ES2055350T3 - Derivados de acidos benzocicloalcenil dihidroxi alcanoicos, procedimientos de preparacion y medicamentos que los contienen. - Google Patents

Derivados de acidos benzocicloalcenil dihidroxi alcanoicos, procedimientos de preparacion y medicamentos que los contienen.

Info

Publication number
ES2055350T3
ES2055350T3 ES90400161T ES90400161T ES2055350T3 ES 2055350 T3 ES2055350 T3 ES 2055350T3 ES 90400161 T ES90400161 T ES 90400161T ES 90400161 T ES90400161 T ES 90400161T ES 2055350 T3 ES2055350 T3 ES 2055350T3
Authority
ES
Spain
Prior art keywords
different
alcoxi
halogen
acids
substitutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400161T
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English (en)
Inventor
Didier Festal
Jean-Yves Nioche
Denis Descours
Robert Bellemin
Jacques Decerprit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
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Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of ES2055350T3 publication Critical patent/ES2055350T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C07C47/238—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

DERIVADOS DE ACIDOS BENZOCICLOALCENIL DIHIDROXI ALCANOICOS, INHIBIDORES DE HMG COA REDUCTASA, ANTAGONISTAS DE RECEPTORES DE TROMBOXANO A2 Y ANTIHONGOS, REPRESENTADOS POR LA FORMULA: (FIG. A), EN LA QUE X = CH2, O O S; R1 Y R2, IGUALES O DIFERENTES = H, ALQUILO C1-C3 O FORMAN JUNTOS UNA CADENA -(CH2)N- (N = 45) EVENTUALMENTE SUSTITUIDA SIMETRICAMENTE POR UNO O DOS RADICALES ALQUILO C1-C3. R3 Y R4, IGUALES O DIFERENTES = H, CF3, HALOGENO (CL, F, BR), N,N-DIALQUILAMINO C1-C5, ALQUILO C1-C4, ALCOXI C1-C5, ALQUILTIO C1-C3 O FENILO EVENTUALMENTE SUSTITUIDO POR DOS SUSTITUYENTES COMO MAXIMO QUE PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAR RADICALES C1-C3, ALCOXI C1-C3 O HALOGENOS (F, CL), ENTENDIENDOSE QUE CUANDO UNO DE R3, R4 REPRESENTA LOS RADICALES CF3, N,N-DIALQUILAMINO, C6H5, O FENILO SUSTITUIDO, SE ENCUENTRA EN LAS POSICIONES 3'', 4'' O 5'' SEGUN LA FORMULA: (FIG. A), Y EL OTRO ES UN ATOMO DE HIDROGENO. R5 Y R6, QUE PUEDEN SER IGUALES O DIFERENTES = H, HALOGENO (F, CL, BR), CF3, ALQUILO C1-C3, ALCOXI C1-C3, C6H5, EVENTUALMENTE SUSTITUIDO POR DOS SUSTITUYENTES COMO MAXIMO, QUE PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAR RADICALES ALQUILO C1-C3, ALCOXI C1-C3 O ATOMOS DE HALOGENO (F, CL), A CONDICION DE QUE CUANDO UNO DE R5, R6 = CF3, C6H5 O FENILO SUSTITUIDO, SE ENCUENTRA EN LA POSICION 6 O 7, EL OTRO ES UN ATOMO DE HIDROGENO. LOS SUSTITUYENTES R3 Y R4 RESPECTIVAMENTE Y R5 Y R6 PUEDEN IGUALMENTE FORMAR JUNTOS, A CONDICION DE ESTAR EN DOS POSICIONES ADYECENTES, DIRRADICALES DE FORMULAS; -CH=CH-CH=CH-, -(CH2)M-, -O(CH2)PO-, EN LAS QUE M = 3 O 4, P = 1 O 2, ENTENDIENDOSE QUE CUANDO R3 Y R4 RESPECTIVAMENTE R5 Y R6 FORMAN LA CADENA -O(CH2)PO-, ESTA ESTA UNIDA A LAS POSICIONES 3'', 4'' O 4'', 5'' RESPECTIVAMENTE 6, 7 SEGUN LA FORMULA: (FIG. A). R7 Y R8 = H O FORMAN JUNTO CON LA UNION C-C EXISTENTE UNA UNION DE GEOMETRIA TRANS; R9 Y R10 = H O FORMAN JUNTOS UN RESTO DIALQUILMETILENO C1-C3. BAJO FORMA DE ACIDOS LIBRES, SALES ESTERES, AMIDAS O (DELTA)-LACTONAS. MEDICAMENTOS HIPOCOLESTEROLEMICOS, ANTITROMBOTICOS Y ANTIHONGOS QUE LOS CONTIENEN.
ES90400161T 1989-01-24 1990-01-22 Derivados de acidos benzocicloalcenil dihidroxi alcanoicos, procedimientos de preparacion y medicamentos que los contienen. Expired - Lifetime ES2055350T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8900790A FR2642065B1 (fr) 1989-01-24 1989-01-24 Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant

Publications (1)

Publication Number Publication Date
ES2055350T3 true ES2055350T3 (es) 1994-08-16

Family

ID=9378002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400161T Expired - Lifetime ES2055350T3 (es) 1989-01-24 1990-01-22 Derivados de acidos benzocicloalcenil dihidroxi alcanoicos, procedimientos de preparacion y medicamentos que los contienen.

Country Status (28)

Country Link
US (1) US5082859A (es)
EP (1) EP0380392B1 (es)
JP (1) JP2561354B2 (es)
AR (1) AR247206A1 (es)
AT (1) ATE104666T1 (es)
AU (1) AU629602B2 (es)
CA (1) CA2008341C (es)
CZ (1) CZ278567B6 (es)
DD (2) DD291749A5 (es)
DE (1) DE69008205T2 (es)
DK (1) DK0380392T3 (es)
DZ (1) DZ1390A1 (es)
ES (1) ES2055350T3 (es)
FR (1) FR2642065B1 (es)
GE (1) GEP19971017B (es)
HU (1) HU206307B (es)
IE (1) IE64243B1 (es)
IL (1) IL93124A (es)
MA (1) MA21737A1 (es)
NO (1) NO173992C (es)
NZ (1) NZ232226A (es)
OA (1) OA09190A (es)
PT (1) PT92945B (es)
RU (1) RU2012554C1 (es)
SK (1) SK278578B6 (es)
TN (1) TNSN90008A1 (es)
YU (1) YU48227B (es)
ZA (1) ZA90511B (es)

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FR2630111B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2630110B1 (fr) * 1988-04-13 1990-07-27 Adir Nouveaux derives heteroarotinoides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1994000424A1 (en) * 1992-06-25 1994-01-06 G.D. Searle & Co. Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
NZ504346A (en) * 1997-12-19 2001-11-30 Warner Lambert Exp Ltd Process for the synthesis of 1,3-diols characterised by either reconcentration step with either trialkylborane or dialkylalkoxyborane or a mixture of both trialkylborane and dialkylalkoxyborane
FR2772761B1 (fr) * 1997-12-23 2000-05-26 Lipha Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant
WO2005007110A2 (en) * 2003-07-11 2005-01-27 Pro-Pharmaceuticals, Inc. Compositions and methods for hydrophobic drug delivery
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
WO2005079314A2 (en) * 2004-02-13 2005-09-01 Pro-Pharmaceuticals, Inc. Compositions and methods used to treat acne and candida
WO2006017417A2 (en) * 2004-08-02 2006-02-16 Pro-Pharmaceuticals, Inc. Compositions and methods for the enhancement of chemotherapy with microbial cytotoxins
EP1827448A1 (en) * 2004-12-15 2007-09-05 Solvay Pharmaceuticals GmbH Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and hmg coa reductase inhibitors
TWI316937B (en) * 2005-03-31 2009-11-11 Schering Corp Spirocyclic thrombin receptor antagonists
WO2007030302A2 (en) * 2005-09-01 2007-03-15 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
RS53461B (en) 2006-07-05 2014-12-31 Takeda Gmbh COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES
CN101570510B (zh) * 2008-04-30 2011-08-31 上海医药工业研究院 喹啉类化合物及其药物组合物、制备方法和应用
JP6224624B2 (ja) 2012-02-02 2017-11-01 ザ・ユニバーシティ・オブ・シドニー 涙膜安定性における改善
MY160723A (en) * 2013-12-30 2017-03-15 Univ Putra Malaysia An anticoagulant
BR112019015107A2 (pt) 2017-01-23 2020-03-10 Dong Wha Pharm. Co., Ltd. Formulação de complexo compreendendo inibidor de hmg-coa redutase e clopidogrel

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DE3063585D1 (en) * 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
FR2642065B1 (fr) 1991-05-24
EP0380392A2 (fr) 1990-08-01
YU12490A (en) 1991-10-31
HU900239D0 (en) 1990-03-28
SK34190A3 (en) 1997-10-08
MA21737A1 (fr) 1990-10-01
JPH02258738A (ja) 1990-10-19
PT92945B (pt) 1995-12-29
NO900309D0 (no) 1990-01-23
YU48227B (sh) 1997-08-22
US5082859A (en) 1992-01-21
AU629602B2 (en) 1992-10-08
FR2642065A1 (fr) 1990-07-27
DE69008205T2 (de) 1994-10-06
ATE104666T1 (de) 1994-05-15
HUT53059A (en) 1990-09-28
CA2008341C (fr) 1997-03-18
PT92945A (pt) 1990-07-31
ZA90511B (en) 1990-10-31
DE69008205D1 (de) 1994-05-26
EP0380392B1 (fr) 1994-04-20
IL93124A0 (en) 1990-11-05
IE64243B1 (en) 1995-07-26
OA09190A (fr) 1992-06-30
NO173992C (no) 1994-03-02
IE900260L (en) 1990-07-24
SK278578B6 (en) 1997-10-08
AU2061392A (en) 1992-10-15
IL93124A (en) 1995-01-24
DK0380392T3 (da) 1994-08-29
DZ1390A1 (fr) 2004-09-13
JP2561354B2 (ja) 1996-12-04
AU647642B2 (en) 1994-03-24
HU206307B (en) 1992-10-28
DD300422A5 (de) 1992-06-11
CZ278567B6 (en) 1994-03-16
AR247206A1 (es) 1994-11-30
NO900309L (no) 1990-07-25
TNSN90008A1 (fr) 1991-03-05
NO173992B (no) 1993-11-22
NZ232226A (en) 1991-09-25
DD291749A5 (de) 1991-07-11
CA2008341A1 (fr) 1990-07-24
CZ34190A3 (en) 1993-08-11
EP0380392A3 (en) 1990-09-12
AU4879790A (en) 1990-09-13
RU2012554C1 (ru) 1994-05-15
GEP19971017B (en) 1997-06-18

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