JPS57142957A - Ester derivative and anticomplementary agent - Google Patents

Ester derivative and anticomplementary agent

Info

Publication number
JPS57142957A
JPS57142957A JP2797481A JP2797481A JPS57142957A JP S57142957 A JPS57142957 A JP S57142957A JP 2797481 A JP2797481 A JP 2797481A JP 2797481 A JP2797481 A JP 2797481A JP S57142957 A JPS57142957 A JP S57142957A
Authority
JP
Japan
Prior art keywords
amidino
compound
anticomplementary
agent
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2797481A
Other languages
Japanese (ja)
Other versions
JPS6360739B2 (en
Inventor
Setsuo Fujii
Takashi Yaegashi
Toyoo Nakayama
Yojiro Sakurai
Shigeki Nunomura
Toshiyuki Okutome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP2797481A priority Critical patent/JPS57142957A/en
Priority to GB8205699A priority patent/GB2095239B/en
Priority to FR8203258A priority patent/FR2500825B1/en
Priority to DE3207033A priority patent/DE3207033C2/en
Publication of JPS57142957A publication Critical patent/JPS57142957A/en
Priority to US06/611,937 priority patent/US4514416A/en
Priority to US06/664,261 priority patent/US4570006A/en
Publication of JPS6360739B2 publication Critical patent/JPS6360739B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(R is H or guanidino group of formulaII) and an acid addition salt thereof.
EXAMPLE: 4-Amidino-2-benzoylophenyl benzoate methanesulfonate.
USE: An antitrypsin, antiplasmin, anticallicrein and antithrombin agents.
PROCESS: A benzoic acid derivative of formula III or a reactive intermediate thereof is reacted with a novel 4-amidino-2-benzoylphenol of formula IV to give the compound of formulaI. 4'-Amidino-2'-benzoylphenyl-4-guanidinobenzoate methanesulfonate salt in the compound of formulaIhas a high water solubility and is usable as an oral and injection agents.
COPYRIGHT: (C)1982,JPO&Japio
JP2797481A 1981-02-27 1981-02-27 Ester derivative and anticomplementary agent Granted JPS57142957A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2797481A JPS57142957A (en) 1981-02-27 1981-02-27 Ester derivative and anticomplementary agent
GB8205699A GB2095239B (en) 1981-02-27 1982-02-26 Novel amidine compounds
FR8203258A FR2500825B1 (en) 1981-02-27 1982-02-26 NOVEL SUBSTITUTED 4-AMIDINO-PHENYL CARBOXYLATE, PREPARATION METHOD THEREOF AND ANTI-COMPLEMENT AGENT COMPRISING SAME
DE3207033A DE3207033C2 (en) 1981-02-27 1982-02-26 Amidine compounds, processes for their preparation and pharmaceutical compositions containing these compounds
US06/611,937 US4514416A (en) 1981-02-27 1984-05-21 Amidine compound, process for producing same and anti-complement agent comprising same
US06/664,261 US4570006A (en) 1981-02-27 1984-10-24 Amidine compound, process for producing same and anti-complement agent comprising same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2797481A JPS57142957A (en) 1981-02-27 1981-02-27 Ester derivative and anticomplementary agent

Publications (2)

Publication Number Publication Date
JPS57142957A true JPS57142957A (en) 1982-09-03
JPS6360739B2 JPS6360739B2 (en) 1988-11-25

Family

ID=12235840

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2797481A Granted JPS57142957A (en) 1981-02-27 1981-02-27 Ester derivative and anticomplementary agent

Country Status (1)

Country Link
JP (1) JPS57142957A (en)

Also Published As

Publication number Publication date
JPS6360739B2 (en) 1988-11-25

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