ATE164834T1 - Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung - Google Patents

Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung

Info

Publication number
ATE164834T1
ATE164834T1 AT94308932T AT94308932T ATE164834T1 AT E164834 T1 ATE164834 T1 AT E164834T1 AT 94308932 T AT94308932 T AT 94308932T AT 94308932 T AT94308932 T AT 94308932T AT E164834 T1 ATE164834 T1 AT E164834T1
Authority
AT
Austria
Prior art keywords
phospholipase
formula
inhibitory effect
pancreatitis
chem
Prior art date
Application number
AT94308932T
Other languages
English (en)
Inventor
Hisao Nakai
Koumei Kamiyasu
Masanori Kawamura
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of ATE164834T1 publication Critical patent/ATE164834T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
AT94308932T 1993-12-03 1994-12-01 Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung ATE164834T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30404893 1993-12-03

Publications (1)

Publication Number Publication Date
ATE164834T1 true ATE164834T1 (de) 1998-04-15

Family

ID=17928422

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94308932T ATE164834T1 (de) 1993-12-03 1994-12-01 Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung

Country Status (10)

Country Link
US (1) US5514713A (de)
EP (1) EP0656349B1 (de)
KR (1) KR0185678B1 (de)
CN (1) CN1035998C (de)
AT (1) ATE164834T1 (de)
CA (1) CA2137106C (de)
DE (1) DE69409471T2 (de)
DK (1) DK0656349T3 (de)
ES (1) ES2115887T3 (de)
TW (1) TW419454B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69508875T2 (de) 1994-09-20 1999-09-16 Ono Pharmaceutical Co Amidinophenol-Derivate als Protease-hemmende Verbindungen
EP0893437A4 (de) * 1996-04-10 2000-12-27 Ono Pharmaceutical Co Tryptase-Inhibitor und Guanidino-Derivate
WO1998013347A1 (en) * 1996-09-26 1998-04-02 Novartis Ag Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
WO2000051623A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3864000A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
EP3192872A1 (de) 2003-08-26 2017-07-19 The Regents of the University of Colorado, a body corporate Inhibitoren der serinproteaseaktivität und deren verwendung in verfahren und zusammensetzungen zur behandlung bakterieller infektionen
US7671057B2 (en) * 2004-11-08 2010-03-02 Ono Pharmaceutical Co., Ltd. Therapeutic agent for type II diabetes comprising protease-inhibiting compound
WO2008058167A2 (en) * 2006-11-07 2008-05-15 Case Western Reserve University Method for treating disorders associated with complement activation
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
US8784847B2 (en) * 2009-04-17 2014-07-22 Merz Pharma Gmbh & Co. Kgaa Synthesis of 1-amino-1,3,3,5,5,-cyclohexane mesylate
CN102225903B (zh) * 2011-04-21 2014-11-26 任建东 脒基胍基取代芳杂环类化合物的合成方法及其用途
CN102491921A (zh) * 2011-12-13 2012-06-13 苏州瑞辉生物医药研发中心有限公司 一种4-胍基苯甲酸（4-甲氧甲酰基）苯酯甲烷磺酸盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (de) * 1956-03-21 1900-01-01
US3095355A (en) * 1961-10-12 1963-06-25 Revlon Aerosol composition
FR2500825B1 (fr) * 1981-02-27 1985-08-23 Torii & Co Ltd Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant
JP3220225B2 (ja) * 1992-04-10 2001-10-22 小野薬品工業株式会社 グアニジノフェノール誘導体

Also Published As

Publication number Publication date
KR950017929A (ko) 1995-07-20
CN1110679A (zh) 1995-10-25
TW419454B (en) 2001-01-21
CA2137106C (en) 2000-02-08
US5514713A (en) 1996-05-07
EP0656349A1 (de) 1995-06-07
KR0185678B1 (ko) 1999-05-15
DK0656349T3 (da) 1998-06-02
DE69409471T2 (de) 1998-08-27
CA2137106A1 (en) 1995-06-04
EP0656349B1 (de) 1998-04-08
CN1035998C (zh) 1997-10-01
ES2115887T3 (es) 1998-07-01
DE69409471D1 (de) 1998-05-14

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee