ATE104666T1 - Abkoemmlinge von benzocycloalkenyldihydroxyalkansaeuren, verfahren zu deren herstellung und diese enthaltende pharmazeutika. - Google Patents

Abkoemmlinge von benzocycloalkenyldihydroxyalkansaeuren, verfahren zu deren herstellung und diese enthaltende pharmazeutika.

Info

Publication number
ATE104666T1
ATE104666T1 AT9090400161T AT90400161T ATE104666T1 AT E104666 T1 ATE104666 T1 AT E104666T1 AT 9090400161 T AT9090400161 T AT 9090400161T AT 90400161 T AT90400161 T AT 90400161T AT E104666 T1 ATE104666 T1 AT E104666T1
Authority
AT
Austria
Prior art keywords
dergents
benzocycloalkenyldihydroxyalkan
acids
preparation
pharmaceuticals containing
Prior art date
Application number
AT9090400161T
Other languages
English (en)
Inventor
Didier Festal
Jean-Yves Nioche
Denis Descours
Robert Bellemin
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Application granted granted Critical
Publication of ATE104666T1 publication Critical patent/ATE104666T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C07C47/238—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
AT9090400161T 1989-01-24 1990-01-22 Abkoemmlinge von benzocycloalkenyldihydroxyalkansaeuren, verfahren zu deren herstellung und diese enthaltende pharmazeutika. ATE104666T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8900790A FR2642065B1 (fr) 1989-01-24 1989-01-24 Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant

Publications (1)

Publication Number Publication Date
ATE104666T1 true ATE104666T1 (de) 1994-05-15

Family

ID=9378002

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9090400161T ATE104666T1 (de) 1989-01-24 1990-01-22 Abkoemmlinge von benzocycloalkenyldihydroxyalkansaeuren, verfahren zu deren herstellung und diese enthaltende pharmazeutika.

Country Status (28)

Country Link
US (1) US5082859A (de)
EP (1) EP0380392B1 (de)
JP (1) JP2561354B2 (de)
AR (1) AR247206A1 (de)
AT (1) ATE104666T1 (de)
AU (1) AU629602B2 (de)
CA (1) CA2008341C (de)
CZ (1) CZ278567B6 (de)
DD (2) DD300422A5 (de)
DE (1) DE69008205T2 (de)
DK (1) DK0380392T3 (de)
DZ (1) DZ1390A1 (de)
ES (1) ES2055350T3 (de)
FR (1) FR2642065B1 (de)
GE (1) GEP19971017B (de)
HU (1) HU206307B (de)
IE (1) IE64243B1 (de)
IL (1) IL93124A (de)
MA (1) MA21737A1 (de)
NO (1) NO173992C (de)
NZ (1) NZ232226A (de)
OA (1) OA09190A (de)
PT (1) PT92945B (de)
RU (1) RU2012554C1 (de)
SK (1) SK278578B6 (de)
TN (1) TNSN90008A1 (de)
YU (1) YU48227B (de)
ZA (1) ZA90511B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2630110B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives heteroarotinoides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2630111B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1994000424A1 (en) * 1992-06-25 1994-01-06 G.D. Searle & Co. Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
JP2001526256A (ja) * 1997-12-19 2001-12-18 ワーナー−ランバート・エクスポート・リミテッド １，３−ジオールの合成方法
FR2772761B1 (fr) * 1997-12-23 2000-05-26 Lipha Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant
CN1838942A (zh) * 2003-07-11 2006-09-27 普罗医药公司 递送疏水性药物的组合物和方法
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
EP1718146A2 (de) * 2004-02-13 2006-11-08 Pro-Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur behandlung von akne und candida
EP1773128A2 (de) * 2004-08-02 2007-04-18 Pro-Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur verbesserung der chemotherapie mit mikrobiellen zytotoxinen
EP1827448A1 (de) * 2004-12-15 2007-09-05 Solvay Pharmaceuticals GmbH Pharmazeutische zusammensetzungen mit nep-hemmern, hemmern des endogenen endothelin-produzierenden systems und hmg-coa-reduktasehemmer
CA2601575A1 (en) * 2005-03-31 2006-10-05 Schering Corporation Spirocyclic thrombin receptor antagonists
EP1919393A2 (de) * 2005-09-01 2008-05-14 Prescient Medical, Inc. Auf eine vorrichtung beschichtete arzneimittel zur behandlung von empfindlichem plaque
ES2378281T3 (es) 2006-07-05 2012-04-10 Nycomed Gmbh Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
CN101570510B (zh) * 2008-04-30 2011-08-31 上海医药工业研究院 喹啉类化合物及其药物组合物、制备方法和应用
AU2013214693B2 (en) 2012-02-02 2017-02-23 Kenneth Gek-Jin OOI Improvements in tear film stability
MY160723A (en) * 2013-12-30 2017-03-15 Univ Putra Malaysia An anticoagulant
JP2020507621A (ja) 2017-01-23 2020-03-12 ドン ファ ファーマシューティカル カンパニー リミテッド ＨＭＧ−ＣｏＡ還元酵素阻害剤およびクロピドグレルを含む複合製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0020018B1 (de) * 1979-05-19 1983-06-01 Beecham Group Plc Chroman-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4556676A (en) 1979-11-01 1985-12-03 Pfizer Inc. Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
ATE60571T1 (de) * 1984-12-04 1991-02-15 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
WO1987004430A2 (en) * 1986-01-16 1987-07-30 Schering Corporation Fused benzazepines
JPS62181276A (ja) * 1986-02-06 1987-08-08 Sagami Chem Res Center ２ｈ−クロメン誘導体
GB8611837D0 (en) * 1986-05-15 1986-06-25 Plessey Co Plc Photochromic spiropyran compounds
NZ225307A (en) * 1987-07-10 1991-06-25 Hoffmann La Roche Heterocyclic containing alkene derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0380392A3 (en) 1990-09-12
EP0380392B1 (de) 1994-04-20
GEP19971017B (en) 1997-06-18
FR2642065A1 (fr) 1990-07-27
AU2061392A (en) 1992-10-15
YU48227B (sh) 1997-08-22
IE900260L (en) 1990-07-24
JPH02258738A (ja) 1990-10-19
HU900239D0 (en) 1990-03-28
DD291749A5 (de) 1991-07-11
PT92945B (pt) 1995-12-29
IL93124A0 (en) 1990-11-05
NO173992B (no) 1993-11-22
IE64243B1 (en) 1995-07-26
US5082859A (en) 1992-01-21
NO900309L (no) 1990-07-25
NZ232226A (en) 1991-09-25
NO900309D0 (no) 1990-01-23
AR247206A1 (es) 1994-11-30
HU206307B (en) 1992-10-28
JP2561354B2 (ja) 1996-12-04
MA21737A1 (fr) 1990-10-01
ES2055350T3 (es) 1994-08-16
DE69008205D1 (de) 1994-05-26
DD300422A5 (de) 1992-06-11
PT92945A (pt) 1990-07-31
RU2012554C1 (ru) 1994-05-15
OA09190A (fr) 1992-06-30
CA2008341A1 (fr) 1990-07-24
FR2642065B1 (fr) 1991-05-24
AU4879790A (en) 1990-09-13
HUT53059A (en) 1990-09-28
CZ34190A3 (en) 1993-08-11
SK34190A3 (en) 1997-10-08
YU12490A (en) 1991-10-31
NO173992C (no) 1994-03-02
DK0380392T3 (da) 1994-08-29
ZA90511B (en) 1990-10-31
AU647642B2 (en) 1994-03-24
EP0380392A2 (de) 1990-08-01
DZ1390A1 (fr) 2004-09-13
CZ278567B6 (en) 1994-03-16
SK278578B6 (en) 1997-10-08
CA2008341C (fr) 1997-03-18
IL93124A (en) 1995-01-24
DE69008205T2 (de) 1994-10-06
TNSN90008A1 (fr) 1991-03-05
AU629602B2 (en) 1992-10-08

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