IL96643A - 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it - Google Patents

3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it

Info

Publication number
IL96643A
IL96643A IL9664390A IL9664390A IL96643A IL 96643 A IL96643 A IL 96643A IL 9664390 A IL9664390 A IL 9664390A IL 9664390 A IL9664390 A IL 9664390A IL 96643 A IL96643 A IL 96643A
Authority
IL
Israel
Prior art keywords
formula
doxorubicin
compound
derivative
deamino
Prior art date
Application number
IL9664390A
Other languages
English (en)
Hebrew (he)
Other versions
IL96643A0 (en
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IL111527A priority Critical patent/IL111527A/en
Publication of IL96643A0 publication Critical patent/IL96643A0/xx
Priority to IL11152794A priority patent/IL111527A0/xx
Publication of IL96643A publication Critical patent/IL96643A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/30Compounds having groups
    • C07C43/313Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
IL9664390A 1989-12-19 1990-12-12 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it IL96643A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL111527A IL111527A (en) 1989-12-19 1990-12-12 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (2)

Publication Number Publication Date
IL96643A0 IL96643A0 (en) 1991-09-16
IL96643A true IL96643A (en) 1995-01-24

Family

ID=26296395

Family Applications (3)

Application Number Title Priority Date Filing Date
IL9664390A IL96643A (en) 1989-12-19 1990-12-12 3 '- Dahmino -'S) - 2 ") - 3 (- Methoxy - 4" - Morpholinyl (-Docsorovicine chirley, its preparation and pharmaceutical preparations containing it
IL111527A IL111527A (en) 1989-12-19 1990-12-12 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL111527A IL111527A (en) 1989-12-19 1990-12-12 1,5-diodo- (S) (2-alkoxy) or benzyloxy (3-oxa-pentanes and their preparation
IL11152794A IL111527A0 (en) 1989-12-19 1994-11-04 1,5-Diiodo-2(s)-alkoxy (or benzyloxy)-3-oxa-pentanes and their preparation

Country Status (28)

Country Link
EP (1) EP0434960B1 (fr)
JP (1) JP3300342B2 (fr)
KR (1) KR0183033B1 (fr)
CN (2) CN1024922C (fr)
AT (1) ATE143023T1 (fr)
AU (1) AU636429B2 (fr)
CA (1) CA2046857C (fr)
CZ (1) CZ281949B6 (fr)
DE (1) DE69028610T2 (fr)
DK (1) DK0434960T3 (fr)
ES (1) ES2094136T3 (fr)
FI (1) FI97389C (fr)
GR (1) GR3021557T3 (fr)
HR (1) HRP921226B1 (fr)
HU (2) HU208148B (fr)
IE (1) IE81174B1 (fr)
IL (3) IL96643A (fr)
MY (1) MY119192A (fr)
NO (2) NO175533C (fr)
NZ (1) NZ243695A (fr)
PT (1) PT96226B (fr)
RU (1) RU2100366C1 (fr)
SI (1) SI9012379B (fr)
SK (1) SK278994B6 (fr)
TW (1) TW208019B (fr)
UA (1) UA27108A1 (fr)
WO (1) WO1991009046A1 (fr)
YU (1) YU48136B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
DE60031793T2 (de) * 1999-12-29 2007-08-23 Immunogen Inc., Cambridge Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
NZ536308A (en) 2002-05-24 2009-01-31 Angiotech Int Ag Compositions and methods for coating medical implants
EP1542739B1 (fr) 2002-09-26 2008-12-10 Angiotech International Ag Enveloppes perivasculaires
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
MXPA05009849A (es) * 2003-03-18 2005-12-06 Pharmacia Italia Spa Terapia combinada que comprende nemorubicina y un inhibidor de la ciclooxigenasa-2.
EP2049530A2 (fr) * 2006-07-12 2009-04-22 Nerviano Medical Sciences S.r.l. Chlorhydrate de némorubicine cristallin
CN101555264B (zh) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
MX2013005972A (es) * 2010-12-02 2013-08-09 Nerviano Medical Sciences Srl Proceso para la preparacion de derivados de morfolinil antraciclina.
DK2991993T3 (en) 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
EP3084445B1 (fr) 2013-12-11 2020-10-28 University of Massachusetts Compositions et procédés de traitement d'une maladie au moyen d'une protéine effectrice t3ss de salmonella (sipa)
RU2715902C2 (ru) 2014-11-05 2020-03-04 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Функционализированные производные морфолинилантрациклина
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技(上海)有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (fr) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclines et leurs conjugués

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
NO176911C (no) 1995-06-21
DK0434960T3 (da) 1996-10-14
CN1079215A (zh) 1993-12-08
CZ281949B6 (cs) 1997-04-16
NO913176L (no) 1991-08-14
HU9200656D0 (en) 1992-05-28
HRP921226A2 (en) 1995-12-31
NO176911B (no) 1995-03-13
EP0434960A1 (fr) 1991-07-03
HUT60232A (en) 1992-08-28
NZ243695A (en) 1993-06-25
FI97389B (fi) 1996-08-30
JP3300342B2 (ja) 2002-07-08
CA2046857C (fr) 2001-06-12
HU208148B (en) 1993-08-30
CN1053238A (zh) 1991-07-24
YU48136B (sh) 1997-05-28
IL96643A0 (en) 1991-09-16
JPH04503679A (ja) 1992-07-02
NO175533C (no) 1994-10-26
SI9012379A (en) 1997-12-31
EP0434960B1 (fr) 1996-09-18
SK621990A3 (en) 1998-05-06
DE69028610D1 (de) 1996-10-24
YU237990A (sh) 1993-05-28
GR3021557T3 (en) 1997-02-28
FI97389C (fi) 1996-12-10
ATE143023T1 (de) 1996-10-15
IL111527A (en) 1998-02-22
KR0183033B1 (ko) 1999-04-01
KR920701228A (ko) 1992-08-11
CA2046857A1 (fr) 1991-06-20
CN1039708C (zh) 1998-09-09
HUT59693A (en) 1992-06-29
CZ621990A3 (en) 1997-01-15
ES2094136T3 (es) 1997-01-16
AU636429B2 (en) 1993-04-29
IL111527A0 (en) 1995-01-24
AU6919491A (en) 1991-07-18
HRP921226B1 (en) 1998-10-31
CN1024922C (zh) 1994-06-08
IE904543A1 (en) 1991-06-19
PT96226B (pt) 1998-06-30
DE69028610T2 (de) 1997-02-06
IE81174B1 (en) 2000-06-14
HU209433B (en) 1994-06-28
SK278994B6 (sk) 1998-05-06
NO940831L (no) 1991-08-14
SI9012379B (sl) 2000-02-29
NO175533B (no) 1994-07-18
TW208019B (fr) 1993-06-21
NO913176D0 (no) 1991-08-14
FI913887A0 (fi) 1991-08-16
UA27108A1 (uk) 2000-02-28
PT96226A (pt) 1991-09-30
MY119192A (en) 2005-04-30
NO940831D0 (no) 1994-03-09
WO1991009046A1 (fr) 1991-06-27
HU912994D0 (en) 1992-01-28
RU2100366C1 (ru) 1997-12-27

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees