DK0656349T3 - Amidinophenolderivater med inhiberende virkning på phospholipase A2 - Google Patents
Amidinophenolderivater med inhiberende virkning på phospholipase A2Info
- Publication number
- DK0656349T3 DK0656349T3 DK94308932.6T DK94308932T DK0656349T3 DK 0656349 T3 DK0656349 T3 DK 0656349T3 DK 94308932 T DK94308932 T DK 94308932T DK 0656349 T3 DK0656349 T3 DK 0656349T3
- Authority
- DK
- Denmark
- Prior art keywords
- phospholipase
- formula
- inhibitory effect
- pancreatitis
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30404893 | 1993-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0656349T3 true DK0656349T3 (da) | 1998-06-02 |
Family
ID=17928422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94308932.6T DK0656349T3 (da) | 1993-12-03 | 1994-12-01 | Amidinophenolderivater med inhiberende virkning på phospholipase A2 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5514713A (es) |
| EP (1) | EP0656349B1 (es) |
| KR (1) | KR0185678B1 (es) |
| CN (1) | CN1035998C (es) |
| AT (1) | ATE164834T1 (es) |
| CA (1) | CA2137106C (es) |
| DE (1) | DE69409471T2 (es) |
| DK (1) | DK0656349T3 (es) |
| ES (1) | ES2115887T3 (es) |
| TW (1) | TW419454B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0703216B1 (en) | 1994-09-20 | 1999-04-07 | Ono Pharmaceutical Co., Ltd. | Amidinophenol derivatives as protease inhibitors |
| WO1997037969A1 (fr) | 1996-04-10 | 1997-10-16 | Ono Pharmaceutical Co., Ltd. | Inhibiteur de tryptase derives de guanidino |
| EP0942903A1 (en) | 1996-09-26 | 1999-09-22 | Novartis AG | Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| US6489308B1 (en) | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| CA2536918A1 (en) | 2003-08-26 | 2005-03-03 | Leland Shapiro | Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules |
| US7671057B2 (en) * | 2004-11-08 | 2010-03-02 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for type II diabetes comprising protease-inhibiting compound |
| US20100063146A1 (en) * | 2006-11-07 | 2010-03-11 | Medof M Edward | Method for treating disorders related to complement activation |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| WO2010118889A1 (en) * | 2009-04-17 | 2010-10-21 | Merz Pharma Gmbh & Co. Kgaa | Synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate |
| CN102225903B (zh) * | 2011-04-21 | 2014-11-26 | 任建东 | 脒基胍基取代芳杂环类化合物的合成方法及其用途 |
| CN102491921A (zh) * | 2011-12-13 | 2012-06-13 | 苏州瑞辉生物医药研发中心有限公司 | 一种4-胍基苯甲酸（4-甲氧甲酰基）苯酯甲烷磺酸盐的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE555319A (es) * | 1956-03-21 | 1900-01-01 | ||
| US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| FR2500825B1 (fr) * | 1981-02-27 | 1985-08-23 | Torii & Co Ltd | Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant |
| JP3220225B2 (ja) * | 1992-04-10 | 2001-10-22 | 小野薬品工業株式会社 | グアニジノフェノール誘導体 |
-
1994
- 1994-12-01 AT AT94308932T patent/ATE164834T1/de not_active IP Right Cessation
- 1994-12-01 EP EP94308932A patent/EP0656349B1/en not_active Expired - Lifetime
- 1994-12-01 DK DK94308932.6T patent/DK0656349T3/da active
- 1994-12-01 DE DE69409471T patent/DE69409471T2/de not_active Expired - Fee Related
- 1994-12-01 CA CA002137106A patent/CA2137106C/en not_active Expired - Fee Related
- 1994-12-01 ES ES94308932T patent/ES2115887T3/es not_active Expired - Lifetime
- 1994-12-02 US US08/352,723 patent/US5514713A/en not_active Expired - Fee Related
- 1994-12-02 KR KR1019940032540A patent/KR0185678B1/ko not_active IP Right Cessation
- 1994-12-03 CN CN94112793A patent/CN1035998C/zh not_active Expired - Fee Related
- 1994-12-09 TW TW083111456A patent/TW419454B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69409471D1 (de) | 1998-05-14 |
| DE69409471T2 (de) | 1998-08-27 |
| CN1110679A (zh) | 1995-10-25 |
| KR950017929A (ko) | 1995-07-20 |
| TW419454B (en) | 2001-01-21 |
| CA2137106A1 (en) | 1995-06-04 |
| US5514713A (en) | 1996-05-07 |
| CN1035998C (zh) | 1997-10-01 |
| EP0656349B1 (en) | 1998-04-08 |
| KR0185678B1 (ko) | 1999-05-15 |
| ES2115887T3 (es) | 1998-07-01 |
| ATE164834T1 (de) | 1998-04-15 |
| CA2137106C (en) | 2000-02-08 |
| EP0656349A1 (en) | 1995-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0656349T3 (da) | Amidinophenolderivater med inhiberende virkning på phospholipase A2 | |
| DE69329996D1 (de) | Inhibitoren retroviraler proteasen | |
| ATE196761T1 (de) | Inhibitoren retroviraler proteasen | |
| CA2180954A1 (en) | Inhibitors of human plasmin derived from the kunitz domains | |
| DE69526330D1 (de) | Serin-protease-inhibitoren: derivate des isothiazolidin-3-on-1,1-dioxids und des 3-oxo-1,2,5-thiadiazolidin-1,1-dioxids | |
| ATE382041T1 (de) | Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen | |
| TR199902060T2 (xx) | Gastrik asit salg�lanmas�n�n inhibisyonu i�in bile�ikler. | |
| FI964317A0 (fi) | Tekijän-Xa-inhibiittoreita | |
| FI915819A (fi) | Hiv- proteas-inhibitorer. | |
| TR200000059T2 (tr) | Piridin türevleri | |
| CA2226256A1 (en) | New thrombin inhibitors, their preparation and use | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| FI935172A0 (fi) | Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad | |
| SE9602263D0 (sv) | New amino acid derivatives | |
| KR940006993A (ko) | 아미디노페놀 유도체, 이의 제조방법 및 이를 함유하는 제약학적 조성물 | |
| DK0436199T3 (da) | Cyklopropylderivatlipoxygenaseinhibitorer | |
| ATE147724T1 (de) | Arylamidoalkyl- und arylaminoalkyl- n- hydroxyharnstoff- und n- hydroxyameisensäureamidderivate mit lipoxygenase inhibierenden aktivität | |
| TR200000907T2 (tr) | Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri. | |
| DK0703216T3 (da) | Amidinophenolderivater som proteaseinhibitorer | |
| NO964269L (no) | 2,3-dihydroksypropyl 2-(1-oksoalkyl)amino-2-deoksogluco-pyranosider, deres fremstilling og anvendelse | |
| DE68906965D1 (de) | Analgetische phenothiazinderivate. | |
| EP0466944A4 (en) | 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same | |
| AU5056690A (en) | Anti-inflammatory 6-substituted amino benzoxazolin-2-one derivatives | |
| FI963645A0 (fi) | Silmänpainetta alentava aine | |
| ES2117558B1 (es) | Composicion oftalmica topica que comprende un derivado de 2-(4-(azolilbutil)-piperazinil-metil)-benzimidazol, principalmente para el tratamiento de la conjuntivitis alergica. |