NAME: CICLESONIDE; NAT. REGISTRATION NO/DATE: NL 34299 20090223; FIRST REGISTRATION: GB - PL 20141/0004 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

Year of fee payment: 5

Extension date: 20160827

SPCC Change of owner's name or address for a supplementary protection certificate

Owner name: TAKEDA GMBH, DE

Free format text: PRODUCT NAME: CICLESONIDE; NAT. REGISTRATION NO/DATE: NL 34299 20090223; FIRST REGISTRATION: GB - PL 20141/0004 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

Extension date: 20160827

SPCT Total transmission of property of a supplementary protection certificate

Owner name: TAKEDA GMBH, DE

Free format text: PRODUCT NAME: CICLESONIDE; NAT. REGISTRATION NO/DATE: NL 34299 20090223; FIRST REGISTRATION: GB - PL 20141/0004 20040416

Spc suppl protection certif: 09C0015

Filing date: 20090330

Extension date: 20160827