DE69512220T2 - Sulfonamidderivate als aspartylprotease-inhibitoren - Google Patents
Sulfonamidderivate als aspartylprotease-inhibitorenInfo
- Publication number
- DE69512220T2 DE69512220T2 DE69512220T DE69512220T DE69512220T2 DE 69512220 T2 DE69512220 T2 DE 69512220T2 DE 69512220 T DE69512220 T DE 69512220T DE 69512220 T DE69512220 T DE 69512220T DE 69512220 T2 DE69512220 T2 DE 69512220T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- hiv
- compounds
- aspartyl protease
- protease inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/82—Amides; Imides in position 3
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- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/88—Nitrogen atoms, e.g. allantoin
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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US20758094A | 1994-03-07 | 1994-03-07 | |
PCT/US1995/002420 WO1995024385A1 (en) | 1994-03-07 | 1995-02-24 | Sulphonamide derivatives as aspartyl protease inhibitors |
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DE69512220D1 DE69512220D1 (en) | 1999-10-21 |
DE69512220T2 true DE69512220T2 (de) | 2000-03-16 |
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DE69512220T Expired - Lifetime DE69512220T2 (de) | 1994-03-07 | 1995-02-24 | Sulfonamidderivate als aspartylprotease-inhibitoren |
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US (1) | US6127372A (de) |
EP (1) | EP0749421B1 (de) |
JP (1) | JPH10500938A (de) |
CN (1) | CN1146201A (de) |
AT (1) | ATE184594T1 (de) |
AU (1) | AU699483B2 (de) |
CA (1) | CA2183653A1 (de) |
DE (1) | DE69512220T2 (de) |
DK (1) | DK0749421T3 (de) |
ES (1) | ES2139195T3 (de) |
GR (1) | GR3032151T3 (de) |
HK (1) | HK1012622A1 (de) |
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MX (1) | MX9603909A (de) |
WO (1) | WO1995024385A1 (de) |
ZA (1) | ZA951688B (de) |
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-
1995
- 1995-02-24 EP EP95911960A patent/EP0749421B1/de not_active Expired - Lifetime
- 1995-02-24 WO PCT/US1995/002420 patent/WO1995024385A1/en active IP Right Grant
- 1995-02-24 US US08/424,372 patent/US6127372A/en not_active Expired - Lifetime
- 1995-02-24 DK DK95911960T patent/DK0749421T3/da active
- 1995-02-24 MX MX9603909A patent/MX9603909A/es unknown
- 1995-02-24 CA CA002183653A patent/CA2183653A1/en not_active Abandoned
- 1995-02-24 JP JP7523497A patent/JPH10500938A/ja active Pending
- 1995-02-24 AT AT95911960T patent/ATE184594T1/de active
- 1995-02-24 CN CN95192473A patent/CN1146201A/zh active Pending
- 1995-02-24 ES ES95911960T patent/ES2139195T3/es not_active Expired - Lifetime
- 1995-02-24 DE DE69512220T patent/DE69512220T2/de not_active Expired - Lifetime
- 1995-02-24 AU AU19332/95A patent/AU699483B2/en not_active Expired
- 1995-03-01 IL IL11284195A patent/IL112841A0/xx unknown
- 1995-03-01 ZA ZA951688A patent/ZA951688B/xx unknown
-
1998
- 1998-12-17 HK HK98113972A patent/HK1012622A1/xx not_active IP Right Cessation
-
1999
- 1999-12-15 GR GR990403237T patent/GR3032151T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA951688B (en) | 1995-12-11 |
ES2139195T3 (es) | 2000-02-01 |
WO1995024385A1 (en) | 1995-09-14 |
AU1933295A (en) | 1995-09-25 |
AU699483B2 (en) | 1998-12-03 |
CA2183653A1 (en) | 1995-09-14 |
MX9603909A (es) | 1997-03-29 |
GR3032151T3 (en) | 2000-04-27 |
JPH10500938A (ja) | 1998-01-27 |
CN1146201A (zh) | 1997-03-26 |
DE69512220D1 (en) | 1999-10-21 |
US6127372A (en) | 2000-10-03 |
DK0749421T3 (da) | 2000-03-20 |
ATE184594T1 (de) | 1999-10-15 |
HK1012622A1 (en) | 1999-08-06 |
EP0749421A1 (de) | 1996-12-27 |
IL112841A0 (en) | 1995-06-29 |
EP0749421B1 (de) | 1999-09-15 |
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Legal Events
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8364 | No opposition during term of opposition |