FR2500825B1 - Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant - Google Patents

Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant

Info

Publication number
FR2500825B1
FR2500825B1 FR8203258A FR8203258A FR2500825B1 FR 2500825 B1 FR2500825 B1 FR 2500825B1 FR 8203258 A FR8203258 A FR 8203258A FR 8203258 A FR8203258 A FR 8203258A FR 2500825 B1 FR2500825 B1 FR 2500825B1
Authority
FR
France
Prior art keywords
amidino
preparation
same
novel substituted
complement agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8203258A
Other languages
English (en)
Other versions
FR2500825A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii and Co Ltd
Original Assignee
Torii and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2797481A external-priority patent/JPS57142957A/ja
Priority claimed from JP14065081A external-priority patent/JPS5841855A/ja
Application filed by Torii and Co Ltd filed Critical Torii and Co Ltd
Publication of FR2500825A1 publication Critical patent/FR2500825A1/fr
Application granted granted Critical
Publication of FR2500825B1 publication Critical patent/FR2500825B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
FR8203258A 1981-02-27 1982-02-26 Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant Expired FR2500825B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2797481A JPS57142957A (en) 1981-02-27 1981-02-27 Ester derivative and anticomplementary agent
JP14065081A JPS5841855A (ja) 1981-09-07 1981-09-07 アミジン化合物

Publications (2)

Publication Number Publication Date
FR2500825A1 FR2500825A1 (fr) 1982-09-03
FR2500825B1 true FR2500825B1 (fr) 1985-08-23

Family

ID=26365984

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8203258A Expired FR2500825B1 (fr) 1981-02-27 1982-02-26 Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant

Country Status (4)

Country Link
US (2) US4514416A (fr)
DE (1) DE3207033C2 (fr)
FR (1) FR2500825B1 (fr)
GB (1) GB2095239B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101481332B (zh) * 2009-02-26 2012-08-29 南京华狮化工有限公司 一种烷氧基芳脒化合物的合成方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US5218137A (en) * 1989-08-29 1993-06-08 Duke University Light activated acyl-enzymes
CA2032420A1 (fr) * 1989-12-22 1991-06-23 Akira Okuyama Derives de la phenylguanidine
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
EP0542363A3 (en) * 1991-11-14 1993-07-14 Glaxo Group Limited Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
WO1993014077A1 (fr) * 1992-01-21 1993-07-22 Glaxo Group Limited Derives d'acide piperidineacetique servant d'inhibiteurs de l'agregation plaquettaire sanguine dependante du fibrinogene
US5302744A (en) * 1992-03-27 1994-04-12 Eastman Kodak Company Phenolic-hydrazide compounds and polyolefin compositions stabilized therewith
US5272162A (en) * 1992-07-02 1993-12-21 G. D. Searle & Co. Platelet aggregation inhibitors
JP2736952B2 (ja) * 1992-09-18 1998-04-08 小野薬品工業株式会社 アミジノフェノール誘導体およびその誘導体を有効成分として含有する薬剤
GB9301289D0 (en) * 1993-01-22 1993-03-17 Smithkline Beecham Plc Novel composition
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
ES2115887T3 (es) * 1993-12-03 1998-07-01 Ono Pharmaceutical Co Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2.
EP0893437A4 (fr) 1996-04-10 2000-12-27 Ono Pharmaceutical Co Inhibiteur de tryptase derives de guanidino
US6417200B1 (en) * 1997-06-26 2002-07-09 Eli Lilly And Company Antithrombotic agents
US6066673A (en) * 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
US6626938B1 (en) 2000-11-16 2003-09-30 Cordis Corporation Stent graft having a pleated graft member
US6887268B2 (en) * 1998-03-30 2005-05-03 Cordis Corporation Extension prosthesis for an arterial repair
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6376515B2 (en) * 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
WO2002004411A1 (fr) 2000-07-07 2002-01-17 The Administrators Of The Tulane Educational Fund Procedes servant a proteger un epithelium pavimenteux contre des lesions occasionnees par des substances nocives et nouveaux agents correspondants
US7314483B2 (en) * 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
PT2404906E (pt) 2006-11-02 2015-11-02 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
CN106831617A (zh) * 2017-01-17 2017-06-13 广州市闻皓生物科技有限公司 一种Selinexor中间体的合成工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD89611A (fr) *
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
JPS56110664A (en) * 1980-02-07 1981-09-01 Torii Yakuhin Kk Guanidinobenzoate and anticomplementary agent
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101481332B (zh) * 2009-02-26 2012-08-29 南京华狮化工有限公司 一种烷氧基芳脒化合物的合成方法

Also Published As

Publication number Publication date
DE3207033C2 (de) 1984-09-13
GB2095239A (en) 1982-09-29
DE3207033A1 (de) 1982-09-30
FR2500825A1 (fr) 1982-09-03
US4514416A (en) 1985-04-30
US4570006A (en) 1986-02-11
GB2095239B (en) 1985-03-06

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Legal Events

Date Code Title Description
ST Notification of lapse