IN2014CN00408A - - Google Patents

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Publication number
IN2014CN00408A
IN2014CN00408A IN408CHN2014A IN2014CN00408A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A IN 408CHN2014 A IN408CHN2014 A IN 408CHN2014A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A
Authority
IN
India
Prior art keywords
formula
relates
pyridine ring
present
membered fused
Prior art date
Application number
Other languages
English (en)
Inventor
Tjeerd A Barf
Christiaan Gerardus Johannes Maria Jans
De Adrianus Petrus Antonius Man
Arthur A Oubrie
Hans C A Raaijmakers
Johannes Bernardus Maria Rewinkel
Jan Gerard Sterrenburg
Jacobus C H M Wijkmans
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014CN00408(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IN2014CN00408A publication Critical patent/IN2014CN00408A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN408CHN2014 2011-07-19 2012-07-11 IN2014CN00408A (enExample)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19
PCT/EP2012/063552 WO2013010868A1 (en) 2011-07-19 2012-07-11 4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as btk- inhibitors

Publications (1)

Publication Number Publication Date
IN2014CN00408A true IN2014CN00408A (enExample) 2015-04-03

Family

ID=47557677

Family Applications (1)

Application Number Title Priority Date Filing Date
IN408CHN2014 IN2014CN00408A (enExample) 2011-07-19 2012-07-11

Country Status (38)

Country Link
US (7) US9290504B2 (enExample)
EP (4) EP3495368B1 (enExample)
JP (6) JP5826931B2 (enExample)
KR (2) KR101702727B1 (enExample)
CN (2) CN106243113B (enExample)
AU (4) AU2012285987C1 (enExample)
BR (1) BR112014001255B1 (enExample)
CA (1) CA2841886C (enExample)
CL (1) CL2014000130A1 (enExample)
CO (1) CO6940411A2 (enExample)
CR (1) CR20140030A (enExample)
CY (2) CY2021010I1 (enExample)
DK (2) DK2734522T3 (enExample)
DO (1) DOP2014000008A (enExample)
EA (2) EA034558B1 (enExample)
EC (1) ECSP14013217A (enExample)
ES (3) ES2904707T3 (enExample)
GT (1) GT201400009A (enExample)
HR (2) HRP20190135T1 (enExample)
HU (3) HUE056249T2 (enExample)
IL (3) IL230511B (enExample)
IN (1) IN2014CN00408A (enExample)
LT (1) LT2734522T (enExample)
MA (1) MA35348B1 (enExample)
MX (1) MX342983B (enExample)
MY (1) MY192354A (enExample)
PE (1) PE20141681A1 (enExample)
PH (2) PH12014500148A1 (enExample)
PL (2) PL2734522T3 (enExample)
PT (1) PT3689878T (enExample)
RS (2) RS58177B1 (enExample)
SG (1) SG10201605913VA (enExample)
SI (2) SI3689878T1 (enExample)
SM (2) SMT201900029T1 (enExample)
TN (1) TN2014000027A1 (enExample)
UA (1) UA115312C2 (enExample)
WO (1) WO2013010868A1 (enExample)
ZA (1) ZA202109164B (enExample)

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US8809273B2 (en) * 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
NZ604040A (en) 2010-06-03 2015-02-27 Pharmacyclics Inc The use of inhibitors of bruton’s tyrosine kinase (btk)
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
SI2710005T1 (sl) 2011-05-17 2017-03-31 Principia Biopharma Inc. Zaviralci tirozinske kinaze
PH12014500122A1 (en) 2011-07-13 2014-03-24 Pharmacyclics Inc Inhibitors of bruton's tyrosine kinase
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
EP3495368B1 (en) * 2011-07-19 2023-05-31 Merck Sharp & Dohme B.V. (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-2-methoxy-n-(pyridin-2-yl)benzamide as btk-inhibitor
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
PL2892900T3 (pl) 2012-09-10 2018-02-28 Principia Biopharma Inc. Związki pyrazolopirymidonowe jako inhibitory kinazy
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
JP6313772B2 (ja) * 2012-10-04 2018-04-18 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション チロシン受容体キナーゼｂｔｋ阻害剤である置換ｎ−（３−（ピリミジン−４−イル）フェニル）アクリルアミド類似体
CN105102000B (zh) 2012-11-01 2021-10-22 无限药品公司 使用pi3激酶亚型调节剂的癌症疗法
WO2014113942A1 (en) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
US9481682B2 (en) 2013-01-23 2016-11-01 Merck Sharp & Dohme Corp. Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
SG10201709926VA (en) 2013-05-30 2017-12-28 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
RU2712220C2 (ru) 2013-07-31 2020-01-27 Мерк Патент Гмбх Пиридины, пиримидины и пиразины в качестве ингибиторов тирозинкиназы брутона и их применение
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NZ716110A (en) 2017-07-28
EP2734522A1 (en) 2014-05-28
US9290504B2 (en) 2016-03-22
SI2734522T1 (sl) 2019-03-29
BR112014001255A2 (pt) 2017-02-21
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RS62760B1 (sr) 2022-01-31
US20160159810A1 (en) 2016-06-09
JP7054721B2 (ja) 2022-04-14
AU2017279778A1 (en) 2018-01-25
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EP4249076A3 (en) 2023-11-01
KR101802689B1 (ko) 2017-11-28
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CN106243113A (zh) 2016-12-21
JP5826931B2 (ja) 2015-12-02
PH12014500148A1 (en) 2014-03-31
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CL2014000130A1 (es) 2014-08-22
PH12017500166B1 (en) 2018-10-26
JP2020189865A (ja) 2020-11-26
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US20160151364A1 (en) 2016-06-02
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EP2734522B1 (en) 2018-10-31
MX2014000746A (es) 2014-05-07
MA35348B1 (fr) 2014-08-01
IL266894B (en) 2022-04-01
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US20180179212A1 (en) 2018-06-28
DK2734522T3 (en) 2019-02-18
EA037644B1 (ru) 2021-04-26
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IL230511B (en) 2019-05-30
US10934296B2 (en) 2021-03-02
PH12017500166A1 (en) 2017-09-04
DOP2014000008A (es) 2014-04-30
BR112014001255B1 (pt) 2019-07-02
PL3689878T3 (pl) 2022-02-14
AU2017279778B2 (en) 2019-09-19
CN106243113B (zh) 2018-12-18
KR101702727B1 (ko) 2017-02-06
UA115312C2 (uk) 2017-10-25
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CN103889987B (zh) 2016-09-14
SMT202100729T1 (it) 2022-01-10
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AU2016203837B2 (en) 2018-01-25
EA201490300A1 (ru) 2014-05-30
CR20140030A (es) 2014-06-03
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US10239883B2 (en) 2019-03-26
IL291489A (en) 2022-05-01
AU2019275591B2 (en) 2020-10-01
EA201992270A2 (ru) 2020-01-16
TN2014000027A1 (en) 2015-07-01
EA034558B1 (ru) 2020-02-20
ZA202109164B (en) 2025-04-30
US20190276456A1 (en) 2019-09-12
HUS2100012I1 (hu) 2021-05-28
HUE041987T2 (hu) 2019-06-28
JP2014520870A (ja) 2014-08-25
JP6749444B2 (ja) 2020-09-02
ECSP14013217A (es) 2015-03-31
IL230511A0 (en) 2014-03-31
US20210230166A1 (en) 2021-07-29
US20230331729A1 (en) 2023-10-19
PE20141681A1 (es) 2014-11-14
RS58177B1 (sr) 2019-03-29
MY192354A (en) 2022-08-17
JP6251220B2 (ja) 2017-12-20
CA2841886C (en) 2016-08-16
JP2022088618A (ja) 2022-06-14
SMT201900029T1 (it) 2019-02-28
AU2016203837A1 (en) 2016-06-30
WO2013010868A1 (en) 2013-01-24
EP3689878B1 (en) 2021-10-06
GT201400009A (es) 2017-09-28
CO6940411A2 (es) 2014-05-09
IL266894A (en) 2019-07-31
HRP20190135T1 (hr) 2019-03-22
AU2012285987C1 (en) 2016-09-08

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