SE378110B - - Google Patents

Info

Publication number
SE378110B
SE378110B SE7206645A SE664572A SE378110B SE 378110 B SE378110 B SE 378110B SE 7206645 A SE7206645 A SE 7206645A SE 664572 A SE664572 A SE 664572A SE 378110 B SE378110 B SE 378110B
Authority
SE
Sweden
Application number
SE7206645A
Inventor
R L Brattsand
K G Claeson
Af Ekenstam B Thuresson
B A Thalen
Original Assignee
Bofors Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bofors Ab filed Critical Bofors Ab
Priority to SE7206645A priority Critical patent/SE378110B/xx
Priority to ZA732956A priority patent/ZA732956B/xx
Priority to IL42154A priority patent/IL42154A/en
Priority to AU55252/73A priority patent/AU478324B2/en
Priority to GB2219573A priority patent/GB1428416A/en
Priority to DE2323216A priority patent/DE2323216C3/de
Priority to CY1012A priority patent/CY1012A/xx
Priority to FI731543A priority patent/FI50711C/fi
Priority to US359913A priority patent/US3928326A/en
Priority to DK277073A priority patent/DK133249C/da
Priority to CA171,781A priority patent/CA1003402A/en
Priority to BE131271A priority patent/BE799728A/fr
Priority to NLAANVRAGE7306979,A priority patent/NL175917C/xx
Priority to SU1918554A priority patent/SU468408A3/ru
Priority to FR7318126A priority patent/FR2185406B1/fr
Priority to JP5623473A priority patent/JPS547794B2/ja
Publication of SE378110B publication Critical patent/SE378110B/xx
Priority to US05/629,390 priority patent/US3992534A/en
Priority to US05/629,493 priority patent/US3996359A/en
Priority to KE2969A priority patent/KE2969A/xx
Priority to HK490/79A priority patent/HK49079A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
SE7206645A 1972-05-19 1972-05-19 SE378110B (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
SE7206645A SE378110B (fr) 1972-05-19 1972-05-19
ZA732956A ZA732956B (en) 1972-05-19 1973-05-01 A process for the separation of stereoisomeric mixtures into their components and components obtained hereby
IL42154A IL42154A (en) 1972-05-19 1973-05-01 Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby
AU55252/73A AU478324B2 (en) 1972-05-19 1973-05-04 A process for the separation of stereoisomeric mixtures into their components and components obtained hereby
GB2219573A GB1428416A (en) 1972-05-19 1973-05-09 Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby
DE2323216A DE2323216C3 (de) 1972-05-19 1973-05-09 Verfahren zur Auftrennung von Stereoisomerengemischen von Pregna-1,4dien-11 -ol-33-dionen
CY1012A CY1012A (en) 1972-05-19 1973-05-09 Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtainned thereby
FI731543A FI50711C (fi) 1972-05-19 1973-05-14 Menetelmä kortikosteroidien stereoisomeeriseosten jakamiseksi stereois omeerikomponenteikseen.
US359913A US3928326A (en) 1972-05-19 1973-05-14 Process for the separation of stereoisomeric mixtures into their components and components obtained hereby
DK277073A DK133249C (da) 1972-05-19 1973-05-17 Fremgangsmade til opspaltning af stereoisomerblandinger af 16alfa,17alfa-alkylidendioxypregnan-11beta,21-diol-3,20-dioner
CA171,781A CA1003402A (en) 1972-05-19 1973-05-18 Process for the separation of steroisomeric mixtures into their components and components obtained hereby
BE131271A BE799728A (fr) 1972-05-19 1973-05-18 Procede pour la separation de steredoisomeres de certains steroides
NLAANVRAGE7306979,A NL175917C (nl) 1972-05-19 1973-05-18 Werkwijze voor het splitsen van isomere mengsels van steroiden, werkwijze voor het bereiden van een farmaceutisch preparaat en aldus verkregen gevormd farmaceutisch preparaat.
SU1918554A SU468408A3 (ru) 1972-05-19 1973-05-18 Способ разделени стереоизомерных смесей
FR7318126A FR2185406B1 (fr) 1972-05-19 1973-05-18
JP5623473A JPS547794B2 (fr) 1972-05-19 1973-05-19
US05/629,390 US3992534A (en) 1972-05-19 1975-11-06 Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US05/629,493 US3996359A (en) 1972-05-19 1975-11-06 Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
KE2969A KE2969A (en) 1972-05-19 1979-06-20 A process for the separation of sterioisomeric mixtures of steroid acetalsinto, their components and components obtained thereby
HK490/79A HK49079A (en) 1972-05-19 1979-07-19 A process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7206645A SE378110B (fr) 1972-05-19 1972-05-19

Publications (1)

Publication Number Publication Date
SE378110B true SE378110B (fr) 1975-08-18

Family

ID=20269238

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7206645A SE378110B (fr) 1972-05-19 1972-05-19

Country Status (17)

Country Link
US (1) US3928326A (fr)
JP (1) JPS547794B2 (fr)
BE (1) BE799728A (fr)
CA (1) CA1003402A (fr)
CY (1) CY1012A (fr)
DE (1) DE2323216C3 (fr)
DK (1) DK133249C (fr)
FI (1) FI50711C (fr)
FR (1) FR2185406B1 (fr)
GB (1) GB1428416A (fr)
HK (1) HK49079A (fr)
IL (1) IL42154A (fr)
KE (1) KE2969A (fr)
NL (1) NL175917C (fr)
SE (1) SE378110B (fr)
SU (1) SU468408A3 (fr)
ZA (1) ZA732956B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404200A (en) * 1980-12-04 1983-09-13 Aktiebolaget Draco 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions

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NL188581C (nl) * 1974-07-15 1992-08-03 Akzo Nv Werkwijze voor het bereiden van 11beta-hydroxy-18-alkylestraanverbindingen.
ZA763131B (en) * 1975-05-27 1978-01-25 Syntex Inc Use of flunisolide to treat respiratory diseases
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SK87295A3 (en) * 1993-01-08 1996-04-03 Astra Ab Novel colon or ileum-specific steroid derivatives
DE19635498A1 (de) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
JP2007504123A (ja) * 2003-08-29 2007-03-01 ランバクシー ラボラトリーズ リミテッド Ｉｖ型ホスホジエステラーゼの阻害剤
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
WO2005100356A1 (fr) 2004-04-09 2005-10-27 Merck & Co., Inc. Inhibiteurs de l'activite d'akt
EP1888050B1 (fr) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer
WO2007031838A1 (fr) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase
US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
WO2007045980A1 (fr) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions d'inhibiteurs de la phosphodiesterase de type iv
US20110021473A1 (en) * 2006-09-22 2011-01-27 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-iv
WO2008035316A2 (fr) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Inhibiteurs de phosphodiestérase
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
WO2008082856A1 (fr) 2006-12-26 2008-07-10 Pharmacyclics, Inc. Procédé d'utilisation des inhibiteurs de l'histone désacétylase et de suivi des biomarqueurs dans une thérapie combinée
MX2009007200A (es) 2007-01-10 2009-07-15 Angeletti P Ist Richerche Bio Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
US20080207659A1 (en) * 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
MX2009009793A (es) 2007-03-14 2009-10-16 Ranbaxy Lab Ltd Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa.
US20110130403A1 (en) * 2007-03-14 2011-06-02 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
ITMI20080645A1 (it) 2008-04-11 2009-10-12 Ind Chimica Srl Procedimento per la preparazione di budesonide
EP2111861A1 (fr) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions d'inhibiteurs de type IV de la phosphodiestérase
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent
WO2010114780A1 (fr) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
SG10201608490VA (en) * 2009-09-11 2016-11-29 Chiesi Farma Spa Isoxazolidine derivatives
GB0916608D0 (en) 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
EA023838B1 (ru) 2009-10-14 2016-07-29 Мерк Шарп Энд Домэ Корп. ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
WO2011097594A2 (fr) 2010-02-08 2011-08-11 Kinagen, Inc. Methodes therapeutiques et compositions impliquant l'inhibition de la kinase allosterique
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
WO2012018754A2 (fr) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Inhibition à médiation par interférence arn de caténine (protéine associée à cadhérine), expression du gène bêta 1 (ctnnb1) à l'aide de petit acide nucléique interférent (sian)
CA2807307C (fr) 2010-08-17 2021-02-09 Merck Sharp & Dohme Corp. Inhibition mediee par des arn interferents de l'expression genique du virus de l'hepatite b (vhb) a l'aide de petits acides nucleiques interferents (pani)
EP2608669B1 (fr) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
EP2615916B1 (fr) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
EP2654748B1 (fr) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
AU2012245971A1 (en) 2011-04-21 2013-10-17 Piramal Enterprises Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
ES2627820T3 (es) 2011-09-13 2017-07-31 Pharmacyclics, Inc. Formulaciones de inhibidor de histona desacetilasa en combinación con bendamustina y usos de las mismas
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3453762B1 (fr) 2012-05-02 2021-04-21 Sirna Therapeutics, Inc. Compositions d'acide nucléique interférent court (sina)
RU2698197C2 (ru) 2012-08-24 2019-08-23 Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем Гетероциклические модуляторы активности hif для лечения заболеваний
US9155747B2 (en) * 2012-09-13 2015-10-13 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
ME02925B (fr) 2012-11-28 2018-04-20 Merck Sharp & Dohme Compositions et procédés pour traiter le cancer
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (fr) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
WO2017222951A1 (fr) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 5-trifluorométhyl-oxadiazoles substitués en 3-aryle et hétéroaryle en tant qu'inhibiteurs de l'histone désacétylase 6 (hdac6)
WO2018089373A2 (fr) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Stéroïdes et leurs conjugués protéiques
CA3063871A1 (fr) 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Conjugues medicamenteux proteiques a base de cyclodextrine
KR20210008008A (ko) 2018-05-09 2021-01-20 리제너론 파마슈티칼스 인코포레이티드 항-msr1 항체 및 이의 사용 방법
EP3833667B1 (fr) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2021126731A1 (fr) 2019-12-17 2021-06-24 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
US20240116945A1 (en) 2022-09-02 2024-04-11 Merck Sharp & Dohme Llc Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof
WO2024091437A1 (fr) 2022-10-25 2024-05-02 Merck Sharp & Dohme Llc Charges utiles de lieur adc dérivées d'exatécan, compositions pharmaceutiques et leurs utilisations
WO2024129628A1 (fr) 2022-12-14 2024-06-20 Merck Sharp & Dohme Llc Charges utiles-lieur d'auristatine, compositions pharmaceutiques et leurs utilisations

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US3133940A (en) * 1956-04-10 1964-05-19 Glaxo Group Ltd Process for the separation of delta-1, 4-3-keto steroid compounds from mixtures thereof with other 3-keto steroids
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3128238A (en) * 1962-09-14 1964-04-07 Lilly Co Eli delta1-dehydrogenation of steroids by fermentation with actinoplanaceae

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404200A (en) * 1980-12-04 1983-09-13 Aktiebolaget Draco 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions

Also Published As

Publication number Publication date
CA1003402A (en) 1977-01-11
ZA732956B (en) 1974-04-24
AU5525273A (en) 1974-11-07
FR2185406A1 (fr) 1974-01-04
DK133249B (da) 1976-04-12
HK49079A (en) 1979-07-27
FI50711B (fr) 1976-03-01
DE2323216B2 (de) 1977-11-03
US3928326A (en) 1975-12-23
NL175917C (nl) 1985-01-16
JPS547794B2 (fr) 1979-04-10
FI50711C (fi) 1976-06-10
GB1428416A (en) 1976-03-17
SU468408A3 (ru) 1975-04-25
DE2323216C3 (de) 1978-06-22
NL175917B (nl) 1984-08-16
DK133249C (da) 1976-09-13
FR2185406B1 (fr) 1976-12-31
NL7306979A (fr) 1973-11-21
DE2323216A1 (de) 1973-11-29
KE2969A (en) 1979-07-20
IL42154A0 (en) 1973-07-30
CY1012A (en) 1979-11-23
JPS4941379A (fr) 1974-04-18
BE799728A (fr) 1973-09-17
IL42154A (en) 1976-12-31

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