ES2098109T3 - Derivados de 1,2,3,4-tetrahidronaftaleno, de cromano y de tiocromano como agentes antitromboticos. - Google Patents
Derivados de 1,2,3,4-tetrahidronaftaleno, de cromano y de tiocromano como agentes antitromboticos.Info
- Publication number
- ES2098109T3 ES2098109T3 ES94402299T ES94402299T ES2098109T3 ES 2098109 T3 ES2098109 T3 ES 2098109T3 ES 94402299 T ES94402299 T ES 94402299T ES 94402299 T ES94402299 T ES 94402299T ES 2098109 T3 ES2098109 T3 ES 2098109T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- thiocroman
- tetrahidronaftalene
- chroman
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- -1 ALKOXI (C1-C6) GROUP Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I) EN LA QUE: R1, R2 IDENTICOS O DIFERENTES REPRESENTA UN ATOMO DE HIDROGENO, DE HALOGENO, UN GRUPO ALKILO, FENILO SUSTITUIDO O NO, BENCILO, PIRIMETILO O IOMIDAZOLIMETILO, TIAZOLILMETILO, PIRIDILO, IMIDAZOLILO O TIAZOLILO, O BIEN R1 Y R2 FORMAN CON LOS ATOMOS DE CARBONO A LOS QUE ESTAN SUJETOS UN CICLO CICLOPENTANO O CICLOHEXANO, R3 REPRESENTA UN GRUPO HIDROXI, ALKOXI (C1-C6) LINEAL O RAMIFICADO O AMINOSUSTITUIDO O NO, R 4 REPRESENTA UN GRUPO ALKILO, FENILO SUSTITUIDO O NO, NAFTILO, PIRIDILO O TIENILO, X REPRESENTA UN GRUPO METILENO, UN ATOMO DE OXIGENO O DE AZUFRE, SUS ENANTIOMEROS, ASI COMO SUS SALES DE ADICION A UNA BASE FARMACEUTICAMENTE ACEPTABLES. MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9312237A FR2711139B1 (fr) | 1993-10-15 | 1993-10-15 | Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2098109T3 true ES2098109T3 (es) | 1997-04-16 |
Family
ID=9451827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94402299T Expired - Lifetime ES2098109T3 (es) | 1993-10-15 | 1994-10-13 | Derivados de 1,2,3,4-tetrahidronaftaleno, de cromano y de tiocromano como agentes antitromboticos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5472979A (es) |
EP (1) | EP0648741B1 (es) |
JP (1) | JP2859138B2 (es) |
AT (1) | ATE146454T1 (es) |
AU (1) | AU676377B2 (es) |
CA (1) | CA2118102C (es) |
CY (1) | CY2141B1 (es) |
DE (1) | DE69401190T2 (es) |
DK (1) | DK0648741T3 (es) |
ES (1) | ES2098109T3 (es) |
FR (1) | FR2711139B1 (es) |
GR (1) | GR3022637T3 (es) |
HK (1) | HK64397A (es) |
NZ (1) | NZ264703A (es) |
ZA (1) | ZA948082B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9509156D0 (en) | 1995-05-05 | 1995-06-28 | Sandoz Ltd | Organic compounds |
DE19647000A1 (de) * | 1996-11-14 | 1998-05-20 | Hoechst Ag | 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
FR2760235B1 (fr) * | 1997-02-28 | 1999-04-09 | Adir | Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2803848B1 (fr) * | 2000-01-19 | 2002-02-15 | Adir | Nouveaux derives de benzenesulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP4490543B2 (ja) * | 2000-03-07 | 2010-06-30 | 日本曹達株式会社 | α−アミノケトン類の製造方法 |
FR2838057B1 (fr) * | 2002-04-05 | 2005-07-08 | Servier Lab | Nouvelle association d'un antithrombotique et d'aspirine |
FR2857593B1 (fr) * | 2003-07-18 | 2005-10-14 | Servier Lab | Composition pharmaceutique orodispersible d'un compose antithrombotique |
FR2860436B1 (fr) * | 2003-10-03 | 2006-01-20 | Servier Lab | Nouvelle association d'un anti-atherothrombotique et d'un antiagregant plaquettaire |
FR2899473B1 (fr) * | 2006-04-07 | 2008-06-13 | Servier Lab | Utilisation d'un compose anti-atherothrombotique pour l'obtention de medicaments destines au traitement des troubles vasculaires |
FR2920772B1 (fr) | 2007-09-11 | 2009-10-23 | Servier Lab | Association entre un anti-atherothrombotique et un inhibiteur de l'enzyme de conversion de l'angiotensine |
EP2098511A1 (en) | 2008-03-07 | 2009-09-09 | Solvias AG | Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring |
WO2012015944A2 (en) | 2010-07-29 | 2012-02-02 | The Trustees Of The University Of Pennsylvania | Novel tetrahydronaphalene antagonists to the thromboxane a2 (tp) receptor |
CN103102292B (zh) * | 2011-11-14 | 2015-05-20 | 上海医药工业研究院 | 一种快速无污染由伯醇氧化为醛的方法 |
US9643919B2 (en) | 2013-04-04 | 2017-05-09 | The Trustees Of The University Of Pennsylvania | Cycloalkyl-dione derivatives and methods of their use |
CN108707115B (zh) * | 2018-07-17 | 2020-09-01 | 成都道合尔医药技术有限公司 | 一种丙烯酸衍生物的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH22076A (en) * | 1983-08-25 | 1988-05-20 | Daiichi Seiyaku Co | Benzocycloalkane derivative |
DE3623941A1 (de) * | 1986-07-16 | 1988-01-28 | Bayer Ag | Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel |
US5206428A (en) * | 1989-11-16 | 1993-04-27 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthalene derivatives and preparation thereof |
JPH05178814A (ja) * | 1991-05-14 | 1993-07-20 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
-
1993
- 1993-10-15 FR FR9312237A patent/FR2711139B1/fr not_active Expired - Fee Related
-
1994
- 1994-10-13 DE DE69401190T patent/DE69401190T2/de not_active Expired - Lifetime
- 1994-10-13 AU AU75820/94A patent/AU676377B2/en not_active Ceased
- 1994-10-13 AT AT94402299T patent/ATE146454T1/de active
- 1994-10-13 DK DK94402299.5T patent/DK0648741T3/da active
- 1994-10-13 CA CA002118102A patent/CA2118102C/fr not_active Expired - Fee Related
- 1994-10-13 EP EP94402299A patent/EP0648741B1/fr not_active Expired - Lifetime
- 1994-10-13 ES ES94402299T patent/ES2098109T3/es not_active Expired - Lifetime
- 1994-10-14 NZ NZ264703A patent/NZ264703A/en not_active IP Right Cessation
- 1994-10-14 ZA ZA948082A patent/ZA948082B/xx unknown
- 1994-10-14 US US08/323,508 patent/US5472979A/en not_active Expired - Lifetime
- 1994-10-14 JP JP6249589A patent/JP2859138B2/ja not_active Expired - Fee Related
-
1997
- 1997-02-21 GR GR970400323T patent/GR3022637T3/el unknown
- 1997-05-15 HK HK64397A patent/HK64397A/xx not_active IP Right Cessation
-
1999
- 1999-11-19 CY CY9900037A patent/CY2141B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA948082B (en) | 1995-06-05 |
JP2859138B2 (ja) | 1999-02-17 |
US5472979A (en) | 1995-12-05 |
HK64397A (en) | 1997-05-23 |
ATE146454T1 (de) | 1997-01-15 |
CY2141B1 (en) | 2002-06-21 |
AU676377B2 (en) | 1997-03-06 |
DK0648741T3 (da) | 1997-06-09 |
FR2711139B1 (fr) | 1995-12-01 |
DE69401190T2 (de) | 1997-07-03 |
EP0648741A1 (fr) | 1995-04-19 |
EP0648741B1 (fr) | 1996-12-18 |
CA2118102A1 (fr) | 1995-04-16 |
AU7582094A (en) | 1995-05-11 |
FR2711139A1 (fr) | 1995-04-21 |
DE69401190D1 (de) | 1997-01-30 |
NZ264703A (en) | 1995-09-26 |
CA2118102C (fr) | 2000-11-07 |
JPH07188155A (ja) | 1995-07-25 |
GR3022637T3 (en) | 1997-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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