ES2162989T3 - Nuevos derivados de la piperazina, de la piperidina y de la 1,2,5,6-tetrahidro-piridina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de la piperazina, de la piperidina y de la 1,2,5,6-tetrahidro-piridina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2162989T3
ES2162989T3 ES96401156T ES96401156T ES2162989T3 ES 2162989 T3 ES2162989 T3 ES 2162989T3 ES 96401156 T ES96401156 T ES 96401156T ES 96401156 T ES96401156 T ES 96401156T ES 2162989 T3 ES2162989 T3 ES 2162989T3
Authority
ES
Spain
Prior art keywords
piperazine
piperidine
piridina
tetrahidro
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96401156T
Other languages
English (en)
Inventor
Jean-Louis Peglion
Aimee Dessinges
Bertrand Goument
Mark Millan
Adrian Newman-Tancredi
Alain Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2162989T3 publication Critical patent/ES2162989T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS COMPUESTOS DE FORMULA I: E LA QUE A-B REPRESENTA: CH SUB,2}CH, CH=C 0 CH{SUB,2}-N, N REPRESENTA CERO O UN NUMERO ENTERO DE 1 A 6 INCLUIDOS, D REPRESENTA UNO DE LOS SIGUIENTES SISTEMAS BICICLICOS: EN LOS QUE R{SUB,1} Y R{SUB,2} IDENTICOS O DIFERENTES, REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO O DE HALOGENO, UN RADICAL ALQUILO O ALCOXI EN CADENA RECTA O RAMIFICADA QUE TIENE DE 1 A 5 ATOMOS DE CARBONO INCLUIDOS O UN RADICAL HIDROXI; Y E REPRESENTA UNO DE LOS SIGUIENTES HETEROCICLOS: SUS FORMAS DE MEZCLA RACEMICA O RACEMATO Y DE ISOMEROS OPTICOS O ENANTIOMEROS, - ASI COMO SUS SALES CON ACIDOS FARMACEUTICAMENTE ACEPTABLE. LOS PRODUCTOS DE LA INVENCION PUEDE UTILIZARSE EN APLICACION TERAPEUTICA.
ES96401156T 1995-05-31 1996-05-30 Nuevos derivados de la piperazina, de la piperidina y de la 1,2,5,6-tetrahidro-piridina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2162989T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506436A FR2734819B1 (fr) 1995-05-31 1995-05-31 Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
ES2162989T3 true ES2162989T3 (es) 2002-01-16

Family

ID=9479526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96401156T Expired - Lifetime ES2162989T3 (es) 1995-05-31 1996-05-30 Nuevos derivados de la piperazina, de la piperidina y de la 1,2,5,6-tetrahidro-piridina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (16)

Country Link
US (2) US5753662A (es)
EP (1) EP0745598B1 (es)
JP (1) JPH08325257A (es)
CN (1) CN1064356C (es)
AT (1) ATE204574T1 (es)
AU (1) AU705374B2 (es)
CA (1) CA2177774C (es)
DE (1) DE69614608T2 (es)
DK (1) DK0745598T3 (es)
ES (1) ES2162989T3 (es)
FR (1) FR2734819B1 (es)
GR (1) GR3037040T3 (es)
NO (1) NO314185B1 (es)
NZ (1) NZ286698A (es)
PT (1) PT745598E (es)
ZA (1) ZA964485B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19637237A1 (de) 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US6436940B2 (en) 1996-12-20 2002-08-20 H. Lundbeck A/S Indane or dihydroindole derivatives
JP2001506657A (ja) * 1996-12-20 2001-05-22 ハー・ルンドベック・アクティーゼルスカブ インダン−又はジヒドロインドール誘導体
WO1998031679A1 (fr) * 1997-01-21 1998-07-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thiophene et leur application medicinale
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2763589B1 (fr) * 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2241172T3 (es) * 1997-10-24 2005-10-16 Neurogen Corporation 1-(2-naftil) y 1-(2-azanaftil)-4-(1-fenilmetil)piperazinas que son ligandos del subtipo de receptor de dopamina d4.
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
US6281216B1 (en) 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
WO1999047513A1 (en) * 1998-03-18 1999-09-23 Taisho Pharmaceutical Co., Ltd. Heteroaromatic derivatives
US6407121B1 (en) 1998-03-19 2002-06-18 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
EP0953567A3 (en) * 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
US6177566B1 (en) * 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
PT2266968E (pt) 2001-07-16 2013-02-25 Genzyme Corp Síntese de udp-glucose: inibidores de n-acil esfingosinaglucosiltransferase
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
US7105513B2 (en) * 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US6960611B2 (en) 2002-09-16 2005-11-01 Institute Of Materia Medica Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE532767T1 (de) * 2006-04-06 2011-11-15 Basf Se Verfahren zur herstellung eines nn-alkyl-lactams mit verbesserter farbqualität
KR20110086869A (ko) * 2008-11-24 2011-08-01 바스프 에스이 개선된 색 품질을 갖는 ｎ-알킬락탐의 제조 방법
WO2010063617A1 (de) 2008-12-04 2010-06-10 Basf Se Mischungen aus itaconsäure oder itaconsäurederivaten und primären aminen zur herstellung von 1,3- und 1,4-alkylmethylpyrrolidonen
WO2010084089A1 (en) 2009-01-22 2010-07-29 Basf Se Mixtures of pvdf, n-alkyllactams and organic carbonate and their applications
US8369001B2 (en) * 2009-07-17 2013-02-05 The United States Of America, As Represented By The Secretary Of The Navy Compact high power terahertz radiation cell
SI2796457T1 (sl) 2009-11-27 2016-10-28 Genzyme Corporation Genz 112638 za zdravljenje Gaucherjeve ali Fabryjeve bolezni v kombinirani terapiji
KR101855471B1 (ko) 2009-12-04 2018-05-09 선오비온 파마슈티컬스 인코포레이티드 다환형 화합물 및 이의 사용 방법
SG11201900687VA (en) 2016-07-29 2019-02-27 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
UA125519C2 (uk) 2016-07-29 2022-04-13 Суновіон Фармасьютікалз Інк. Сполуки і композиції і їх застосування
JP7146782B2 (ja) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク 統合失調症を処置する方法
CA3070993A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
SG11202007823PA (en) 2018-02-16 2020-09-29 Sunovion Pharmaceuticals Inc Salts, crystal forms, and production methods thereof
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
IL297248A (en) 2020-04-14 2022-12-01 Sunovion Pharmaceuticals Inc (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3377347A (en) * 1963-06-14 1968-04-09 Ciba Geigy Corp Cyclobutene derivatives
DE2037852C3 (de) * 1970-07-30 1980-06-26 Boehringer Sohn Ingelheim Neue Piperazinderivate und Verfahren zu ihrer Herstellung
US3859438A (en) * 1971-07-08 1975-01-07 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl-2)-n-bicyclic aryl-piperazine and method of use
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DE4321366A1 (de) * 1993-06-26 1995-01-05 Merck Patent Gmbh Piperidine und Piperazine

Also Published As

Publication number Publication date
ATE204574T1 (de) 2001-09-15
EP0745598B1 (fr) 2001-08-22
US5753662A (en) 1998-05-19
ZA964485B (en) 1996-12-12
PT745598E (pt) 2001-11-30
AU705374B2 (en) 1999-05-20
CN1064356C (zh) 2001-04-11
NZ286698A (en) 1998-02-26
NO962210L (no) 1996-12-02
DE69614608T2 (de) 2002-07-04
GR3037040T3 (en) 2002-01-31
CA2177774A1 (fr) 1996-12-01
US5684020A (en) 1997-11-04
NO962210D0 (no) 1996-05-30
FR2734819B1 (fr) 1997-07-04
AU5455896A (en) 1996-12-12
EP0745598A1 (fr) 1996-12-04
DE69614608D1 (de) 2001-09-27
CN1142494A (zh) 1997-02-12
NO314185B1 (no) 2003-02-10
DK0745598T3 (da) 2001-10-08
FR2734819A1 (fr) 1996-12-06
JPH08325257A (ja) 1996-12-10
CA2177774C (fr) 2001-07-24

Similar Documents

Publication Publication Date Title
ES2162989T3 (es) Nuevos derivados de la piperazina, de la piperidina y de la 1,2,5,6-tetrahidro-piridina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK0481522T3 (da) Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE
ITMI921203A1 (it) Derivati di s-triazina come agenti fotostabilizzanti
MX9207074A (es) Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende
ES2179823T3 (es) Inmunosupresor macrolido.
ES2071510T3 (es) Derivados de pirrolidina y de tiazolidina, su preparacion y los medicamentos que les contienen.
DK0491664T3 (da) Indolderivater som serotonin-antagonister
DK0444659T3 (da) Farmaceutisk opløsning indeholdende derivater af FK 506
ES2147907T3 (es) Nuevos acidos y esteres 2,2-dimetil-omega-fenoxi-alcanoicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2091310T3 (es) Nuevos derivados de la n-benzoil-prolina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
MX9203360A (es) Derivados de hexahidroazepinas y composiciones farmaceuticas que los contienen.
ES2098109T3 (es) Derivados de 1,2,3,4-tetrahidronaftaleno, de cromano y de tiocromano como agentes antitromboticos.
NO954609L (no) Niopecotiske syrederivater som antitrombiske forbindelser
ES2043863T3 (es) Procedimiento para preparar derivados de la 1,2,5,6-tetrahidropiridina.
ES2071458T3 (es) Nuevos compuestos amidicos de 1-(alcoxi-bencil)-piperacinas, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2077473T3 (es) Nuevos compuestos tiocromanicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DE68902490T2 (de) Pharmazeutische zusammensetzung.
PT916671E (pt) Novos inibidores de metaloproteases processo para a sua preparacao e as suas composicoes farmaceuticas que os contem
ES2189108T3 (es) Nuevas oxazinas dissustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
ES2098517T3 (es) Derivados de 1,2,4-tiadiazino(3,4-b)benzotiazol, su preparacion y los medicamentos que los contienen.
ES2095714T3 (es) Nuevas amino-alquil-cromonas, sus procedimientos de preparacion y las composiciones farmaceuticas que las contienen.
DK0468445T3 (da) Fremgangsmåde til fremstilling af 6-(substitueret aminopropionyl)-derivater af forskolin
ES2067461T3 (es) Derivados isoprenoides y agentes anti-ulcerosos que contienen los mismos.
ES2123038T3 (es) Nuevos derivados pirrolo-tieno-pirazinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DK0763516T3 (da) Fremstilling og anvendelse af rene enantiomerer af 8-halogen-6-hydroxyoctansyrer, deres alkylestere og deres salte med rene enantiomerer af alfa-methylbenzylamin

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 745598

Country of ref document: ES