FI915920A - Serotoninantagonister. - Google Patents
Serotoninantagonister. Download PDFInfo
- Publication number
- FI915920A FI915920A FI915920A FI915920A FI915920A FI 915920 A FI915920 A FI 915920A FI 915920 A FI915920 A FI 915920A FI 915920 A FI915920 A FI 915920A FI 915920 A FI915920 A FI 915920A
- Authority
- FI
- Finland
- Prior art keywords
- serotoninantagonister
- chem
- useful
- formula
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909027424A GB9027424D0 (en) | 1990-12-18 | 1990-12-18 | Improvements in or relating to organic compounds |
GB909027425A GB9027425D0 (en) | 1990-12-18 | 1990-12-18 | Improvements in or relating to organic compounds |
GB919113596A GB9113596D0 (en) | 1991-06-24 | 1991-06-24 | Improvements in or relating to organic compounds |
Publications (4)
Publication Number | Publication Date |
---|---|
FI915920A0 FI915920A0 (fi) | 1991-12-16 |
FI915920A true FI915920A (fi) | 1992-06-19 |
FI102069B1 FI102069B1 (fi) | 1998-10-15 |
FI102069B FI102069B (fi) | 1998-10-15 |
Family
ID=27265408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI915920A FI102069B (fi) | 1990-12-18 | 1991-12-16 | Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmist amiseksi |
Country Status (22)
Country | Link |
---|---|
US (2) | US5272154A (fi) |
EP (1) | EP0491664B1 (fi) |
JP (1) | JP2740777B2 (fi) |
KR (1) | KR920011489A (fi) |
AT (1) | ATE163648T1 (fi) |
AU (1) | AU651640B2 (fi) |
CA (1) | CA2057391A1 (fi) |
CZ (1) | CZ280647B6 (fi) |
DE (1) | DE69129009T2 (fi) |
DK (1) | DK0491664T3 (fi) |
ES (1) | ES2113368T3 (fi) |
FI (1) | FI102069B (fi) |
GR (1) | GR3026506T3 (fi) |
HU (1) | HU211081B (fi) |
IE (1) | IE914387A1 (fi) |
IL (1) | IL100384A (fi) |
MX (1) | MX9102582A (fi) |
MY (1) | MY109983A (fi) |
NZ (1) | NZ240993A (fi) |
PT (1) | PT99829B (fi) |
SG (1) | SG47026A1 (fi) |
SK (1) | SK278597B6 (fi) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69111816T4 (de) * | 1990-08-31 | 1996-08-01 | Nippon Shinyaku Co Ltd | Indolederivate und ihre verwendung als serotonin-antagoniste. |
IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
BR0212477A (pt) * | 2001-09-12 | 2004-08-24 | Upjohn Co | 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças |
HUP0402289A2 (hu) | 2001-10-02 | 2005-02-28 | Pharmacia & Upjohn Company | Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
CA2464333C (en) * | 2001-10-26 | 2011-07-26 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
MXPA04004373A (es) | 2001-11-09 | 2004-08-11 | Upjohn Co | Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades. |
EP1476448A2 (en) * | 2002-02-19 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Azabicyclic compounds for the treatment of disease |
US6858613B2 (en) * | 2002-02-19 | 2005-02-22 | Pfizer Inc. | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease |
JP4890762B2 (ja) | 2002-09-25 | 2012-03-07 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、及びベンゾイソチアゾール、並びにそれらの調製及び使用 |
JP2006506395A (ja) * | 2002-11-01 | 2006-02-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | CNS疾患の治療のための、α7ニコチンアゴニスト活性及び5HT3アンタゴニスト活性を有する化合物 |
DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
CN103724343A (zh) * | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
WO2006001894A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
BRPI0510212A (pt) * | 2004-05-07 | 2007-10-16 | Memory Pharm Corp | 1h-indazóis, benzotiazóis, 1,2 - benzoisoxazóis, 1,2-benzoisotiazóis, e cromonas e a preparação e usos dos mesmos |
DE602005016446D1 (de) * | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
DE602005014566D1 (de) * | 2004-11-05 | 2009-07-02 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
MX2007007328A (es) | 2004-12-22 | 2007-07-25 | Memory Pharm Corp | Ligandos del receptor alfa-7 nicotinico y preparacion y sus usos. |
CA2588037A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
NZ560828A (en) * | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
US8106066B2 (en) * | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
CN104193741B (zh) * | 2007-10-01 | 2016-08-24 | 阿尔法梅根有限责任公司 | 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物 |
JOP20130213B1 (ar) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
WO2016007630A1 (en) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
PL3201203T3 (pl) | 2014-09-29 | 2021-11-22 | Takeda Pharmaceutical Company Limited | Krystaliczna postać 1-(1-metylo-1h-pirazol-4-ilo)-n-((1r,5s,7s)-9-metylo-3-oksa-9-azabicyklo[3.3.1]nonan-7-ylo)-1h-indolo-3-karboksyamidu |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
EP0189002B1 (en) * | 1984-12-20 | 1993-03-03 | Sandoz Ag | Treatment of gastrointestinal disorders using 5-ht3 antagonists |
DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | Hoffmann La Roche | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
US4859662A (en) * | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
ATE152623T1 (de) * | 1986-12-17 | 1997-05-15 | Glaxo Group Ltd | Verwendung von heterozyklischen derivaten zur herstellung von arzneimitteln |
EP0278173B1 (en) * | 1986-12-17 | 1993-11-03 | Glaxo Group Limited | Use of heterocyclic derivatives in the treatment of depressions |
GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
US4939144A (en) * | 1987-10-22 | 1990-07-03 | Glaxo Group Limited | Tricyclic ketone derivatives as 5-HT antagonists |
EP0340270B1 (en) * | 1987-11-14 | 1992-07-15 | Beecham Group Plc | 5-ht 3? receptor antagonists for treatment of cough and bronchoconstriction |
DE3810552A1 (de) * | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
DK185489A (da) * | 1988-04-22 | 1989-10-23 | Duphar Int Res | Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse |
US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
GB8814277D0 (en) * | 1988-06-16 | 1988-07-20 | Glaxo Group Ltd | Chemical compounds |
IL91167A (en) * | 1988-08-02 | 1993-06-10 | Glaxo Group Ltd | Substituted 2-(imidazolymethyl)-pyrido- (and azepino-) indol-1-one derivatives, their preparation and pharmaceutical compositions containing them |
FR2639944B1 (fr) * | 1988-12-06 | 1991-01-18 | Adir | Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
IT1228293B (it) * | 1989-02-06 | 1991-06-07 | Angeli Inst Spa | Benzoderivati di composti eterociclici contenenti azoto. |
GB8904551D0 (en) * | 1989-02-28 | 1989-04-12 | Glaxo Group Ltd | Chemical compounds |
ZA902794B (en) * | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
GB8916682D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Pharmaceutical compounds |
-
1991
- 1991-12-04 HU HU913792A patent/HU211081B/hu not_active IP Right Cessation
- 1991-12-16 SK SK3815-91A patent/SK278597B6/sk unknown
- 1991-12-16 MY MYPI91002317A patent/MY109983A/en unknown
- 1991-12-16 DE DE69129009T patent/DE69129009T2/de not_active Expired - Fee Related
- 1991-12-16 AU AU89791/91A patent/AU651640B2/en not_active Ceased
- 1991-12-16 IL IL10038491A patent/IL100384A/en not_active IP Right Cessation
- 1991-12-16 SG SG1996002729A patent/SG47026A1/en unknown
- 1991-12-16 CZ CS913815A patent/CZ280647B6/cs not_active IP Right Cessation
- 1991-12-16 EP EP91810981A patent/EP0491664B1/en not_active Expired - Lifetime
- 1991-12-16 DK DK91810981T patent/DK0491664T3/da active
- 1991-12-16 FI FI915920A patent/FI102069B/fi active IP Right Grant
- 1991-12-16 MX MX9102582A patent/MX9102582A/es unknown
- 1991-12-16 ES ES91810981T patent/ES2113368T3/es not_active Expired - Lifetime
- 1991-12-16 AT AT91810981T patent/ATE163648T1/de not_active IP Right Cessation
- 1991-12-16 NZ NZ240993A patent/NZ240993A/en unknown
- 1991-12-17 KR KR1019910023435A patent/KR920011489A/ko not_active Application Discontinuation
- 1991-12-17 IE IE438791A patent/IE914387A1/en not_active Application Discontinuation
- 1991-12-17 PT PT99829A patent/PT99829B/pt not_active IP Right Cessation
- 1991-12-17 JP JP3333271A patent/JP2740777B2/ja not_active Expired - Lifetime
- 1991-12-17 CA CA002057391A patent/CA2057391A1/en not_active Abandoned
- 1991-12-18 US US07/809,815 patent/US5272154A/en not_active Expired - Fee Related
-
1995
- 1995-04-21 US US08/426,558 patent/US5543426A/en not_active Expired - Fee Related
-
1998
- 1998-04-03 GR GR980400689T patent/GR3026506T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2740777B2 (ja) | 1998-04-15 |
FI102069B1 (fi) | 1998-10-15 |
NZ240993A (en) | 1994-08-26 |
EP0491664B1 (en) | 1998-03-04 |
US5543426A (en) | 1996-08-06 |
ES2113368T3 (es) | 1998-05-01 |
AU651640B2 (en) | 1994-07-28 |
HU913792D0 (en) | 1992-02-28 |
DK0491664T3 (da) | 1998-09-28 |
SG47026A1 (en) | 1998-03-20 |
KR920011489A (ko) | 1992-07-24 |
IL100384A0 (en) | 1992-09-06 |
JPH04308590A (ja) | 1992-10-30 |
FI915920A0 (fi) | 1991-12-16 |
PT99829A (pt) | 1992-12-31 |
CZ280647B6 (cs) | 1996-03-13 |
GR3026506T3 (en) | 1998-07-31 |
HUT61543A (en) | 1993-01-28 |
MX9102582A (es) | 1993-01-01 |
US5272154A (en) | 1993-12-21 |
HU211081B (en) | 1995-10-30 |
IE914387A1 (en) | 1992-07-01 |
DE69129009T2 (de) | 1998-07-23 |
AU8979191A (en) | 1992-06-25 |
MY109983A (en) | 1997-10-31 |
EP0491664A1 (en) | 1992-06-24 |
IL100384A (en) | 1996-05-14 |
PT99829B (pt) | 2000-08-31 |
ATE163648T1 (de) | 1998-03-15 |
CS381591A3 (en) | 1992-07-15 |
DE69129009D1 (de) | 1998-04-09 |
SK278597B6 (en) | 1997-11-05 |
FI102069B (fi) | 1998-10-15 |
CA2057391A1 (en) | 1992-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: NOVARTIS AG |
|
GB | Transfer or assigment of application |
Owner name: NOVARTIS AG |