ATE229963T1 - Phosphinsäurederivate mit metallopeptidase- inhibitorischer wirkung - Google Patents
Phosphinsäurederivate mit metallopeptidase- inhibitorischer wirkungInfo
- Publication number
- ATE229963T1 ATE229963T1 AT96920784T AT96920784T ATE229963T1 AT E229963 T1 ATE229963 T1 AT E229963T1 AT 96920784 T AT96920784 T AT 96920784T AT 96920784 T AT96920784 T AT 96920784T AT E229963 T1 ATE229963 T1 AT E229963T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- inhibitory effect
- phosphinic acid
- metallopeptidase inhibitory
- metallopeptidase
- Prior art date
Links
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI001257A IT1276710B1 (it) | 1995-06-14 | 1995-06-14 | Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi |
| PCT/EP1996/002416 WO1997000261A1 (en) | 1995-06-14 | 1996-06-04 | Phosphinic acid derivatives with metallopeptidase inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229963T1 true ATE229963T1 (de) | 2003-01-15 |
Family
ID=11371809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920784T ATE229963T1 (de) | 1995-06-14 | 1996-06-04 | Phosphinsäurederivate mit metallopeptidase- inhibitorischer wirkung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5716943A (de) |
| EP (1) | EP0832085B1 (de) |
| JP (1) | JPH11507653A (de) |
| AT (1) | ATE229963T1 (de) |
| AU (1) | AU713081B2 (de) |
| CA (1) | CA2224555A1 (de) |
| DE (1) | DE69625482T2 (de) |
| DK (1) | DK0832085T3 (de) |
| ES (1) | ES2187656T3 (de) |
| IT (1) | IT1276710B1 (de) |
| WO (1) | WO1997000261A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777780B1 (fr) * | 1998-04-22 | 2001-05-04 | Inst Nat Sante Rech Med | Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent |
| FR2882752B1 (fr) * | 2005-03-01 | 2007-05-04 | Servier Lab | Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| EP2768822B1 (de) | 2011-10-21 | 2017-12-06 | Chiesi Farmaceutici S.p.A. | Derivate von 1-phenyl-2-pyridinyl-alkyl-alkoholen als phosphodiesterase inhibitoren |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
| US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
| US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
| IT1254521B (it) * | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
| IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
| US5476847A (en) * | 1994-06-29 | 1995-12-19 | Schering Corporation | Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors |
-
1995
- 1995-06-14 IT IT95MI001257A patent/IT1276710B1/it active IP Right Grant
-
1996
- 1996-06-04 WO PCT/EP1996/002416 patent/WO1997000261A1/en active IP Right Grant
- 1996-06-04 ES ES96920784T patent/ES2187656T3/es not_active Expired - Lifetime
- 1996-06-04 EP EP96920784A patent/EP0832085B1/de not_active Expired - Lifetime
- 1996-06-04 CA CA002224555A patent/CA2224555A1/en not_active Abandoned
- 1996-06-04 AT AT96920784T patent/ATE229963T1/de not_active IP Right Cessation
- 1996-06-04 AU AU62216/96A patent/AU713081B2/en not_active Ceased
- 1996-06-04 DE DE69625482T patent/DE69625482T2/de not_active Expired - Fee Related
- 1996-06-04 DK DK96920784T patent/DK0832085T3/da active
- 1996-06-04 JP JP9502578A patent/JPH11507653A/ja not_active Ceased
- 1996-06-06 US US08/671,149 patent/US5716943A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1276710B1 (it) | 1997-11-03 |
| ITMI951257A1 (it) | 1996-12-14 |
| DE69625482D1 (de) | 2003-01-30 |
| AU6221696A (en) | 1997-01-15 |
| DK0832085T3 (da) | 2003-04-22 |
| WO1997000261A1 (en) | 1997-01-03 |
| ES2187656T3 (es) | 2003-06-16 |
| DE69625482T2 (de) | 2003-10-30 |
| AU713081B2 (en) | 1999-11-25 |
| EP0832085A1 (de) | 1998-04-01 |
| EP0832085B1 (de) | 2002-12-18 |
| US5716943A (en) | 1998-02-10 |
| ITMI951257A0 (it) | 1995-06-14 |
| CA2224555A1 (en) | 1997-01-03 |
| JPH11507653A (ja) | 1999-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0832085 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |