GR3026506T3 - Indole derivatives as serotonin antagonists - Google Patents

Indole derivatives as serotonin antagonists

Info

Publication number
GR3026506T3
GR3026506T3 GR980400689T GR980400689T GR3026506T3 GR 3026506 T3 GR3026506 T3 GR 3026506T3 GR 980400689 T GR980400689 T GR 980400689T GR 980400689 T GR980400689 T GR 980400689T GR 3026506 T3 GR3026506 T3 GR 3026506T3
Authority
GR
Greece
Prior art keywords
indole derivatives
serotonin antagonists
serotonin
antagonists
derivatives
Prior art date
Application number
GR980400689T
Other languages
English (en)
Inventor
Arnold Keith Dixon
Rudolf Karl Andreas Giger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909027424A external-priority patent/GB9027424D0/en
Priority claimed from GB909027425A external-priority patent/GB9027425D0/en
Priority claimed from GB919113596A external-priority patent/GB9113596D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of GR3026506T3 publication Critical patent/GR3026506T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR980400689T 1990-12-18 1998-04-03 Indole derivatives as serotonin antagonists GR3026506T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909027424A GB9027424D0 (en) 1990-12-18 1990-12-18 Improvements in or relating to organic compounds
GB909027425A GB9027425D0 (en) 1990-12-18 1990-12-18 Improvements in or relating to organic compounds
GB919113596A GB9113596D0 (en) 1991-06-24 1991-06-24 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
GR3026506T3 true GR3026506T3 (en) 1998-07-31

Family

ID=27265408

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400689T GR3026506T3 (en) 1990-12-18 1998-04-03 Indole derivatives as serotonin antagonists

Country Status (22)

Country Link
US (2) US5272154A (el)
EP (1) EP0491664B1 (el)
JP (1) JP2740777B2 (el)
KR (1) KR920011489A (el)
AT (1) ATE163648T1 (el)
AU (1) AU651640B2 (el)
CA (1) CA2057391A1 (el)
CZ (1) CZ280647B6 (el)
DE (1) DE69129009T2 (el)
DK (1) DK0491664T3 (el)
ES (1) ES2113368T3 (el)
FI (1) FI102069B1 (el)
GR (1) GR3026506T3 (el)
HU (1) HU211081B (el)
IE (1) IE914387A1 (el)
IL (1) IL100384A (el)
MX (1) MX9102582A (el)
MY (1) MY109983A (el)
NZ (1) NZ240993A (el)
PT (1) PT99829B (el)
SG (1) SG47026A1 (el)
SK (1) SK278597B6 (el)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8405891A (en) * 1990-08-31 1992-03-30 Nippon Shinyaku Co. Ltd. Indole derivative and medicine
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
CA2460075A1 (en) * 2001-09-12 2003-03-20 Donn Gregory Wishka Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases
HUP0402289A2 (hu) 2001-10-02 2005-02-28 Pharmacia & Upjohn Company Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
JP2005510492A (ja) * 2001-10-26 2005-04-21 ユニバーシティ オブ コネチカット 新規な種類の効力のあるカンナビミメティックリガンド
JP2005510523A (ja) 2001-11-09 2005-04-21 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー アザ二環式フェニル縮合複素環式化合物、及びα７ＮＡＣＨＲリガンドとしての当該化合物の使用
BR0307782A (pt) * 2002-02-19 2005-01-04 Upjohn Co Compostos azabiciclo para o tratamento de doença
WO2003070732A1 (en) * 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
WO2004029050A1 (en) 2002-09-25 2004-04-08 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
CA2503786A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
JP4824578B2 (ja) 2003-12-22 2011-11-30 メモリー・ファーマシューティカルズ・コーポレイション インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
CA2560741C (en) 2004-03-25 2013-08-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7488737B2 (en) * 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
JP2007538011A (ja) * 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
WO2006052889A2 (en) * 2004-11-05 2006-05-18 Theravance, Inc. Quinolinone-carboxamide compounds
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
US7419989B2 (en) * 2004-12-22 2008-09-02 Theravance, Inc. Indazole-carboxamide compounds
US7625924B2 (en) * 2004-12-22 2009-12-01 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2217597B1 (en) 2007-10-01 2011-03-30 Comentis, Inc. Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
JP2017524736A (ja) 2014-07-11 2017-08-31 アルファーマゲン，エルエルシー アルファ７−ニコチン性アセチルコリン受容体活性を調節するためのキヌクリジン化合物
WO2016053947A1 (en) 2014-09-29 2016-04-07 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
DE3687080T2 (de) * 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US4859662A (en) * 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US4973594A (en) * 1986-12-17 1990-11-27 Glaxo Group Limited Medicaments
ES2074981T3 (es) * 1986-12-17 1995-10-01 Glaxo Group Ltd Uso de derivados heterociclicos en el tratamiento de trastornos cognoscitivos.
GB8701022D0 (en) * 1987-01-19 1987-02-18 Beecham Group Plc Treatment
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
EP0340270B1 (en) * 1987-11-14 1992-07-15 Beecham Group Plc 5-ht 3? receptor antagonists for treatment of cough and bronchoconstriction
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8814277D0 (en) * 1988-06-16 1988-07-20 Glaxo Group Ltd Chemical compounds
ATE138659T1 (de) * 1988-08-02 1996-06-15 Glaxo Group Ltd Lactamderivate
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
ZA902794B (en) * 1989-04-18 1991-04-24 Duphar Int Res New 3-n substituted carbamoyl-indole derivatives
GB8916682D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Pharmaceutical compounds

Also Published As

Publication number Publication date
NZ240993A (en) 1994-08-26
PT99829A (pt) 1992-12-31
FI915920A (fi) 1992-06-19
JP2740777B2 (ja) 1998-04-15
FI915920A0 (fi) 1991-12-16
IL100384A0 (en) 1992-09-06
CS381591A3 (en) 1992-07-15
DE69129009D1 (de) 1998-04-09
PT99829B (pt) 2000-08-31
HU913792D0 (en) 1992-02-28
EP0491664B1 (en) 1998-03-04
MY109983A (en) 1997-10-31
EP0491664A1 (en) 1992-06-24
KR920011489A (ko) 1992-07-24
AU8979191A (en) 1992-06-25
US5272154A (en) 1993-12-21
JPH04308590A (ja) 1992-10-30
SK278597B6 (en) 1997-11-05
HU211081B (en) 1995-10-30
DE69129009T2 (de) 1998-07-23
IL100384A (en) 1996-05-14
DK0491664T3 (da) 1998-09-28
US5543426A (en) 1996-08-06
HUT61543A (en) 1993-01-28
FI102069B (fi) 1998-10-15
SG47026A1 (en) 1998-03-20
AU651640B2 (en) 1994-07-28
ES2113368T3 (es) 1998-05-01
CA2057391A1 (en) 1992-06-19
CZ280647B6 (cs) 1996-03-13
ATE163648T1 (de) 1998-03-15
IE914387A1 (en) 1992-07-01
MX9102582A (es) 1993-01-01
FI102069B1 (fi) 1998-10-15

Similar Documents

Publication Publication Date Title
GR3026506T3 (en) Indole derivatives as serotonin antagonists
ZA917744B (en) Fused ring analogs of nitrogen containing nonaromatic heterocycles.
HUT61153A (en) Process for producing substituted and heterocyclic phthalides
MY107157A (en) Quinuclidine derivatives.
NZ225820A (en) Piperidyl substituted indole derivatives and pharmaceutical compositions
HU9401468D0 (en) 1,3-substituted cycloalkenes and cycloalkanes
HUT66596A (en) Process for preparing piperidine derivatives
ES2062374T3 (es) Heteroarilpiperazinas, agentes antipsicoticos.
DK0444853T3 (da) Hexahydrobenz(cd)indoler
DE69309259D1 (de) 3,4&#39;-didesoxymycaminosyltylonolid-derivate und herstellung davon
FI913506A0 (fi) Foerfarande foer framstaellning av 6-(substituerat aminopropionyl)-derivat av forskolin.
HU913212D0 (en) New ergoline derivatives
ATE91487T1 (de) Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.