IN2014CN02114A - - Google Patents
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- Publication number
- IN2014CN02114A IN2014CN02114A IN2114CHN2014A IN2014CN02114A IN 2014CN02114 A IN2014CN02114 A IN 2014CN02114A IN 2114CHN2014 A IN2114CHN2014 A IN 2114CHN2014A IN 2014CN02114 A IN2014CN02114 A IN 2014CN02114A
- Authority
- IN
- India
- Prior art keywords
- hemagglutinin polypeptides
- glycosylation sites
- same
- flu hemagglutinin
- flu
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 abstract 3
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 3
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 3
- 101710176177 Protein A56 Proteins 0.000 abstract 3
- 239000000185 hemagglutinin Substances 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000013595 glycosylation Effects 0.000 abstract 2
- 238000006206 glycosylation reaction Methods 0.000 abstract 2
- 206010022000 influenza Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
- C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536924P | 2011-09-20 | 2011-09-20 | |
| US201161565899P | 2011-12-01 | 2011-12-01 | |
| US201261607526P | 2012-03-06 | 2012-03-06 | |
| US201261648525P | 2012-05-17 | 2012-05-17 | |
| US201261670108P | 2012-07-10 | 2012-07-10 | |
| US201261684481P | 2012-08-17 | 2012-08-17 | |
| PCT/US2012/056122 WO2013043729A1 (en) | 2011-09-20 | 2012-09-19 | Influenza virus vaccines and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN02114A true IN2014CN02114A (cs) | 2015-05-29 |
Family
ID=47914828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2114CHN2014 IN2014CN02114A (cs) | 2011-09-20 | 2012-09-19 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10131695B2 (cs) |
| EP (2) | EP2758075B1 (cs) |
| JP (4) | JP6498439B2 (cs) |
| KR (1) | KR20140068205A (cs) |
| CN (3) | CN108164602A (cs) |
| AR (1) | AR090392A1 (cs) |
| AU (2) | AU2012312529B2 (cs) |
| BR (1) | BR112014006694A2 (cs) |
| CA (1) | CA2849434A1 (cs) |
| EA (1) | EA201490659A1 (cs) |
| ES (1) | ES2953393T3 (cs) |
| HK (1) | HK1200102A1 (cs) |
| IL (2) | IL231547B (cs) |
| IN (1) | IN2014CN02114A (cs) |
| MX (1) | MX2014003308A (cs) |
| SG (1) | SG11201400743VA (cs) |
| WO (1) | WO2013043729A1 (cs) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| US8673314B2 (en) | 2009-05-26 | 2014-03-18 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| WO2011103453A2 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| US10183069B2 (en) | 2011-03-21 | 2019-01-22 | Altimmune Inc. | Rapid and prolonged immunologic-therapeutic |
| IN2014CN02114A (cs) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| CN108641002A (zh) | 2012-12-18 | 2018-10-12 | 西奈山伊坎医学院 | 流感病毒疫苗及其用途 |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| ES2837392T3 (es) * | 2013-10-02 | 2021-06-30 | Medimmune Llc | Anticuerpos anti-influenza A neutralizantes y usos de los mismos |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
| WO2015164674A1 (en) * | 2014-04-23 | 2015-10-29 | Moderna Therapeutics, Inc. | Nucleic acid vaccines |
| EP3149479A2 (en) * | 2014-05-30 | 2017-04-05 | Sanofi Pasteur Inc. | Expression and conformational analysis of engineered influenza hemagglutinin |
| IL249704B (en) * | 2014-07-10 | 2021-03-25 | Janssen Vaccines & Prevention Bv | Influenza virus vaccines and their uses |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| WO2016118937A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| WO2016179099A1 (en) * | 2015-05-04 | 2016-11-10 | Epivax, Inc. | Modified h7 hemagluttinin glycoprotein of the influenza a/shanghai/2/2013 h7 sequence |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3303384B1 (en) | 2015-06-01 | 2021-08-25 | Medimmune, LLC | Neutralizing anti-influenza binding molecules and uses thereof |
| WO2016205347A1 (en) * | 2015-06-16 | 2016-12-22 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
| CN116271017A (zh) | 2016-01-13 | 2023-06-23 | 免疫医疗有限责任公司 | 治疗甲型流感的方法 |
| US10063211B2 (en) | 2016-02-03 | 2018-08-28 | Qualcomm Incorporated | Compact bypass and decoupling structure for millimeter-wave circuits |
| RU2022108149A (ru) * | 2016-02-03 | 2022-05-05 | СиДжи ДИСКАВЕРИ, ИНК. | Композиции гемагглютинина гриппа с гетерологичными эпитопами и/или измененными сайтами расщепления при созревании |
| JP6868763B2 (ja) * | 2016-04-01 | 2021-05-12 | パナソニックＩｐマネジメント株式会社 | インフルエンザウィルスに結合する抗体 |
| IL263416B2 (en) | 2016-06-03 | 2024-10-01 | Sanofi Pasteur Inc | Modification of transgenic influenza hemagglutinin polypeptides |
| US20190125859A1 (en) * | 2016-06-03 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| BR112018075032A2 (pt) | 2016-06-15 | 2019-03-26 | Icahn School Of Medicine At Mount Sinai | proteínas de hemaglutinina do vírus influenza e seus uso |
| KR20240042570A (ko) | 2016-09-02 | 2024-04-02 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 안정화된 그룹 2 인플루엔자 헤마글루티닌 줄기 영역 삼량체 및 그의 용도 |
| WO2018085488A1 (en) * | 2016-11-02 | 2018-05-11 | Iowa State University Research Foundation, Inc. | Universal mammalian influenza vaccine |
| US20180128545A1 (en) * | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018175560A1 (en) * | 2017-03-22 | 2018-09-27 | The Scripps Research Institute | Nanoparticle immunogens to elicit responses against the influenza receptor binding site on the hemagglutinin head domain |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| JP7614841B2 (ja) * | 2018-04-03 | 2025-01-16 | サノフイ | 抗原性呼吸器合胞体ウイルスポリペプチド |
| EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
| WO2019222674A1 (en) * | 2018-05-18 | 2019-11-21 | Chan Zuckerberg Biohub, Inc. | Epitope restriction for antibody selection |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| US20210225457A1 (en) * | 2018-07-13 | 2021-07-22 | University Of Georgia Research Foundation | Methods for generating pan-epitopic immunogens of influenza h3 virus, compositions and methods of use thereof |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN109096376A (zh) * | 2018-09-20 | 2018-12-28 | 扬州大学 | 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法 |
| KR102098585B1 (ko) * | 2018-11-21 | 2020-04-08 | 고려대학교 산학협력단 | 교차 면역원성을 갖는 h2 아형 인플루엔자 바이러스 및 이를 포함하는 백신 |
| JP7621270B2 (ja) | 2019-04-05 | 2025-01-24 | アカデミア シニカ | シアリダーゼ耐性糖およびその調製および使用方法 |
| WO2020210149A1 (en) * | 2019-04-06 | 2020-10-15 | Altimmune Inc | Broad and long-lasting influenza vaccine |
| TWI817041B (zh) * | 2019-09-20 | 2023-10-01 | 中央研究院 | 嵌合血球凝集素蛋白質及包含其之疫苗組成物 |
| CA3158145A1 (en) * | 2019-10-15 | 2021-04-22 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
| US12285437B2 (en) | 2019-10-30 | 2025-04-29 | The Research Foundation For The State University Of New York | Reversing the undesirable pH-profile of doxorubicin via activation of a disubstituted maleamic acid prodrug at tumor acidity |
| CA3182526A1 (en) | 2020-05-08 | 2021-11-11 | Academia Sinica | Chimeric influenza vaccines |
| CN112111503B (zh) * | 2020-08-24 | 2023-04-07 | 河北省动物疫病预防控制中心 | 同时预防禽流感h5和h9亚型的腺病毒载体二价苗及其制备方法 |
| WO2022155649A1 (en) * | 2021-01-12 | 2022-07-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herpes simplex virus type 1 derived influenza vaccine |
| CN113082187B (zh) * | 2021-04-09 | 2023-06-27 | 北京红太阳药业有限公司 | 小柴胡提取物与阿奇霉素联合在治疗病毒性肺炎中的应用 |
| IL318755A (en) | 2021-04-12 | 2025-04-01 | Academia Sinica | Improved vaccine for the coronavirus |
| TW202334429A (zh) | 2021-10-01 | 2023-09-01 | 中央研究院 | Sars-cov-2棘蛋白特異性抗體及其用途 |
| CA3268566A1 (en) | 2023-04-08 | 2024-10-17 | Rock Biomedical Inc | METHODS AND COMPOSITIONS FOR TARGETED DISTRIBUTION BY POLYMERSOMES |
| WO2025092866A1 (zh) * | 2023-10-31 | 2025-05-08 | 仁景(苏州)生物科技有限公司 | 一种多价流感mRNA疫苗 |
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| JP6294828B2 (ja) | 2011-11-28 | 2018-03-14 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | インフルエンザウイルスワクチンおよびその使用 |
| CA2894506C (en) | 2012-12-11 | 2021-08-10 | Vib Vzw | Anti-influenza antibody |
| CN108641002A (zh) | 2012-12-18 | 2018-10-12 | 西奈山伊坎医学院 | 流感病毒疫苗及其用途 |
| MX2015008847A (es) | 2013-01-10 | 2015-10-30 | Novartis Ag | Composiciones inmunogenicas de virus de influenza y usos de las mismas. |
| WO2014141125A2 (en) | 2013-03-13 | 2014-09-18 | Novartis Ag | Influenza virus reassortment |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| IL241552B2 (en) | 2013-03-14 | 2023-09-01 | Contrafect Corp | Preparation and methods based on neutralizing antibodies administered intranasally for increased therapeutic efficacy |
| CN105007938A (zh) | 2013-03-15 | 2015-10-28 | 宾夕法尼亚大学理事会 | 流感核酸分子和由其制备的疫苗 |
| PL235555B1 (pl) | 2014-06-24 | 2020-09-07 | Inst Biotechnologii I Antybiotykow | Wyizolowany i oczyszczony polipeptyd hemaglutyniny (HA ) wirusa grypy H5N1, kompozycja zawierająca polipeptyd i jej zastosowanie, przeciwciało wiążące się specyficznie z polipeptydem oraz sposób otrzymywania tego polipeptydu |
| WO2016118937A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| WO2016205347A1 (en) | 2015-06-16 | 2016-12-22 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
| US20190125859A1 (en) | 2016-06-03 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| BR112018075032A2 (pt) | 2016-06-15 | 2019-03-26 | Icahn School Of Medicine At Mount Sinai | proteínas de hemaglutinina do vírus influenza e seus uso |
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2012
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| BR112014006694A2 (pt) | 2020-11-17 |
| JP2020096604A (ja) | 2020-06-25 |
| CN104185476A (zh) | 2014-12-03 |
| EP2758075B1 (en) | 2023-05-03 |
| AU2018202388A1 (en) | 2018-04-26 |
| US20190106461A1 (en) | 2019-04-11 |
| US20150132330A1 (en) | 2015-05-14 |
| CA2849434A1 (en) | 2013-03-28 |
| IL262123A (en) | 2018-11-29 |
| MX2014003308A (es) | 2015-03-09 |
| IL231547A0 (en) | 2014-04-30 |
| EP4241785A2 (en) | 2023-09-13 |
| AR090392A1 (es) | 2014-11-12 |
| AU2012312529B2 (en) | 2018-01-04 |
| JP2022091775A (ja) | 2022-06-21 |
| JP2014530003A (ja) | 2014-11-17 |
| AU2012312529A1 (en) | 2014-03-27 |
| SG11201400743VA (en) | 2014-04-28 |
| CN108164602A (zh) | 2018-06-15 |
| EP4241785A3 (en) | 2023-09-27 |
| EP2758075A4 (en) | 2015-05-20 |
| KR20140068205A (ko) | 2014-06-05 |
| US10131695B2 (en) | 2018-11-20 |
| EA201490659A1 (ru) | 2014-11-28 |
| CN116162175A (zh) | 2023-05-26 |
| JP6498439B2 (ja) | 2019-04-17 |
| HK1200102A1 (en) | 2015-07-31 |
| JP2018110585A (ja) | 2018-07-19 |
| IL231547B (en) | 2018-10-31 |
| EP2758075A1 (en) | 2014-07-30 |
| WO2013043729A1 (en) | 2013-03-28 |
| ES2953393T3 (es) | 2023-11-10 |
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