ES2115887T3 - Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2. - Google Patents

Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2.

Info

Publication number
ES2115887T3
ES2115887T3 ES94308932T ES94308932T ES2115887T3 ES 2115887 T3 ES2115887 T3 ES 2115887T3 ES 94308932 T ES94308932 T ES 94308932T ES 94308932 T ES94308932 T ES 94308932T ES 2115887 T3 ES2115887 T3 ES 2115887T3
Authority
ES
Spain
Prior art keywords
formula
derivatives
phosfolipase
amidinofenoles
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94308932T
Other languages
English (en)
Inventor
Hisao Nakai
Koumei Kamiyasu
Masanori Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2115887T3 publication Critical patent/ES2115887T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

DERIVADOS DE AMIDINOFENOL DE LA FORMULA (I) Y SALES DE ADICION DE ACIDO DE ESTOS (EN LOS QUE R1 Y R2 SON ALQUILO, ALCOXI, ACILO, HALOGENO, NITRO BENZOILO, COOR4; A ES UN GRUPO ALQUILENO ENLAZADO DE LA FORMULA (II); R3 ES UN GRUPO DE LA FORMULA (III), (IV) TIENEN ACTIVIDADES INHIBITORIAS SOBRE FOSFOLIPASA A2 Y PROTEASAS (ESPECIALMENTE TRIPSINA), Y SON UTILES PARA LA PREVENCION Y/O EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, ENFERMEDADES ALERGICAS, COAGULACION INTRAVASCULAR DISEMINADA, PANCREATTIS, GRAVEDAD EN PACNCREATITIS Y FALLOS EN MULTIPLES ORGANOS.
ES94308932T 1993-12-03 1994-12-01 Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2. Expired - Lifetime ES2115887T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30404893 1993-12-03

Publications (1)

Publication Number Publication Date
ES2115887T3 true ES2115887T3 (es) 1998-07-01

Family

ID=17928422

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94308932T Expired - Lifetime ES2115887T3 (es) 1993-12-03 1994-12-01 Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2.

Country Status (10)

Country Link
US (1) US5514713A (es)
EP (1) EP0656349B1 (es)
KR (1) KR0185678B1 (es)
CN (1) CN1035998C (es)
AT (1) ATE164834T1 (es)
CA (1) CA2137106C (es)
DE (1) DE69409471T2 (es)
DK (1) DK0656349T3 (es)
ES (1) ES2115887T3 (es)
TW (1) TW419454B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE178589T1 (de) 1994-09-20 1999-04-15 Ono Pharmaceutical Co Amidinophenol-derivate als protease-hemmende verbindungen
WO1997037969A1 (fr) 1996-04-10 1997-10-16 Ono Pharmaceutical Co., Ltd. Inhibiteur de tryptase derives de guanidino
WO1998013347A1 (en) * 1996-09-26 1998-04-02 Novartis Ag Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
AU3731400A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
WO2000051625A1 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
EP2520654B8 (en) 2003-08-26 2017-04-19 The Regents of the University of Colorado, a body corporate Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
WO2006057152A1 (ja) * 2004-11-08 2006-06-01 Ono Pharmaceutical Co., Ltd. タンパク質分解酵素阻害化合物からなる糖尿病治療剤
US20100063146A1 (en) * 2006-11-07 2010-03-11 Medof M Edward Method for treating disorders related to complement activation
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
KR20120006059A (ko) * 2009-04-17 2012-01-17 메르츠 파마 게엠베하 운트 코. 카가아 1-아미노-1,3,3,5,5-펜타메틸사이클로헥산 메실레이트의 합성
CN102225903B (zh) * 2011-04-21 2014-11-26 任建东 脒基胍基取代芳杂环类化合物的合成方法及其用途
CN102491921A (zh) * 2011-12-13 2012-06-13 苏州瑞辉生物医药研发中心有限公司 一种4-胍基苯甲酸（4-甲氧甲酰基）苯酯甲烷磺酸盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (es) * 1956-03-21 1900-01-01
US3095355A (en) * 1961-10-12 1963-06-25 Revlon Aerosol composition
GB2095239B (en) * 1981-02-27 1985-03-06 Torii & Co Ltd Novel amidine compounds
JP3220225B2 (ja) * 1992-04-10 2001-10-22 小野薬品工業株式会社 グアニジノフェノール誘導体

Also Published As

Publication number Publication date
EP0656349B1 (en) 1998-04-08
CN1110679A (zh) 1995-10-25
DE69409471D1 (de) 1998-05-14
KR0185678B1 (ko) 1999-05-15
EP0656349A1 (en) 1995-06-07
TW419454B (en) 2001-01-21
CA2137106A1 (en) 1995-06-04
ATE164834T1 (de) 1998-04-15
KR950017929A (ko) 1995-07-20
US5514713A (en) 1996-05-07
CN1035998C (zh) 1997-10-01
DE69409471T2 (de) 1998-08-27
DK0656349T3 (da) 1998-06-02
CA2137106C (en) 2000-02-08

Similar Documents

Publication Publication Date Title
ES2115887T3 (es) Derivados de amidinofenoles con actividad de inhibidores de fosfolipasa a2.
ES2155069T3 (es) Inhibidores de proteasas retrovirales.
DE69526330D1 (de) Serin-protease-inhibitoren: derivate des isothiazolidin-3-on-1,1-dioxids und des 3-oxo-1,2,5-thiadiazolidin-1,1-dioxids
BR9707010A (pt) Derivados de aminoácidos sulfonados e inibidores de metalproteinase contendo os mesmos
DK0752987T3 (da) Pyrimidinylderivater som interleukininhibitorer
FI964317A (fi) Tekijän-Xa-inhibiittoreita
TR199901191T2 (xx) Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
CA2226256A1 (en) New thrombin inhibitors, their preparation and use
TR199701654T1 (xx) 4-Fenilaminotiyazol t�revleri.
FI915819A (fi) Hiv- proteas-inhibitorer.
ES2066033T3 (es) Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
SE9602646D0 (sv) Pharmaceutically-useful compounds
FI935172A0 (fi) Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad
NO983992L (no) Serinprotease inhibitorer
NO983991L (no) Serin-protease-inhibitorer
ATE147724T1 (de) Arylamidoalkyl- und arylaminoalkyl- n- hydroxyharnstoff- und n- hydroxyameisensäureamidderivate mit lipoxygenase inhibierenden aktivität
EE200100315A (et) Amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
DK0703216T3 (da) Amidinophenolderivater som proteaseinhibitorer
EP0466944A4 (en) 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same
ATE292682T1 (de) Serin-proteinase-inhibitoren
DE69307726T2 (de) Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer
ES2062332T3 (es) Benzoxazolonas antiinflamatorias.
IT1263041B (it) Derivati di s,s'-bis(carbossammidofenil)-disolfuro ad attivita' cardiovascolare

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 656349

Country of ref document: ES