MX9300256A - Derivados de acido acetico y proceso para su preparacion. - Google Patents
Derivados de acido acetico y proceso para su preparacion.Info
- Publication number
- MX9300256A MX9300256A MX9300256A MX9300256A MX9300256A MX 9300256 A MX9300256 A MX 9300256A MX 9300256 A MX9300256 A MX 9300256A MX 9300256 A MX9300256 A MX 9300256A MX 9300256 A MX9300256 A MX 9300256A
- Authority
- MX
- Mexico
- Prior art keywords
- represent
- carbon atoms
- group
- hydrogen atom
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a derivados de ácido acético y los derivados farmacéuticamente aceptables de los mismos y sales y solvatos de los mismos, donde: X1 y Y1, representan CH o N; X2 representa CH o, cuando X1 representa CH, también puede representar N; Y2 representa N o, cuando Y1 representa N, también puede representar CH; Z representa N o N+R5; R1 representa un átomo de hidrógeno o un grupo hidroxilo, R2 representa un átomo de hidrógeno o, cuando tanto X1 y X2 representan CH, también pueden representar un átomo de flúor, cloro o bromo o un grupo alquilo de 1 a 4 átomos de carbono; R3 representa un átomo de hidrógeno o, cuando tanto Y1 y Y2 representan N, también puede representar un grupo alquilo de 1 a 4 átomos de carbono o hidroximetilo; R4 representa un átomo de hidrógeno o, cuando Z representa N, R4 también puede representar un grupo alquilo de 1 a 4 átomos de carbono; R5 representa un grupo alquilo de 1 a 4 átomos de carbono o fenilalquilo de 1 a 4 átomos de carbono; R6 representa un grupo naftilo; un grupo tiofenilo; un grupo fenilo sin sustituir; un grupo fenilo sustituido, R7 y R8, que pueden ser los mismos o diferentes representan H o alquilo de 1 a 4 átomos de carbono o, conjuntamente con el átomo de nitrógeno al cual están unidos, forman un anillo de 5 a 7 miembros saturados. Los compuestos inhiben la agregación de las plaquetas de la sangre, dependiente del fibrinógeno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929201171A GB9201171D0 (en) | 1992-01-21 | 1992-01-21 | Chemical compounds |
GB929206004A GB9206004D0 (en) | 1992-03-19 | 1992-03-19 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9300256A true MX9300256A (es) | 1993-07-01 |
Family
ID=26300182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9300256A MX9300256A (es) | 1992-01-21 | 1993-01-20 | Derivados de acido acetico y proceso para su preparacion. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0623120A1 (es) |
JP (1) | JPH07503459A (es) |
CN (1) | CN1077953A (es) |
AU (1) | AU3351293A (es) |
IL (1) | IL104446A0 (es) |
MX (1) | MX9300256A (es) |
WO (1) | WO1993014077A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
DK0691959T3 (da) * | 1993-03-29 | 1999-04-26 | Zeneca Ltd | Heterocykliske derivater som blodpladeaggregations-inhibitorer |
NZ262942A (en) * | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
CN1113875C (zh) | 1994-05-04 | 2003-07-09 | 拜尔公司 | 取代的芳族硫代羧酰胺及其作为除草剂的用途 |
USRE39263E1 (en) * | 1994-05-04 | 2006-09-05 | Bayer Aktiengesellschaft | Substituted aromatic thiocarboxylic acid amides and their use as herbicides |
IL116893A (en) * | 1995-02-10 | 2000-02-29 | Yamanouchi Pharma Co Ltd | Piperazine derivatives and pharmaceutical compositions containing them |
WO1996024583A1 (fr) * | 1995-02-10 | 1996-08-15 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives de benzamidine et leur composition medicinale |
AU6318896A (en) * | 1995-07-06 | 1997-02-05 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
DE19524765A1 (de) * | 1995-07-07 | 1997-01-09 | Boehringer Mannheim Gmbh | Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
KR20000005117A (ko) * | 1996-03-30 | 2000-01-25 | 로셰 디아그노스틱스 게엠베하 | 신규한 옥사졸리딘 유도체, 이들의 제조 방법 및 이들을 함유하는 약제 |
NZ334389A (en) * | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
DE19652919A1 (de) * | 1996-12-19 | 1998-06-25 | Solvay Pharm Gmbh | Piperazinophenyl- und Piperazinophenyloxy-carbonsäure-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
AR013693A1 (es) * | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
RU2203887C2 (ru) | 1998-02-27 | 2003-05-10 | Санкио Компани, Лимитед | Циклические аминопроизводные, фармацевтическая композиция и способ профилактики заболевания |
CA2521621C (en) * | 2003-04-15 | 2011-11-01 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
US7777036B2 (en) | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
BRPI0515478A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase |
TW200626154A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
CA2598459A1 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity |
MX2007009949A (es) | 2005-02-16 | 2007-09-26 | Schering Corp | Pirazinil-piperazin-piperidinas sustituidas con heteroarilo con actividad antagonista de cxcr3. |
JP2008530220A (ja) * | 2005-02-16 | 2008-08-07 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する、ピラジニルで置換されたピペラジン−ピペリジン |
AU2006214378A1 (en) * | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity |
EP1858895B1 (en) * | 2005-02-16 | 2012-06-20 | Schering Corporation | Piperazine-piperidines with cxcr3 antagonist activity |
CA2598456A1 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Heterocyclic substituted piperazines with cxcr3 antagonist activity |
CN101208089A (zh) | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
EP1948629A1 (en) | 2005-10-31 | 2008-07-30 | Janssen Pharmaceutica N.V. | Substituted piperazines and piperidines as modulators of the neuropeptide y2 receptor |
WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
US9908851B2 (en) * | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
JP6458270B2 (ja) | 2013-08-16 | 2019-01-30 | デューク ユニバーシティ | 置換されたヒドロキサム酸化合物 |
WO2015024021A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
EP3760202A1 (en) | 2017-02-28 | 2021-01-06 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
US11040955B2 (en) | 2017-02-28 | 2021-06-22 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
US20200071322A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibiting (alpha-v)(beta-6) integrin |
CN113075343B (zh) * | 2020-01-04 | 2024-02-23 | 东莞市东阳光仿制药研发有限公司 | 一种羟胺及其盐的检测方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2500825B1 (fr) * | 1981-02-27 | 1985-08-23 | Torii & Co Ltd | Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant |
US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
PT84171B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem |
GB9122016D0 (en) * | 1991-10-16 | 1991-11-27 | Glaxo Group Ltd | Chemical compounds |
-
1993
- 1993-01-15 JP JP5512158A patent/JPH07503459A/ja active Pending
- 1993-01-15 AU AU33512/93A patent/AU3351293A/en not_active Abandoned
- 1993-01-15 WO PCT/EP1993/000100 patent/WO1993014077A1/en not_active Application Discontinuation
- 1993-01-15 EP EP93902223A patent/EP0623120A1/en not_active Withdrawn
- 1993-01-20 CN CN93102386A patent/CN1077953A/zh active Pending
- 1993-01-20 MX MX9300256A patent/MX9300256A/es unknown
- 1993-01-20 IL IL104446A patent/IL104446A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL104446A0 (en) | 1993-05-13 |
CN1077953A (zh) | 1993-11-03 |
EP0623120A1 (en) | 1994-11-09 |
JPH07503459A (ja) | 1995-04-13 |
WO1993014077A1 (en) | 1993-07-22 |
AU3351293A (en) | 1993-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9300256A (es) | Derivados de acido acetico y proceso para su preparacion. | |
ES410732A1 (es) | Procedimiento para la preparacion de derivados olefinicos de piperidino-4-sustituidos. | |
ES445659A1 (es) | Procedimiento para la obtencion de derivados olefinicos de amino acidos. | |
ES2055056T3 (es) | Derivados de pirimidopirimidina. | |
PT96890A (pt) | Processo para a preparacao de novos derivados com estrutura naftalenica e de composicoes farmaceuticas que os contem | |
PT90805A (pt) | Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contem | |
SE7501197L (es) | ||
ATE103592T1 (de) | Carbamoylpyrrolidonderivate, ihre verwendung und herstellung. | |
SE7908995L (sv) | Heterocykliska foreningar | |
IE40752B1 (en) | -aryl-4-substituted piperidinoalkanol derivatives | |
ES2036213T3 (es) | Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos. | |
GB1087243A (en) | Improvements in or relating to naphthalene derivatives and the manufacture thereof | |
BG60338B2 (en) | Thienothiazines | |
ES8601956A1 (es) | Un metodo para preparar derivados de 3-metilflavona | |
PT97766A (pt) | Processo depreparacao de derivados de isocromano e de composicoes farmaceuticas que os contem | |
ES461268A1 (es) | Procedimiento de preparacion de nuevos derivados de amino- benzociclohepteno. | |
NO871339D0 (no) | Fremgangsmaate for fremstilling av nye pyridinkarboksylsyrederivater. | |
NO885224D0 (no) | Fremgangsmte for fremstilling av 1,4-disubstituerte-piperidinylderivater. | |
AR031856A1 (es) | 2-aminoalquil-tieno[2,3-d]pirimidinas | |
ES543790A0 (es) | Procedimiento de preparacion de nuevos derivados a-etilami- noetoxibencilalcoholicos con un grupo fenil sustituido en situacion a y de sus sales de adicion acidas y amonicas cua-ternarias | |
SE7713968L (sv) | Basiskt alkylerade ditiosalicylsyraamider, sett for framstellning derav samt anvendning derav som lekemedel | |
MY107827A (en) | Isoquinolline compounds, compositions and use | |
SE8100122L (sv) | Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa | |
SE7713864L (sv) | Nortropinkarbazatderivat och forfarande for framstellning av dem | |
KR860004007A (ko) | 폴리사이클릭 화합물의 제조방법과 그 약학적제제 |