IL93124A - History of Benzocycloalkylene Dihydroxyalkyl Acid Preparation and Pharmaceutical Preparations Containing Them - Google Patents

History of Benzocycloalkylene Dihydroxyalkyl Acid Preparation and Pharmaceutical Preparations Containing Them

Info

Publication number
IL93124A
IL93124A IL9312490A IL9312490A IL93124A IL 93124 A IL93124 A IL 93124A IL 9312490 A IL9312490 A IL 9312490A IL 9312490 A IL9312490 A IL 9312490A IL 93124 A IL93124 A IL 93124A
Authority
IL
Israel
Prior art keywords
denotes
formula
compound
hydrogen atom
erythro
Prior art date
Application number
IL9312490A
Other languages
English (en)
Hebrew (he)
Other versions
IL93124A0 (en
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of IL93124A0 publication Critical patent/IL93124A0/xx
Publication of IL93124A publication Critical patent/IL93124A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C07C47/238—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
IL9312490A 1989-01-24 1990-01-22 History of Benzocycloalkylene Dihydroxyalkyl Acid Preparation and Pharmaceutical Preparations Containing Them IL93124A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8900790A FR2642065B1 (fr) 1989-01-24 1989-01-24 Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant

Publications (2)

Publication Number Publication Date
IL93124A0 IL93124A0 (en) 1990-11-05
IL93124A true IL93124A (en) 1995-01-24

Family

ID=9378002

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9312490A IL93124A (en) 1989-01-24 1990-01-22 History of Benzocycloalkylene Dihydroxyalkyl Acid Preparation and Pharmaceutical Preparations Containing Them

Country Status (28)

Country Link
US (1) US5082859A (de)
EP (1) EP0380392B1 (de)
JP (1) JP2561354B2 (de)
AR (1) AR247206A1 (de)
AT (1) ATE104666T1 (de)
AU (1) AU629602B2 (de)
CA (1) CA2008341C (de)
CZ (1) CZ278567B6 (de)
DD (2) DD291749A5 (de)
DE (1) DE69008205T2 (de)
DK (1) DK0380392T3 (de)
DZ (1) DZ1390A1 (de)
ES (1) ES2055350T3 (de)
FR (1) FR2642065B1 (de)
GE (1) GEP19971017B (de)
HU (1) HU206307B (de)
IE (1) IE64243B1 (de)
IL (1) IL93124A (de)
MA (1) MA21737A1 (de)
NO (1) NO173992C (de)
NZ (1) NZ232226A (de)
OA (1) OA09190A (de)
PT (1) PT92945B (de)
RU (1) RU2012554C1 (de)
SK (1) SK278578B6 (de)
TN (1) TNSN90008A1 (de)
YU (1) YU48227B (de)
ZA (1) ZA90511B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2630111B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2630110B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives heteroarotinoides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5504106A (en) * 1992-06-25 1996-04-02 G. D. Searle & Co. Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
WO1999032434A1 (en) * 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols
FR2772761B1 (fr) 1997-12-23 2000-05-26 Lipha Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant
WO2005007110A2 (en) * 2003-07-11 2005-01-27 Pro-Pharmaceuticals, Inc. Compositions and methods for hydrophobic drug delivery
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
EP1718146A2 (de) * 2004-02-13 2006-11-08 Pro-Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur behandlung von akne und candida
WO2006017417A2 (en) * 2004-08-02 2006-02-16 Pro-Pharmaceuticals, Inc. Compositions and methods for the enhancement of chemotherapy with microbial cytotoxins
MX2007006279A (es) * 2004-12-15 2007-06-14 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema de produccion de endotelina endogena, e inhibidores de hmg coa-reductasa.
US7776889B2 (en) * 2005-03-31 2010-08-17 Schering Corporation Spirocyclic thrombin receptor antagonists
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
ES2378281T3 (es) 2006-07-05 2012-04-10 Nycomed Gmbh Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
CN101570510B (zh) * 2008-04-30 2011-08-31 上海医药工业研究院 喹啉类化合物及其药物组合物、制备方法和应用
AU2013214693B2 (en) 2012-02-02 2017-02-23 Kenneth Gek-Jin OOI Improvements in tear film stability
MY160723A (en) * 2013-12-30 2017-03-15 Univ Putra Malaysia An anticoagulant
US20200129440A1 (en) 2017-01-23 2020-04-30 Dong Wha Pharm. Co., Ltd. Complex formulation comprising hmg-coa reductase inhibitor and clopidogrel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3063585D1 (en) * 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
US4556676A (en) * 1979-11-01 1985-12-03 Pfizer Inc. Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
ATE60571T1 (de) * 1984-12-04 1991-02-15 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
WO1987004430A2 (en) * 1986-01-16 1987-07-30 Schering Corporation Fused benzazepines
JPS62181276A (ja) * 1986-02-06 1987-08-08 Sagami Chem Res Center ２ｈ−クロメン誘導体
GB8611837D0 (en) * 1986-05-15 1986-06-25 Plessey Co Plc Photochromic spiropyran compounds
EP0298466A3 (de) * 1987-07-10 1990-10-24 F. Hoffmann-La Roche Ag Substituierte Alkencarbonsäureamide und Derivate

Also Published As

Publication number Publication date
GEP19971017B (en) 1997-06-18
FR2642065B1 (fr) 1991-05-24
JPH02258738A (ja) 1990-10-19
SK34190A3 (en) 1997-10-08
AU2061392A (en) 1992-10-15
EP0380392B1 (de) 1994-04-20
IL93124A0 (en) 1990-11-05
PT92945B (pt) 1995-12-29
JP2561354B2 (ja) 1996-12-04
MA21737A1 (fr) 1990-10-01
TNSN90008A1 (fr) 1991-03-05
CZ34190A3 (en) 1993-08-11
RU2012554C1 (ru) 1994-05-15
CA2008341A1 (fr) 1990-07-24
HU900239D0 (en) 1990-03-28
FR2642065A1 (fr) 1990-07-27
OA09190A (fr) 1992-06-30
IE900260L (en) 1990-07-24
EP0380392A3 (en) 1990-09-12
HUT53059A (en) 1990-09-28
DE69008205D1 (de) 1994-05-26
US5082859A (en) 1992-01-21
ES2055350T3 (es) 1994-08-16
DD291749A5 (de) 1991-07-11
AR247206A1 (es) 1994-11-30
AU647642B2 (en) 1994-03-24
CA2008341C (fr) 1997-03-18
NZ232226A (en) 1991-09-25
DK0380392T3 (da) 1994-08-29
DD300422A5 (de) 1992-06-11
DE69008205T2 (de) 1994-10-06
DZ1390A1 (fr) 2004-09-13
NO173992C (no) 1994-03-02
EP0380392A2 (de) 1990-08-01
PT92945A (pt) 1990-07-31
ZA90511B (en) 1990-10-31
NO900309L (no) 1990-07-25
SK278578B6 (en) 1997-10-08
YU48227B (sh) 1997-08-22
YU12490A (en) 1991-10-31
AU4879790A (en) 1990-09-13
HU206307B (en) 1992-10-28
CZ278567B6 (en) 1994-03-16
NO173992B (no) 1993-11-22
ATE104666T1 (de) 1994-05-15
IE64243B1 (en) 1995-07-26
NO900309D0 (no) 1990-01-23
AU629602B2 (en) 1992-10-08

Similar Documents

Publication Publication Date Title
IL93124A (en) History of Benzocycloalkylene Dihydroxyalkyl Acid Preparation and Pharmaceutical Preparations Containing Them
FI80027C (fi) Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 4-fenyl-1,3-dioxan-cis-5-ylalkenoylsyraderivat.
SU515457A3 (ru) Способ получени производных 3-алкил-6,6а7,8,10,10а,-гексагидро-9н-дибензо( , )-пиран-9она
AU753287B2 (en) Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions and preparation process
EP0123543B1 (de) Leukotrienantagonisten, deren Herstellung und Verwendung sowie diese enthaltende Zusammensetzungen
HUT77515A (hu) Hidrogénezett benzopirán- és naftalinszármazékok, ezeket tartalmazó gyógyszerkészítmények és intermedierjeik
US4609744A (en) 4-oxo-benzopyran carboxylic acids
CA1258863A (en) Cyclohexane derivatives
US4975455A (en) New heteroarotinoid compounds
US5183924A (en) Derivatives of benzocycloalkenyldihydroxyalkanoic acids, processes of preparation and medications containing them
JPH06329665A (ja) 新規な置換ベンゾジオキシン類、その製造法及びそのベンゾジオキシン類を含有する製剤組成物
EP1121338A1 (de) Eine methode zur herstellung von diaryl-substituierten heterocyclischen verbindungen, einschliesslich tetrahydrofurane
US5173498A (en) Substituted 3-thia- and 3-oxa-alkylflavones, a process for their preparation, the use thereof, medicaments based on these compounds and intermediates
FR2630111A1 (fr) Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3652162B1 (de) Neuartige synthese von zwischenprodukten für die herstellung von alpha-tocopherol
JPS5943466B2 (ja) シス−ヘキサヒドロジベンゾピラノン類の製法
HRP920760A2 (en) Process for the preparation of benzocycloalkenyl dihydroxy alkane acid derivatives and medicaments containing them
JP2012500811A (ja) ヘキサヒドロジベンゾピラノン類の改良合成方法
JPH06116257A (ja) ベンゾフラン誘導体及びその用途
MXPA01000562A (en) Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions and preparation process

Legal Events

Date Code Title Description
KB Patent renewed
HP Change in proprietorship
RH Patent void