IN2012DN02736A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02736A IN2012DN02736A IN2736DEN2012A IN2012DN02736A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A IN 2736DEN2012 A IN2736DEN2012 A IN 2736DEN2012A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A
- Authority
- IN
- India
- Prior art keywords
- compounds
- toll
- vaccine
- adjuvants
- receptors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23921709P | 2009-09-02 | 2009-09-02 | |
| PCT/US2010/047587 WO2011049677A1 (fr) | 2009-09-02 | 2010-09-01 | Composés et compositions utilisés en tant que modulateurs de l'activité tlr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02736A true IN2012DN02736A (fr) | 2015-09-11 |
Family
ID=43625759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2736DEN2012 IN2012DN02736A (fr) | 2009-09-02 | 2010-09-01 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9045470B2 (fr) |
| EP (1) | EP2473508B1 (fr) |
| JP (1) | JP5525614B2 (fr) |
| CN (1) | CN102712636B (fr) |
| AR (1) | AR078153A1 (fr) |
| AU (1) | AU2010308524B2 (fr) |
| BR (1) | BR112012004696B8 (fr) |
| CA (1) | CA2772657C (fr) |
| CL (1) | CL2012000535A1 (fr) |
| CY (1) | CY1119618T1 (fr) |
| DK (1) | DK2473508T3 (fr) |
| EA (1) | EA020962B1 (fr) |
| ES (1) | ES2627669T3 (fr) |
| HR (1) | HRP20170707T1 (fr) |
| HU (1) | HUE032323T2 (fr) |
| IN (1) | IN2012DN02736A (fr) |
| JO (1) | JO3257B1 (fr) |
| LT (1) | LT2473508T (fr) |
| MX (1) | MX2012002654A (fr) |
| PE (1) | PE20121156A1 (fr) |
| PL (1) | PL2473508T3 (fr) |
| PT (1) | PT2473508T (fr) |
| SI (1) | SI2473508T1 (fr) |
| TW (1) | TWI445708B (fr) |
| UY (1) | UY32874A (fr) |
| WO (1) | WO2011049677A1 (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8926990B2 (en) | 2009-10-13 | 2015-01-06 | Rutgers, The State University Of New Jersey | Treatment and diagnosis of inflammatory disorders and HIV |
| US10149889B2 (en) | 2005-11-25 | 2018-12-11 | Rutgers, The State University Of New Jersey | Compositions for the treatment of cancer, and methods for testing and using the same |
| KR101687841B1 (ko) | 2008-12-09 | 2016-12-19 | 길리애드 사이언시즈, 인코포레이티드 | 톨-유사 수용체의 조절제 |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| MX339146B (es) | 2009-12-15 | 2016-05-13 | Novartis Ag | Suspension homogenea de compuestos inmunopotenciadores y usos de los mismos. |
| EP2402028A1 (fr) * | 2010-07-01 | 2012-01-04 | Sanofi Pasteur | Vaccins d'entérovirus pour la prévention et le traitement du diabète de type 1 (II) |
| PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
| RS54489B1 (en) | 2010-07-06 | 2016-06-30 | Glaxosmithkline Biologicals Sa | LIPOSOMS WITH LIPIDS THAT HAVE IMPROVED PKA VALUE FOR RNA RELEASE |
| EP2590670B1 (fr) | 2010-07-06 | 2017-08-23 | GlaxoSmithKline Biologicals SA | Procédé pour induire une réponse immunitaire par administration d'arn |
| PL3970742T3 (pl) | 2010-08-31 | 2022-09-19 | Glaxosmithkline Biologicals S.A. | Pegylowane liposomy do dostarczania rna kodującego immunogen |
| US20120177681A1 (en) * | 2010-09-01 | 2012-07-12 | Manmohan Singh | Formulation of immunopotentiators |
| US20140030292A1 (en) | 2010-10-11 | 2014-01-30 | Novartis Ag | Antigen delivery platforms |
| ES2681698T3 (es) | 2011-03-02 | 2018-09-14 | Glaxosmithkline Biologicals Sa | Vacunas de combinación con menores dosis de antígeno y/o adyuvante |
| US9352017B2 (en) | 2011-03-16 | 2016-05-31 | Rutgers, The State University Of New Jersey | Combination therapy with leukotoxin |
| US8900626B2 (en) * | 2011-06-20 | 2014-12-02 | Senju Usa, Inc. | Transdermal drug delivery system and method of using the same |
| US11896636B2 (en) * | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
| JP2014525429A (ja) | 2011-09-01 | 2014-09-29 | ノバルティス アーゲー | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ抗原のアジュバント添加処方物 |
| FI123955B (en) * | 2011-11-25 | 2014-01-15 | Oncos Therapeutics Ltd | Oncolytic adenovirus |
| RU2014140336A (ru) * | 2012-03-07 | 2016-04-27 | Новартис Аг | Иммунологически полезные соли аргинина |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| US20150030630A1 (en) * | 2012-03-07 | 2015-01-29 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
| RU2014140521A (ru) * | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| EP2674170B1 (fr) | 2012-06-15 | 2014-11-19 | Invivogen | Nouvelles compositions d'agonistes TLR7 et/ou TLR8 conjugués à des lipides |
| AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| CN104736165A (zh) * | 2012-08-31 | 2015-06-24 | 诺华股份有限公司 | 用于针对金黄色葡萄球菌的免疫的稳定化的蛋白质 |
| EP2732825B1 (fr) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugués d'un agoniste de TLR7 et/ou TLR8 avec un agoniste de TLR2 |
| CN103845731B (zh) * | 2012-12-05 | 2015-12-02 | 复旦大学 | 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用 |
| MX2015008847A (es) * | 2013-01-10 | 2015-10-30 | Novartis Ag | Composiciones inmunogenicas de virus de influenza y usos de las mismas. |
| WO2014118305A1 (fr) | 2013-02-01 | 2014-08-07 | Novartis Ag | Administration intradermique de compositions immunologiques comprenant des agonistes des récepteurs de type toll |
| EP2769738B1 (fr) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugués TLR7 et/ou TLR8 et agonistes polycationiques TLR2 |
| SG11201509265SA (en) | 2013-05-10 | 2015-12-30 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
| CN104338129B (zh) * | 2013-07-26 | 2017-05-24 | 中国科学院上海巴斯德研究所 | 雷帕霉素作为疫苗佐剂的用途及制备方法 |
| CA2954056C (fr) | 2014-07-11 | 2020-04-28 | Gilead Sciences, Inc. | Modulateurs de recepteurs de type toll pour le traitement du vih |
| JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｏｌｌ様受容体モジュレーターの固体形態 |
| EP3061826A1 (fr) | 2015-02-27 | 2016-08-31 | Novartis AG | Réplicons du flavivirus |
| CN109415429B (zh) * | 2016-06-30 | 2023-04-28 | 美国政府(由卫生和人类服务部的部长所代表) | Herv-e反应性t细胞受体及使用方法 |
| CA3036349A1 (fr) * | 2016-09-09 | 2018-03-15 | Takeda Pharmaceutical Company Limited | Compose cyclique presentant une activite inhibitrice du recepteur de type toll 4 (tlr 4) |
| AR111760A1 (es) | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| EP3802519A1 (fr) * | 2018-06-04 | 2021-04-14 | Apros Therapeutics, Inc. | Composés de pyrimidine contenant des groupes acides utiles pour traiter des maladies liées à la modulation de tlr7 |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| AU2019402189B2 (en) | 2018-12-20 | 2023-04-13 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| JP7287708B2 (ja) | 2019-02-08 | 2023-06-06 | プロジェニア インコーポレイテッド | Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途 |
| BR112021015783A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina-2,6-diona e usos dos mesmos |
| BR112021015672A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos |
| EP4076445A1 (fr) | 2019-12-20 | 2022-10-26 | Nammi Therapeutics, Inc. | Compositions liposomales formulées et/ou co-formulées contenant des promédicaments agonistes de récepteurs de type toll (« tlr ») utiles dans le traitement du cancer et méthodes associées |
| KR20220116257A (ko) | 2019-12-20 | 2022-08-22 | 노파르티스 아게 | 골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물 |
| CN115666637A (zh) | 2020-03-02 | 2023-01-31 | 蛋白科技先锋 | 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法 |
| CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| WO2022009157A1 (fr) | 2020-07-10 | 2022-01-13 | Novartis Ag | Combinaisons de lhc165 et de spartalizumab pour le traitement de tumeurs solides |
| JP2023536164A (ja) | 2020-08-03 | 2023-08-23 | ノバルティス アーゲー | ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| EP4194006A1 (fr) | 2020-08-04 | 2023-06-14 | Progeneer Inc. | Vaccin à arnm comprenant un adjuvant permettant un contrôle cinétique |
| WO2022031011A1 (fr) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | Ensemble adjuvant à action cinétique |
| JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| WO2023109909A1 (fr) * | 2021-12-15 | 2023-06-22 | 上海翊石医药科技有限公司 | Composés hétérocycliques aromatiques, leur procédé de préparation et leurs utilisations |
| WO2023214325A1 (fr) | 2022-05-05 | 2023-11-09 | Novartis Ag | Dérivés de pyrazolopyrimidine et leurs utilisations en tant qu'inhibiteurs de tet2 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| JP2000511769A (ja) | 1996-04-02 | 2000-09-12 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| WO1997043303A1 (fr) | 1996-05-14 | 1997-11-20 | Smithkline Beecham Corporation | Nouveaux composes |
| AU5194598A (en) | 1996-10-31 | 1998-05-22 | Human Genome Sciences, Inc. | (streptococcus pneumoniae) antigens and vaccines |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| ES2301181T3 (es) | 1997-08-21 | 2008-06-16 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Mutantes nuevos de bacterias mucosas gram negativas y su aplicacion en vacunas. |
| JPH1180156A (ja) * | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
| CA2671261A1 (fr) | 1997-11-06 | 1999-05-20 | Novartis Vaccines And Diagnostics S.R.L. | Antigenes de neisseria |
| EP2319931A1 (fr) | 1997-11-26 | 2011-05-11 | Inhibitex, Inc. | Proteines liant la matrice extracellulaire issues du staphilococcus aureus |
| BR9906927A (pt) | 1998-01-14 | 2001-11-20 | Chiron Spa | Proteìnas de neisseria meningitidis |
| JP2002516251A (ja) | 1998-04-23 | 2002-06-04 | ユーエイビー リサーチ ファンデーション | 肺炎球菌表面プロテインＣ（ＰｓｐＣ）のエピトープ領域およびその菌株選択、ならびにそのための使用法 |
| NZ541361A (en) | 1998-05-01 | 2008-04-30 | Inst Genomic Research | Neisseria meningitidis antigens and compositions relating to SEQ ID Nos:2916, 2918 and 2920 |
| GB9810193D0 (en) | 1998-05-12 | 1998-07-08 | Smithkline Beecham Biolog | Novel compounds |
| EP1144640A3 (fr) | 1998-07-27 | 2001-11-28 | Microbial Technics Limited | Acides nucleiques et proteines de streptococcus pneumoniae |
| EP2053126A1 (fr) | 1998-07-27 | 2009-04-29 | Sanofi Pasteur Limited | Protéines de pneumonie à streptocoques et molécules d'acide nucléique |
| AU772547B2 (en) | 1998-08-31 | 2004-04-29 | Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin, The | Polypeptides and polynucleotides from coagulase-negative staphylococci |
| BR9913340A (pt) | 1998-08-31 | 2001-11-06 | Inhibitex Inc | Composição, vacina, e, processos de gerar uma resposta imune, e de inibir a colonização microbiana em um animal |
| EP1144998A3 (fr) | 1998-10-09 | 2002-08-07 | Chiron Corporation | Sequences genomiques de neisseria et procedes d'utilisation |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| WO2000037105A2 (fr) | 1998-12-21 | 2000-06-29 | Medimmune, Inc. | Proteines de streptococcus pneumoniae et fragments immunogenes pour vaccins |
| CN1198932C (zh) | 1999-03-26 | 2005-04-27 | 科特克斯(Om)有限公司 | 肺炎链球菌抗原 |
| ES2360296T3 (es) | 1999-06-10 | 2011-06-02 | Medimmune, Llc | Vacunas y proteínas de setreptococcus pneumoniae. |
| EP1075841A1 (fr) | 1999-08-13 | 2001-02-14 | Erasmus Universiteit Rotterdam | Vaccins pneumococciques |
| AU1917501A (en) | 1999-11-12 | 2001-06-06 | University Of Iowa Research Foundation, The | Control of neisserial membrane synthesis |
| ES2507100T3 (es) | 2000-01-17 | 2014-10-14 | Novartis Vaccines And Diagnostics S.R.L. | Vacuna OMV suplementada contra meningococo |
| BR0108711A (pt) | 2000-02-28 | 2004-06-22 | Chiron Spa | Expressão heteróloga de proteìnas de neisseria |
| AU2001249345A1 (en) | 2000-03-21 | 2001-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in prokaryotes |
| AU5577201A (en) | 2000-04-27 | 2001-11-07 | Med Immune Inc | Immunogenic pneumococcal protein and vaccine compositions thereof |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| US6495079B1 (en) | 2000-06-28 | 2002-12-17 | Prisma Fibers, Inc. | Process to prepare polymeric fibers with improved color and appearance |
| EP1297005B1 (fr) | 2000-07-03 | 2009-08-26 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation contre une infection par chlamydia pneumoniae |
| AU2001287645A1 (en) | 2000-07-20 | 2002-02-05 | Hansa Medical Ab | Fh-binding protein of streptococcus pneumiae |
| AU2001280883A1 (en) | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| AU8743001A (en) | 2000-08-28 | 2002-03-13 | Aventis Pasteur | Moraxella polypeptides and corresponding dna fragments and uses thereof |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| CA2426738A1 (fr) | 2000-10-26 | 2002-05-02 | David William Holden | Genes streptococciques |
| NZ560966A (en) | 2000-10-27 | 2010-06-25 | Novartis Vaccines & Diagnostic | Nucleic acids and proteins from streptococcus groups A & B |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| WO2002077183A2 (fr) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification de genes essentiels dans des microorganismes |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0108079D0 (en) | 2001-03-30 | 2001-05-23 | Microbial Technics Ltd | Protein |
| US7407664B2 (en) | 2001-05-18 | 2008-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Peptide vaccines against group A streptococci |
| EP2339344A1 (fr) | 2001-06-15 | 2011-06-29 | Inhibitex, Inc. | Anticorps monoclonaux et polyclonaux à réaction croisée qui reconnaissent des protéines de surface de staphylocoques à coagulase négative et de staphylocoques dores |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| US7410647B2 (en) | 2001-08-02 | 2008-08-12 | University Of Sheffield | Antigenic polypeptides |
| KR100982204B1 (ko) | 2001-12-12 | 2010-09-14 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 클라미디아 트라코마티스에 대한 면역화 |
| GB0203403D0 (en) | 2002-02-13 | 2002-04-03 | Chiron Spa | Chlamydia cytotoxic-T cell epitopes |
| AU2003242955B2 (en) | 2002-04-02 | 2009-04-09 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
| GB0210128D0 (en) | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
| US20060147477A1 (en) | 2002-06-11 | 2006-07-06 | Glaxo Group Limited | Immunogenic compositions |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| SI2255826T1 (sl) | 2002-08-02 | 2016-07-29 | Glaxosmithkline Biologicals S.A. | Neisserijski vakcinski sestavki, ki obsegajo kombinacijo antigenov |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| US20070036828A1 (en) | 2002-09-13 | 2007-02-15 | Chiron Corporation | Group b streptococcus vaccine |
| SI1549338T1 (sl) | 2002-10-11 | 2011-04-29 | Novartis Vaccines & Diagnostic | Polipeptidna cepiva za ĺ iroko zaĺ äśito pred hipervirulentnimi miningokoknimi rodovi |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| NZ543467A (en) | 2003-04-10 | 2008-07-31 | Novartis Vaccines & Diagnostic | The severe acute respiratory syndrome coronavirus |
| AU2004230244B2 (en) | 2003-04-15 | 2011-09-22 | Intercell Ag | S. pneumoniae antigens |
| DE10327439A1 (de) * | 2003-06-18 | 2005-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazopyridazinon- und Imidazopyridonderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| MXPA05013260A (es) | 2003-06-26 | 2006-03-09 | Chiron Corp | Composiciones inmunogenicas para chlamydia trachomatis. |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| PT1648500E (pt) | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
| CN1918176A (zh) | 2004-02-18 | 2007-02-21 | 默克公司 | 用于诱导针对金黄色葡萄球菌的保护性免疫反应的多肽 |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| US20080095777A1 (en) | 2004-09-22 | 2008-04-24 | Glaxosmithkline Biologicals S.A. | Immunogenic Composition for Use in Vaccination Against Staphylococcei |
| NZ555937A (en) | 2005-01-27 | 2009-05-31 | Childrens Hosp & Res Ct Oak | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| BRPI0620755A2 (pt) | 2005-12-27 | 2011-11-22 | Obetech Llc | adenovìrus adipogênicos como um biomarcardor para doenças |
| EP1998800A2 (fr) | 2006-01-18 | 2008-12-10 | University Of Chicago | Compositions et procédés se rapportant à des protéines de bactéries staphylococciques |
| MX2008010604A (es) | 2006-02-17 | 2009-03-05 | Novartis Ag | Purificacion y uso de pilosidades de streptococcus pneumoniae y proteinas pilosas. |
| ATE539079T1 (de) * | 2006-03-23 | 2012-01-15 | Novartis Ag | Imidazochinoxalinverbindungen als immunmodulatoren |
| JP2009531387A (ja) | 2006-03-30 | 2009-09-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| AR060188A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Procedimiento de conjugacion |
| BRPI0909037B8 (pt) * | 2008-03-03 | 2021-05-25 | Irm Llc | compostos moduladores da atividade de tlr, e composição farmacêutica |
| EP2440245B1 (fr) * | 2009-06-10 | 2017-12-06 | GlaxoSmithKline Biologicals SA | Vaccins contenant benzonaphtyridines |
| CN102760226B (zh) * | 2011-04-29 | 2015-07-01 | 贵州师范大学 | 一种基于实心正方形的试卷客观题答题卡定位方法 |
-
2010
- 2010-08-31 TW TW099129346A patent/TWI445708B/zh active
- 2010-08-31 JO JOP/2010/0304A patent/JO3257B1/ar active
- 2010-09-01 IN IN2736DEN2012 patent/IN2012DN02736A/en unknown
- 2010-09-01 LT LTEP10807754.6T patent/LT2473508T/lt unknown
- 2010-09-01 EP EP10807754.6A patent/EP2473508B1/fr active Active
- 2010-09-01 PE PE2012000285A patent/PE20121156A1/es active IP Right Grant
- 2010-09-01 EA EA201200406A patent/EA020962B1/ru not_active IP Right Cessation
- 2010-09-01 PL PL10807754T patent/PL2473508T3/pl unknown
- 2010-09-01 WO PCT/US2010/047587 patent/WO2011049677A1/fr active Application Filing
- 2010-09-01 MX MX2012002654A patent/MX2012002654A/es unknown
- 2010-09-01 ES ES10807754.6T patent/ES2627669T3/es active Active
- 2010-09-01 JP JP2012528021A patent/JP5525614B2/ja active Active
- 2010-09-01 SI SI201031468A patent/SI2473508T1/sl unknown
- 2010-09-01 DK DK10807754.6T patent/DK2473508T3/en active
- 2010-09-01 US US12/874,153 patent/US9045470B2/en active Active
- 2010-09-01 HU HUE10807754A patent/HUE032323T2/en unknown
- 2010-09-01 CN CN201080049422.8A patent/CN102712636B/zh active Active
- 2010-09-01 BR BR112012004696A patent/BR112012004696B8/pt active IP Right Grant
- 2010-09-01 CA CA2772657A patent/CA2772657C/fr active Active
- 2010-09-01 PT PT108077546T patent/PT2473508T/pt unknown
- 2010-09-01 AU AU2010308524A patent/AU2010308524B2/en active Active
- 2010-09-02 UY UY0001032874A patent/UY32874A/es unknown
- 2010-09-02 AR ARP100103222A patent/AR078153A1/es active IP Right Grant
-
2012
- 2012-02-29 CL CL2012000535A patent/CL2012000535A1/es unknown
-
2015
- 2015-04-24 US US14/696,165 patent/US20150225432A1/en not_active Abandoned
-
2017
- 2017-05-11 HR HRP20170707TT patent/HRP20170707T1/hr unknown
- 2017-06-08 CY CY20171100605T patent/CY1119618T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2012DN02736A (fr) | ||
| SG178954A1 (en) | Immunogenic compositions including tlr activity modulators | |
| JO3065B1 (ar) | مركبات وتركيبات كمعدلات لفاعلية tlr | |
| MX341395B (es) | Compuestos (lipopeptidos basados en cisteina) y composiciones como agonistas de tlr2 usados para el tratamiento de infecciones, inflamaciones, enfermedades respiratorias, etc. | |
| AU2012253757A8 (en) | Partially saturated tricyclic compounds and methods of making and using same | |
| MX344238B (es) | Compuestos de tetrazol y métodos para preparar y usar los mismos. | |
| UA115983C2 (uk) | Інгібітори днк-пк | |
| MX343687B (es) | Compuestos sulfonamida tricíclica y métodos para su fabricación y uso. | |
| MX347471B (es) | Vacunas que comprenden colesterol y cpg como moleculas portadoras-adyuvantes unicas. | |
| UA103930C2 (ru) | Соединения и композиция для лечения паразитарных болезней | |
| PH12015501637A1 (en) | Inactivated dengue virus vaccine with aluminium-free adjuvant | |
| MX2012004078A (es) | Compuestos y composiciones como moduladores de la actividad de gpr119. | |
| MX2011013032A (es) | Inhibidores de fosfatidilinositol 3-cinasa. | |
| MX2015005732A (es) | Compuestos tricíclicos y métodos para hacer y utilizar los mismos. | |
| MX2011011618A (es) | Agentes terapeuticos 713. | |
| TN2012000217A1 (en) | The use of an l3 and/or l5 source as a vaccine or as a diagnostic for a parasitic disease | |
| BR112013023354A2 (pt) | vacina para rinite equina | |
| EA201291384A1 (ru) | Терапевтические агенты 976 | |
| TN2010000338A1 (en) | Vaccine comprising a ribosomal protein extract (rpe) and optionally a th1-promoting adjuvant | |
| TN2010000463A1 (en) | Compositions and methods for preparing and using same | |
| MX361456B (es) | Uso de una fuente de l3 y/o l5 como vacuna o como diagnostico para una enfermedad parasitaria. | |
| UA97289C2 (ru) | Соединения и их композиция как модуляторы gpr119 активности |