DK0491664T3 - Indolderivater som serotonin-antagonister - Google Patents
Indolderivater som serotonin-antagonisterInfo
- Publication number
- DK0491664T3 DK0491664T3 DK91810981T DK91810981T DK0491664T3 DK 0491664 T3 DK0491664 T3 DK 0491664T3 DK 91810981 T DK91810981 T DK 91810981T DK 91810981 T DK91810981 T DK 91810981T DK 0491664 T3 DK0491664 T3 DK 0491664T3
- Authority
- DK
- Denmark
- Prior art keywords
- indole derivatives
- serotonin antagonists
- serotonin
- antagonists
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909027424A GB9027424D0 (en) | 1990-12-18 | 1990-12-18 | Improvements in or relating to organic compounds |
GB909027425A GB9027425D0 (en) | 1990-12-18 | 1990-12-18 | Improvements in or relating to organic compounds |
GB919113596A GB9113596D0 (en) | 1991-06-24 | 1991-06-24 | Improvements in or relating to organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0491664T3 true DK0491664T3 (da) | 1998-09-28 |
Family
ID=27265408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91810981T DK0491664T3 (da) | 1990-12-18 | 1991-12-16 | Indolderivater som serotonin-antagonister |
Country Status (22)
Country | Link |
---|---|
US (2) | US5272154A (da) |
EP (1) | EP0491664B1 (da) |
JP (1) | JP2740777B2 (da) |
KR (1) | KR920011489A (da) |
AT (1) | ATE163648T1 (da) |
AU (1) | AU651640B2 (da) |
CA (1) | CA2057391A1 (da) |
CZ (1) | CZ280647B6 (da) |
DE (1) | DE69129009T2 (da) |
DK (1) | DK0491664T3 (da) |
ES (1) | ES2113368T3 (da) |
FI (1) | FI102069B (da) |
GR (1) | GR3026506T3 (da) |
HU (1) | HU211081B (da) |
IE (1) | IE914387A1 (da) |
IL (1) | IL100384A (da) |
MX (1) | MX9102582A (da) |
MY (1) | MY109983A (da) |
NZ (1) | NZ240993A (da) |
PT (1) | PT99829B (da) |
SG (1) | SG47026A1 (da) |
SK (1) | SK278597B6 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69111816D1 (de) * | 1990-08-31 | 1995-09-07 | Nippon Shinyaku Co Ltd | Indolederivate und ihre verwendung als serotonin-antagoniste. |
IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
CA2460075A1 (en) * | 2001-09-12 | 2003-03-20 | Donn Gregory Wishka | Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases |
BR0213612A (pt) | 2001-10-02 | 2004-08-24 | Upjohn Co | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
EP1448557A4 (en) * | 2001-10-26 | 2005-02-02 | Univ Connecticut | HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS |
EP1442037A1 (en) | 2001-11-09 | 2004-08-04 | PHARMACIA & UPJOHN COMPANY | Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands |
CA2476681A1 (en) * | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
AU2003217275A1 (en) * | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclic compounds for the treatment of disease |
RU2391341C2 (ru) | 2002-09-25 | 2010-06-10 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, их получение и применение |
AU2003269401A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases |
PT1697378E (pt) * | 2003-12-22 | 2008-02-28 | Memory Pharm Corp | Indoles, 1h-indazoles, 1,2-benzisoxazoles e 1,2-benzisotiazoles, sua preparação e utilizações |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
NZ550534A (en) | 2004-03-25 | 2009-07-31 | Memory Pharm Corp | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
EP1745046B1 (en) * | 2004-05-07 | 2011-04-13 | Memory Pharmaceuticals Corporation | 1 h-indazoles, benzothiazoles, 1,2-benziosoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
EP1807422B1 (en) * | 2004-11-05 | 2009-09-02 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
US7396933B2 (en) * | 2004-11-05 | 2008-07-08 | Theravance, Inc. | Quinolinone-carboxamide compounds |
ATE469897T1 (de) * | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
AU2005319248A1 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
BRPI0608392A2 (pt) * | 2005-03-02 | 2009-12-29 | Theravance Inc | compostos de quinolinona como agonistas do receptor 5-ht4 |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
WO2009046025A1 (en) * | 2007-10-01 | 2009-04-09 | Comentis, Inc. | Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
JOP20130213B1 (ar) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
WO2016007630A1 (en) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
JP7055017B2 (ja) | 2014-09-29 | 2022-04-15 | 武田薬品工業株式会社 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
DE3587151T2 (de) * | 1984-12-20 | 1993-07-15 | Sandoz Ag | Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten. |
EP0200444B1 (en) * | 1985-04-27 | 1992-11-11 | Beecham Group Plc | Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
US4859662A (en) * | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
DE3788057T2 (de) * | 1986-12-17 | 1994-03-03 | Glaxo Group Ltd | Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen. |
DE3752062T2 (de) * | 1986-12-17 | 1997-09-11 | Glaxo Group Ltd | Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln |
GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
JPH01258673A (ja) * | 1987-10-22 | 1989-10-16 | Glaxo Group Ltd | ケトン誘導体 |
AU616706B2 (en) * | 1987-11-14 | 1991-11-07 | Beecham Group Plc | 5-ht3 receptor antagonists for treatment of cough and bronchoconstriction |
DE3810552A1 (de) * | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
DK185489A (da) * | 1988-04-22 | 1989-10-23 | Duphar Int Res | Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse |
US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
GB8814277D0 (en) * | 1988-06-16 | 1988-07-20 | Glaxo Group Ltd | Chemical compounds |
NZ230154A (en) * | 1988-08-02 | 1991-10-25 | Glaxo Group Ltd | Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition |
FR2639944B1 (fr) * | 1988-12-06 | 1991-01-18 | Adir | Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
NZ233285A (en) * | 1989-04-18 | 1992-06-25 | Duphar Int Res | Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions |
GB8916682D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Pharmaceutical compounds |
-
1991
- 1991-12-04 HU HU913792A patent/HU211081B/hu not_active IP Right Cessation
- 1991-12-16 DE DE69129009T patent/DE69129009T2/de not_active Expired - Fee Related
- 1991-12-16 SK SK3815-91A patent/SK278597B6/sk unknown
- 1991-12-16 EP EP91810981A patent/EP0491664B1/en not_active Expired - Lifetime
- 1991-12-16 AU AU89791/91A patent/AU651640B2/en not_active Ceased
- 1991-12-16 MX MX9102582A patent/MX9102582A/es unknown
- 1991-12-16 CZ CS913815A patent/CZ280647B6/cs not_active IP Right Cessation
- 1991-12-16 DK DK91810981T patent/DK0491664T3/da active
- 1991-12-16 ES ES91810981T patent/ES2113368T3/es not_active Expired - Lifetime
- 1991-12-16 FI FI915920A patent/FI102069B/fi active IP Right Grant
- 1991-12-16 AT AT91810981T patent/ATE163648T1/de not_active IP Right Cessation
- 1991-12-16 SG SG1996002729A patent/SG47026A1/en unknown
- 1991-12-16 MY MYPI91002317A patent/MY109983A/en unknown
- 1991-12-16 IL IL10038491A patent/IL100384A/en not_active IP Right Cessation
- 1991-12-16 NZ NZ240993A patent/NZ240993A/en unknown
- 1991-12-17 IE IE438791A patent/IE914387A1/en not_active Application Discontinuation
- 1991-12-17 KR KR1019910023435A patent/KR920011489A/ko not_active Application Discontinuation
- 1991-12-17 PT PT99829A patent/PT99829B/pt not_active IP Right Cessation
- 1991-12-17 CA CA002057391A patent/CA2057391A1/en not_active Abandoned
- 1991-12-17 JP JP3333271A patent/JP2740777B2/ja not_active Expired - Lifetime
- 1991-12-18 US US07/809,815 patent/US5272154A/en not_active Expired - Fee Related
-
1995
- 1995-04-21 US US08/426,558 patent/US5543426A/en not_active Expired - Fee Related
-
1998
- 1998-04-03 GR GR980400689T patent/GR3026506T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU8979191A (en) | 1992-06-25 |
PT99829B (pt) | 2000-08-31 |
CA2057391A1 (en) | 1992-06-19 |
IL100384A0 (en) | 1992-09-06 |
NZ240993A (en) | 1994-08-26 |
HU211081B (en) | 1995-10-30 |
EP0491664B1 (en) | 1998-03-04 |
HUT61543A (en) | 1993-01-28 |
SG47026A1 (en) | 1998-03-20 |
FI102069B1 (fi) | 1998-10-15 |
FI915920A0 (fi) | 1991-12-16 |
US5272154A (en) | 1993-12-21 |
JP2740777B2 (ja) | 1998-04-15 |
MX9102582A (es) | 1993-01-01 |
US5543426A (en) | 1996-08-06 |
FI915920A (fi) | 1992-06-19 |
FI102069B (fi) | 1998-10-15 |
ATE163648T1 (de) | 1998-03-15 |
IL100384A (en) | 1996-05-14 |
CS381591A3 (en) | 1992-07-15 |
DE69129009D1 (de) | 1998-04-09 |
SK278597B6 (en) | 1997-11-05 |
HU913792D0 (en) | 1992-02-28 |
AU651640B2 (en) | 1994-07-28 |
JPH04308590A (ja) | 1992-10-30 |
IE914387A1 (en) | 1992-07-01 |
KR920011489A (ko) | 1992-07-24 |
EP0491664A1 (en) | 1992-06-24 |
MY109983A (en) | 1997-10-31 |
PT99829A (pt) | 1992-12-31 |
DE69129009T2 (de) | 1998-07-23 |
GR3026506T3 (en) | 1998-07-31 |
ES2113368T3 (es) | 1998-05-01 |
CZ280647B6 (cs) | 1996-03-13 |
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