DE69329996D1 - Inhibitoren retroviraler proteasen - Google Patents

Inhibitoren retroviraler proteasen

Info

Publication number
DE69329996D1
DE69329996D1 DE69329996T DE69329996T DE69329996D1 DE 69329996 D1 DE69329996 D1 DE 69329996D1 DE 69329996 T DE69329996 T DE 69329996T DE 69329996 T DE69329996 T DE 69329996T DE 69329996 D1 DE69329996 D1 DE 69329996D1
Authority
DE
Germany
Prior art keywords
inhibitors
retroviral proteases
chem
retroviral
proteases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69329996T
Other languages
English (en)
Other versions
DE69329996T2 (de
Inventor
Michael Clare
Anthony Decrescenzo
Nicholas Freskos
Paul Getman
Martin Heintz
Ko-Chung Lin
August Mueller
Lea Reed
Joseph Rogier
Jeffrey Talley
Lawrence Vazquez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE69329996D1 publication Critical patent/DE69329996D1/de
Publication of DE69329996T2 publication Critical patent/DE69329996T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69329996T 1992-05-21 1993-05-04 Inhibitoren retroviraler proteasen Expired - Fee Related DE69329996T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88670092A 1992-05-21 1992-05-21
PCT/US1993/004208 WO1993023379A1 (en) 1992-05-21 1993-05-04 Retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
DE69329996D1 true DE69329996D1 (de) 2001-04-12
DE69329996T2 DE69329996T2 (de) 2001-09-06

Family

ID=25389564

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329996T Expired - Fee Related DE69329996T2 (de) 1992-05-21 1993-05-04 Inhibitoren retroviraler proteasen

Country Status (11)

Country Link
US (10) US5648364A (de)
EP (4) EP0641325B1 (de)
JP (1) JPH07508020A (de)
AT (1) ATE199545T1 (de)
AU (1) AU667376B2 (de)
CA (1) CA2136312A1 (de)
DE (1) DE69329996T2 (de)
DK (1) DK0641325T3 (de)
ES (1) ES2155069T3 (de)
GR (1) GR3035526T3 (de)
WO (1) WO1993023379A1 (de)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
EP0565631B1 (de) * 1991-01-02 1996-09-18 Merrell Pharmaceuticals Inc. Antivirale verbindungen
ATE199545T1 (de) * 1992-05-21 2001-03-15 Monsanto Co Inhibitoren retroviraler proteasen
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU680009B2 (en) * 1993-07-08 1997-07-17 Aventisub Ii Inc. Difluoro statone analogs
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
US5587514A (en) * 1993-11-08 1996-12-24 Emory University Diastereoselective synthesis of hydroxyethylene dipeptide isosteres
DE69512220T2 (de) * 1994-03-07 2000-03-16 Vertex Pharmaceuticals Inc. Sulfonamidderivate als aspartylprotease-inhibitoren
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JP4014220B2 (ja) 1995-01-20 2007-11-28 ジー．ディー．サール アンド カンパニー ビス−スルホンアミドヒドロキシエチルアミノ レトロ ウイルスプロテアーゼインヒビター
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
DK1086076T3 (da) 1998-06-19 2005-03-29 Vertex Pharma Sulfonamidinhibitorer af aspartylprotease
EP1095022A1 (de) 1998-07-08 2001-05-02 G.D. Searle & Co. Inhibitoren von retoviraler protease
AU5221699A (en) * 1998-07-31 2000-02-21 Surx, Inc. Limited heat transfer devices and methods to shrink tissues
CZ299699B6 (cs) * 1998-12-14 2008-10-22 Sk Corporation Zpusob výroby [3S-(3alfa, 4alfabeta, 8alfabeta)]-N-terc-butyl-dekahydro-3-izochinolinkarboxamidu s vysokým optickým výtežkem
KR100277723B1 (ko) * 1998-12-14 2001-01-15 남창우 광학적으로 순수한 데카하이드로이소퀴놀린카르복사미드의 연속제조공정
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

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EP0104041B1 (de) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Enzyminhibitoren
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Also Published As

Publication number Publication date
GR3035526T3 (en) 2001-06-29
AU667376B2 (en) 1996-03-21
DE69329996T2 (de) 2001-09-06
US5648364A (en) 1997-07-15
US5643924A (en) 1997-07-01
EP0957093A3 (de) 2000-04-12
US7312333B2 (en) 2007-12-25
US6762187B2 (en) 2004-07-13
US5948790A (en) 1999-09-07
US20080103311A1 (en) 2008-05-01
US20030195227A1 (en) 2003-10-16
US20060166895A1 (en) 2006-07-27
JPH07508020A (ja) 1995-09-07
ATE199545T1 (de) 2001-03-15
WO1993023379A1 (en) 1993-11-25
EP0641325B1 (de) 2001-03-07
US5756534A (en) 1998-05-26
US6506759B1 (en) 2003-01-14
US20050004230A1 (en) 2005-01-06
CA2136312A1 (en) 1993-11-25
US6180646B1 (en) 2001-01-30
EP0957093A2 (de) 1999-11-17
US7026485B2 (en) 2006-04-11
EP0641325A1 (de) 1995-03-08
DK0641325T3 (da) 2001-04-17
ES2155069T3 (es) 2001-05-01
AU4232793A (en) 1993-12-13
EP1148050A1 (de) 2001-10-24
EP1447398A1 (de) 2004-08-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee